scholarly journals COMBINED TREATMENT OF PATHOSOSPERMIA WITH ADJUVANT THERAPY WITH SPEROTON COM- PLEX IN PATIENTS WITH VARICOCELE

2020 ◽  
pp. 48-56
Author(s):  
E. А. Povelitsa ◽  
N. I. Dosta ◽  
O.V. Parhomenko ◽  
A.M. Shesternja
Keyword(s):  
Adjuvant Therapy ◽  
Spermatic Cord ◽  
Varicose Veins ◽  
Combined Treatment ◽  
Study Groups ◽  
Reproductive Age ◽  
Fragmentation Index ◽  
Mobile Forms ◽  
Before And After ◽  
Dna Fragmentation Index

OBJECTIVE To evaluate the effectiveness of combined treatment of pathozoospermia in patients with varicocele by performing micro- surgical phlebectomy of varicose veins of the spermatic cord in combination with adjuvant therapy with the Speroton complex MATERIAL AND METHODS Twenty microsurgical phlebectomies of varicose veins of the spermatic cord were performed in patients with pathozoo- spermia (oligoasthenospermia) against the background of varicocele with the appointment of the Speroton complex in the postoperative period for 3 months with an assessment of spermogram parameters before and after the operation in comparison with a group of 20 men with pathozocelemia without the use of adjuvant therapy. The study of morphological and functional parameters of spermogram of men of reproductive age (18-49 years) without signs of immune infertility (MAR-test IgG <10%) before and after the start of treatment was carried out. The average age of men was 33 ± 2.3 years (M ± m). RESULTS All patients with infertility in combination with varicocele had oligoasthenozoospermia before treatment. Three months after the start of treatment in the study groups, there was a statistically significant improvement in sperm counts due to an increase in the concentration of spermatozoa in 1 ml of ejaculate, an increase in the number of progressively mobile forms and total motility of spermatozoa by 50-68%, an increase in the number of live sperm by 19-20% and a decrease in the num- ber of dead forms of spermatozoa by 30-35%. A statistically significant decrease in the DNA fragmentation index by 34-52% (p <0.05) was found in all study groups. It was found that combination therapy, including microsurgical phlebectomy of the spermatic cord veins using the Speroton complex for 3 months, statistically significantly led to an increase in the concentration of spermatozoa in 1 ml of ejaculate (38.6 [38.2; 69.4]), an increase in progressively mobile forms (49.2 [26.7; 47.2]%) and general motility (72.2 [35.3; 64.7]%) of spermatozoa and viable forms (67.8 [39.3; 81.7] %), a decrease in the DNA fragmenta- tion index compared with the spermogram indicators of patients who underwent only microsurgical phlebectomy (p <0.05 for all study indicators). In the group of patients after combined treatment with the inclusion of adjuvant therapy of the Speroton complex, there was a statistically significant decrease in the sperm DNA fragmentation index to almost normal values (12.1 ± 1.1%) compared with the group of patients who underwent only surgery (17.2 ± 0.8%) (p = 0.01). Combined treatment (micro- surgical phlebectomy of the veins of the spermatic cord in combination with adjuvant therapy Speroton) of pathozoospermia in men of reproductive age with infertility on the background of varicocele can significantly improve the morphofunctional parameters of spermogram after 3 months from the start of treatment compared to men who underwent only surgical correction of varicocele.

scholarly journals Combined treatment of oligoasthenospermia by postoperative Speroton therapy in patients with varicocele

2020 ◽  
Vol 21 (2) ◽  
pp. 64-69
Author(s):  
E. A. Povelitsa ◽  
V. E. Leanovich ◽  
N. I. Dosta ◽  
O. V. Parhomenko ◽  
A. M. Shesternya
Keyword(s):  
Spermatic Cord ◽  
Varicose Veins ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Sperm Concentration ◽  
Study Groups ◽  
Reproductive Age ◽  
Control Group ◽  
Study Objective ◽  
Before And After

The study objective is to evaluate the effectiveness of the Speroton complex therapy in combined treatment of oligoasthenospermia in patients with varicocele after microsurgical phlebectomy of varicose veins of the spermatic cord.Materials and methods. Microsurgical phlebectomy of the spermatic cord was performed in 40 men (mean age 33.0 ± 2.3 years) with oligoasthenospermia and varicocele. The patients were divided into 2 groups: the main group included 20 men who were treated with the Speroton complex for 3 months in the postoperative period, and the control group included 20 men who did not take Speroton. The spermogram parameters were evaluated before and after the operation.Results. Three months after the start of treatment, a statistically significant improvement in spermogram indicators was noted in all study groups. It was determined that combined therapy that included the Speroton complex administration for 3 months, statistically significantly led to the more considerable increase in sperm parameters than in control group: the sperm concentration increased to 38.6 and 28.9 mln/ml, respectively, the percentage of progressive motile sperm – to 49.2 and 39.4 %, the percentage of motile forms – to 72.2 and 43.8 %, viable forms – to 67.8 and 58.1 %, and the percentage of sperm with DNA fragmentation decreased to 12.1 and 17.2 %, respectively, in the main and control groups.Conclusion. Combined treatment with postoperative Speroton therapy for men of reproductive age with infertility and varicocele determines the more significant improvement in the parameters of sperm than performing only surgical correction of varicocele.

Influence of obesity on sperm DNA fragmentation index and outcomes of IVF programs

2015 ◽  
Vol 61 (5) ◽  
pp. 48-55 ◽  
Author(s):  
Irina Ivanovna Vitiazeva ◽  
Marina Victorovna Altashina ◽  
Tatiana Vladimirovna Mun ◽  
Ekaterina Anatolievna Troshina
Keyword(s):  
Body Mass Index ◽  
Dna Fragmentation ◽  
Body Mass ◽  
Reproductive Age ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Fragmentation Index ◽  
Sperm Dna ◽  
Sperm Dna Fragmentation Index ◽  
Dna Fragmentation Index

The reduction of the birth rates in the developed countries and increase in the frequency of male infertility stimulate the extensive investigations for the factors that negatively affect the reproductive system of the men and causing their infertility. The excessive body weight and obesity in the men of the reproductive age can promote the development of infertility. One of the mechanisms by which excess fat tissue has a negative impact on male fertility is disturbance of spermatogenesis. The authors aggregate scientific publications concerning the macroscopic and ultrastructural disturbances of spermatogenesis in men with obesity. We present the results of the study conducted at the Department of ART Endocrinology Research Center, targeted at the revelation of the relationship of body mass index of men of reproductive age, semen parameters, sperm DNA fragmentation index, as well as the influence of body mass index on outcomes of in vitro fertilization programs.

scholarly journals Endothelial Dysfunction in the Pathogenesis of Chronic Inflammatory Processes of the Internal Genital Organs in Women

2018 ◽  
Vol 24 (4) ◽  
Author(s):  
Natalya Drohomyretska ◽  
Natalya Henyk
Keyword(s):  
Endothelial Dysfunction ◽  
Functional Activity ◽  
Varicose Veins ◽  
Study Groups ◽  
Control Group ◽  
Plasma Coagulation ◽  
Endothelin 1 ◽  
Before And After ◽  
Inflammatory Processes ◽  
Group 2

The objective of the work: to study the changes of the functional activity of the endothelium and the plasma-coagulation link of hemostasis in women with chronic inflammatory processes of the internal genital organs (CIPIGO) with and without varicose veins of the small pelvis (VVSP).Materials and methods: 68 women with chronic inflammatory processes of the internal genital organs against the background of varicose veins of the small pelvis (group 1); 52 women with chronic inflammatory processes of the pelvic organs without varicose veins of the small pelvis (group 2); 30 practically healthy women (control group) were examined before and after the treatment. The age of women was between 18 and 45 years old. All the patients of the study groups received the treatment offered by us, which included a diosmine-containing phlebotropic preparation normoven, 500 mg twice a day in continuous mode and a donor of nitric oxide tivortin aspartatum, 5 ml 3 times per os for 14 days each month during six months.Determination of concentration of endothelin-1, prostacyclin was performed by immunoassay using a set of reagents from the firm “Biomediсa” (Austria); the determination of D-dimers in blood plasma was performed by latex-test of the firm “Organon-Tekhnika”.Results of workIn women with CIPIGO with and without VVSP, the increased production of endothelin-1, which has a pro-aggregate and pro-inflammatory effect, was determined. At the same time, the decrease of the synthesis of prostacyclin, which has anti-aggregant properties, was noted. In evaluating the indicators of coagulograms in patients of the studied groups, the propensity for hypercoagulation was revealed, as evidenced by an increase in the level of fibrinogen and a rise of index of the phospholipid-dependent coagulation tests. The decrease of the percentage of fibrinolytic blood activity and the increase in plasma concentration of the molecular marker of thrombophilia D-dimer can be considered as activation of intravascular coagulopathy and the presence of endothelial dysfunction.Conclusions: 1. Our studies found endothelial dysfunction and violations of the plasma-coagulation linkage of hemostasis in both studied groups. 2. After the performed treatment, the improvement of the functional activity of the endothelium and normalization of the main parameters of the plasma-coagulation linkage of hemostasis were observed.

scholarly journals THE EFFICACY OF A COMBINED IPL PROTOCOL AND A HYALURONIC ACID DRUG WITH MANNITOL FOR THE TREATMENT OF HYPERPIGMENTATION

2021 ◽  
Vol 3 (10(74)) ◽  
pp. 8-15
Author(s):  
E. Glagoleva ◽  
N. Podoplekina ◽  
N. Petrishchev ◽  
T. Grishacheva
Keyword(s):  
Hyaluronic Acid ◽  
Combined Treatment ◽  
Treatment Protocol ◽  
Study Groups ◽  
Evidence Base ◽  
Diverse Range ◽  
Doppler Flowmetry ◽  
Before And After ◽  
Facial Area ◽  
Experimental Group

Relevance: Today the world of therapeutic cosmetology is filled with a diverse range of methods, both laser and injection. They are aimed at the correction of various aesthetic problems. The most common complaint of a patient at a doctor-cosmetologist appointment is the presence of areas of hyperpigmentation in the facial area. In order to achieve a satisfactory result, the therapy of this pathology should be based on knowledge of the pathogenesis. In addition, it is necessary to take into account the possibility of side effects after laser treatment, which is the most frequent method chosen by doctors. Also, it is worth minimizing the risk of hyperpigmentation by improving the metabolic function of tissues. That is why the combined protocols open up the most promising horizons for the treatment of such difficult-to-correct pathology as hyperpigmentation. The aim of our study was to create an evidence base for the effectiveness of a combined treatment protocol using an IPL system in combination with a drug based on hyaluronic acid and mannitol. Materials and methods: The study involved female patients aged 18 to 45 years with a diagnosis of melasma Code L81.1; Other melanin hyperpigmentation L81.4. The study included patients who had not previously undergone laser and injection procedures in order to correct hyperpigmentation over the past 5-6 months. To evaluate the results, Antera 3D 3B visualizer in the “melanin” mode was used, as well as a laser Doppler flowmetry device Lazma-D. Results: A positive clinical result on the Antera 3D imager was observed in all study groups. It was statistically revealed that the variable Anadn did not differ between the control and experimental groups F (1.30) = 4.031, p = 0.050, ns), as well as before and after treatment (F (1.30) = 0.825, p = 0.368, ns ); the variable Afad did not differ between the control and experimental groups (F (1.30) = 2.483, p = 0.121, ns), as well as before and after treatment (F (1.30) = 3.142, p = 0.082, ns); the variable Mpm increased (p = 0.002) in the experimental group F (1.30) = 5.366, p = 0.024) after the exposure (F (1.30) = 4.718, p = 0.034); the Mpl variable did not differ between the control and experimental groups (F (1.30) = 0.61, p = 0.436, ns), as well as before and after treatment (F (1.30) = 0.028, p = 0.868, ns); The POM variable increased (p = 0.003) in the experimental group F (1.30) = 7.778, p = 0.007) after the treatment (F (1.30) = 8.541, p = 0.005). Conclusions: A significant improvement in the index of oxidative metabolism in tissues suggests that the combined protocol of hyperpigmentation therapy is the most effective and safe. In addition, such therapy allows physiological skin support during IPL therapy in combination with a preparation based on hyaluronic acid and mannitol. 

A STUDY ON THE VARIATION IN CA 72-4 LEVELS OF THE GASTRIC CANCER’S PATIENTS BEFORE AND AFTER SURGERY TREATMENT

2011 ◽  
pp. 81-87
Author(s):  
Thi Thu Huong Hoang ◽  
Minh Vuong Nguyen
Keyword(s):  
Gastric Cancer ◽  
Study Groups ◽  
University Hospital ◽  
Control Group ◽  
Central Hospital ◽  
Before And After

Objectives: Studying on the variation in CA 72-4 levels of the gastric cancer’s patients before and after 10 days and 30 days surgery treatment. Materials and methods: The studying group included 42 gastric cancer’s patients who were examinated and treated in cancerology service of Hue University Hospital and gastroenterology service of Hue Central Hospital. The control group included 30 healthy normal examinated at Hue University Hospital. The study groups were clinical, endoscopic anatopathologic examination diagnosed with gastric cancer and quantitative levels of CA 72-4 in three times points: before surgerying, after surgerying 10 days and 30 days postoperatively. Rerults: The concentration of CA 72-4 in gastric cancer’s patients was 10.06 ± 16.49 U/ml. Clearly higher than the control group 1.2 ± 0.4 U/ml(p <0.01). The rate increased levels of CA 72-4 in gastric cancer’s patients before surgerying was 27.5% and the control group was 0%. After 10 days of surgery, CA 72-4 level was 5.56 ± 8.55 U/ml; 82.5% of patients have reduced levels of CA 72-4 and 17.5% no changes; there are 0% increased cases. After 30 days of surgery, CA 72-4 level was 3.79 ± 6,52 U/ml. CA 72-4 level 10 days after surgering have decreased significantly compared to before surgery (p < 0.05) and 30 days after surgery have decreased significantly compared to after 10 days (p < 0.05). 30 days postoperatively, 90% patients had reduced levels of CA 72-4, 10% no changes, no patient had increased levels of CA 72-4 and no patient be relapsed after 30 days of treatment. Conclusions: CA 72-4 concentrations before surgerying increased 27.5%, after surgery 10 days and 30 days reduced step by step, no case have increased CA 72-4 levels, no case relapsed after 30 days.

Evaluation of Metal Contents in Correlation with Phytosanitary Treatments at Vineyard

2017 ◽  
Vol 68 (6) ◽  
pp. 1289-1293
Author(s):  
Oana Mihai ◽  
Octav Pantea ◽  
Daniela Roxana Popovici ◽  
Catalina Gabriela Gheorghe
Keyword(s):  
Soil Samples ◽  
Flame Atomic Absorption ◽  
Mobile Forms ◽  
Before And After ◽  
Phytosanitary Treatment ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Ph Range ◽  
In The Beginning ◽  
Short Time

The present work aims with the evaluation of copper, manganese and zinc concentrations (mobile forms) from vineyard soil before and after phytosanitary treatment with Curzate Manox and Dithane M-45 compounds, during and after remanence period. Different vineyard soils types were collected at 0-20 cm and 20-40 cm depths. Flame Atomic Absorption Spectroscopy (FAAS) method was used for measurements of the micronutrients. The soil samples were analyzed after 5 and 21 days after treatment application. Since copper is mainly accumulates in the upper layer following fungicidal sprays application, high levels of copper concentrations are obtained. The soil samples exhibits different behavior in terms of manganese and zinc contents. Manganese and zinc levels are classified as medium in the beginning of the experiment (Mn-M0 and Zn-M0), whereas these levels increased in the soil samples (at moments M1- 5 days and M2- 21 days after treatment). This behavior can be due to the Mancozeb decomposition, knowing that Mancozeb decomposes in the pH range 5-9 and it remains short time into the soil.

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