scholarly journals Endothelial Dysfunction in the Pathogenesis of Chronic Inflammatory Processes of the Internal Genital Organs in Women

2018 ◽  
Vol 24 (4) ◽  
Author(s):  
Natalya Drohomyretska ◽  
Natalya Henyk
Keyword(s):  
Endothelial Dysfunction ◽  
Functional Activity ◽  
Varicose Veins ◽  
Study Groups ◽  
Control Group ◽  
Plasma Coagulation ◽  
Endothelin 1 ◽  
Before And After ◽  
Inflammatory Processes ◽  
Group 2

The objective of the work: to study the changes of the functional activity of the endothelium and the plasma-coagulation link of hemostasis in women with chronic inflammatory processes of the internal genital organs (CIPIGO) with and without varicose veins of the small pelvis (VVSP).Materials and methods: 68 women with chronic inflammatory processes of the internal genital organs against the background of varicose veins of the small pelvis (group 1); 52 women with chronic inflammatory processes of the pelvic organs without varicose veins of the small pelvis (group 2); 30 practically healthy women (control group) were examined before and after the treatment. The age of women was between 18 and 45 years old. All the patients of the study groups received the treatment offered by us, which included a diosmine-containing phlebotropic preparation normoven, 500 mg twice a day in continuous mode and a donor of nitric oxide tivortin aspartatum, 5 ml 3 times per os for 14 days each month during six months.Determination of concentration of endothelin-1, prostacyclin was performed by immunoassay using a set of reagents from the firm “Biomediсa” (Austria); the determination of D-dimers in blood plasma was performed by latex-test of the firm “Organon-Tekhnika”.Results of workIn women with CIPIGO with and without VVSP, the increased production of endothelin-1, which has a pro-aggregate and pro-inflammatory effect, was determined. At the same time, the decrease of the synthesis of prostacyclin, which has anti-aggregant properties, was noted. In evaluating the indicators of coagulograms in patients of the studied groups, the propensity for hypercoagulation was revealed, as evidenced by an increase in the level of fibrinogen and a rise of index of the phospholipid-dependent coagulation tests. The decrease of the percentage of fibrinolytic blood activity and the increase in plasma concentration of the molecular marker of thrombophilia D-dimer can be considered as activation of intravascular coagulopathy and the presence of endothelial dysfunction.Conclusions: 1. Our studies found endothelial dysfunction and violations of the plasma-coagulation linkage of hemostasis in both studied groups. 2. After the performed treatment, the improvement of the functional activity of the endothelium and normalization of the main parameters of the plasma-coagulation linkage of hemostasis were observed.

scholarly journals Vasculotoxicity of Chemotherapy: Assessment оf Endothelial Dysfunction Biomarkers’ Levels in Gastric Cancer Patients

Kardiologiia ◽  
2020 ◽  
Vol 60 (5) ◽  
pp. 35-40
Author(s):  
Yu. Yu. Kirichenko ◽  
Yu. N. Belenkov ◽  
E. V. Privalova ◽  
Yu. I. Naymann ◽  
E. P. Gitel ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Healthy Volunteers ◽  
Stomach Cancer ◽  
Specific Treatment ◽  
Study Groups ◽  
Main Group ◽  
Control Group ◽  
Instrumental Evaluation ◽  
Oncological Patients ◽  
Before And After

Aim To evaluate dynamics of biomarkers for endothelial dysfunction (ED), including endothelin-1 (ET-1) and von Willebrand factor (VWF) in patients with stomach cancer (adenocarcinoma) before and after polychemotherapy (PCT); to compare these results with respective values in healthy volunteers and patients with cardiovascular diseases (CVD); to study correlations of the ED biomarkers with indexes of instrumental evaluation of endothelial dysfunction.Material and methods The study included 75 participants, including 25 healthy volunteers (control group), 25 patients with documented CVDs (arterial hypertension + ischemic heart disease), and 25 patients of the main group with histologically documented stage II-IV stomach cancer (adenocarcinoma) who received different courses of PCT with platinum-based agents (oxaliplatin, cisplatin) and fluoropyrimidines (5 fluorouracil, capecitabin). Laboratory measurement of ED biomarkers, computerized nailfold video capillaroscopy (CNVC), and finger laser photoplethysmography (PPG) (methods for noninvasive evaluation of vascular wall and ED), electrocardiography, 24-h ECG Holter monitoring, and echocardiography (EchoCG) were performed for all patients of the main group prior to PCT and within one months after the last course completion. This evaluation was performed once for healthy volunteers and patients of the CVD group upon inclusion into the study.Results In the main group, ET-1 levels were non-significantly lower than normal and did not change during the courses of antitumor treatment (0.95 [0.6; 1.4] and 0.94 [0.7; 1.4] pg /ml (р<0.9) before and after PCT, respectively). Statistically significant differences were found between the control group and oncological patients after the treatment (р<0.04). Levels of VWF remained within the normal range in all examined participants and did not significantly differ between study groups, including oncological patients before and after the specific treatment (р>0.05 for all comparisons). The correlation analysis detected significant correlations of ET-1 levels with functional disorders of microcirculation, ET-1 with the occlusion index (rs=0.56; p=0.005), ЕТ-1 with percentage of capillary restoration (PCR, rs= –0.72; p=0.018) and with the incidence rate of supraventricular extrasystole (rs=0.48; p=0.032).Conclusion The dynamics of ED biomarkers was studied for the first time in patients with stomach cancer receiving a specific antitumor therapy. Although no significant changes in ЕТ-1 and VWF were observed during the PCT (probably due to exhaustion of the endothelial system and a small patient sample), these indexes can be considered as early vasculotoxicity markers due to the presence of significant correlations with indexes of impaired endothelial function according to the results of instrumental evaluation.

scholarly journals Combined treatment of oligoasthenospermia by postoperative Speroton therapy in patients with varicocele

2020 ◽  
Vol 21 (2) ◽  
pp. 64-69
Author(s):  
E. A. Povelitsa ◽  
V. E. Leanovich ◽  
N. I. Dosta ◽  
O. V. Parhomenko ◽  
A. M. Shesternya
Keyword(s):  
Spermatic Cord ◽  
Varicose Veins ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Sperm Concentration ◽  
Study Groups ◽  
Reproductive Age ◽  
Control Group ◽  
Study Objective ◽  
Before And After

The study objective is to evaluate the effectiveness of the Speroton complex therapy in combined treatment of oligoasthenospermia in patients with varicocele after microsurgical phlebectomy of varicose veins of the spermatic cord.Materials and methods. Microsurgical phlebectomy of the spermatic cord was performed in 40 men (mean age 33.0 ± 2.3 years) with oligoasthenospermia and varicocele. The patients were divided into 2 groups: the main group included 20 men who were treated with the Speroton complex for 3 months in the postoperative period, and the control group included 20 men who did not take Speroton. The spermogram parameters were evaluated before and after the operation.Results. Three months after the start of treatment, a statistically significant improvement in spermogram indicators was noted in all study groups. It was determined that combined therapy that included the Speroton complex administration for 3 months, statistically significantly led to the more considerable increase in sperm parameters than in control group: the sperm concentration increased to 38.6 and 28.9 mln/ml, respectively, the percentage of progressive motile sperm – to 49.2 and 39.4 %, the percentage of motile forms – to 72.2 and 43.8 %, viable forms – to 67.8 and 58.1 %, and the percentage of sperm with DNA fragmentation decreased to 12.1 and 17.2 %, respectively, in the main and control groups.Conclusion. Combined treatment with postoperative Speroton therapy for men of reproductive age with infertility and varicocele determines the more significant improvement in the parameters of sperm than performing only surgical correction of varicocele.

scholarly journals Izuchenie vliyaniya sulodeksida na endoteliy-zavisimuyu vazodilatatsiyu mozgovykh sosudov u zhivotnykhso streptozototsin-indutsirovannym sakharnym diabetom

2011 ◽  
Vol 14 (3) ◽  
pp. 12-15 ◽  
Author(s):  
Ivan Nikolaevich Tyurenkov ◽  
Andrey Vladislavovich Voronkov ◽  
Anna Al'bertovna Slietsans ◽  
Evgenia Viktorovna Petrova ◽  
Grigoriy Leonidovich Snigur
Keyword(s):  
Physiological Saline ◽  
Immunohistochemical Analysis ◽  
Saline Group ◽  
Male Rats ◽  
Control Group ◽  
Brain Vessels ◽  
Endothelin 1 ◽  
Before And After ◽  
Enhanced Expression ◽  
Group 2

Aim. To analyse effects of sulodexide on endothelium-dependent vasodilation (EDVD) of brain vessels in animals with experimental diabetes mellitus. Materials and methods. The study was performed on 45 Wistar male rats (180-219 g b.w.) allocated to 3 equal groups. Group 1 served as control, group 2 included rats with DM given physiological saline, group 3 was comprised of animals with DM given sulodexide (30 LRU for 4 weeks). The endothelial dysfunction (ED) was simulated by inducing DM (single v/v injection of 50 mg/kg streptozotocin). A month later, the endothelium-dependent and independent vasodilation was tested by registration of circulation in brain vessels in the projection of the middle cerebral artery, determination of Pourcelot?s and Gosling?s indices before and after administration of 0.001 mg/kg acetylcholine (Acros organics, USA), 300 mg/kg L-arginine (Acros organics, USA), 0.007 mg/kg nitroglycerin (MTKh, Moscow), 10 mg/kg nitro-L-arginine (Acros organics, USA). Samples for immunohistochemical analysis were prepared using antibodies against e-NOS and endothelin-1 (Novocastra TM) as recommended by the manufacturer. STATISTICA/w7.0 program for Windows (StatSoft Inc., USA) was used for basic statistical analysis of the results of all experiments. Results. Administration of acetylcholine to DM rats caused a much greater (2.58-fold) decrease of EDVD than in control animals whereas endothelium-independent vasodilation remained unaltered (following nitroglycerin administration); Pourcelot?s and Gosling?s indices significantly increased. DM rats given sulodexide showed lower Pourcelot?s and Gosling?s indices than untreated animals. Thus, impaired expression of antibodies against e-NOS and enhanced expression of anti-endothelin-1 antibodies (specific markers of endothelial disturbance) suggest development of ED in DM and endothelium protection by sulodexide that increases the eNOS level and decreases the endothelin-1 level thereby improving EDVD. Conclusion. Administration of sulodexide to DM rats increases the eNOS level and decreases the endothelin-1 level thereby improving EDVD.

scholarly journals PENGARUH PEMBERIAN ULTRASOUND THERAPY DAN NEUROMUSCULAR TAPING DALAM MENINGKATAN AKTIVITAS FUNGSIONAL PADA KASUS OSTEOARTHRITIS LUTUT

2019 ◽  
Author(s):  
Trisna Narta Dewi, A.A.N ◽  
Yudi Pramana ◽  
Eka Septian Utama, A.A.Gd ◽  
Surya Adhitya P.Gd
Keyword(s):  
Functional Activity ◽  
Joint Disease ◽  
Control Group ◽  
Ultrasound Therapy ◽  
Functional Activities ◽  
A Value ◽  
Significant Difference ◽  
Before And After ◽  
Group 2 ◽  
Group 1

Background: Osteoarthritis is a complaint characterized by abnormalities in the cartilage of joints and bones nearby, this complaint is commonly felt and has become a chronic joint disease. Cartilage abnormalities will result in bones rubbing against each other, resulting in symptoms of stiffness, pain and restriction of movement in the joints that will affect the quality of functional activities performed. The aim of this study was to determine the effect of ultrasound therapy and neuromuscular taping (nmt) in increasing functional activity in cases of knee osteoarthritis.Research method: The study used experimental with randomized design type pre test and post test control group design. The study was divided into 2 groups, namely group 1 would receive Ultrasound intervention and group 2 would receive Ultrasound and neuromuscular taping intervention. The number of samples in this study was 11 samples per group so that the total number of samples in the two groups was 22 respondents. Measurements of knee functional activity values were measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.Results: Group 1 with a value of p = 0,000 (p <0.05) which showed a significant difference between the value of tenderness before and after the intervention of ultrasound therapy. Group 2 obtained a value of p = 0,000 (p <0.05) indicating there was a significant difference between the value of tenderness before and after the intervention of ultrasound therapy and neuromuscular taping. The results of the calculation of the mean difference were p = 0,0001, the data showed that there was no difference in influence between groups, which means that the provision of ultrasound therapy and neuromuscular taping was no better in increasing functional activities of knee OA patients compared to ultrasound therapy.Conclusion: the provision of ultrasound therapy and neuromuscular taping is not better in increasing

scholarly journals MEDICAL-SOCIAL PECULIARITIES OF CHRONIC INFLAMMATORY PROCESSES OF THE INTERNAL GENITAL ORGANS IN WOMEN AGAINST THE BACKGROUND OF VARICOSITY OF PELVIS MINOR

2021 ◽  
pp. 43-50
Author(s):  
N. V. Drohomyretska
Keyword(s):  
Physical Activity ◽  
Sexual Dysfunction ◽  
Negative Impact ◽  
Varicose Veins ◽  
Color Doppler ◽  
Significant Proportion ◽  
Control Group ◽  
Inflammatory Processes ◽  
Group 2 ◽  
Group 1

Aim of the research. Study the peculiarities of chronic inflammatory processes of the internal genital organs in women against the background of varicose veins of the pelvis minor. Materials and methods. In the comparative aspect, the main points of the clinical characteristics of 30 women of the control and 120 patients of the main groups (with chronic inflammatory processes of the internal genital organs against the background of varicose veins of the pelvis, isolated chronic inflammatory processes of the internal genital organs) are represented in the work. Results. Performed researches have shown that the vast majority of women in the group 1 were engaged in manual labor, of which 32 were workers ((47,1±6,1) %), 13 – were housewives ((19,1±4,8) %). The proportion of unemployed among patients of the group 2 was 1.2-fold higher than of the group 1, prolonged static load in a standing or sitting position was observed in 38 ((55,9±6,0) %) and in 7 ((10,5±3,7) %) cases, respectively; excessive physical activity, especially related to the lifting of loads – in 12 (23,1±4,6) %) and in 6 (11,05±4,4) %) cases, respectively; and this definitely made the negative impact on the venous hemodynamics. Statistical calculations showed that the risk of VPM (varicosity of pelvis minor) in female workers was significantly higher compared to the control group (OR 3,56; 95 % CI 1,29-9,80; p=0,02) and group 2 (OR 2,67; 95 % CI 1,21-5,86; p=0,02). Analysis of the peculiarities of genital function has shown that the early sexual activity (up to 18 years) was started by 19 ((27,9±5,4) %) women of the group 1, by 22 women ((42,3±6,9) %) – of the group 2, that was 1,8-fold more than in patients of the control group (7; (23,3±4,7) %). The women of the group 1 were found to have a significantly higher risk of sexual dysfunction compared to the group 2: dyspareunia (OR 2,39; 95 % CI 1,14-5,04; p=0,03) and anorgasmia (OR 2,60; 95 % CI 1,12-6,06; p=0,04). Regarding the use of contraceptives, it was found that almost half of the patients of the first group resorted to interrupted sexual intercourse, which adversely affects the venous hemodynamics of the pelvis and significantly increases the risk of VPM against the background of CIPIGO (chronic inflammatory processes of the internal genital organs) (OR 2,41; 95 % CI 1,11-5,24; p=0,04). Studying the reproductive history of patients, it was determined that women in the group 1 have had 3,4-fold higher birth parity compared to the group 2 (p<0,05), which can also be considered a leading risk factor for VPM. In addition, in the research groups there was a significant proportion of miscarriages (4,7-fold more in the group 1; p<0,05) and stillbirths, which may be a consequence of the past acute inflammatory diseases of specific etiology. Conclusions. Anamnestic data (static lifestyle and physical activity, miscarriages, high parity of childbirth), as well as peculiarities of the clinical course of chronic inflammatory processes of the internal genital organs in women against the background of varicose veins of the pelvis minor (severe chronic pelvic pain, swelling and aching fornices, dyspareunia, sexual dysfunction) should be the leading factors in the selection of patients for the use of an advanced diagnostic algorithm (ultrasound examination of the lesser pelvic veins in combination with color Doppler examination).

scholarly journals Role of markers of inflammation and endothelial dysfunction in the prognosis of the development of cardiovascular complications in patients with coronary artery disease and metabolic syndrome after coronary stenting

Kardiologiia ◽  
2020 ◽  
Vol 60 (8) ◽  
pp. 98-105
Author(s):  
A. V. Svarovskaya ◽  
A. T. Teplyakov ◽  
A. M. Gusakova ◽  
A. A. Garganeeva
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Roc Curve ◽  
Cardiovascular Events ◽  
Control Group ◽  
Endothelin 1 ◽  
Atherosclerosis Progression ◽  
Group 2 ◽  
Group 1

Aim To study the role of inflammation markers and endothelial dysfunction in predicting the risk of cardiovascular event following a percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) and metabolic syndrome (MS).Materials and methods 80 patients (72 men; median age, 56 (50;63) years) with IHD and PCI were evaluated. Based on the presence of MS according to NCEP-ATP III criteria, patients were divided into two groups, group 1 without MS (n=32) and group 2 with MS (n=48). The control age- and sex-matched group included 15 people without cardiovascular diseases. Serum concentrations of tumor necrosis factor α (TNFα), interleukin 6 (IL-6), IL-10, lipoprotein-associated phospholipase A2 (LP-PLA2), and endothelin 1 were measured by enzyme-linked immunosorbent assay (ELISA). Patients were followed up for 12 months after PCI with evaluation of the incidence of adverse cardiovascular events. Statistical analysis was performed with Statistica 10.0 and Medcalc 19.2.6 software. Differences between variables were considered statistically significant at р<0.05. Potential predictors were determined by the ROC analysis with construction of ROC curves, calculation of AUC (area under the curve), identification of COP (cut-off point by the Youden’s index), and sensitivity (Se) and specificity corresponding to the COP.Results Patients with MS had statistically significantly higher serum levels of inflammatory markers than patients of the control group. Concentration of the intravascular inflammation marker, PL-PLA2, was 2.7 times higher in group 1 and 5.1 times higher in group 2 than in the control group (р<0.001). Concentrations of endothelin 1 were 1.9 times higher in group 1 and 3.7 times higher in the MS group compared to the control. At one year after PCI, the incidence of adverse outcomes in the form of cardiovascular events was higher for patients with MS: 10 (20.8 %) cases of stent restenosis and 13 (27.1 %) episodes of coronary atherosclerosis progression according to results of repeated coronarography vs. 2 (6.3%) restenosis cases (χ2–10.853; р=0.002) and 2 (6.3%) episodes of atherosclerosis progression (χ2–23.651; р=0.001) for patients without MS. The groups did not differ in rates of myocardial infarction and cardiac death. The most significant predictors of unfavorable prognosis were LP-PLA2 concentration >983.83 ng/ml (area under the ROC curve, 0.867; sensitivity, 80 %; specificity, 100%; р<0.001) and endothelin 1 overexpression >0.852 fmol/ml (area under the ROC curve, 0.885; sensitivity, 85.5 %; specificity, 83.6 %; р<0.001).Conclusion Patients with MS were characterized by more pronounced imbalance of pro- and anti-inflammatory factors. Concentrations of LP-PLA2 >983.83 ng/ml and endothelin 1 >0.852 fmol/ml were shown to be predictors of unfavorable prognosis for patients with IHD and MS after PCI with coronary stenting.

scholarly journals Severity of inflammatory syndrome and endothelial dysfunction in steatosis and liver fibrosis

2021 ◽  
Vol 38 (4) ◽  
pp. 54-61
Author(s):  
I. A. Bulatova ◽  
A. M. Miftakhova ◽  
I. L. Gulyaeva
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Fibrosis ◽  
Proinflammatory Cytokines ◽  
Functional Activity ◽  
Liver Steatosis ◽  
Serum Levels ◽  
Study Groups ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Inflammatory Syndrome

Objective. To evaluate the severity of the inflammatory syndrome by the serum concentration of proinflammatory cytokines of tumor necrosis factor alpha (TNF-) and interleukin-6, endothelial dysfunction syndrome (ED) by the level of vasculoendothelial growth factor (VEGF) and the functional activity of Willebrand factor (WF) in the blood of patients with nonalcoholic liver steatosis (NALS) and liver fibrosis (LF) of viral genesis. Materials and methods. 52 patients with NALS and 27 patients with LF of viral etiology (hepatitis C) were examined. The control group included 20 practically healthy individuals. The concentrations of TNF-, IL-6 and VEGF were determined in the blood by enzyme immunoassay. The functional activity of WF was measured by the level of aggregation with the inducer ristocetin using laser aggregometer. Results. According to the results of ELISA, an increase in serum levels of proinflammatory cytokines TNF- and IL-6 was registered in patients of both study groups in comparison with the control, being more pronounced in patients with viral LF. Hyperproduction of VEGF was observed in both groups of patients, and the concentration of this marker was significantly higher in viral LF than in patients with NALS (p = 0.002). The functional activity of WF in patients with NALS and in the group with LF also significantly exceeded the control values, but there were no significant differences between the nosological forms (p = 0.675). Conclusions. The course of NALS and viral LF is characterized by the development of an inflammatory syndrome and ED, associated with an increase in the production of proinflammatory cytokines TNF- and IL-6 and hyperproduction of VEGF, more pronounced in LF. The functional activity of WF also increases in both nosological forms, but without significant differences.

A STUDY ON THE VARIATION IN CA 72-4 LEVELS OF THE GASTRIC CANCER’S PATIENTS BEFORE AND AFTER SURGERY TREATMENT

2011 ◽  
pp. 81-87
Author(s):  
Thi Thu Huong Hoang ◽  
Minh Vuong Nguyen
Keyword(s):  
Gastric Cancer ◽  
Study Groups ◽  
University Hospital ◽  
Control Group ◽  
Central Hospital ◽  
Before And After

Objectives: Studying on the variation in CA 72-4 levels of the gastric cancer’s patients before and after 10 days and 30 days surgery treatment. Materials and methods: The studying group included 42 gastric cancer’s patients who were examinated and treated in cancerology service of Hue University Hospital and gastroenterology service of Hue Central Hospital. The control group included 30 healthy normal examinated at Hue University Hospital. The study groups were clinical, endoscopic anatopathologic examination diagnosed with gastric cancer and quantitative levels of CA 72-4 in three times points: before surgerying, after surgerying 10 days and 30 days postoperatively. Rerults: The concentration of CA 72-4 in gastric cancer’s patients was 10.06 ± 16.49 U/ml. Clearly higher than the control group 1.2 ± 0.4 U/ml(p <0.01). The rate increased levels of CA 72-4 in gastric cancer’s patients before surgerying was 27.5% and the control group was 0%. After 10 days of surgery, CA 72-4 level was 5.56 ± 8.55 U/ml; 82.5% of patients have reduced levels of CA 72-4 and 17.5% no changes; there are 0% increased cases. After 30 days of surgery, CA 72-4 level was 3.79 ± 6,52 U/ml. CA 72-4 level 10 days after surgering have decreased significantly compared to before surgery (p < 0.05) and 30 days after surgery have decreased significantly compared to after 10 days (p < 0.05). 30 days postoperatively, 90% patients had reduced levels of CA 72-4, 10% no changes, no patient had increased levels of CA 72-4 and no patient be relapsed after 30 days of treatment. Conclusions: CA 72-4 concentrations before surgerying increased 27.5%, after surgery 10 days and 30 days reduced step by step, no case have increased CA 72-4 levels, no case relapsed after 30 days.

scholarly journals Biomechanical properties of the bone during implant placement

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ádám László Nagy ◽  
Zsolt Tóth ◽  
Tamás Tarjányi ◽  
Nándor Tamás Práger ◽  
Zoltán Lajos Baráth
Keyword(s):  
Bone Structure ◽  
Biomechanical Properties ◽  
Control Group ◽  
Dynamic Tests ◽  
Bone Model ◽  
Implant Placement ◽  
Significant Difference ◽  
Before And After ◽  
Group 2 ◽  
Post Hoc

Abstract Background In this research the biomechanical properties of a bone model was examined. Porcine ribs are used as experimental model. The objective of this research was to investigate and compare the biomechanical properties of the bone model before and after implant placement. Methods The bone samples were divided in three groups, Group 1 where ALL-ON-FOUR protocol was used during pre-drilling and placing the implants, Group 2 where ALL-ON-FOUR protocol was used during pre-drilling, and implants were not placed, and Group 3 consisting of intact bones served as a control group. Static and dynamic loading was applied for examining the model samples. Kruskal–Wallis statistical test and as a post-hoc test Mann–Whitney U test was performed to analyze experimental results. Results According to the results of the static loading, there was no significant difference between the implanted and original ribs, however, the toughness values of the bones decreased largely on account of predrilling the bones. The analysis of dynamic fatigue measurements by Kruskal–Wallis test showed significant differences between the intact and predrilled bones. Conclusion The pre-drilled bone was much weaker in both static and dynamic tests than the natural or implanted specimens. According to the results of the dynamic tests and after a certain loading cycle the implanted samples behaved the same way as the control samples, which suggests that implantation have stabilized the skeletal bone structure.

scholarly journals Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Oya Türkoğlu ◽  
Elif Azarsız ◽  
Gülnur Emingil ◽  
Necil Kütükçüler ◽  
Gül Atilla
Keyword(s):  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Study Groups ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Proteinase 3 ◽  
Cathepsin C ◽  
Probing Depth ◽  
Inflammatory Processes ◽  
Crevicular Fluid

Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases.Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA.Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting ageP<0.05. No differences were found in GCF cathepsin C levels among the study groupsP>0.05. Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amountsP<0.01but not with cathepsin C total amountsP>0.05.Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.

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