Metal-Based Nanomaterials Incorporate with Ultrasound as Acceptable Approach towards Cancer Therapy

Among current biological researches, there have a plenty of works related cancer therapy issues by using functional or pure-phased composites in non-invasive strategies. Especially in fabricating anticancer candidates, functional composites are divided into different sorts with different characteristics. Additionally, nanotechnology provides various approaches in utilizing composites’ functionality for cancer diagnostics and therapeutics. Compared with previous Photodynamic Therapy (PDT), Photo-Thermal Therapy (PTT), chemotherapy and radiotherapy, ultrasound is used to activate sonosensitizer to produce cytotoxic Reactive Oxygen Species (ROS) toward target cancer cells. In recent years, the form of Sonodynamic Therapy (SDT) has been making much effort to develop highly efficient metal based Nanomaterials (NMs) as sonosensitizers, which can efficiently generate ROS and has the advantages of deeper tissue penetration. However, the traditional sonosensitizers, such as porphyrins, hypericin, and curcumins suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy. For contrasting this limitation, the metal based inorganic NMs show biocompatibility, controllable physicochemical properties, and ease of achieving multifunctional properties, which greatly expanded their application in SDT. In this review, we systematically summarize the metal based inorganic NMs as carrier of molecular sonosensitizers, and produce ROS under ultrasound. Moreover, the prospects of advanced metal based further materials application are also discussed.

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Design and Application of Inorganic Nanoparticles for Sonodynamic Cancer Therapy

Biomaterials Science ◽

10.1039/d0bm01875a ◽

2021 ◽

Author(s):

LIhong Sun ◽

Ping Wang ◽

Jinxia Zhang ◽

Yang Sun ◽

Suhui Sun ◽

...

Keyword(s):

Photodynamic Therapy ◽

Side Effects ◽

Cancer Therapy ◽

Patient Compliance ◽

Inorganic Nanoparticles ◽

Tissue Penetration ◽

Sonodynamic Therapy ◽

Significant Attention ◽

Design And Application

As an alternative to photodynamic therapy (PDT), ultrasound-triggered tumor sonodynamic therapy (SDT) has garnered significant attention, owing to its high tissue penetration, few side effects, and reliable patient compliance. A...

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Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker

Scientific Reports ◽

10.1038/s41598-020-79903-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Skaidre Jankovskaja ◽

Johan Engblom ◽

Melinda Rezeli ◽

György Marko-Varga ◽

Tautgirdas Ruzgas ◽

...

Keyword(s):

Skin Cancer ◽

Relative Increase ◽

Cancer Biomarker ◽

Cancer Diagnostics ◽

Sampling Time ◽

Skin Permeability ◽

Experimental Conditions ◽

Non Invasive

AbstractThe tryptophan to kynurenine ratio (Trp/Kyn) has been proposed as a cancer biomarker. Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics. By performing in vitro pig skin permeability studies, we conclude that non-invasive topical sampling of Trp and Kyn is feasible. We explore the influence of different experimental conditions, which are relevant for the clinical in vivo setting, such as pH variations, sampling time, and microbial degradation of Trp and Kyn. The permeabilities of Trp and Kyn are overall similar. However, the permeated Trp/Kyn ratio is generally higher than unity due to endogenous Trp, which should be taken into account to obtain a non-biased Trp/Kyn ratio accurately reflecting systemic concentrations. Additionally, prolonged sampling time is associated with bacterial Trp and Kyn degradation and should be considered in a clinical setting. Finally, the experimental results are supported by the four permeation pathways model, predicting that the hydrophilic Trp and Kyn molecules mainly permeate through lipid defects (i.e., the porous pathway). However, the hydrophobic indole ring of Trp is suggested to result in a small but noticeable relative increase of Trp diffusion via pathways across the SC lipid lamellae, while the shunt pathway is proposed to slightly favor permeation of Kyn relative to Trp.

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A nanostructured microfluidic device for plasmonic-assisted electrochemical detection of hydrogen peroxide released from cancer cells

Nanoscale ◽

10.1039/d0nr07608b ◽

2021 ◽

Author(s):

Carolina del Real Mata ◽

Roozbeh Siavash Moakhar ◽

Sayed Iman Isaac Hosseini ◽

Mahsa Jalali ◽

Sara Mahshid

Keyword(s):

Hydrogen Peroxide ◽

Cancer Cells ◽

Real Time ◽

Electrochemical Detection ◽

Microfluidic Device ◽

Cancer Biomarker ◽

Cancer Diagnostics ◽

Liquid Biopsies ◽

Non Invasive

Non-invasive liquid biopsies offer hope for a rapid, risk-free, real-time glimpse into cancer diagnostics. Recently, hydrogen peroxide (H2O2) is identified as a cancer biomarker due to continued release from cancer...

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Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Journal of Visualized Experiments ◽

10.3791/50480 ◽

2013 ◽

Cited By ~ 4

Author(s):

Stuart J. Corr ◽

Brandon T. Cisneros ◽

Leila Green ◽

Mustafa Raoof ◽

Steven A. Curley

Keyword(s):

Gold Nanoparticles ◽

Cancer Therapy ◽

Biological Systems ◽

Non Invasive

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A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3176 ◽

2021 ◽

Vol 17 (10) ◽

pp. 2003-2013

Author(s):

Jingxin Fu ◽

Yian Wang ◽

Haowen Li ◽

Likang Lu ◽

Hui Ao ◽

...

Keyword(s):

Cancer Therapy ◽

Tumor Targeting ◽

Low Dose ◽

Drug Loading ◽

Tumor Therapy ◽

High Dose ◽

Inhibition Rate ◽

Tumor Inhibition ◽

Nano Formulation ◽

Tumor Inhibition Rate

Background: The use of chemotherapeutic drugs is restricted in the tumor-therapy because of the severely toxic and side effects among most important factors. The active herbal extracts are always used as a high dose while in the tumortherapy to achieve good anti-tumor effects. Hydrous icaritin has a high activity while there are few existing dosage forms as a result of low solubility in water and poor bioavailability. Results: The prepared hydrous icaritin nanorods (DP-HICT NRs) using mPEG2000-DSPE as a stabilizer, presented a narrow distribution of particle size with of 217 nm and a properly high drug-loading content of approximately 65.3±1.5%. A low dose of hydrous icaritin nano-formulation shows remarkable efficacy in cancer therapy (tumor inhibition rate: 61.36±10.80%) compared with the same dose of Paclitaxel injection (tumor inhibition rate: 66.80±4.43%), which approved as medicaments. Not only that, DP-HICT NRs can escape the clearance of the immune system and enhance targeting ability to the tumor site with only one excipient and such a low dose. Conclusions: This kind of nanoparticles contain a low dose of HICT used mPEG2000-DSPE as a stabilizer, while can achieve good tumor targeting as some active targeting agents and an anti-tumor effect as the PTX injection. There are broad prospects in drug safety, anti-tumor efficacy and even prognosis.

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Passive and Active Tumor Targeting of Polysaccharide Nanocarriers for Cancer Therapy

Polysaccharide-based Nano-Biocarrier in Drug Delivery ◽

10.1201/9780429449437-16 ◽

2018 ◽

pp. 323-338

Author(s):

Miltu Kumar Ghosh ◽

Falguni Patra

Keyword(s):

Cancer Therapy ◽

Tumor Targeting

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Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

International Journal of Molecular Sciences ◽

10.3390/ijms222212549 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12549

Author(s):

Nkune Williams Nkune ◽

Heidi Abrahamse

Keyword(s):

Photodynamic Therapy ◽

Metastatic Melanoma ◽

Water Solubility ◽

Three Dimensional ◽

New Developments ◽

Non Invasive ◽

Promising Strategy ◽

Skin Malignancy ◽

Therapeutic Outcomes ◽

D Cell

Metastatic melanoma (MM) is a skin malignancy arising from melanocytes, the incidence of which has been rising in recent years. It poses therapeutic challenges due to its resistance to chemotherapeutic drugs and radiation therapy. Photodynamic therapy (PDT) is an alternative non-invasive modality that requires a photosensitizer (PS), specific wavelength of light, and molecular oxygen. Several studies using conventional PSs have highlighted the need for improved PSs for PDT applications to achieve desired therapeutic outcomes. The incorporation of nanoparticles (NPs) and targeting moieties in PDT have appeared as a promising strategy to circumvent various drawbacks associated with non-specific toxicity, poor water solubility, and low bioavailability of the PSs at targeted tissues. Currently, most studies investigating new developments rely on two-dimensional (2-D) monocultures, which fail to accurately mimic tissue complexity. Therefore, three-dimensional (3-D) cell cultures are ideal models to resemble tumor tissue in terms of architectural and functional properties. This review examines various PS drugs, as well as passive and active targeted PS nanoparticle-mediated platforms for PDT treatment of MM on 2-D and 3-D models. The overall findings of this review concluded that very few PDT studies have been conducted within 3-D models using active PS nanoparticle-mediated platforms, and so require further investigation.

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Host-cell-assisted construction of folate-engineered nanocarrier based on viral light particle for targeted cancer therapy

Nanoscale ◽

10.1039/d1nr04903h ◽

2021 ◽

Author(s):

Cheng Lv ◽

Jian Ao ◽

Ji Wang ◽

Man Tang ◽

An-An Liu ◽

...

Keyword(s):

Side Effects ◽

Cancer Therapy ◽

Host Cell ◽

Tumor Targeting ◽

Light Particle ◽

Targeted Cancer Therapy ◽

Normal Cells ◽

Specific Tumor

Targeted cancer therapy has aroused broad interests of researchers due to its accuracy in specific tumor targeting and few side effects on normal cells. In the last decades, oncolytic viral...

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