scholarly journals Platelet Indices as Potential Monitoring Biomarkers in COVID-19: A New Hope

2021 ◽  
Vol 25 (1) ◽  
pp. 134-139
Author(s):  
Attika Khalid ◽  
Sami Saeed ◽  
Madeeha Rehan ◽  
Nadia Arif
Keyword(s):  
Serum Ferritin ◽  
Mean Platelet Volume ◽  
Inflammatory Markers ◽  
Significant Positive Correlation ◽  
Pearson Correlation ◽  
P Value ◽  
Platelet Volume ◽  
Platelet Indices ◽  
Positive Correlation ◽  
The Relationship

Objective: To investigate the relationship between established acute inflammatory markers in COVID-19 patients with Mean platelet volume (MPV) and Platelet large cell ratio (P-LCR). Materials and Methods: This was a retrospective longitudinal study conducted at Fauji Foundation Hospital, Rawalpindi from 10th June to 10th August 2020. Biochemical parameters i.e. CRP, serum ferritin, LDH, and pro-BNP as well as hematological parameters (MPV and P-LCR) were noted once every week during admission of all the COVID-19 positive patients.Data were analyzed using IBM-SPSS version 23. Repeated measure ANOVA using a generalized linear model was done to check the trend of values during the duration of their stay. Pearson Correlation analysis and regression models were estimated to check the relationship of MPV and P-LCR with C- reactive protein, serum Ferritin, LDH, and pro-BNP. P-values less than 0.05 were considered statistically significant. Results: The mean age of the studied group was 55.47 (SD=±15.0) years with the female to male ratio being 2:1. Mean platelet volume showed a statistically significant positive correlation with the established set of inflammatory markers other than pro-BNP with a p-value of less than 0.05.P-LCR however showed a positive correlation with CRP (p-value of less than 0.05) only with no significant correlation with other biochemical markers. Conclusion: MPV is reported on routine complete blood count report (CBC). It is readily available at even the most under-resourced health centers; therefore reporting the platelet indices does not require extra testing, sampling, or reagent cost. A statistically significant positive correlation amongst the established acute inflammatory markers and relatively understudied platelet indices (MPV) in COVID-19 provides a cost-effective, readily available, and time-efficient tool for marking disease progression.

scholarly journals Correlation between Occurrence of Psychosomatic Disorders and Age during COVID-19 Lockdown

2021 ◽  
Author(s):  
Hetvi Bharatbhai Jethloja ◽  
Priyanka Birjubhai Unadkat ◽  
Radhika Kanaiyalal Raichura ◽  
Janvi Narendrasinh Rana ◽  
Nidhi Sudhir Ved
Keyword(s):  
Significant Positive Correlation ◽  
Pearson Correlation ◽  
P Value ◽  
Psychosomatic Disorders ◽  
Psychosomatic Disorder ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Scale Scores ◽  
The Mean ◽  
Group 2

Introduction: The Coronavirus Disease-2019 (COVID-19) has caused a serious threat to people’s mental health causing psychosomatic disorders such as panic disorder, anxiety, and depression. Aim: To find out the correlation between the occurrence of psychosomatic disorders and age during the COVID-19 lockdown phase. Materials and Methods: This cross-sectional, observational study was conducted in Department of Physiotherapy at RK University, Rajkot, Gujarat, India. Males and females of age ≥21 years, with an ability to understand and fill Google form were recruited for the study. The subjects were divided into four groups according to age 21-34 years, 35-54 years, 55-64 years, and 65 years and older. There were 250 participants in each group. The subjects were asked to fill the COVID-19 Peritraumatic Distress Index (CPDI). Data were analysed by using software Statistical Package for the Social Science (SPSS) version 20. The normality of data was checked by the Shapiro Wilk test. Data followed parametric type so; Pearson correlation test was applied to find out the correlation between age and CPDI score. Results: The mean age of the population was 49.24±18.14 years. The mean CPDI scale scores were 27.572, 31.948, 31.364, and 35.328, respectively from groups 1 to 4. There was a significant positive correlation (p-value=0.031) in group 4, while no significance was found in group 1 (p-value=0.074), group 2 (p-value=0.067), and group 3 (p-value=0.062) Conclusion: There was a significant positive correlation between age and psychosomatic disorder occurrence in the geriatric age group (65 years and older) in the Rajkot city.

scholarly journals TO STUDY THE ROLE OF PLATELET INDICES (MPV, PDW, PCT, PLCR) AS PROGNOSTIC MARKERS IN COMPARISON WITH APACHE II AND SAPS 3 SCORES IN SEVERE SEPSIS

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Ramesh Kumar ◽  
Laxmi . ◽  
Maniram Kumhar ◽  
Arunarya .
Keyword(s):  
Severe Sepsis ◽  
Prognostic Marker ◽  
Mean Platelet Volume ◽  
Prognostic Markers ◽  
Apache Ii ◽  
Apache Ii Score ◽  
P Value ◽  
Platelet Volume ◽  
Platelet Indices ◽  
Saps 3

Background: Platelet indices including mean platelet volume (MPV), platelet volume distribution width (PDW), plateletcrit (PCT) and platelet large cell ratio (PLCR), these indices can be measured by an inexpensive and readily available routine blood count and may be useful as a prognostic marker in patients with sepsis Methods: This study was planned to establish platelet indices as a prognostic marker in comparison with APACHE II and SAPS 3 score in severe sepsis patients admitted in Medical Intensive Care Unit under Department of Medicine, Jawahar Lal Nehru Medical College & Hospital, Ajmer. Results: In our study, higher Mean Platelet Volume(MPV) on day 7 was associated with higher APACHE II score, and this difference was statistically significant (p value-0.001). Also, higher Mean Platelet Volume (MPV) on day 7 was associated with higher SAPS III score, and this difference was statistically significant (p value-0.01). Conclusion: In developing countries like India platelet indices (specially MPV and PDW) measured on admission and subsequently can be used as prognostic markers in severe sepsis in emergency and critical care setup. Keywords: MPV, Sepsis, APACHE II, SAPS 3

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEIKUTSERTAAN SUAMI DALAM KELUARGA BERENCANA DI WILAYAH PUSKESMAS KECAMATAN PULOGADUNG JAKARTA TIMUR

2017 ◽  
Vol 5 (1) ◽  
pp. 107-118
Author(s):  
Willa Follona Follona
Keyword(s):  
Family Planning ◽  
Role Models ◽  
Significant Positive Correlation ◽  
Health Workers ◽  
P Value ◽  
Positive Correlation ◽  
Number Of Children ◽  
Family Planning Programs ◽  
The Relationship

The responsibility of men in terms of family planning is very important in the role of family planning programs. However, there is an imbalance in the number of contraceptive participation in female and male FP acceptors. The participation of men is still very low, compared to female. The purpose of this study is to analyze the relationship between husband characteristics seen from the factors of age, education, occupation, ethnicity, religion, income, number of children, also about husband knowledge, attitudes husband and wife / family support, and access to media / participation of husband as KB acceptor. This is across sectional study of 90 husbands chosen purposively in Pulogadung Sub District in September 2016. The results showed that there was a significant positive correlation between knowledge with the participation of respondents as Family Planning acceptors, the higher the knowledge level, the higher the participation of husband as the acceptors of family planning with p value 0.022 (OR = 4,818; 95% CI 1.476 to 15.728). There was a significant positive correlation between attitudes with the participation of respondents as familyplanning acceptors, the higher the attitudes they have, the higher the participation of husbands as the acceptors of family planning p value 0,007 (OR = 13,813; 95% CI 2,286 to 66,111). Health workers are expected to further promote the promotion of male KB acceptor services, through the provision of family planning education in the form of counseling and family approaches concerning the importance of family planning for men. For those have become acceptors are expected to be role models by spreading to their peer.

MO867THE SIGNIFICANCE OF THE MEAN PLATELET VOLUME AS A BIOMARKER IN HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Abdulla Al-Sayyari
Keyword(s):  
Vascular Access ◽  
Triglyceride Level ◽  
Mean Platelet Volume ◽  
Pearson Correlation ◽  
Chronic Hemodialysis ◽  
Platelet Volume ◽  
Av Fistula ◽  
Positive Correlation ◽  
Dialysis Vintage ◽  
The Mean

Abstract Background and Aims The mean platelet volume was found to be an important biomarker in certain medical conditions. We evaluate its significance in patients on chronic hemodialysis Method Adult stable patients on chronic hemodialysis for at least six months were included. MPV together with certain demographic ( age, sex, BMI, dialysis vintage, cause of CKD, medication taken, mode of dialysis, type of vascular access) and laboratory parameters (Hb, albumin, Kt/V, PTH, CRP serum lipids) were measured and recorded The correlation between these parameters and MPV was evaluated using Pearson correlation coefficient and the MPV in the absence or presence of the demographic parameters was calculated independent t test Results One hundred and twenty- three patients were studied. The mean age was 60.0± 18.4 and 48.7% were male and diabetes was the cause of CKD in 56.3% ; 72.6% were on hemodialysis and 27.4% on hemodiafiltration , 52.1% used AV fistula and 47.9% used permcath as vascular access; 50.9% were on aspirin Comparing the mean MPV above and below the 50th percentiles in different parameters revealed no significant differences. No significant correlation was found between MPV and duration on dialysis, age, weight, BM, erythropoietin dose per week, PTH, hemoglobin, albumin, CRP, number of admissions in the preceding year yea, LDL or HDL. However , there was a mild positive correlation with triglyceride level (Pearson coefficient = 0.2 (P=0.02). Conclusion No significant correlation or association was found between the MPV and any of the clinical demographic or laboratory parameter measured except that there was a mild positive correlation with triglyceride level.

scholarly journals Relationship Between Insulin Resistance and Mean Platelet Volume in Gestational Diabetes Mellitus

2015 ◽  
Vol 7 (02) ◽  
pp. 112-115 ◽  
Author(s):  
Suleyman Baldane ◽  
Suleyman Hilmi Ipekci ◽  
Aysegul Kebapcilar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Hypoglycemic Agents ◽  
Platelet Volume ◽  
Positive Correlation ◽  
The Relationship

ABSTRACT Objectives: A few studies have investigated the relationship between mean platelet volume (MPV) and gestational diabetes mellitus (GDM), and in these studies the relationship between MPV and insulin resistance has not been analyzed. Our aim in this study was to compare MPV values of the pregnant women with or without GDM and evaluate the relationship between MPV and homeostasis model assessment insulin resistance index (HOMA-IR) in pregnant women. Materials and Methods: One hundred and fourteen with GDM measurements being obtained before any dietary advice or therapy with insulin or hypoglycemic agents were given, and 76 with healthy pregnant women were included the study. Results: In the group with GDM, MPV value was found to be significantly higher than that of the control group (10.2 fl [8.0–12.2] vs. 9.9 fl [5.81–10.9], P = 0.004). HOMA-IR value was detected to be significantly higher in the group with GDM (2.46 [1.5–5.88] vs. 1.30 [0.17–2.92], P < 0.001). A positive correlation between MPV and HOMA-IR was found (r = 0.30, P = 0.002). Conclusion: We have shown that MPV was significantly elevated in GDM patients when compared to healthy pregnant women. Furthermore, we found that there was a positive correlation between MPV and HOMA-IR.

scholarly journals P084 C-Reactive Protein Correlates with Tumor Necrosis Factor-α in Ulcerative Colitis

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S184-S186
Author(s):  
P McDonagh ◽  
F O’Connell ◽  
J O’Connell ◽  
R Argue ◽  
R Corcoran ◽  
...  
Keyword(s):  
Disease Activity ◽  
Significant Positive Correlation ◽  
P Value ◽  
C Reactive Protein ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Mayo Score ◽  
Tnf Α ◽  
The Mean ◽  
The Relationship

Abstract Background Monitoring disease activity in Ulcerative colitis (UC) is essential. Inflammatory markers like C-Reactive Protein (CRP) and faecal calprotectin have been shown to correlate with clinical and endoscopic disease activity. To date the relationship between CRP and the inflammatory analytes within the colonic microenvironment have not been analysed. Methods Our primary aim was to evaluate the relationship between CRP and key inflammatory cytokine, TNF-α, in UC patients. We also sought to investigate whether CRP correlates with clinical parameters. Ethical approval was granted by our Research Ethics Committee. Patients over the age of 17 with a confirmed diagnosis of UC presenting for colonoscopy were offered the opportunity to participate. Basic patient demographics and Mayo score were recorded. At endoscopy colonic biopsies were taken and cultured in dimethyl sulfoxide (DMSO). Multiplex inflammatory and angiogenic enzyme-linked immunosorbent assay (ELISAs) were performed to evaluate the colonic microenvironment and assess real time secretion of TNF-α. Correlations were carried out on SPSS 24 and plotted using R Studio corrplot. Results 26 patients with UC participated in the study. The mean Mayo score was 4 (range 0–10). At endoscopy 15% had severe colitis (Mayo endoscopy sub-score 3), 31% had moderate disease, 54% had mild disease. 35% of patients were receiving biologic therapy. The mean CRP was 6.19mg/L (range 1–48.35mg/L), albumin 43.5g/L (range 31-49g/L). CRP had a negative correlation with albumin (r=-0.585, p-value 0.002). CRP had a statistically significant positive correlation with clinical, endoscopic and total Mayo scores (r= 0.469, 0.543, 0.526. p-values 0.016, 0.004, 0.006, respectively). Bleeding at colonoscopy also correlated very strongly with an elevated CRP (r=0.859, p-value=0.00). CRP had a moderate positive correlation with TNF-α (r=0.603, p-value=0.001) and VEGF receptor (r=0.492, p-value=0.011) levels. Conclusion CRP displayed a statistically significant positive correlation with the Mayo score. There was a significant correlation between the CRP and TNF-α expression within the colonic micro-environment. TNF-α is a key cytokine and therapeutic target in UC, its relationship with CRP has not been previously assessed. CRP is produced primarily by hepatocytes and is activated by TNF-α, interleukin 6 and interleukin 1β. It therefore stands to reason that there would be correlation between the two. The importance of TNF-α in UC is well known, this study supports and provides new evidence for the use of CRP as a non-invasive marker of disease activity.

scholarly journals Effect of COVID-19 on platelet count and its indices

2020 ◽  
Vol 66 (8) ◽  
pp. 1122-1127 ◽  
Author(s):  
Ertuğrul Güçlü ◽  
Havva Kocayiğit ◽  
Hüseyin Doğuş Okan ◽  
Unal Erkorkmaz ◽  
Yusuf Yürümez ◽  
...  
Keyword(s):  
Platelet Count ◽  
Oxygen Saturation ◽  
Mean Platelet Volume ◽  
P Value ◽  
Platelet Volume ◽  
Distribution Width ◽  
Unit Increase ◽  
The Mean ◽  
The Relationship ◽  
Auxiliary Test

SUMMARY BACKGROUND Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width. METHODS In total, 215 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant. RESULTS The patients’ mean age was 64,32 ± 16,07 years. According to oxygen saturation, 81 patients had moderate and 134 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times. CONCLUSION In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.

scholarly journals Platelet indices evaluation in patients with dengue fever

2018 ◽  
Vol 6 (6) ◽  
pp. 2054 ◽  
Author(s):  
Payal Mukker ◽  
Smitha Kiran
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Mean Platelet Volume ◽  
Dengue Infection ◽  
P Value ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Significant Difference

Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count, mean platelet volume (MPV), platecrit and Platelet distribution width (PDW) along with routine blood parameters hemoglobin(Hb), hematocrit, WBC, Platelet count, serum bilirubin, liver enzymes (AST, ALT) of 123 patients were collected. These 123 patients were grouped into three according to the platelet count (<20000,20000-100000, >100000). All the test results are available in hospital database. This was accessed using inpatient numbers obtained from medical records department of our institution. All analysis was done using free to use software R and values were rounded off to the nearest decimal point. Non normally distributed parameters were expressed as median (IQR). Parameters which did not follow normal distribution were analyzed with Kruskall Wallis test and the values are expressed as mean (SD) and a p value <0.05 was considered statistically significant.Results: Platelet indices PDW (57±13.8 vs. 55.4±6.9, p value 0.001) and MPV (9.2±0.09 vs. 13.8±1.3fL, p value <0.001) values were significantly altered in dengue fever with platelet counts below 20,000 compared to platelet count more than one lakh group. Similarly, the Platelet index (MPVxPDW\PLCxPCT), MPV\PLC, MPV\Platecrit, PDW\PLC and PDW\Platecrit ratio showed statistically significant difference between the different platelet groups.Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, platecrit are useful to monitor dengue fever.

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