Mean Platelet Volume Shows a Significant Positive Correlation with hs-CRP in Korean Patients with Various Disease Conditions

Objective: To investigate the relationship between established acute inflammatory markers in COVID-19 patients with Mean platelet volume (MPV) and Platelet large cell ratio (P-LCR). Materials and Methods: This was a retrospective longitudinal study conducted at Fauji Foundation Hospital, Rawalpindi from 10th June to 10th August 2020. Biochemical parameters i.e. CRP, serum ferritin, LDH, and pro-BNP as well as hematological parameters (MPV and P-LCR) were noted once every week during admission of all the COVID-19 positive patients.Data were analyzed using IBM-SPSS version 23. Repeated measure ANOVA using a generalized linear model was done to check the trend of values during the duration of their stay. Pearson Correlation analysis and regression models were estimated to check the relationship of MPV and P-LCR with C- reactive protein, serum Ferritin, LDH, and pro-BNP. P-values less than 0.05 were considered statistically significant. Results: The mean age of the studied group was 55.47 (SD=±15.0) years with the female to male ratio being 2:1. Mean platelet volume showed a statistically significant positive correlation with the established set of inflammatory markers other than pro-BNP with a p-value of less than 0.05.P-LCR however showed a positive correlation with CRP (p-value of less than 0.05) only with no significant correlation with other biochemical markers. Conclusion: MPV is reported on routine complete blood count report (CBC). It is readily available at even the most under-resourced health centers; therefore reporting the platelet indices does not require extra testing, sampling, or reagent cost. A statistically significant positive correlation amongst the established acute inflammatory markers and relatively understudied platelet indices (MPV) in COVID-19 provides a cost-effective, readily available, and time-efficient tool for marking disease progression.

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ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

Cells ◽

10.3390/cells9091981 ◽

2020 ◽

Vol 9 (9) ◽

pp. 1981

Author(s):

Moritz Messner ◽

Santhosh Kumar Ghadge ◽

Thomas Maurer ◽

Michael Graber ◽

Simon Staggl ◽

...

Keyword(s):

Chronic Inflammation ◽

Significant Positive Correlation ◽

Inflammatory Marker ◽

Cross Sectional Study ◽

Premature Aging ◽

Lamin A ◽

Cross Sectional ◽

Positive Correlation ◽

Hs Crp ◽

Hutchinson Gilford Progeria Syndrome

Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expressed in the blood of healthy individuals due to alternative splicing. Previously, we found an association of increased progerin mRNA with overweight and chronic inflammation (hs-CRP). Here, we aimed to elucidate correlations of ZMPSTE24, lamin A/C and progerin with the inflammatory marker hs-CRP. In this retrospective, cross-sectional study we analyzed blood samples from 110 heart failure patients for quantitative mRNA expression of ZMPSTE24, lamin A/C, progerin and hs-CRP protein. Spearman correlations and linear regression analyses including adjustments for age, gender and ejection fraction showed a significant positive correlation of lnprogerin with lnZMPSTE24 (n = 110; r = 0.33; p = 0.0004) and lnlamin A/C (n = 110; r = 0.82, p < 0.0001), whereas no association was observed between lnlamin A/C and lnZMPSTE24 expression. Further analyses showed a significant positive correlation of lnhs-CRP with lnZMPSTE24 (n = 110; r = 0.21; p = 0.01) and lnlamin A/C (n = 110; r = 0.24; p = 0.03). We conclude that chronic inflammation is associated with increased expression of ZMPSTE24 and lamin A/C mRNA. Both markers also positively correlate with increased expression of the premature aging marker progerin which may be linked to cardiovascular aging.

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Mean platelet volume in Korean patients with acute ischemic stroke: A gender difference

Platelets ◽

10.3109/09537104.2012.658109 ◽

2012 ◽

Vol 24 (1) ◽

pp. 75-76 ◽

Cited By ~ 27

Author(s):

Sun Young Cho ◽

You La Jeon ◽

Seok Keun Choi ◽

Jin-Tae Suh ◽

Hee Joo Lee ◽

...

Keyword(s):

Ischemic Stroke ◽

Gender Difference ◽

Acute Ischemic Stroke ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Korean Patients

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Mean Platelet Volume inMycobacterium tuberculosisInfection

BioMed Research International ◽

10.1155/2016/7508763 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 10

Author(s):

Min Young Lee ◽

Young Jin Kim ◽

Hee Joo Lee ◽

Sun Young Cho ◽

Tae Sung Park

Keyword(s):

Patient Group ◽

Mean Platelet Volume ◽

Inflammatory Marker ◽

Control Group ◽

Significant Relation ◽

Platelet Volume ◽

Positive Correlation ◽

Inflammatory Conditions ◽

High Incidence ◽

Group A

Introduction.Mean platelet volume (MPV) has been thought as a useful index of platelet activation. It is supposed that MPV is also associated with several inflammatory and infectious diseases. Korea still has a high incidence of tuberculosis (TB). The aim of this study was to investigate MPV as an inflammatory marker in TB patients. Materials and Methods.MPV were determined in 221 patients with TB and 143 individuals for control group. MPV was estimated by an Advia 2120 (Siemens Healthcare Diagnostics, Tarrytown, NY, USA).Results.In the TB patient group, a positive correlation was found between CRP and MPV. Age and MPV had a positive correlation in TB patient group.Conclusions.We conclude that there is a significant relation between MPV and inflammatory conditions. MPV can be an inflammatory marker to determine the disease activity in TB patients.

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THE CORRELATION BETWEEN THE MEAN PLATELET VOLUME VALUES WITH THROMBOCYTE AGGREGATION IN NEPHROPATHY DIABETIC PATIENTS

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v25i1.1510 ◽

2019 ◽

Vol 25 (1) ◽

pp. 79

Author(s):

Agus Sunardi ◽

Nadjwa Zamalek Dalimoenthe ◽

Coriejati Rita ◽

Adhi Kristianto Sugianli

Keyword(s):

Diabetic Nephropathy ◽

Platelet Aggregation ◽

Mean Platelet Volume ◽

Cross Sectional Study ◽

Endothelial Damage ◽

Diabetic Patients ◽

Platelet Volume ◽

Cross Sectional ◽

Positive Correlation ◽

Chronic Hyperglycemia

Diabetic nephropathy is the most important cause of end-stage renal failure. Chronic hyperglycemia will cause glomerular endothelial damage, and this damage will stimulate hemostasis activation including platelets so that platelet aggregation will increase. The increase of platelet aggregation will increase platelet consumption, which further stimulates thrombopoiesis which will lead to immature platelets of large size to be released into the circulation. This research aimed to determine the positive correlation between MPV with platelet aggregation in patients with diabetic nephropathy. This study was an analytic observational study with a cross-sectional study design. The research was conducted in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to October 2017. A total of 52 subjects who met the inclusion criteria were included in the study. Mean platelet volume and platelet aggregation were performed with venous examination with EDTA and sodium citrate 3.2% anticoagulants. The result of platelet aggregation examination showing platelet hyper-aggregation was found in 44.2% of subjects, 50% normal-aggregation, 5.8% hypo-aggregation. While the median value of MPV in this study was 9.2 fL with the range of 8.00 – 11.80 fL. A positive correlation was found between MPV value with platelet aggregation with r= 0.067, p= 0.634. The conclusion was that there was no correlation between MPV values with platelet aggregation in diabetic nephropathy patients. This small and insignificant r-value might be due to several factors that also affect platelet aggregation in diabetic nephropathy patients, requiring further investigation.

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MO867THE SIGNIFICANCE OF THE MEAN PLATELET VOLUME AS A BIOMARKER IN HEMODIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab098.0059 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Abdulla Al-Sayyari

Keyword(s):

Vascular Access ◽

Triglyceride Level ◽

Mean Platelet Volume ◽

Pearson Correlation ◽

Chronic Hemodialysis ◽

Platelet Volume ◽

Av Fistula ◽

Positive Correlation ◽

Dialysis Vintage ◽

The Mean

Abstract Background and Aims The mean platelet volume was found to be an important biomarker in certain medical conditions. We evaluate its significance in patients on chronic hemodialysis Method Adult stable patients on chronic hemodialysis for at least six months were included. MPV together with certain demographic ( age, sex, BMI, dialysis vintage, cause of CKD, medication taken, mode of dialysis, type of vascular access) and laboratory parameters (Hb, albumin, Kt/V, PTH, CRP serum lipids) were measured and recorded The correlation between these parameters and MPV was evaluated using Pearson correlation coefficient and the MPV in the absence or presence of the demographic parameters was calculated independent t test Results One hundred and twenty- three patients were studied. The mean age was 60.0± 18.4 and 48.7% were male and diabetes was the cause of CKD in 56.3% ; 72.6% were on hemodialysis and 27.4% on hemodiafiltration , 52.1% used AV fistula and 47.9% used permcath as vascular access; 50.9% were on aspirin Comparing the mean MPV above and below the 50th percentiles in different parameters revealed no significant differences. No significant correlation was found between MPV and duration on dialysis, age, weight, BM, erythropoietin dose per week, PTH, hemoglobin, albumin, CRP, number of admissions in the preceding year yea, LDL or HDL. However , there was a mild positive correlation with triglyceride level (Pearson coefficient = 0.2 (P=0.02). Conclusion No significant correlation or association was found between the MPV and any of the clinical demographic or laboratory parameter measured except that there was a mild positive correlation with triglyceride level.

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Mean platelet volume in Korean patients with hepatic diseases

Platelets ◽

10.3109/09537104.2011.652715 ◽

2012 ◽

Vol 23 (8) ◽

pp. 648-649 ◽

Cited By ~ 21

Author(s):

Sun Young Cho ◽

Anbok Lee ◽

Hee Joo Lee ◽

Jin-Tae Suh ◽

Tae Sung Park

Keyword(s):

Mean Platelet Volume ◽

Platelet Volume ◽

Korean Patients ◽

Hepatic Diseases

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Association of Mean Platelet Volume (MPV) in Relation to Disease Activity in Lupus

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i48a33225 ◽

2021 ◽

pp. 105-110

Author(s):

M. Abhishek ◽

A. Gowrishankar ◽

M. Kavitha

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Clinical Remission ◽

Complete Blood Count ◽

Inverse Correlation ◽

Classification Criteria ◽

Platelet Volume ◽

Positive Correlation ◽

A Prospective Study

Introduction: Among the various clinical and biochemical parameters which are employed to monitor the disease activity in Systemic Lupus Erythematosus (SLE), Mean Platelet Volume, which is a platelet activation biomarker has been recently studied. We intended at evaluating the MPV in patients with active SLE and comparing it with the same patients who were in clinical remission, and to study the correlation between MPV and SLEDAI. We also studied the correlation between MPV and ESR, complements C3 and C4. Methods: This is a prospective study conducted for a period of 12 months, in which 50 consecutive patients who were recently diagnosed with SLE according to the SLICC classification criteria were included. Complete blood count with MPV levels along with ESR, were measured at the first visit to the hospital and were repeated at every visit till they attained clinical remission. Analysis of MPV was done at first visit and at remission. Complements C3 and C4 was done at the first visit and at remission. The results were then tabulated and statistically analysed using SPSS 25. A Pearson’s correlation test was done to assess the relation between MPV, ESR and SLEDAI. Results: Patients with active disease had a decreased MPV as compared to those in clinical remission (10.91fl, 13.11fl, p=0.011). We observed a weak positive correlation between MPV and SLEDAI (r=0.034, p=0.011). We observed no correlation between MPV and ESR, C3 and C4. Meanwhile, SLEDAI showed a positive correlation with C3 and C4; there was no correlation with ESR though. Conclusion: MPV is reduced in patients with active SLE and displayed an inverse correlation with SLEDAI.

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Relationship Between Insulin Resistance and Mean Platelet Volume in Gestational Diabetes Mellitus

Journal of Laboratory Physicians ◽

10.4103/0974-2727.163134 ◽

2015 ◽

Vol 7 (02) ◽

pp. 112-115 ◽

Cited By ~ 4

Author(s):

Suleyman Baldane ◽

Suleyman Hilmi Ipekci ◽

Aysegul Kebapcilar

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Mean Platelet Volume ◽

Hypoglycemic Agents ◽

Platelet Volume ◽

Positive Correlation ◽

The Relationship

ABSTRACT Objectives: A few studies have investigated the relationship between mean platelet volume (MPV) and gestational diabetes mellitus (GDM), and in these studies the relationship between MPV and insulin resistance has not been analyzed. Our aim in this study was to compare MPV values of the pregnant women with or without GDM and evaluate the relationship between MPV and homeostasis model assessment insulin resistance index (HOMA-IR) in pregnant women. Materials and Methods: One hundred and fourteen with GDM measurements being obtained before any dietary advice or therapy with insulin or hypoglycemic agents were given, and 76 with healthy pregnant women were included the study. Results: In the group with GDM, MPV value was found to be significantly higher than that of the control group (10.2 fl [8.0–12.2] vs. 9.9 fl [5.81–10.9], P = 0.004). HOMA-IR value was detected to be significantly higher in the group with GDM (2.46 [1.5–5.88] vs. 1.30 [0.17–2.92], P < 0.001). A positive correlation between MPV and HOMA-IR was found (r = 0.30, P = 0.002). Conclusion: We have shown that MPV was significantly elevated in GDM patients when compared to healthy pregnant women. Furthermore, we found that there was a positive correlation between MPV and HOMA-IR.

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