scholarly journals Estimation of bone mineral density and algorithms of 10-year risk of osteoporotic fractures in women

2021 ◽  
pp. 31-34
Author(s):  
E. Yu. Lukyanets
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Circulatory System ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Diagnosis Of Osteoporosis ◽  
Endocrine Diseases ◽  
Increased Risk ◽  
Average Body ◽  
Average Body Weight

Osteoporosis is the fourth most common after cardiovascular, cancer and endocrine diseases. With an increase in life expectancy, it becomes one of the main causes of deterioration in health and an increase in mortality. Aim of the study. Assess bone mineral density using ultrasonic densitometry and the risk of osteoporotic fractures among women in Cherkasy region. Materials and methods. The study was based on a survey of 43 women in the Odessa region, the average age of the subjects was 56,4±9,9 years, the average body weight was 73,5±11,6 kg, height 164,9±5,9 cm, the average BMI was 27,1±4,3. All women were divided into groups by age with a ten-year interval and by densitometry indices. Results. Decreased bone density was found in 58,1 % of subjects, osteoporosis - 2 (4,8%). Women with osteopenia and osteoporosis have an increased risk of fractures and significantly reduced ultrasound densitometry compared to respondents with normal BMD. The structure of concomitant pathology was dominated by diseases of the circulatory system (22 cases;51,2 %) and digestive organs (12; 27,9 %). More than half of women (26; 60,5 %) had a total of 50 comorbidities, with an average of 1.2 cases of comorbidity. Conclusions. Most women had osteopenic manifestations. Age significantly correlates with BMD parameters. The number of women with changes in the structure of bone tissue increases with age. Algorithms for assessing the 10-year risk of FRAX and Q-Fracture fractures are significantly correlated with densitometry. The combination of ultrasonic densitometry with algorithms for assessing the risk of osteoporotic fractures increases the diagnosis of osteoporosis.

scholarly journals Association Between moleculars and Osteoporotic Fracture Risk:A systematical review

2020 ◽  
Author(s):  
Jie-Yu Liu ◽  
Jia-Xiang Wang ◽  
Li Xu ◽  
Shu-Feng Lei ◽  
Fei-Yan Deng
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Elderly Population ◽  
Early Recognition ◽  
Osteoporotic Fractures ◽  
Middle Aged ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Increased Risk

AbstractOsteoporosis is a systemic chronic skeletal disease, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs). OFs are associated with high mortality and morbidity, and seriously affect the life quality of patients. Osteoporosis is prevalent in the middle-aged and elderly population, especially the postmenopausal women. With population aging, osteoporosis becomes a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing OFs. In light of the high heritability and complex pathogenesis of OP, comprehensive consideration of significant biological/biochemical factors is necessary for accurate risk evaluation. For this purpose, we reviewed recent research progress on moleculars which are diagnostic and/or predictive of OFs risk. Future integrative analyses and systematic evaluation of these moleculars may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence to contribute to preventing OFs in the world.Graphical AbstractOsteoporosis, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs), is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. We focused on several types of important molecules, including proteins/peptides, RNAs, lipids, to gain comprehensive understanding and to generate novel perspectives in predicting and diagnosing OFs.

Bones of Contention: A Comprehensive Literature Review of Non-SSRI Antidepressant Use and Bone Health

2019 ◽  
Vol 33 (6) ◽  
pp. 340-352 ◽  
Author(s):  
Clodagh Power ◽  
Richard Duffy ◽  
James Mahon ◽  
Kevin McCarroll ◽  
Brian A. Lawlor
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Age Groups ◽  
Osteoporotic Fractures ◽  
Risk Groups ◽  
Mineral Density ◽  
Increased Risk ◽  
Antidepressant Use

Osteoporotic fractures are associated with major morbidity and mortality, particularly among older age groups. In recent decades, selective serotonin reuptake inhibitors (SSRI) antidepressants have been linked to reduced bone mineral density and increased risk of fragility fracture. However, up to one-third of antidepressant prescriptions are for classes other than SSRIs. Older patients, who are particularly vulnerable to osteoporosis and its clinical and psychosocial consequences, may be prescribed non-SSRI antidepressants preferentially because of increasing awareness of the risks SSRIs pose to bone health. However, to date, the skeletal effects of non-SSRI antidepressants have not been comprehensively reviewed. In this article, we collate and review the available data and discuss the findings. Based on the current literature, we tentatively suggest that tricyclic antidepressants may increase the risk of fracture via mechanisms other than a direct effect on bone mineral density. The risk is apparently confined to current users only and is greatest in the earliest stage of treatment, diminishing thereafter. There is, as yet, insufficient data to conclusively determine the effects of other antidepressant classes on bone. Judicious prescribing of antidepressants among higher risk groups necessitates a thorough review of the individual’s risk factors for osteoporosis as well as attention to their falls risk. Further longitudinal, rigorously controlled studies are needed to answer some of the remaining questions on the effects of non-SSRI antidepressants on bone and the mechanisms by which they are exerted.

scholarly journals THE VALUE OF OSTEOPONTIN AS A DIAGNOSTIC BIOMARKER IN POSTMENOPAUSAL OSTEOPOROSIS; A REVIEW.

2020 ◽  
Vol 12 ◽  
pp. 27
Author(s):  
Amira A. Atta ◽  
Keyword(s):  
Bone Mineral Density ◽  
Early Detection ◽  
Postmenopausal Osteoporosis ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Dual Energy ◽  
Diagnostic Biomarker ◽  
Mineral Density ◽  
Diagnosis Of Osteoporosis ◽  
X Ray

Although increased awareness of morbidity and costs related to osteoporotic fractures, real progress achieved only through early detection of osteoporosis before any fractures occur. Dual Energy X-ray Absorptiometry (DEXA) is commonly used for diagnosis of osteoporosis by measuring bone mineral density (BMD

scholarly journals Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up

2021 ◽  
Vol 18 (15) ◽  
pp. 8144
Author(s):  
Gabriella Martino ◽  
Federica Bellone ◽  
Carmelo M. Vicario ◽  
Agostino Gaudio ◽  
Andrea Caputo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Rating Scale ◽  
Osteoporotic Fractures ◽  
Oral Bisphosphonates ◽  
Mineral Density ◽  
X Ray ◽  
Hamilton Anxiety Rating Scale ◽  
Anxiety Levels

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

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