Constitutional Approach as a Factor of Sports Injury Prevention

A career in professional sports depends on a number of factors related both directly to the athlete’s body and to the influence of external factors. Age, sport, health, personal trainer, training conditions, etc. – all this is important to achieve the result. However, the athlete’s constitutional features are significant and fundamental for achieving the result. These are not just morphological signs, but also a tendency to the occurrence of injuries and individual psychological characteristics as well as their correspondence to the functional capabilities of the athlete’s body. It is the individual mental characteristics that determine the type of response to the result of the competition (especially negative), the motivational aspect for achieving the result and recovering from injuries. This is important, since injuries are one of the primary problems of sports (regardless of the type), and the number of injuries and traumatological pathologies reaches 44% of the total number of nosologies. Aim. To substantiate the possibility and expediency of using integrative medicine methods in the rehabilitation treatment of sports injuries of the ankle joint. Material and methods. The research object was 38 male athletes involved in game sports, 18 – 26 years old with moderate ankle injuries, sports experience – 10 – 18 years, sports qualifications from the 1st category to the master of sports (MS). The patients were randomly divided into two groups. In the main group – 20 athletes – the rehabilitation schemes included: classical acupuncture, homotoxicology, hirudotherapy, post-isometric relaxation. To comfortably accompany the recovery process, a collegial model of the relationship between a doctor and an athlete was used. The control group consisted of 18 athletes with applied standard recovery rehabilitation scheme. Results and discussion. In athletes in both groups, the clinical manifestations of the disease were stopped at the same time (within6–8 days). Functional recovery of the injured joint in the main group was observed by the 16th day, in the control group – by the 22nd day. Athletes of the main observation group started competitive activity on average after 23 days, in the control group – after 28 days. Conclusion. The use of integrative medicine methods in athletes allowed to shorten the recovery period, reduce the dosage of painkillers, sedatives, anti-inflammatory drugs, accelerate the psychological adaptation of the athlete to the changed life situation and provide relief for injured athletes to undergo rehabilitation treatment, practically preserving overall physical performance.

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Influence of comprehensive physical rehabilitation on the restoration of motor deficiency in patients suffered ischemic stroke

Psychiatry Neurology and Medical Psychology ◽

10.26565/2312-5675-2021-17-04 ◽

2021 ◽

Keyword(s):

Ischemic Stroke ◽

Secondary Prevention ◽

Speech Therapy ◽

Recovery Period ◽

Main Group ◽

Physical Rehabilitation ◽

Rehabilitation Treatment ◽

Treatment Standard ◽

Motor Deficiency ◽

Cerebral Ischemic

The article consideres the issue of restoring lost motor function through comprehensive physical rehabilitation. The results of a study of 84 patients with cerebral ischemic stroke (CIS) are presented. The study of patients was conducted in the recovery period (from 3 to 6 months after the vascular accident). The average age of patients was 64.2±1.7 years. During the study all patients were divided into two groups depending on the type of rehabilitation treatment. The main group consisted of 43 patients who received standard medicines therapy aimed at secondary prevention (antihypertensive, hypocholesterolemic, hypoglycemic and other medicines), as well as therapy aimed at the correction and prevention of neurocognitive and dyscirculatory disorders (medicines with metabolic and vasoactive action) during the entire period of supervision. All patients of the main group underwent a course of comprehensive physical rehabilitation treatment. The latter included classes in kinesiotherapy, occupational therapy, speech therapy classes and, if necessary, patients received psycho-correctional and psychotherapeutic methods of treatment. The second (comparison) group consisted of 41 patients who received only drug treatment: standard basic therapy in the framework of secondary prevention of CIS and therapy aimed at the correction and prevention of neurocognitive, dyscirculatory disorders. The results of our study showed that the use of a comprehensive rehabilitation treatment program consisting of physical and medical methods are signifi cantly more eff ective for patients with motor disorders who have suff ered an ischemic stroke compared with the use of only drug therapy in these patients.

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Clinical evaluation of the effectiveness of treatment of the hand-foot syndrome – skin toxicity of antitumor target therapy with multi-kinase inhibitors

Endocrine Surgery ◽

10.14341/serg9704 ◽

2018 ◽

Vol 12 (3) ◽

pp. 140-149 ◽

Cited By ~ 1

Author(s):

Evgeniya A. Shatokhina ◽

Larisa S. Kruglova ◽

Oleg A. Shukhov

Keyword(s):

Lipoic Acid ◽

Kinase Inhibitors ◽

Clinical Manifestations ◽

Main Group ◽

Betamethasone Dipropionate ◽

Control Group ◽

Positive Trend ◽

Alpha Lipoic Acid ◽

Significant Difference ◽

Hand Foot Syndrome

Background. The effective treatment of the hand-foot syndrome is a necessary component of the complex treatment of patients receiving antitumor therapy with multikinase inhibitors. Aims. The assessment of a new effective method for the treatment of palm-plantar syndrome in patients receiving multi-kinase inhibitors. Materials and methods. There are 27 patients received antitumor treatment with multi-kinase inhibitors and had clinical manifestations of the hand-foot syndrome (HFS) for observation. The main group (14 patients) used a combination of an alpha-lipoic acid at a dose of 600 mg per day per os and an ointment containing 0.005% calcipotriol and 0.05% betamethasone dipropionate 2 times a day. The control group, included 13 patients, used a combination with a cream containing 10% urea and ointment containing 0.05% betamethasone dipropionate. Results. After a week of treatment, the regression of the skin process was observed in both groups, but it was more evident in the main group: significant differences in severity of erythema, paresthesia, pain and burning sensation, the Dermatological Life Quality Index (DLQI) were observed at this stage of therapy (p < 0.05). After 2 weeks of therapy: a more positive trend in the main group in terms of erythema, paresthesia and burning, but the most significant difference is DLQI – 17.4 in the main group and 22.8 in the control group (p < 0.0001). At the end of the 3rd week of therapy: differences with the main characteristics of erythema, desquamation, paresthesia (p < 0.0008), pain (p < 0.0001), DLQI (p < 0.0001). At the end point of the study (after 4 weeks of therapy), significant differences were found in reducing the symptoms and the main parameters for evaluating the effectiveness of DLQI in patients of the main group with a reliability of p < 0.0001. The high correlation of DLQI was found with erythema, pain, burning, paresthesia and desquamation. Conclusions. The treatment of the hand-foot plantar syndrome combined using alpha-lipoic acid inside and topical therapy in the form of an ointment containing calcipotriol and betamethasone dipropionate, can be recommended for patients receiving targeted therapy with multi-kinaseinhibitors.

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FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS

10.25005/2074-0581-2020-22-3-427-433 ◽

2020 ◽

pp. 427-433

Author(s):

M.A. YUSUPOVA ◽

◽

K.I. ISMOILOV ◽

Keyword(s):

Humoral Immunity ◽

Phagocytic Activity ◽

Clinical Manifestations ◽

Main Group ◽

Phagocytic Index ◽

Control Group ◽

Mixed Infections ◽

Secondary Immunodeficiency ◽

Group I ◽

Cellular And Humoral Immunity

Objective: To study the features of clinical manifestations, cellular and humoral immunity of newborns with intrauterine mixed infections (IUMI). Methods: A comprehensive survey of 45 infants with IUMI was carried out. Depending on the classification of IUMI they were divided into 3 main groups: group I – 24 patients (53%) with the viral-bacterial association, group II – 12 patients (27%) with the viral-viral association, and group III – 9 patients (20%) with the viral-parasitic association. The control group consisted of 10 newborns born from uninfected, somatically healthy mothers. Diagnosis of IUMI was based on the detection of specific antibodies of the IgA, IgG and IgM classes, as well as phagocytic activity and phagocytic index of leukocytes. In addition, general clinical, biochemical, bacteriological and instrumental research methods have been conducted. Results: The blood serum IgA and IgM indices in patients of the main group were significantly higher, and the mean IgG values were lower compared to the control group. Analysis of cellular immunity parameters in the main group showed a decrease in the number of mature T-lymphocytes (CD3), B-lymphocytes (CD20), the number of T-helpers and cells that produce IL-2 in the peripheral blood, compared with the control group. In the main group, there was also an increase in the number of apoptosis cells (CD95), cells with high cytotoxic activity (CD25, CD71) and the percentage of natural killer cells (CD16). A decrease in the phagocytic activity and phagocytic index of neutrophils was recorded, which indicates the insufficiency of the nonspecific component of immunity. Conclusions: In newborns, various changes were found both on the part of specific and nonspecific components of immunity. This indicates the development of secondary immunodeficiency in this category of patients and makes it necessary to add to the main treatment of immune corrective therapy. Keywords: Congenital infections, mixed intrauterine infections, TORCH syndrome, opportunistic infections, secondary immunodeficiency.

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Results of the inclusion of osteopathic correction in the complex therapy of patients with chronic gastritis

Russian Osteopathic Journal ◽

10.32885/2220-0975-2021-1-80-89 ◽

2021 ◽

pp. 80-89

Author(s):

R. T. Fazlyakhmetov ◽

R. R. Saﬁullin ◽

A. V. Ustinov

Keyword(s):

Helicobacter Pylori ◽

Gastric Mucosa ◽

Chronic Gastritis ◽

Eradication Therapy ◽

Clinical Manifestations ◽

Integrated Approach ◽

Main Group ◽

Control Group ◽

Study Results ◽

Complex Therapy

Introduction. Many key questions regarding the etiology, pathogenesis, clinical manifestations and treatment of chronic gastritis remain open. So, despite the success of chronic gastritis pharmacotherapy, much attention is paid to non-drug methods of therapy, in particular, osteopathy. However, evidences of the osteopathic methods effectiveness for the chronic gastritis treatment, obtained by objective instrumental methods, are insufﬁciently presented in the modern literature.The goal of research — to study the results of osteopathic correction inclusion in the complex therapy of patients with chronic gastritis.Materials and methods. The study involved 50 patients with chronic gastritis, divided by simple randomization into a control group (25 people) and a main group (25 people). The participants in the control group received standard eradication therapy according to a three-component scheme. The participants of the main group additionally received osteopathic correction. In both groups, at the beginning and at the end of the study, there were performed ﬁbroesophagogastroduodenoscopy with targeted biopsy to assess the gastric mucosa state, Helicobacter pylori identiﬁcation, and intragastric pH-metry to assess gastric juice acidity.Results. According to the study results, a statistically signiﬁcant (p<0,05) decrease in edema and hyperemia of gastric mucosa was found in the control and main groups. There was a statistically signiﬁcant (p<0,001) decrease in gastric aciditywith osteopathic accompaniment, compared with unaccompanied drug treatment. In both groups, there was a statistically signiﬁcant (p<0,05) decrease in the incidence of Helicobacter pylori carriage. Conclusion. Based on the obtained results, it can be assumed that an integrated approach using osteopathic correction in the treatment of chronic gastritis may be more effective than the standard course of treatment.

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Hepatoprotective therapy with low molecular weight sugar drug for pregnant women with liver dysfunction amid early toxicosis and hepatotoxicity

Voprosy ginekologii akušerstva i perinatologii ◽

10.20953/1726-1678-2021-2-34-43 ◽

2021 ◽

Vol 20 (2) ◽

pp. 19-28

Author(s):

E.V. Mozgovaya ◽

◽

M.A. Kryshnya ◽

E.V. Shelaeva ◽

S.V. Nagorneva ◽

...

Keyword(s):

Molecular Weight ◽

Pregnant Women ◽

Bile Acids ◽

Alanine Aminotransferase ◽

Clinical Manifestations ◽

Main Group ◽

Control Group ◽

Low Molecular Weight ◽

Sugar Solution ◽

Drug Induced

Objective. To assess the efficacy and safety of low molecular weight sugar solution as a hepatoprotector in the first trimester of pregnancy in patients with liver functional disorders against the background of early toxicosis and / or hepatotoxicity. Patients and methods. The study included 70 patients: the main group (n = 30) – pregnant women with functional hepatopathies who received therapy with drug Heptrong; the control group (n = 30) – pregnant women who received standard treatment, of which 15 patients had hepatotoxicity (essential phospholipid therapy) and 15 patients with early toxicosis (intravenous saline fluid therapy, Cerucal), as well as 10 pregnant women with early toxicosis who were treated without drugs (the placebo group). Results. Pregnant women with early toxicosis noted a decrease in its clinical manifestations against the use of the drug Heptrong after 2.3 ± 0.8 days from the onset of therapy; by the end of therapy, all patients had no vomiting, and nausea stopped in 80%, which was not observed in comparison groups. The normalization of alanine aminotransferase (≤40 U/L) occurred in 80% of pregnant women in the main group (p < 0.01) and in 66% (p < 0.01) when treating with essential phospholipids. The normalization of alanine aminotransferase (≤40 U/L) occurred in 90% (p < 0.01) and 33.3% (p = 0.03), respectively. A significant decrease in the level of bile acids (from 8.49 ± 2.1 μmol/L to 2.74 ± 1.1 μmol/L; p < 0.05) and improvement in the indicators of the antioxidant system – an increase in total antiradical activity (from 804.0.0 ± 10.5 μmol/L to 839.0 ± 11.0 μmol/L; p < 0.05) and a decrease in the level of conjugated dienes (from 3.77 ± 0.2 μmol/L to 3.26 ± ± 0.1 μmol/L; p < 0.05) – were observed only in the main group. A number of other indicators of the “liver panel” tended to improve only in the main group. Conclusion. Heptrong is an effective hepatoprotective drug, which considerably improves the state of pregnant women during early toxicosis and helps to reduce liver transaminases and bile acids in pregnant women with hepatotoxicity. Due to the antiinflammatory and pronounced antioxidant effect, which is not observed in standard pharmacological treatment, Heptrong can be used to prevent late obstetric complications. Key words: Heptrong, drug-induced hepatopathies, “liver panel” indicators, early toxicosis

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STUDY OF RIVAROXABAN FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS AFTER LOWER EXTREMITY FRACTURES IN RUSSIAN CLINICAL PRACTICE

N N Priorov Journal of Traumatology and Orthopedics ◽

10.32414/0869-8678-2018-1-47-51 ◽

2018 ◽

pp. 47-51

Author(s):

M. V. Belov

Keyword(s):

Lower Extremity ◽

Dabigatran Etexilate ◽

Clinical Manifestations ◽

Bleeding Risk ◽

Recurrent Dislocation ◽

Main Group ◽

Control Group ◽

Thromboembolism Prophylaxis ◽

Vein Thrombosis ◽

Femur Fractures

Thepurposeof the study was to evaluate the efficacy and safety of rivaroxaban in patients after surgical treatment for the lower extremity fractures.Patients and methods. Retrospective multicenter study included 663 patients with femur fractures, 43 patients with complications after total hip arthroplasty (periprosthetic femur fractures, recurrent dislocation) and 10 patients with shinbone fractures. The majority (81.99%) of patients were elderly or senile. In postoperative period all patients received a standard prophylactic dose of anticoagulants. Out of them 75 (main group) – rivaroxaban (10 mg/day), 241 (control group) – other drugs (enoxaparin – 40 mg/day and dabigatran etexilate 150 or 220 mg/day). The efficacy of prophylaxis was assessed by clinical picture and Doppler ultrasound scans.Results.Average bed day made up 9.28. During hospitalization no cases of PE were recorded. In the main and control groups the rate of deep vein thrombosis with clinical manifestations made up 1.89 and 3.31%, respectively. No cases of fatal bleeding occurred. Signs of continuous bleeding in the area of surgical intervention (soaking dressings or recurring wound hematomas) in the main group was recorded rarely (3.15%) than in the control one (8.29%).Conclusion.Reduction of VTE rate with no increase in bleeding risk indicates the feasibility of rivaroxaban use for postoperative PE prophylaxis in patients with lower extremity fractures.

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Enterosorbent for endotoxicosis as a factor influencing the development of young cattle

Agrarian Bulletin of the ◽

10.32417/article_5dcd861e566fb0.98677225 ◽

2019 ◽

Vol 190 (11) ◽

pp. 66-70

Author(s):

А. КРАСНОПЕРОВ ◽

A. KRASNOPEROV ◽

С. Малков ◽

S. Malkov ◽

Наталья Верещак ◽

...

Keyword(s):

Clinical Symptoms ◽

Recovery Period ◽

Clinical Manifestations ◽

The Body ◽

Control Group ◽

Phagocytic Cells ◽

Immunological Parameters ◽

Endogenous Intoxication ◽

Newborn Calves ◽

Young Cattle

Abstract. Purpose – study the effect of enterosorbent on the immunological parameters of blood and the productivity of young cattle. Methods. The object of the study was newborn calves from 2 to 6 days of age (n = 54). Studies on the enterosorbent based on colloidal silicon dioxide (CSD) for calves with alimentary dyspepsia have been carried out. During the experiment, the clinical condition of the animals, the increase in live body weight were evaluated, blood samples were taken for immunohematological studies. Results. In calves at 2–6 days of age, alimentary dyspepsia is accompanied by the development of endogenous intoxication of the body. Animals show leukocytosis – 16.60 ± 5.11×109/l; leukocyte shift to the left with an increase in the number of adolescent and stab neutrophils – 1.41 ± 0.23×109/l; monocytes up to 1.21 ± 0.13x×109/l; circulating immune complexes (CIC) level in blood serum up to 202.4 ± 8.5 cu Under conditions of endogenous intoxication, the immunological protection of the organism was characterized by an increase in the number of phagocytic cells to 71 % of the total number of granulocytes. Clinical symptoms of endogenous intoxication in 86 % of cases disappeared by the 5th day of the use of enterosorbent CSD in the treatment regimen of calves with alimentary dyspepsia. This is associated with blocking and weakening the inflammatory response in the gastrointestinal tract. The effect of enterosorbent CSD on the immunological parameters was expressed in a balanced stabilization of the processes of phagocytosis and immunogenesis. The trend towards normalization of immunological parameters was registered: the level of the CIC was significantly reduced to 97.5 ± 5.48 cu; the phagocytic activity (PA) of the neutrophilic cells was 50.1 ± 2.4 %. Treatment of animals according to the basic scheme approved by the farm turned out to be less effective. In calves that did not receive enterosorbent CSD, in 11 % of cases, clinical manifestations of endogenous intoxication were recorded up to and including 14 days. In these animals, the level of the CIC remained high – 143.6 ± 8.57 cu, the voltage of phagocytic function was noted – 64.3 ± 7.6 % and the imbalance in the ratio of T/B-lymphocytes – 1.13 (normal 1.5–2.0). The effect of the CSD enterosorbent on the calves productivity was reflected in the fact that the rate of weight gain during the experiment was higher in the experimental group. At 4 months, their weight was 149.17 ± 13.57 kg, while in the control group and the comparison group – 135.00 ± 5.00 and 130.00 ± 22.73 kg, respectively. Scientific novelty. Alimentary dyspepsia causes the development of endogenous intoxication in the body of newborn calves. The lack of therapeutic measures leads to a long recovery period and a decrease in productivity.

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Dynamics of Recovery of Functions of the Nasal Cavity in Patients with Aspirin-Intolerant Polypous Rhinosinusitis in the Postoperative Period

Archive of Clinical Medicine ◽

10.21802/acm.2016.2.1 ◽

2016 ◽

Vol 22 (2) ◽

pp. 201621

Author(s):

Ivanna Koshel

Keyword(s):

Nasal Cavity ◽

Postoperative Period ◽

Recovery Process ◽

Main Group ◽

Control Group ◽

Nasal Breathing ◽

Rapid Improvement ◽

Postoperative Rehabilitation ◽

Physiological Functions ◽

Surgical Interventions

Surgical interventions in the nasal cavity are accompanied by reactive phenomena in the postoperative period. On their background the process of physiological regeneration is disorganized resulting in impaired physiological functions of the nasal cavity.The objective of the research was to study the recovery process of the main physiological functions of the nasal cavity in patients with aspirin-intolerant polypous rhinosinusitis in the postoperative period.Materials and methods. 80 patients with aspirin-intolerant polypous rhinosinusitis at the age of 24-57 years were operated on.All the patients were divided into 2 groups: the control group included 30 patients; the main group comprised 50 patients.Patients of the control group received nasal cavity cleaning, nasal mucosa anemisation, irrigation therapy since the first day of the postoperative period.Patients of the main group received an herbal drug BNO-101 additionally. The effectiveness was assessed on the 3rd, 7th and 10th days of treatment.Results. The postoperative rehabilitation with the inclusion of botanical preparation BNO-101 provided a significant improvement of nasal breathing, mucociliary transport rate and indicators of nasal peak flowmetry compared to the control group. Despite subjective improvement of nasal breathing the indicators of the peak expiratory flow rate in the main group were 34.2% lower than the norm while in the control group they were 54.7% lower than normal ones thereby justifying further treatment.Conclusions. The postoperative rehabilitation of patients with aspirin-intolerant polypous rhinosinusitis provided more rapid improvement of the main functions of the nasal cavity compared to the control group.

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Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-193-9-27-32 ◽

2021 ◽

pp. 27-32

Author(s):

A. S. Klimova ◽

E. V. Shrayner ◽

A. I. Khavkin ◽

N. V. Kokh ◽

G. I. Lifshits ◽

...

Keyword(s):

Clinical Symptoms ◽

Polymorphic Locus ◽

Clinical Manifestations ◽

Main Group ◽

Control Group ◽

Significant Difference ◽

Taqman Pcr ◽

Pcr Method ◽

H Pylori ◽

Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

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Dynamics of the painful syndrome, cardial dysfunction and cerebral disorders at patients suffering vertebral cardialgies while treatment of intraosteal blockades

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2009-1(2)-125-128 ◽

2009 ◽

Vol 8 (1(2)) ◽

pp. 125-128

Author(s):

V. A. Filimonov ◽

Ye. L. Sokov ◽

L. Ye. Kornilova

Keyword(s):

Clinical Manifestations ◽

Main Group ◽

Control Group ◽

Ischemic Disease ◽

Painful Syndrome ◽

The Given ◽

Universal Mechanism

177 patients with clinical manifestations of thoracocervical osteochondrosis with vertebro-cardial syndrome and ischemic disease of heart were inspected. 94 patients (main group) underwent a course of intraosteal blockades, while 83 patients (control group) underwent a course of paravertebral blocades. Higher therapeutical effectiveness of intraosteal blockades in treatment of the given patients compared to paravertebral blockades was revealed. Osteogenetic factor can be considered a universal mechanism of forming spondilogenic cardio-cerebral disorders.

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