scholarly journals The Zika virus: outcome and follow up in Brazil’s northeast women

10.3823/2586 ◽  
2019 ◽  
Vol 11 ◽  
Author(s):  
Modesto Leite Rolim Neto ◽  
Cristiano Nogueira Marques ◽  
Arthur Rafhael Amorim Alves Esmeraldo ◽  
Francisca Patricia de Melo Santos Leite ◽  
Dábylla Cynthia Carvalho Bezerra
Keyword(s):  
Zika Virus ◽  
Neurological Disorders ◽  
Short Communication ◽  
Fetal Brain ◽  
Public Health Emergency ◽  
World Health ◽  
Exponential Increase ◽  
Skull Growth ◽  
Health Organization

The World Health Organization (WHO) declared a Public Health Emergency of Inter- national Concern in response to a cluster of microcephaly (restricted fetal brain and skull growth) and neurological disorders likely associated with Zika virus. A Short Communication that focus on The exponential increase and extreme severity of Zika virus (ZIKV), contrasting with evidence that Include: discovery or development of new information’s, novelty in modeling  scientific, elucidation of mechanisms editorials and channels of information.

scholarly journals Progress of COVID-19 Epidemic in Pakistan

2020 ◽  
Vol 32 (4) ◽  
pp. 154-156 ◽  
Author(s):  
Khadijah Abid ◽  
Yashfika Abdul Bari ◽  
Maryam Younas ◽  
Sehar Tahir Javaid ◽  
Abira Imran
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Short Communication ◽  
Health Sector ◽  
Public Health Emergency ◽  
World Health ◽  
First Case ◽  
The World ◽  
Health Organization ◽  
Shed Light

The outbreak of corona virus initiated as pneumonia of unknown cause in December 2019 in Wuhan, China, which has been now spreading rapidly out of Wuhan to other countries. On January 30, 2020, the World Health Organization (WHO) declared coronavirus outbreak as the sixth public health emergency of international concern (PHEIC), and on March 11, 2020, the WHO announced coronavirus as pandemic. Coronavirus is thought to be increasing in Pakistan. The first case of coronavirus was reported from Karachi on February 26, 2020, with estimated populace of Pakistan as 204.65 million. Successively, the virus spreads into various regions nationwide and has currently become an epidemic. The WHO has warned Pakistan that the country could encounter great challenge against the outbreak of coronavirus in the coming days. This short communication is conducted to shed light on the epidemic of coronavirus in the country. It would aid in emphasizing the up-to-date situation in a nutshell and the measures taken by the health sector of Pakistan to abate the risk of communication.

scholarly journals Immunological Assays used to Support Efficacy of Zika Virus Vaccines

2019 ◽  
Vol 4 (3) ◽  
pp. 97
Author(s):  
Kenneth H. Eckels ◽  
Rafael A. De La Barrera ◽  
Joseph Robert Putnak
Keyword(s):  
Public Health ◽  
Public Sector ◽  
Zika Virus ◽  
Public Health Emergency ◽  
World Health ◽  
Vaccine Candidates ◽  
The World ◽  
Private And Public ◽  
Immunological Assays ◽  
Health Organization

In February of 2016, the World Health Organization (WHO) declared Zika virus (ZIKV) a Public Health Emergency of International Concern. This prompted a rapid response from both the private and public sector resulting in the generation of several promising vaccine candidates. In this review, we discuss published scientific efforts associated with these novel vaccines, emphasizing the immunological assays used to evaluate their immunogenicity and efficacy, and support future licensure.

Zika

2017 ◽  
Vol 10 (4) ◽  
pp. 224-227
Author(s):  
Rabia Aftab
Keyword(s):  
Public Health ◽  
Pregnant Women ◽  
Zika Virus ◽  
Public Health Emergency ◽  
World Health ◽  
Global Public Health ◽  
Geographic Spread ◽  
The World ◽  
Public Health Threat ◽  
Health Organization

The Zika virus (ZIKV), first discovered in 1947, has emerged as a global public health threat over the last decade, with an accelerated geographic spread of the virus occurring in the last 5 years. The World Health Organization (WHO) predicts that millions of cases of ZIKV are likely to occur in the Americas between 2016 and 2017. These projections, in conjunction with an increase in newborn microcephaly cases that are suspected to be ZIKV-associated, prompted the WHO to declare a public health emergency of international concern in February 2016. With the current media attention, it is likely that GPs will be consulted on th topic, particularly by pregnant women.

scholarly journals ZIKA VIRUS: A BRIEF REVIEW

2020 ◽  
pp. 21-24
Author(s):  
KANAAN AL-TAMEEMI ◽  
RAIAAN KABAKLI
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Zika Virus ◽  
Diagnostic Techniques ◽  
Public Health Emergency ◽  
World Health ◽  
The World ◽  
Global Concern ◽  
Health Organization

This review highlights the Zika virus which is considered a global concern due to its rapid pandemic potential and effect on humans, and according to its pandemic status, the World Health Organization declared on February 2016 it as a “Public Health Emergency of International Concern.” Therefore, we define the epidemiology of Zika virus in addition to its pathogenesis, diagnostic techniques, and treatment.

scholarly journals An initiative of cooperation in Zika virus research: the experience of the ZIKABRA study in Brazil

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Silvana Pereira Giozza ◽  
◽  
Ximena Pamela Díaz Bermúdez ◽  
Edna Oliveira Kara ◽  
Guilherme Amaral Calvet ◽  
...  
Keyword(s):  
Public Health ◽  
Human Resources ◽  
Zika Virus ◽  
Research Capacity ◽  
Public Health Emergency ◽  
World Health ◽  
International Governance ◽  
Public Health Response ◽  
Laboratory Equipment ◽  
Health Organization

Abstract Background The Zika virus outbreak has triggered a set of local and global actions for a rapid, effective, and timely public health response. A World Health Organization (WHO) initiative, supported by the Department of Chronic Condition Diseases and Sexually Transmitted Infections (DCCI) of the Health Surveillance Secretariat (SVS), Brazil Ministry of Health (MoH) and other public health funders, resulted in the start of the “Study on the persistence of Zika virus in body fluids of patients with ZIKV infection in Brazil – ZIKABRA study”. The ZIKABRA study was designed to increase understanding of how long ZIKV persists in bodily fluids and informing best measures to prevent its transmission. Data collection began in July 2017 and the last follow up visit occurred in 06/26/2020. Methods A framework for the ZIKABRA Cooperation initiative is provided through a description and analysis of the mechanisms, strategies and the ethos that have guided the models of international governance and technical cooperation in health for scientific exchange in the context of a public health emergency. Among the methodological strategies, we included a review of the legal documents that supported the ZIKABRA Cooperation; weekly documents produced in the meetings and working sessions; technical reports; memorandum of understanding and the research protocol. Conclusion We highlight the importance of working in cooperation between different institutional actors to achieve more significant results than that obtained by each group working in isolation. In addition, we point out the advantages of training activities, ongoing supervision, the construction of local installed research capacity, training academic and non-academic human resources, improvement of laboratory equipment, knowledge transfer and the availability of the ZIKABRA study protocol for development of similar studies, favoring the collective construction of knowledge to provide public health emergency responses. Strategy harmonization; human resources and health services; timing and recruiting particularities and processing institutional clearance in the different sites can be mentioned as challenges in this type of initiative.

scholarly journals Zika virus- threat to human race

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
D. K. Awasthi ◽  
Sarita Chauhan
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Zika Virus ◽  
Public Health Emergency ◽  
World Health ◽  
Human Race ◽  
Aedes Mosquitoes ◽  
The World ◽  
Virus Zika ◽  
Health Organization

Zika virus was found in monkey of Zika forest of Uganda. Zika and Ebola viruses are fatal. Zika virus is spread through Aedes mosquitoes. The World Health Organization(WHO) has declared a public health emergency for Zika virus. Zika virus was first of all isolated in 1947. Fever and pain caused by Zika virus is cured by Acetaminophane medicine. Zika virus causes microcephali disease.

Coronavirus diseases and pregnancy: COVID-19,SARS, and MERS

2020 ◽  
pp. 276-289
Author(s):  
Mobina Fathi ◽  
Kimia Vakili ◽  
Niloofar Deravi
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Retardation ◽  
Negative Impact ◽  
World Health ◽  
Wuhan City ◽  
Intrauterine Growth ◽  
Exponential Increase ◽  
The World ◽  
Health Organization ◽  
Respiratory Droplets

Around the end of December 2019, a new beta-coronavirus from Wuhan City, Hubei Province, China began to spread rapidly. The new virus, called SARS-CoV-2, which could be transmitted through respiratory droplets, had a range of mild to severe symptoms, from simple cold in some cases to death in others. The disease caused by SARS-CoV-2 was named COVID-19 by WHO and has so far killed more people than SARS and MERS. Following the widespread global outbreak of COVID-19, with more than 132758 confirmed cases and 4955 deaths worldwide, the World Health Organization declared COVID-19 a pandemic disease in January 2020. Earlier studies on viral pneumonia epidemics has shown that pregnant women are at greater risk than others. During pregnancy, the pregnant woman is more prone to infectious diseases. Research on both SARS-CoV and MERS-CoV, which are pathologically similar to SARS-CoV-2, has shown that being infected with these viruses during pregnancy increases the risk of maternal death, stillbirth, intrauterine growth retardation and, preterm delivery. With the exponential increase in cases of COVID-19 throughout the world, there is a need to understand the effects of SARS-CoV-2 on the health of pregnant women, through extrapolation of earlier studies that have been conducted on pregnant women infected with SARS-CoV, and MERS-CoV. There is an urgent need to understand the chance of vertical transmission of SARS-CoV-2 from mother to fetus and the possibility of the virus crossing the placental barrier. Additionally, since some viral diseases and antiviral drugs may have a negative impact on the mother and fetus, in which case, pregnant women need special attention for the prevention, diagnosis, and treatment of COVID-19.

ARIMA model for forecasting COVID-19 Death cases in India (Preprint)

2020 ◽  
Author(s):  
Jeya Sutha M
Keyword(s):  
Arima Model ◽  
Public Health Emergency ◽  
World Health ◽  
The People ◽  
The World ◽  
The Status ◽  
The Government ◽  
Health Organization ◽  
Spread Of Infection ◽  
Death Cases

UNSTRUCTURED COVID-19, the disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly contagious disease. On January 30, 2020 the World Health Organization declared the outbreak as a Public Health Emergency of International Concern. As of July 25, 2020; 15,947,292 laboratory-confirmed and 642,814 deaths have been reported globally. India has reported 1,338,928 confirmed cases and 31,412 deaths till date. This paper presents different aspects of COVID-19, visualization of the spread of infection and presents the ARIMA model for forecasting the status of COVID-19 death cases in the next 50 days in order to take necessary precaution by the Government to save the people.

scholarly journals Programme for Harmonization to the International Scale in Latin America for BCR-ABL1 quantification in CML patients: findings and recommendations

2020 ◽  
Vol 58 (12) ◽  
pp. 2025-2035
Author(s):  
María Sol Ruiz ◽  
María Belén Sánchez ◽  
Yuly Masiel Vera Contreras ◽  
Evangelina Agrielo ◽  
Marta Alonso ◽  
...  
Keyword(s):  
Latin America ◽  
Myeloid Leukemia ◽  
World Health ◽  
Molecular Response ◽  
Limit Of Quantification ◽  
International Scale ◽  
Deep Molecular Response ◽  
Health Organization ◽  
First Time

AbstractObjectivesThe quantitation of BCR-ABL1 mRNA is mandatory for chronic myeloid leukemia (CML) patients, and RT-qPCR is the most extensively used method in testing laboratories worldwide. Nevertheless, substantial variation in RT-qPCR results makes inter-laboratory comparability hard. To facilitate inter-laboratory comparative assessment, an international scale (IS) for BCR-ABL1 was proposed.MethodsThe laboratory-specific conversion factor (CF) to the IS can be derived from the World Health Organization (WHO) genetic reference panel; however, this material is limited to the manufacturers to produce and calibrate secondary reference reagents. Therefore, we developed secondary reference calibrators, as lyophilized cellular material, aligned to the IS. Our purpose was both to re-evaluate the CF in 18 previously harmonized laboratories and to propagate the IS to new laboratories.ResultsOur field trial including 30 laboratories across Latin America showed that, after correction of raw BCR-ABL1/ABL1 ratios using CF, the relative mean bias was significantly reduced. We also performed a follow-up of participating laboratories by annually revalidating the process; our results support the need for continuous revalidation of CFs. All participating laboratories also received a calibrator to determine the limit of quantification (LOQ); 90% of them could reproducibly detect BCR-ABL1, indicating that these laboratories can report a consistent deep molecular response. In addition, aiming to investigate the variability of BCR-ABL1 measurements across different RNA inputs, we calculated PCR efficiency for each individual assay by using different amounts of RNA.ConclusionsIn conclusion, for the first time in Latin America, we have successfully organized a harmonization platform for BCR-ABL1 measurement that could be of immediate clinical benefit for monitoring the molecular response of patients in low-resource regions.

scholarly journals Trials and Tribulations: mHealth Clinical Trials in the COVID-19 Pandemic

2021 ◽  
Author(s):  
Praveen Indraratna ◽  
Uzzal Biswas ◽  
Jennifer Yu ◽  
Guenter Schreier ◽  
Sze-Yuan Ooi ◽  
...  
Keyword(s):  
Decompensated Heart Failure ◽  
Hospital Staff ◽  
Outpatient Setting ◽  
World Health ◽  
Randomised Control Trial ◽  
Contact Method ◽  
Model Of Care ◽  
Coronary Syndrome ◽  
Health Organization

Introduction: Mobile phone-based interventions in cardiovascular disease are growing in popularity. A randomised control trial (RCT) for a novel smartphone app-based model of care, named TeleClinical Care - Cardiac (TCC-Cardiac), commenced in February 2019, targeted at patients being discharged after care for an acute coronary syndrome or episode of decompensated heart failure. The app was paired to a digital sphygmomanometer, weighing scale and a wearable fitness band, all loaned to the patient, and allowed clinicians to respond to abnormal readings. The onset of the COVID-19 pandemic necessitated several modifications to the trial in order to protect participants from potential exposure to infection. The use of TCC-Cardiac during the pandemic inspired the development of a similar model of care (TCC-COVID), targeted at patients being managed at home with a diagnosis of COVID-19. Methods: Recruitment for the TCC-Cardiac trial was terminated shortly after the World Health Organization announced COVID-19 as a global pandemic. Telephone follow-up was commenced, in order to protect patients from unnecessary exposure to hospital staff and patients. Equipment was returned or collected by a ‘no-contact’ method. The TCC-COVID app and model of care had similar functionality to the original TCC-Cardiac app. Participants were enrolled exclusively by remote methods. Oxygen saturation and pulse rate were measured by a pulse oximeter, and symptomatology measured by questionnaire. Measurement results were manually entered into the app and transmitted to an online server for medical staff to review. Results: A total of 164 patients were involved in the TCC-Cardiac trial, with 102 patients involved after the onset of the pandemic. There were no hospitalisations due to COVID-19 in this cohort. The study was successfully completed, with only three participants lost to follow-up. During the pandemic, 5 of 49 (10%) of patients in the intervention arm were readmitted compared to 12 of 53 (23%) in the control arm. Also, in this period, 28 of 29 (97%) of all clinically significant alerts received by the monitoring team were managed successfully in the outpatient setting, avoiding hospitalisation. Patients found the user experience largely positive, with the average rating for the app being 4.56 out of 5. 26 patients have currently been enrolled for TCC-COVID. Recruitment is ongoing. All patients have been safely and effectively monitored, with no major adverse clinical events or technical malfunctions. Patient satisfaction has been high. Conclusion: The TCC-Cardiac RCT was successfully completed despite the challenges posed by COVID-19. Use of the app had an added benefit during the pandemic as participants could be monitored safely from home. The model of care inspired the development of an app with similar functionality designed for use with patients diagnosed with COVID-19.

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