Give Me a Few Hours: Exploring Short Timescales in Rubin Observatory Cadence Simulations

Abstract The limiting temporal resolution of a time-domain survey in detecting transient behavior is set by the time between observations of the same sky area. We analyze the distribution of visit separations for a range of Vera C. Rubin Observatory cadence simulations. Simulations from families v1.5–v1.7.1 are strongly peaked at the 22 minute visit pair separation and provide effectively no constraint on temporal evolution within the night. This choice will necessarily prevent Rubin from discovering a wide range of astrophysical phenomena in time to trigger rapid follow-up. We present a science-agnostic metric to supplement detailed simulations of fast-evolving transients and variables and suggest potential approaches for improving the range of timescales explored.

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Time-Domain Instrumentation at ESO

Proceedings of the International Astronomical Union ◽

10.1017/s1743921318002508 ◽

2017 ◽

Vol 14 (S339) ◽

pp. 172-175

Author(s):

V. D. Ivanov

Keyword(s):

Time Resolution ◽

Time Domain ◽

Response Mode ◽

Rapid Response ◽

X Ray ◽

European Southern Observatory ◽

Wide Range ◽

Quasar Variability ◽

X Ray Binaries

AbstractOver the years the European Southern Observatory (ESO) has offered a number of time-domain instruments that enable the user to achieve time resolution as small as milliseconds. They have been used for a wide range of applications, from binary studies with Lunar occultations, characterisation of X-ray binaries and exoplanet transits, to quasar variability. Furthermore, ESO provides a target-of-opportunity (ToO) rapid-response-mode (RRM) channel to trigger quick follow-up observations within as little delay as minutes after a transient has been detected. This talk reviewed the available time-domain observing modes and instruments at ESO, giving priority to FORS2, HAWKI and UltraCam. It described the ToO and RRM, and gave examples of the most common science cases that take advantage of those channels and capabilities.

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Cerebellotrigeminal Dermal Dysplasia (Gómez-López-Hernández Syndrome)

Journal of Pediatric Neurology ◽

10.1055/s-0038-1667021 ◽

2018 ◽

Vol 16 (05) ◽

pp. 362-368 ◽

Cited By ~ 1

Author(s):

Federica Sullo ◽

Agata Polizzi ◽

Stefano Catanzaro ◽

Selene Mantegna ◽

Francesco Lacarrubba ◽

...

Keyword(s):

De Novo ◽

Chromosomal Rearrangements ◽

Number Of Patients ◽

Wide Range ◽

Visual Problems ◽

Neurodevelopmental Abnormalities ◽

Clinical Triad ◽

High Degree ◽

Motor Handicap

Cerebellotrigeminal dermal (CTD) dysplasia is a rare neurocutaneous disorder characterized by a triad of symptoms: bilateral parieto-occipital alopecia, facial anesthesia in the trigeminal area, and rhombencephalosynapsis (RES), confirmed by cranial magnetic resonance imaging. CTD dysplasia is also known as Gómez-López-Hernández syndrome. So far, only 35 cases have been described with varying symptomatology. The etiology remains unknown. Either spontaneous dominant mutations or de novo chromosomal rearrangements have been proposed as possible explanations. In addition to its clinical triad of RES, parietal alopecia, and trigeminal anesthesia, CTD dysplasia is associated with a wide range of phenotypic and neurodevelopmental abnormalities.Treatment is symptomatic and includes physical rehabilitation, special education, dental care, and ocular protection against self-induced corneal trauma that causes ulcers and, later, corneal opacification. The prognosis is correlated to the mental development, motor handicap, corneal–facial anesthesia, and visual problems. Follow-up on a large number of patients with CTD dysplasia has never been reported and experience is limited to few cases to date. High degree of suspicion in a child presenting with characteristic alopecia and RES has a great importance in diagnosis of this syndrome.

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MOSAIK and FMI-Based Co-Simulation Applied to Transient Stability Analysis of Grid-Forming Converter Modulated Wind Power Plants

Applied Sciences ◽

10.3390/app11052410 ◽

2021 ◽

Vol 11 (5) ◽

pp. 2410

Author(s):

Nakisa Farrokhseresht ◽

Arjen A. van der Meer ◽

José Rueda Torres ◽

Mart A. M. M. van der Meijden

Keyword(s):

Power System ◽

Time Domain ◽

Power Plants ◽

Transient Stability ◽

Renewable Energy Sources ◽

Critical Factor ◽

Primary Control ◽

Simulation Approach ◽

Wide Range ◽

Grid Side

The grid integration of renewable energy sources interfaced through power electronic converters is undergoing a significant acceleration to meet environmental and political targets. The rapid deployment of converters brings new challenges in ensuring robustness, transient stability, among others. In order to enhance transient stability, transmission system operators established network grid code requirements for converter-based generators to support the primary control task during faults. A critical factor in terms of implementing grid codes is the control strategy of the grid-side converters. Grid-forming converters are a promising solution which could perform properly in a weak-grid condition as well as in an islanded operation. In order to ensure grid code compliance, a wide range of transient stability studies is required. Time-domain simulations are common practice for that purpose. However, performing traditional monolithic time domain simulations (single solver, single domain) on a converter-dominated power system is a very complex and computationally intensive task. In this paper, a co-simulation approach using the mosaik framework is applied on a power system with grid-forming converters. A validation workflow is proposed to verify the co-simulation framework. The results of comprehensive simulation studies show a proof of concept for the applicability of this co-simulation approach to evaluate the transient stability of a dominant grid-forming converter-based power system.

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Zebrafish Models to Study New Pathways in Tauopathies

International Journal of Molecular Sciences ◽

10.3390/ijms22094626 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4626

Author(s):

Clément Barbereau ◽

Nicolas Cubedo ◽

Tangui Maurice ◽

Mireille Rossel

Keyword(s):

Cognitive Deficits ◽

Tau Protein ◽

Common Point ◽

Transgenic Models ◽

Synaptic Loss ◽

Wide Range ◽

Transgenic Lines ◽

Functional Consequences ◽

The Common

Tauopathies represent a vast family of neurodegenerative diseases, the most well-known of which is Alzheimer’s disease. The symptoms observed in patients include cognitive deficits and locomotor problems and can lead ultimately to dementia. The common point found in all these pathologies is the accumulation in neural and/or glial cells of abnormal forms of Tau protein, leading to its aggregation and neurofibrillary tangles. Zebrafish transgenic models have been generated with different overexpression strategies of human Tau protein. These transgenic lines have made it possible to highlight Tau interacting factors or factors which may limit the neurotoxicity induced by mutations and hyperphosphorylation of the Tau protein in neurons. Several studies have tested neuroprotective pharmacological approaches. On few-days-old larvae, modulation of various signaling or degradation pathways reversed the deleterious effects of Tau mutations, mainly hTauP301L and hTauA152T. Live imaging and live tracking techniques as well as behavioral follow-up enable the analysis of the wide range of Tau-related phenotypes from synaptic loss to cognitive functional consequences.

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The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

Journal of Clinical Medicine ◽

10.3390/jcm10020231 ◽

2021 ◽

Vol 10 (2) ◽

pp. 231

Author(s):

Giacinto Triolo ◽

Piero Barboni ◽

Giacomo Savini ◽

Francesco De Gaetano ◽

Gaspare Monaco ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Pressure ◽

Clinical Relevance ◽

Anterior Segment ◽

Angle Closure ◽

Current Evidence ◽

Optical Coherence ◽

Iridocorneal Angle ◽

Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

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Processing GOTO data with the Rubin Observatory LSST Science Pipelines I: Production of coadded frames

Publications of the Astronomical Society of Australia ◽

10.1017/pasa.2020.45 ◽

2021 ◽

Vol 38 ◽

Author(s):

J. R. Mullaney ◽

L. Makrygianni ◽

V. Dhillon ◽

S. Littlefair ◽

K. Ackley ◽

...

Keyword(s):

Gravitational Wave ◽

Time Domain ◽

Wide Area ◽

Wide Field ◽

Process Data ◽

Data Production ◽

The Time Domain ◽

Further Development ◽

High Cadence

Abstract The past few decades have seen the burgeoning of wide-field, high-cadence surveys, the most formidable of which will be the Legacy Survey of Space and Time (LSST) to be conducted by the Vera C. Rubin Observatory. So new is the field of systematic time-domain survey astronomy; however, that major scientific insights will continue to be obtained using smaller, more flexible systems than the LSST. One such example is the Gravitational-wave Optical Transient Observer (GOTO) whose primary science objective is the optical follow-up of gravitational wave events. The amount and rate of data production by GOTO and other wide-area, high-cadence surveys presents a significant challenge to data processing pipelines which need to operate in near-real time to fully exploit the time domain. In this study, we adapt the Rubin Observatory LSST Science Pipelines to process GOTO data, thereby exploring the feasibility of using this ‘off-the-shelf’ pipeline to process data from other wide-area, high-cadence surveys. In this paper, we describe how we use the LSST Science Pipelines to process raw GOTO frames to ultimately produce calibrated coadded images and photometric source catalogues. After comparing the measured astrometry and photometry to those of matched sources from PanSTARRS DR1, we find that measured source positions are typically accurate to subpixel levels, and that measured L-band photometries are accurate to $\sim50$ mmag at $m_L\sim16$ and $\sim200$ mmag at $m_L\sim18$ . These values compare favourably to those obtained using GOTO’s primary, in-house pipeline, gotophoto, in spite of both pipelines having undergone further development and improvement beyond the implementations used in this study. Finally, we release a generic ‘obs package’ that others can build upon, should they wish to use the LSST Science Pipelines to process data from other facilities.

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Clinical and Forensic Aspects of the Different Subtypes of Argyria

Journal of Clinical Medicine ◽

10.3390/jcm10102086 ◽

2021 ◽

Vol 10 (10) ◽

pp. 2086

Author(s):

Luís Mota ◽

Ricardo Jorge Dinis-Oliveira

Keyword(s):

Systemic Absorption ◽

Histopathological Analysis ◽

Wide Range ◽

Silver Deposits ◽

Specific Tissue ◽

Eye Lesions ◽

Dark Blue ◽

Typical Skin ◽

Viable Treatment

Argyria encompasses the different cosmetic alterations that can develop if enough silver particles deposit in a specific tissue, typically in the skin, ranging from localized dark-blue macules to a generalized slate-gray/bluish tinge following systemic absorption. This work aims to fully review the state of the art regarding pathophysiology, diagnosis, treatment, and relevant clinical and forensic features of argyria. Argyria has been diagnosed in a wide range of ages, both sexes and varied ethnicities, with no known individual predisposing factors. Ultraviolet radiation with subsequence increases of melanin production aggravates the discoloration due to a reduction in the silver deposits. Physical examination and silver exposure in the anamnesis can be highly suggestive of the diagnosis, but a histopathological analysis with Energy-Dispersive X-ray Spectroscopy is required to unequivocally determine the discoloration etiology. Safe and effective treatment has only been accomplished with laser techniques, though only a few cases have been reported and with limited follow-up time. In conclusion, argyria typically has an occupational or iatrogenic etiology. It should be suspected when a patient presents with typical skin or eye lesions. A seemingly viable treatment modality, with laser technology, is finally within the horizon.

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Penile Mondor’s in a Covid-19 patient on prophylactic anti-thrombosis with rivaroxaban: a case report

African Journal of Urology ◽

10.1186/s12301-021-00200-7 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Murat Tuğrul Eren ◽

Hakan Özveri ◽

Hilal Kurtoğlu

Keyword(s):

Male Patient ◽

Antibody Test ◽

Inflammatory Cells ◽

Thromboembolism Prophylaxis ◽

Case Presentation ◽

Subacute Phase ◽

Dorsal Vein ◽

Wide Range ◽

Underlying Causes

Abstract Background Penile Mondor’s disease (PMD) is thrombophlebitis of the superficial dorsal vein of the penis. Following the occurrence of thrombotic events in the affected veins, the lumen often becomes occluded with fibrin and inflammatory cells. A hyper-coagulative state is one of the underlying causes although most cases of PMD are idiopathic. Coronavirus disease-2019 infection (COVID-19) is associated with frequent thrombotic events. Inflammation and thrombosis play a central role in the course and outcome of COVID-19, which can predispose to both venous and arterial thromboembolism. In this report, we present a 33-year-old male patient diagnosed with PMD during the subacute phase of COVID-19 infection while on prophylactic antithrombotic treatment. Case Presentation A 33-year-old male patient was diagnosed as PMD which occurred during the subacute phase of COVID-19 infection, while he was on active treatment of COVID-19 by prophylactic antithrombotic Rivaroxaban 15 mg therapy and curative antiviral medication. There was no recent sexual intercourse or trauma to the genitals. His PCR test for COVID-19 had become negative, and antibody test was positive at the time of his PMD’s onset. Rivaroxaban was replaced by Enoxaparin (8000 IU/0.8 ml.), a low molecular weight heparin administered subcutaneously and twice daily. On the third day of this medication, all coagulative measurements returned to normal. PMD disappeared in the second week. Conclusion Low-dose Rivaroxaban 15 mg is not safe for some COVID-19-associated thromboembolism prophylaxis, and careful follow-up is critical due to the possibility of a wide range of pathologic thrombotic manifestations in COVID-19 infection.

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RELATIONSHIP OF ELEVATED BLOOD TYROSINE TO THE ULTIMATE INTELLECTUAL PERFORMANCE OF PREMATURE INFANTS

PEDIATRICS ◽

10.1542/peds.49.2.218 ◽

1972 ◽

Vol 49 (2) ◽

pp. 218-224 ◽

Cited By ~ 2

Author(s):

John H. Menkes ◽

Doris W. Welcher ◽

Helene S. Levi ◽

Joseph Dallas ◽

Neil E. Gretsky

Keyword(s):

Birth Weight ◽

Premature Infants ◽

Maximum Level ◽

Intellectual Performance ◽

Wide Range Achievement Test ◽

Follow Up Study ◽

Wide Range ◽

Significant Difference ◽

Picture Completion

Blood tyrosine concentrations were followed from birth to nursery discharge in 71 premature infants fed a high protein formula supplemented by 60 mg/day of ascorbic acid. In 89% of infants blood tyrosine concentrations were abnormal, and in 38% of infants the maximum level observed was 15.0 mg/100 ml or higher. Maximum blood tyrosine levels correlated significantly with gestational age (p = < 0.05) but not with birth weight. In a follow-up study performed at 15 months of age, infants with high tyrosine levels had no increase in the incidence of neurological abnormalities. Between 7 and 8 years of age a second follow-up study was performed on 62 children. This included a WISC, a Wide-Range Achievement Test (WRAT), and tests for psychomotor and language maturity. Two children had died in the interval, and five of the 62 were retarded for full testing. The full scale WISC I.Q. of all children correlated with birth weight at the 10% confidence level (p = < 0.1). The mean WISC I.Q. of high and low tyrosine subjects was 82.9 and 81.6 respectively. When infants were grouped by birth weight, a significant difference was detected in subjects weighing 2,000 gm or more. High tyrosine infants had a significantly lower performance I.Q. than low tyrosine infants (82.4 and 97.8 respectively; p = < 0.02). Significant differences were recorded in the scores on Object Assembly, Picture Assembly, and Picture Completion of the WISC. Significant differences were also seen on the Spelling subtest of the WRAT (p = < 0.02). We observed no adverse effect of high tyrosine levels on the intellectual performance of smaller premature infants, who on the whole have a greater risk for other complications of prematurity.

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Abstract P002: Heavy Alcohol Consumption Increases the Risk of Atrial Fibrillation -Circulatory Risk in Communities Study(CIRCS)

Circulation ◽

10.1161/circ.127.suppl_12.ap002 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Fumihiko Sano ◽

Tetsuya Ohira ◽

Akihiko Kitamura ◽

Hironori Imano ◽

Renzhe Cui ◽

...

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Medical History ◽

Moderate Alcohol Consumption ◽

Heavy Alcohol ◽

Ethanol Drinking ◽

Wide Range ◽

Detailed Medical History ◽

Heavy Alcohol Consumption

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

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