scholarly journals Helicobacter Pylori Infection in Children with Type 1 Diabetes Mellitus

2014 ◽  
Vol 2 (1) ◽  
pp. 114-118 ◽  
Author(s):  
Sohair B. Fayed ◽  
Soha M. Abd El Dayem ◽  
Ensaf Khalil ◽  
Mona Abd El Kader ◽  
Eatemad Abd El Halim
Keyword(s):  
Age Of Onset ◽  
Virulent Strain ◽  
Glycosylated Hemoglobin ◽  
Diabetic Patients ◽  
Diabetic Children ◽  
Cytotoxin Associated Gene A ◽  
Control Of Diabetes ◽  
H Pylori ◽  
Cag A

Objective: To evaluate H. pylori infection and virulent strain in diabetic children. Patients: In this study 53 type 1 diabetics and 53 of normal volunteers were included. Methods: All studied children were subjected to assessment of glycosylated hemoglobin (HbA1), Anti H. pylori antibodies (IgA, IgG, IgM), Anti-cytotoxin associated gene A antibodies (Anti Cag A IgG). Results: Anti H. pylori antibodies IgA, IgG, total antibodies and anti Cag A IgG were significantly higher in diabetics. Diabetic patients with positive anti Cag A IgG had a lower age of onset of diabetes, higher age of patients, body mass index (BMI) and HbA1. Conclusion: High prevalence of infection with the virulent strain of H. pylori among diabetic children with older age, large BMI, high HbA1 and younger age of onset of disease. The screening for the virulent strain in diabetic patients with poor metabolic control is mandatory. Control of diabetes is essential to present the infection with H. pylori.

scholarly journals Association between Antioxidant Enzyme Activities and Enterovirus-Infected Type 1 Diabetic Children

2018 ◽  
Vol 27 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Adel Abdel-Moneim ◽  
Waled M. El-Senousy ◽  
Mahmoud Abdel-Latif ◽  
Rehab G. Khalil
Keyword(s):  
Antioxidant Enzymes ◽  
Cell Damage ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Antioxidant Enzyme Activities ◽  
Rt Pcr ◽  
Reactive Protein ◽  
Diabetic Children

Objective: To examine the effect of infection with Enterovirus (EV) in children with type 1 diabetes (T1D) on the activities of serum antioxidant enzymes in diabetic and nondiabetic controls. Subjects and Methods: Three hundred and eighty-two diabetic and 100 nondiabetic children were tested for EV RNA using reverse transcriptase (RT)-PCR. The activities of serum superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were also estimated in diabetic patients infected with EV (T1D-EV+), those not infected with EV (T1D-EV–), and in nondiabetic controls. Results: The frequency of EV was higher in diabetic children (100/382; 26.2%) than in healthy controls (0/100). Levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP) were significantly higher but C-peptide was significantly lower in diabetic children than in controls. CRP levels were higher in the T1D-EV+ group than in the T1D-EV– group, and higher in all diabetic children than in nondiabetic controls. The activities of the antioxidant enzymes GPx, SOD, and CAT decreased significantly in diabetic children compared to in controls. Moreover, the activities of the enzymes tested were significantly reduced in the T1D-EV+ group compared to in the T1D-EV– group. Conclusion: Our data indicate that EV infection correlated with a decrease in the activity of antioxidant enzymes in the T1D-EV+ group compared to in the T1D-EV– group; this may contribute to β cell damage and increased inflammation.

scholarly journals Pancreas transplantation: review

2015 ◽  
Vol 13 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Roberto Ferreira Meirelles Júnior ◽  
Paolo Salvalaggio ◽  
Alvaro Pacheco-Silva
Keyword(s):  
Pancreas Transplantation ◽  
Glycosylated Hemoglobin ◽  
The United States ◽  
Diabetes Patient ◽  
Pancreas Transplant ◽  
First Year ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Simultaneous Pancreas Kidney

ABSTRACT Vascularized pancreas transplantation is the only treatment that establishes normal glucose levels and normalizes glycosylated hemoglobin levels in type 1 diabetic patients. The first vascularized pancreas transplant was performed by William Kelly and Richard Lillehei, to treat a type 1 diabetes patient, in December 1966. In Brazil, Edison Teixeira performed the first isolated segmental pancreas transplant in 1968. Until the 1980s, pancreas transplants were restricted to a few centers of the United States and Europe. The introduction of tacrolimus and mycophenolate mofetil in 1994, led to a significant outcome improvement and consequently, an increase in pancreas transplants in several countries. According to the International Pancreas Transplant Registry, until December 31st, 2010, more than 35 thousand pancreas transplants had been performed. The one-year survival of patients and pancreatic grafts exceeds 95 and 83%, respectively. The better survival of pancreatic (86%) and renal (93%) grafts in the first year after transplantation is in the simultaneous pancreas-kidney transplant group of patients. Immunological loss in the first year after transplant for simultaneous pancreas-kidney, pancreas after kidney, and pancreas alone are 1.8, 3.7, and 6%, respectively. Pancreas transplant has 10 to 20% surgical complications requiring laparotomy. Besides enhancing quality of life, pancreatic transplant increases survival of uremic diabetic patient as compared to uremic diabetic patients on dialysis or with kidney transplantation alone.

The relationship between P-wave dispersion and diastolic functions in diabetic children

2010 ◽  
Vol 20 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Reşit Köken ◽  
Tevfik Demir ◽  
Tolga Altuğ Şen ◽  
Ahmet Afşin Kundak ◽  
Osman Öztekin ◽  
...  
Keyword(s):  
Wave Dispersion ◽  
P Wave ◽  
Diabetic Patients ◽  
P Wave Dispersion ◽  
Velocity Time Integral ◽  
Time Integral ◽  
Maximum Duration ◽  
Diabetic Children ◽  
Diastolic Functions

AbstractObjectiveThe aim of this study was to investigate the relations between the P-wave dispersion and diastolic functions in type 1 diabetic children.PatientsA total of 33 diabetic patients without any cardiovascular disease, with a mean age of 12.3 plus or minus 4.2 years, and 29 healthy controls, with a mean age of 10.4 plus or minus 3.9 years were enrolled for this study. Left and right ventricular functions were assessed by using standard pulsed-wave Doppler echocardiography. P-wave dispersion was calculated by measuring minimum and maximum P-wave duration values on the surface electrocardiogram.ResultsFor the diabetic patients, P-wave maximum duration and dispersion was found to be significantly increased compared with healthy controls. Likewise, mitral A velocity and A velocity time integral was significantly increased while the isovolumic contraction time was significantly higher in the diabetics. In tricuspid valve measurements, however, A velocity time integral was found to be significantly higher, whereas the deceleration time was significantly lower in the diabetics. No relation was found between the left ventricle diastolic functions and duration of diabetes, HbA1c levels and P-wave dispersion in the diabetic children. No correlation was found between the diastolic functions and P-wave minimum, maximum duration, and dispersion for all the participants.ConclusionIn type-1 diabetic children, the diastolic functions of both the ventricles were observed to be affected negatively together. Diabetes might be causing the prolongation of P-wave dispersion, but there was no relationship between the diastolic functions and P-wave dispersion in the diabetic children.

scholarly journals Prevalence and pattern of dyslipidemia in an Egyptian children and adolescents with type 1 diabetes

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Hend Soliman ◽  
Amany Ibrahim
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Children And Adolescents ◽  
Glycosylated Hemoglobin ◽  
Laboratory Data ◽  
Density Lipoprotein ◽  
Diabetes Duration ◽  
Egyptian Children ◽  
Diabetic Children

Abstract Background Hyperglycemia and dyslipidemia are commonly found metabolic abnormalities in diabetic children and adolescents and both increase the risk of cardiovascular disease. This study aimed to assess the prevalence and the pattern of dyslipidemia in Egyptian children and adolescents with type 1 diabetes (T1DM) and determine its relation with the glycemic control. Results This retrospective study included 806 children and adolescents with T1DM; 358 (44.42%) males and 448 (55.58%) females. Their mean age was 11.71 ± 3.6 years. Clinical and laboratory data were recruited from patients’ files. Laboratory data include the most recent fasting lipid profile (triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL)), and the mean glycosylated hemoglobin (HbA1c) levels over the preceding year presented in percentage were calculated. Dyslipidemia in children and adolescents with T1DM represented 70.47% (568 patients). No statistically significant differences were detected between patients with and without dyslipidemia. As regards the pattern of dyslipidemia, high LDL and low HDL were the most frequent abnormalities in the study group; 62.16%, 60.21%, respectively. Patients with poor glycemic control (HbA1c > 7.5%) represent 73.45% and they were significantly older, with longer diabetes duration and higher TC, TG, and LDL compared to patients with good glycemic control. Significant positive correlations were found between HbA1c, TG, TC, and LDL with the age and diabetes duration. Conclusion We detected high prevalence of dyslipidemia in children and adolescents with T1DM. Therefore, dyslipidemia should be screened for in earlier ages in Egyptian children and adolescents suffering from T1DM. Programs directed to the prevention of dyslipidemia should be conducted, particularly for this group, in order to prevent/delay cardiovascular complications related to dyslipidemia. Also, parents should receive proper education targeting the prevention, control, and care of their diabetic children with dyslipidemia.

scholarly journals Relationship between circulating endothelial progenitor cells and endothelial dysfunction in children with type 1 diabetes: a novel paradigm of early atherosclerosis in high-risk young patients

2013 ◽  
Vol 168 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Barbara Głowińska-Olszewska ◽  
Marcin Moniuszko ◽  
Andrzej Hryniewicz ◽  
Marta Jeznach ◽  
Małgorzata Rusak ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Function ◽  
Diabetic Patients ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Increased Risk ◽  
Diabetic Children

ObjectiveThe low number of circulating endothelial progenitor cells (EPCs) has emerged as a biomarker of cardiovascular (CV) risk in adults. Data regarding EPCs in paediatric populations with CV risk factors are limited. The aim of the study was to estimate the EPC number and its relationship with vascular function and structure in children with type 1 diabetes mellitus (T1DM).Design and methodsWe performed a comparative analysis of 52 children with T1DM (mean age 14.5 years; diabetes duration, 6.0 years; HbA1c level, 8.5%) and 36 healthy age- and gender-matched control children. EPCs were identified and analysed by flow cytometry with the use of MABs directed against CD34, CD144 (VE-cadherin) and CD309 (VEGFR-2). sICAM-1, hsCRP, thrombomodulin and adiponectin levels were also assessed. We evaluated vascular function (flow-mediated dilation (FMD)) and structure (carotid intima–media thickness (IMT)) ultrasonographically.ResultsFrequencies of CD34+ cells were similar in both groups (P=0.30). In contrast, frequencies of CD34+VE-cadherin+ cells were significantly higher in diabetic children compared with the healthy group (P=0.003). Similarly, diabetic patients tended to present with higher frequencies of CD34+VEGFR+ cells (P=0.06). FMD was lower (6.9 vs 10.5%, P=0.002) and IMT was higher (0.50 vs 0.44 mm, P=0.0006) in diabetic children. We demonstrated a significant relationship between CD34+VEGFR-2+ cells and BMI (r=0.3, P=0.014), HDL (r=−0.27, P=0.04), sICAM-1 (r=0.47, P=0.023) and FMD (r=−0.45, P<0.001). Similarly, frequencies of CD34+VE-cadherin+ cells were significantly correlated with BMI (r=0.32, P=0.02) and FMD (r=−0.31, P=0.03).ConclusionsWe demonstrated here that increased frequencies of EPCs observed in diabetic children are negatively correlated with endothelial function. Further studies are warranted to assess whether this phenomenon might result from effective mobilisation of EPCs in order to repair damaged endothelium in children at increased risk for atherosclerosis.

scholarly journals Cognitive Dysfunction in Diabetic Patients with Special Reference to Age of Onset, Duration and Control of Diabetes

2012 ◽  
Vol 54 (1-2) ◽  
pp. 67-75 ◽  
Author(s):  
Priyam Mukherjee ◽  
Srijan Mazumdar ◽  
Soumik Goswami ◽  
Jayeeta Bhowmik ◽  
Subhro Chakroborty ◽  
...  
Keyword(s):  
Special Reference ◽  
Cognitive Dysfunction ◽  
Age Of Onset ◽  
Diabetic Patients ◽  
Control Of Diabetes ◽  
And Control

The Patient-Doctor Relationship and Metabolic Control in Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

1993 ◽  
Vol 23 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Heimo Viinamäki ◽  
Leo Niskanen ◽  
Timo Korhonen ◽  
Veikko Tähkä
Keyword(s):  
Metabolic Control ◽  
Self Esteem ◽  
Physician Satisfaction ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Direct Estimate ◽  
Cross Sectional ◽  
Control Of Diabetes ◽  
The Impact

Objective: Our hypothesis was that patient-doctor relationship experienced positively by the patient is associated with adequate compliance behavior and thus to the long-term metabolic control of diabetes. Method: Cross-sectional study of 100 consecutive adult patients with Type 1 diabetes treated in a diabetes out-patient department. From a questionnaire, four scores (direct estimate of physician, satisfaction with the place of treatment, self-esteem score, security with the patient-doctor relationship) determining the patient-doctor relationship were formed. In score 3 (self-esteem score) the impact of the patient-doctor relationship to the patients' self-esteem was indirectly estimated. The anonymous data taken from diabetes register including information about treatment of diabetes, metabolic control and end-organ complications were returned together with the questionnaire. On the basis of GHbA1c diabetic patients were divided into two groups: with adequate metabolic control (GHbA1c ⩽ 8.0%) or with poor/moderate control (GHbA1c > 8.0%). Results: In univariate analyses the score 3 associated with metabolic control ( p < 0.001). In logistic regression analyses the nephropathy ( t = 2.80, p < 0.05) and score 3 ( t = 3.98, p < 0.001) were associated with metabolic control. Conclusion: Patient's positively-experienced patient-doctor relationship was associated with good metabolic control of diabetes.

scholarly journals INSULIN RESISTANCE AND CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS AT MEDICINE DEPARTMENT OF GMC, BETTIAH, BIHAR

2020 ◽  
pp. 1-2
Author(s):  
Sumit Kumar ◽  
Dharmendra Prasad ◽  
Parshuram Yugal ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Glycosylated Hemoglobin ◽  
Diabetic Patients ◽  
Medicine Department ◽  
Increased Risk

Background and Aims : Diabetes mellitus (DM) is a chronic disease which can evolve towards devastating micro- and macrovascular complications. DM is the most frequent cause of chronic kidney disease (CKD). Insulin resistance plays an important role in the natural history of type 1 diabetes. The purpose of the study was to determine the prevalence of CKD in T1DM and the correlation with insulin resistance (IR) in patients with CKD. Materials and Methods : The study was conducted over a period of two years (2014–2015) and included patients with DM admitted in Medicine Department of ANMMCH, Gaya, Bihar. The study design was an epidemiological, transversal, noninterventional type. Finally, the study group included 200 subjects with type 1 DM. Insulin resistance (IR) was estimated by eGDR. The subjects with eGDR ≤ 7.5mg/kg/min were considered with insulin resistance. Results : CKD was found in 44% of the patients. Analyzing statistically the presence of CKD, we found highly significant differences between patients with CKD and those without CKD regarding age and sex of the patients, the duration of diabetes, glycosylated hemoglobin (HbA1c), the estimated glucose disposal rate (eGDR), and the presence of hypertension, dyslipidemia, and hyperuricaemia. In patients with CKD, age and diabetes duration are significantly higher than in those who do not have this complication. CKD is more frequent in males than in females (50.9% men versus 34.5% women, ). From the elements of metabolic syndrome, high blood pressure, hyperuricemia, and dyslipidemia are significantly increased in diabetic patients with CKD. eGDR value (expressed as mg•kg−1•min−1) is lower in patients with CKD than in those without CKD (15.92 versus 6.42, ) indicating the fact that patients with CKD show higher insulin resistance than those without CKD. Conclusions. This study has shown that insulin resistance is associated with an increased risk of CKD, but, due to the cross-sectional design, the causal relationship cannot be assessed.

scholarly journals Sclerodactyly and Diabetic Complications among Egyptian Adolescent Type 1 Diabetic Patient

2019 ◽  
Vol 7 (23) ◽  
pp. 4004-4009
Author(s):  
Soha M. El Dayem ◽  
Abo El Magd El Bohy ◽  
Ahmed A. Battah
Keyword(s):  
Diabetic Complications ◽  
Clinical Laboratory ◽  
Microvascular Complications ◽  
Glycosylated Hemoglobin ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Skin Thickness ◽  
Laboratory Assessment ◽  
Limited Joint Mobility

BACKGROUND: One of the common complications of diabetic patients is sclerodactyly which is considered as a part of limited joint mobility. AIM: To assess sclerodactyly in adolescent type 1 diabetics and to detect its relation to other diabetic complications. METHODS: Sixty-three diabetics and 60 controls were studied. Clinical, laboratory assessment, ultrasonography of the skin, carotid artery intima-media thickness (cIMT) & renal colour duplex were done for all participants. RESULTS: Sclerodactyly was positive in 12 (19%) of diabetics. Patients with sclerodactyly had a significantly thickened skin compared to patients without sclerodactyly and controls, P = 0.0001. Male diabetics had significantly thickened skin (p = 0.0001). Diabetic patients with sclerodactyly had significant higher systolic blood pressure (p = 0.03), cholesterol (p = 0.05) and triglyceride (p = 0.004) and lower HDL-c (p = 0.04). Skin thickness had a significant positive correlation with age of diabetic patients (p = 0.02), waist/height ratio (p = 0.04), glycosylated hemoglobin (p = 0.03), albumin/creatinine ratio (p = 0.03), and cIMT (p = 0.03). CONCLUSION: Ultrasound easily diagnoses sclerodactyly. Diabetic patients had a high prevalence of sclerodactyly with increased macrovascular and microvascular complications. Sclerodactyly may be a marker for diabetic vascular complications. Frequent follow up of diabetic patients for early detection of sclerodactyly in uncontrolled diabetic patients is recommended. It could be an alarming sign for microalbuminuria, hypertension, hyperlipidaemia and atherosclerosis.

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