scholarly journals Antigenotoxic and Antioxidant Activity of Methanol Stem Bark Extract of Napoleona Vogelii Hook & Planch (Lecythidaceae) In Cyclophosphamide-Induced Genotoxicity

2017 ◽  
Vol 5 (7) ◽  
pp. 866-874 ◽  
Author(s):  
Victor Ikumawoyi ◽  
Esther Agbaje ◽  
Olufunsho Awodele
Keyword(s):  
Unsaturated Fatty Acids ◽  
Antioxidant Activities ◽  
Stem Bark ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Bark Extract ◽  
Sprague Dawley ◽  
Spectrometry Analysis ◽  
Sprague Dawley Rats ◽  
Stem Bark Extract

BACKGROUND: Napoleona vogelii is used in traditional medicine for cancer management.AIM: The study was conducted to evaluate the antigenotoxic and antioxidant activities of methanol stem bark extract of N. vogelii in male Sprague Dawley rats.MATERIALS AND METHOD: Thirty male Sprague Dawley rats were randomly divided into group 1 (control) administered 10 mL/kg distilled water, groups 2 and 3 were co-administered 100 mg/kg, 200 mg/kg of N. vogelli and 5 mg/kg cyclophosphamide (CPA) respectively for 7 days p.o. Groups 4 and 5 were administered only 5 mg/kg CPA and 200 mg/kg NV respectively.RESULTS: The LD50 oral was greater than 4 g/kg. There were significant (p < 0.0001) increases in plasma enzymatic and non-enzymatic antioxidant enzymes and significant (p < 0.0001) decrease in percentage micronuclei in bone marrow of extract treated rats compared to rats administered 5 mg/kg CPA alone. There was steatosis pointing to cytotoxic injury in the liver of rats co-administered 200 mg/kg NV and 5 mg/kg CPA. Gas chromatography-mass spectrometry analysis of the extract showed the presence of phytol and unsaturated fatty acids.CONCLUSION: N. vogelii possesses antigenotoxic and antioxidant activities associated with the presence of phytochemicals, phytol and unsaturated fatty acids.

Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague–Dawley rats

2013 ◽  
Vol 55 ◽  
pp. 617-626 ◽  
Author(s):  
Seo-Ho Shin ◽  
Kyo-Hwan Koo ◽  
Jin-Sook Bae ◽  
Seung-Bum Cha ◽  
In-Soo Kang ◽  
...  
Keyword(s):  
Oral Dose ◽  
Stem Bark ◽  
Bark Extract ◽  
Sprague Dawley ◽  
Toxicity Studies ◽  
Rhus Verniciflua ◽  
Sprague Dawley Rats ◽  
Stem Bark Extract

The hypotensive mechanisms for the aqueous stem bark extract of Musanga cecropioides in Sprague-Dawley rats

2006 ◽  
Vol 106 (2) ◽  
pp. 203-207 ◽  
Author(s):  
A.A. Adeneye ◽  
O.P. Ajagbonna ◽  
F.B.O. Mojiminiyi ◽  
I.P. Odigie ◽  
P.D. Ojobor ◽  
...  
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Stem Bark Extract

scholarly journals Spondias purpurea L. Stem Bark Extract: Antioxidant and in vitro Photoprotective Activities

2021 ◽  
Author(s):  
Francisco Alessandro Rodrigues ◽  
Priscylla Giffony ◽  
Sarah dos Santos ◽  
Jhonyson Guedes ◽  
Maria Elenir Ribeiro ◽  
...  
Keyword(s):  
Active Ingredient ◽  
Antioxidant Activities ◽  
Stem Bark ◽  
Ultra Performance Liquid Chromatography ◽  
Bark Extract ◽  
Protection Factor ◽  
Phenolic Constituents ◽  
Stem Bark Extract ◽  
Spondias Purpurea

Plant phenolic extracts are widely recognized as an important source of natural antioxidant substances and potential compounds for cosmetic formulations. This study aimed to evaluate the chemical profile, photoprotective and antioxidant activities of stem bark extract of Spondias purpurea L. (ciriguela) and its application in photoprotective formulations. Thirty phenolic constituents were annotated by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry in mode negative (UPLC‑QTOF-MS2). The stem bark extract antioxidant and chelation potential, expressed in half maximal inhibitory concentration (IC50), showed 6.25 and 352.22 μg mL−1, respectively. The phenolic extract was used as an active ingredient in six sunscreen formulations, with concentrations ranging from 0.2 to 10%. The ultraviolet (UV) protection properties of the formulations were evaluated by sun protection factor (SPF) values obtained in 0.2 mg mL−1 (0.495 to 2.27) and 2.0 mg mL−1 (2.29 to 15.87). The SPF value for the extract (14.37 and 26.16) was high, but there was a reduction in the base formulation. However, these results suggested that the bioactive extracted of stem bark of Spondias purpurea L. has interesting potential to reduce the damage caused by UV radiation and may be utilized as an active ingredient in a sunscreen formulation.

scholarly journals Hydroethanolic Stem Bark Extract of Burkea africana Attenuates Vincristine-Induced Peripheral Neuropathy in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Yakubu Jibira ◽  
Eric Boakye-Gyasi ◽  
Wonder Kofi Mensah Abotsi ◽  
Isaac Kingsley Amponsah ◽  
Donatus Wewura Adongo ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Stem Bark ◽  
Nerve Tissue ◽  
Bark Extract ◽  
Lipid Peroxidation Product ◽  
Sprague Dawley ◽  
Withdrawal Threshold ◽  
Tissue Homogenates ◽  
Peroxidation Product ◽  
Stem Bark Extract

Context. The stem bark of the savanna tree Burkea africana (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases. Objective. This study seeks to investigate the possible antiallodynic and antihyperalgesic effects of the hydroethanolic stem bark extract of B. africana in a vincristine-induced peripheral neuropathy model in rats. Materials and Methods. 0.1 mg kg−1 vincristine was administered intraperitoneally for 5 days followed by 2 days break and continued for another 5 days to establish peripheral neuropathy in Sprague Dawley rats. Effects of Burkea africana extract (BAE) (50–1000 mg kg−1, p.o.) and pregabalin (10–100 mg kg−1, i.p.) were assessed on tactile, intermediate, mechanical, cold, and hot allodynia as well as in the Randall–Sellito test. Moreover, the levels of total proteins, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in sciatic nerve tissue homogenates were assayed. Results. BAE (50–1000 mg kg−1p.o.) showed significant antiallodynic and antihyperalgesic effects similar to pregabalin by increasing paw withdrawal latency and paw withdrawal threshold in all the behavioral tests used. Also, the extract decreased the levels of MDA (a lipid peroxidation product) as well as MPO and caused a significant increase in endogenous antioxidants (GSH) and antioxidant enzymes (SOD and CAT) in tissue homogenates of treated rats. Conclusions. Results from this study indicate that the hydroethanolic stem bark extract of B. africana exhibits antiallodynic and antihyperalgesic effects in vincristine-induced peripheral neuropathy in rats.

scholarly journals Analgesic, Non-ulcerogenic and Antioxidant Activities of the Aqueous Stem Bark Extract of Morinda lucida (Rubiaceae) in Mice

2017 ◽  
Vol 11 (3) ◽  
pp. 1-10 ◽  
Author(s):  
Mezui Christophe ◽  
Amang Perfusion ◽  
Bougnom Pascal ◽  
Malepa Ginette ◽  
Tchinda Serges ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract

scholarly journals Comparative Phytochemical and in vitro Antioxidant Screening of the Root and Stem Bark of Annona muricata Linn

2020 ◽  
pp. 48-61
Author(s):  
C. E. Anarado ◽  
F. M. Chukwubueze ◽  
C. J. O. Anarado ◽  
N. L. Umedum ◽  
C. B. Nwanya
Keyword(s):  
Ethyl Acetate ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Solvent Polarity ◽  
Stem Bark ◽  
Bark Extract ◽  
Root Extract ◽  
Annona Muricata ◽  
Stem Bark Extract

Aim: To compare the phytochemicals and antioxidant activities of stem bark and root extracts of Annona muricata. Methodology: The stem bark and root of Annona muricata were collected, washed, air-dried, ground and each extracted with methanol, ethyl acetate and n-hexane. The extracts were analysed for the presence of phytochemicals. Antioxidant screening was also carried out on the samples. Results: Cardiac glycosides were present in all the extracts of both root and stem bark. Alkaloids were present in moderate abundance in all the extracts except the ethyl acetate stem bark extract. Saponins and tannins were found in methanol extracts of both parts and also in very high abundance but the stem contained higher amount of saponins while alkaloids and tannins were found more in the root. Flavonoids were only found in the ethyl acetate stem bark extract.  Steroids were absent in all the extracts except n-hexane root extract. The root showed greater enzymatic antioxidant activities than the stem bark. The solvent polarity affected the phytochemical found in each extract.  The antioxidant activities of the catalase, superoxidase dismutase and glutathione peroxidase were significantly higher in the root of Annona muricata than in the stem. Conversely, peroxidase showed a significantly higher activity in the stem than in the root. Conclusion: The stem bark and root exhibited good antioxidant properties, so there is need to isolate the compounds responsible for antioxidant property exhibited by the plant parts.

scholarly journals Analgesic and antioxidant activities of stem bark extract and fractions of Petersianthus macrocarpus

2016 ◽  
Vol 8 (3) ◽  
pp. 181
Author(s):  
SundayAdeleke Adesegun ◽  
CelestinaIfeoma Orabueze ◽  
HerbertAlexander Coker
Keyword(s):  
Antioxidant Activities ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract
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