scholarly journals Clinical Signs and Laboratory Parameters as Predictors of Mortality among Hospitalized Human Immunodeficiency Virus-Infected Adult Patients at Tertiary Hospital in Surabaya

2021 ◽  
Vol 9 (B) ◽  
pp. 497-502
Author(s):  
Rentha Monica Simamora ◽  
Muhammad Vitanata Arfijanto ◽  
Musofa Rusli ◽  
Budi Utomo ◽  
Cennikon Pakpahan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Multivariate Analysis ◽  
Platelet Count ◽  
Liver Enzymes ◽  
Clinical Signs ◽  
Tertiary Hospital ◽  
Bivariate Analysis ◽  
Elevated Liver Enzymes ◽  
Immunodeficiency Virus ◽  
Hiv Aids

BACKGROUND: The morbidity and mortality rates due to human immunodeficiency virus (HIV) infection are still high despite various and advanced efforts in the management given for HIV/AIDS patients. AIM: This study proposed that clinical signs and laboratory parameters could be expected to predict the patient’s mortality. METHODS: This retrospective study was done by collecting 408 medical records of adult HIV/AIDS inpatients at a tertiary hospital in Surabaya from January 1, 2017, to December 31, 2019. Bivariate analysis using Chi-square test was carried out on nine variables, which were Glasgow Coma Scale (GCS) <15, hypotension, PaO2/FiO2 <400 mmHg, elevated liver enzymes, hemoglobin levels <10 mg/dl, platelet count <150,000/mm3, eGFR <60 ml/min/1.73 m2, albumin levels <3.5 mg/dl, and body mass index (BMI) <18.5 kg/m2. Variables which met the criteria would be included in the multivariate analysis using logistic regression. RESULTS: Based on bivariate analysis, mortality was found to be significantly associated with GCS <15, hypotension, PaO2/FiO2, elevated liver enzymes, platelet count <100,000 mm3, eGFR <60 ml/1.73kg/m2, albumin levels <3.5 mgdl, and BMI <18.5 kg/m2. However, based on multivariate analysis, there were five variables which were found to be able to independently predict the patients’ mortality, those were GCS <15 (OR 11.625), hypotension (OR 6.062), PaO2/FiO2< 400 mmHg (OR 7.794), eGFR <60 ml/min/1.73 m2 (OR 2.646), and albumin levels <3.5 mg/dl (OR 4.091). CONCLUSION: GCS <15, hypotension, PaO2/FiO2 <400 mmHg, eGFR <60 ml/1.73g/m2, and albumin levels <3.5 mg/dl were found as the independent risk factors which could predict the hospitalized HIV/AIDS patients’ mortality.

Tingkat Pengetahuan Mahasiswa Tentang Hiv/Aids Di Akademi Kebidanan Sandi Karsa Makassar

2017 ◽  
Vol 5 (2) ◽  
pp. 1-12
Author(s):  
Nur Syamsi NL
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

AIDS (Acquired Immunodeficiency Syndrome) adalah syndrom yang timbul akibat adanya virus HIV (Human Immunodeficiency Virus) yang menyerang sistem kekebalan tubuh manusia. HIV/AIDS dapat menular melalui darah, sperma, cairan vagina, dan ASI (Air Susu Ibu). Penelitian ini dilakukan di Akademi Kebidanan Sandi Karsa Makassar yang terletak di jalan Bung lorong 2, Kelurahan Tamalanrea, Kecamatan Tamalanrea Jaya, Makassar. Jenis penelitian yang digunakan dalam penelitian ini bersifat deskriptif. Besarnya sampel yang digunakan adalah 30 responden dari 600 populasi yang dipilih secara Total Sampling. Di mana dalam pengambilan data digunakan instrumen berupa kuesioner yang dibagikan kepada responden. Dari keseluruhan responden didapatkan tingkat pengetahuan mahasiswa Akademi Kebidanan Sandi Karsa Makassar yang diteliti didapat 15 mahasiswa (50%) yang tingkat pengetahuan baik tentang HIV/AIDS dan terdapat 14 mahasiswa (46,7%) yang tingkat pengetahuan cukup tentang HIV/AID dan terdapat 1 mahasiswa (3,3%) yang tingkat pengetahuan kurang tentang HIV/AIDS

Pengetahuan dan Sikap Wanita Pekerja Seks (WPS) dalam Upaya Penanggulangan HIV/AIDS dengan Persuasi Penggunaan Kondom di Eks Lokalisasi Gempol Porong Kabupaten Banyuwangi Tahun 2019

2021 ◽  
Vol 2 (1) ◽  
pp. 55-63
Author(s):  
Machria Rachman
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Chi Square ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

HIV (Human Immunodeficiency Virus)  dan AIDS (Acquired Immunodeficiency Syndrome masih menjadi ancaman kesehatan masyarakat secara global. Prevalensi HIV/AIDS di Kabupaten Banyuwangi juga cukup tinggi yakni 4.557 kasus. Cara penularan HIV terbesar adalah melalui hubungan seksual (71 %). Sejumlah 18,23% orang dengan HIV/AIDS (ODHA) adalah wanita pekerja seks (WPS). Meskipun lokalisasi di Banyuwangi telah resmi ditutup pada tahun 2013, namun praktik prostitusi masih terselubung dijalankan. Hubungan seksual tanpa kondom menjadi mata rantai penyebaran HIV/AIDS di masyarakat. Tujuan penelitian ini adalah untuk mengetahui korelasi pengetahuan dan sikap WPS dengan persuasi penggunaan kondom di eks lokalisasi Gempol Porong Kabupaten Banyuwangi. Desain penelitian adalah analitik kuantitatif dengan menggunakan pendekatan cross sectional. Sampel penelitian yaitu WPS di Eks Lokalisasi Gempol Porong berjumlah 32 orang yang diambil dengan teknik Total sampling. Pengambilan data dengan metode angket dan dianalisis statistik menggunakan SPSS 20.0 version. Hasil penelitian menunjukkan bahwa WPS yang memiliki pengetahuan rendah dalam penanggulangan HIV/AIDS sebanyak 56,2 %, sikap negatif sebesar 53,1% dan sebanyak 59,4% tidak melakukan persuasi penggunaan kondom. Analisis uji chi-Square menunjukkan ada hubungan antara pengetahuan WPS dalam penanggulangan HIV/AIDS dengan persuasi penggunaan kondom (ρ = 0,002α), serta ada hubungan antara sikap WPS dalam upaya penanggulangan HIV/AIDS dengan persuasi penggunaan kondom (nilai ρ = 0,000α). Variabel yang berpengaruh terhadap penanggulangan HIV/AIDS dengan persuasi penggunaan kondom adalah sikap, dengan  probabilitas sikap negatif WPS sebesar 78%. Penelitian ini diharapkan dapat memberikan masukan pihak terkait guna peningkatan 100% penggunaan kondom sehingga dapat menekan angka pertumbuhan HIV/AIDS di Kabupaten Banyuwangi.

scholarly journals EFFECT OF ANTIRETROVIRAL TREATMENT REGIMENS ON LIVER ENZYMES IN HUMAN IMMUNODEFICIENCY VIRUS PATIENTS

2018 ◽  
Vol 11 (8) ◽  
pp. 95
Author(s):  
Adiga Sachidananda Mn ◽  
Adiga Usha S
Keyword(s):  
Human Immunodeficiency Virus ◽  
Highly Active Antiretroviral Therapy ◽  
Liver Enzymes ◽  
Cd4 Count ◽  
Treatment Regimens ◽  
Highly Active ◽  
Significant Difference ◽  
Immunodeficiency Virus ◽  
Slight Elevation ◽  
The Difference

Objective: Treatment of human immunodeficiency virus (HIV) with highly active antiretroviral therapy is complicated due to its effect on liver enzymes along with associated risk of opportunistic infection and its treatment. The objective of the study was to compare the effect of two zidovudine and lamivudine-based regimens on liver enzymes and to correlate them with age and CD4 count in HIV patients.Methods: In this retrospective study, patients who have received zidovudine+lamivudine+nevirapine (ZLN) or zidovudine+lamivudine+efavirenz (ZLE) at least for 1 year were included. Baseline, 6-month, and 1-year values of aspartate amino transferase (AST), alanine amino transferase (ALT), and CD4 count were collected. One-way analysis of variance and unpaired t-test were used to compare the difference in AST, ALT, and CD4 count value within basal, 6 months, and 1 year of two group and between the groups, respectively. Pearson’s correlation was used for correlation study.Results: Elevation of AST levels in patients who had received ZLN regimen at different interval was significant statistically. There was a statistically significant elevation of ALT level at 6 months. There was no significant change in AST and ALT values in patients who had received ZLE regimen. Between the two regimens, there was statistically significant difference in AST and ALT values at 6 months and 1 year. There was no correlation between age and CD4 count with liver enzymes.Conclusion: We conclude from the study that nevirapine containing zidovudine regimen showed a slight elevation in AST. The efavirenz regimen did not show a change in AST and ALT.

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