scholarly journals miR‑342‑3p suppresses cell migration and invasion in preeclampsia by targeting platelet‑derived growth factor receptor α

2019 ◽  
Author(s):  
Xiuhua Yang ◽  
Feng Guo
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Tissue Transglutaminase Is an Essential Participant in the Epidermal Growth Factor-stimulated Signaling Pathway Leading to Cancer Cell Migration and Invasion

2009 ◽  
Vol 284 (27) ◽  
pp. 17914-17925 ◽  
Author(s):  
Marc A. Antonyak ◽  
Bo Li ◽  
Andrew D. Regan ◽  
Qiyu Feng ◽  
Stephanie S. Dusaban ◽  
...  
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tissue Transglutaminase ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Epidermal Growth

KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor‐β1 expression

2018 ◽  
Vol 120 (1) ◽  
pp. 493-506 ◽  
Author(s):  
Shumei Liang ◽  
Qingmin Yao ◽  
Deying Wei ◽  
Ming Liu ◽  
Feng Geng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Migration ◽  
Growth Factor ◽  
Cancer Cell ◽  
Transforming Growth Factor ◽  
Ovarian Cancer Cell ◽  
Transforming Growth Factor Β1 ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

2008 ◽  
Vol 28 (22) ◽  
pp. 6773-6784 ◽  
Author(s):  
William Kong ◽  
Hua Yang ◽  
Lili He ◽  
Jian-jun Zhao ◽  
Domenico Coppola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Growth Factor ◽  
Tight Junction ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Migration And Invasion ◽  
Advanced Malignancy ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion

ABSTRACT Transforming growth factor β (TGF-β) signaling facilitates metastasis in advanced malignancy. While a number of protein-encoding genes are known to be involved in this process, information on the role of microRNAs (miRNAs) in TGF-β-induced cell migration and invasion is still limited. By hybridizing a 515-miRNA oligonucleotide-based microarray library, a total of 28 miRNAs were found to be significantly deregulated in TGF-β-treated normal murine mammary gland (NMuMG) epithelial cells but not Smad4 knockdown NMuMG cells. Among upregulated miRNAs, miR-155 was the most significantly elevated miRNA. TGF-β induces miR-155 expression and promoter activity through Smad4. The knockdown of miR-155 suppressed TGF-β-induced epithelial-mesenchymal transition (EMT) and tight junction dissolution, as well as cell migration and invasion. Further, the ectopic expression of miR-155 reduced RhoA protein and disrupted tight junction formation. Reintroducing RhoA cDNA without the 3′ untranslated region largely reversed the phenotype induced by miR-155 and TGF-β. In addition, elevated levels of miR-155 were frequently detected in invasive breast cancer tissues. These data suggest that miR-155 may play an important role in TGF-β-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention.

scholarly journals Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion

2011 ◽  
Vol 43 (2) ◽  
pp. 111 ◽  
Author(s):  
In-hae Kwak ◽  
Yun-Hye Shin ◽  
Myeongdeok Kim ◽  
Hyun-Young Cha ◽  
Hyun-Ja Nam ◽  
...  
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Cell ◽  
Migration And Invasion ◽  
Scatter Factor ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Hepatocyte Growth

scholarly journals Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-κB Transcription Factors

2007 ◽  
Vol 282 (9) ◽  
pp. 6001-6011 ◽  
Author(s):  
Jiangong Niu ◽  
Zhe Chang ◽  
Bailu Peng ◽  
Qianghua Xia ◽  
Weiqin Lu ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Cell Migration ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Migration And Invasion ◽  
Fibroblast Growth ◽  
Cell Migration And Invasion

Inhibition of platelet‐derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation

1997 ◽  
Vol 11 (13) ◽  
pp. 1119-1126 ◽  
Author(s):  
Marukka Myllärniemi ◽  
Lazaro Calderon ◽  
Karl Lemström ◽  
Elisabeth Buchdunger ◽  
Pekka Häyry
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Smooth Muscle Cell ◽  
Receptor Tyrosine Kinase ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Smooth Muscle Cell Migration ◽  
Cell Migration And Proliferation
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