scholarly journals Third-generation cephalosporin resistance in gram-negative bacteria in the community: a growing public health concern

2014 ◽  
Vol 29 (1) ◽  
pp. 27 ◽  
Author(s):  
Sun Hee Park
Keyword(s):  
Public Health ◽  
Generation Cephalosporin ◽  
Health Concern ◽  
Gram Negative Bacteria ◽  
Third Generation ◽  
Public Health Concern ◽  
Gram Negative ◽  
Cephalosporin Resistance

scholarly journals Super-Cationic Peptide Dendrimers—Synthesis and Evaluation as Antimicrobial Agents

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 695
Author(s):  
Estelle J. Ramchuran ◽  
Isabel Pérez-Guillén ◽  
Linda A. Bester ◽  
René Khan ◽  
Fernando Albericio ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Antimicrobial Agents ◽  
Health Concern ◽  
Gram Negative Bacteria ◽  
Cationic Peptide ◽  
Public Health Concern ◽  
Gram Negative ◽  
Peptide Dendrimers ◽  
Microbial Infections ◽  
Lead Candidate

Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the super-cationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.

scholarly journals Superbugs in the supermarket? Assessing the rate of contamination with third-generation cephalosporin-resistant gram-negative bacteria in fresh Australian pork and chicken

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Jade E. McLellan ◽  
Joshua I. Pitcher ◽  
Susan A. Ballard ◽  
Elizabeth A. Grabsch ◽  
Jan M. Bell ◽  
...  
Keyword(s):  
Generation Cephalosporin ◽  
Gram Negative Bacteria ◽  
Third Generation ◽  
Gram Negative

An Overview of the Activities of Cefiderocol Against Sensitive and Multidrug- Resistant (MDR) Bacteria

2020 ◽  
Vol 20 (18) ◽  
pp. 1908-1916
Author(s):  
Manaf AlMatar ◽  
Osman Albarri ◽  
Essam A. Makky ◽  
Işıl Var ◽  
Fatih Köksal
Keyword(s):  
Multidrug Resistant ◽  
Therapeutic Agents ◽  
Health Concern ◽  
Side Chain ◽  
Gram Negative Bacteria ◽  
Drug Resistant ◽  
Public Health Concern ◽  
Gram Negative ◽  
Penicillin Binding Proteins ◽  
The Public

The need for new therapeutics and drug delivery systems has become necessary owing to the public health concern associated with the emergence of multidrug-resistant microorganisms. Among the newly discovered therapeutic agents is cefiderocol, which was discovered by Shionogi Company, Japan as an injectable siderophore cephalosporin. Just like the other β-lactam antibiotics, cefiderocol exhibits antibacterial activity via cell wall synthesis inhibition, especially in Gram negative bacteria (GNB); it binds to the penicillin-binding proteins, but its unique attribute is that it crosses the periplasmic space of bacteria owing to its siderophore-like attribute; it also resists the activity of β-lactamases. Among all the synthesized compounds with the modified C-7 side chain, cefiderocol (3) presented the best and well-balanced activity against multi-drug resistant (MDR) Gram negative bacteria, including those that are resistant to carbapenem. İn this article, an overview of the recent studies on cefiderocol was presented.

scholarly journals Comparative Activity of Several Antimicrobial Agents against Nosocomial Gram-Negative Rods Isolated across Canada

1995 ◽  
Vol 6 (2) ◽  
pp. 76-82 ◽  
Author(s):  
Shelley R Scriver ◽  
Canadian Antimicrobial Resistance Study Group ◽  
Donald E Low
Keyword(s):  
Antimicrobial Agents ◽  
Wide Spectrum ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Beta Lactamase ◽  
Gram Negative ◽  
The Third ◽  
Cephalosporin Resistance ◽  
Third Generation Cephalosporins ◽  
Group 1

In 1992, a surveillance study was performed in Canada to determine the susceptibility of nosocomial Gram-negative rods to several wide spectrum antimicrobials. Consecutive isolates from 10 institutions, as well as additional strains of selected species of Enterobacteriaceae that are known to possess the Bush group 1 beta-lactamase, were tested for susceptibility to 12 antimicrobials. Third-generation cephalosporin resistance was found to be as high as 29% inEnterobacter cloacaethat possesses the Bush group 1 beta-lactamase and less than 4% in those isolates not possessing this enzyme. Cefepime equalled or exceeded the activity of the third-generation cephalosporins against the species of Enterobacteriaceae that demonstrated resistance to the third-generation cephalosporins.

scholarly journals Third-Generation Cephalosporin Resistance in Intrinsic Colistin-Resistant Enterobacterales Isolated from Retail Meat

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1437
Author(s):  
Justice Opare Odoi ◽  
Sayo Takayanagi ◽  
Montira Yossapol ◽  
Michiyo Sugiyama ◽  
Tetsuo Asai
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Generation Cephalosporin ◽  
Resistant Bacteria ◽  
Third Generation ◽  
Phenotypic Resistance ◽  
Retail Meats ◽  
Cephalosporin Resistance ◽  
Retail Meat

Consumption of retail meat contaminated with antimicrobial-resistant (AMR) bacteria is a common route for transmitting clinically relevant resistant bacteria to humans. Here, we investigated the genotypic and phenotypic resistance profiles of intrinsic colistin-resistant (ICR) Enterobacterales isolated from retail meats. ICR Enterobacterales were isolated from 103 samples of chicken, 103 samples of pork, and 104 samples of beef purchased from retail shops in Japan, using colistin-containing media, and their antimicrobial susceptibility was examined. Serratia spp. (440 isolates) showed resistance to cefotaxime (19 isolates, 4.3%), tetracycline (15 isolates, 3.4%), and other antimicrobials (<1%). Hafnia spp. (136) showed resistance to cefotaxime (12 isolates, 8.6%), ceftazidime (four isolates, 2.9%), and tetracycline (two isolates, 1.4%). Proteus spp. (39) showed resistance to chloramphenicol (four isolates, 10.3%), sulfamethoxazole-trimethoprim (four isolates, 10.3%), cefotaxime (two isolates, 5.1%), kanamycin (two isolates, 5.1%), and gentamicin (one isolate, 2.6%). Cedecea spp. (22) were resistant to tetracycline (two isolates, 9.1%) whereas Morganella spp. (11) were resistant to tetracycline (four isolates, 36.4%) and chloramphenicol (one isolate, 9.2%). The resistance genes blafonA, blaACC, and blaDHA were detected in cefotaxime-resistant Serratia spp., Hafnia spp., and Morganella spp. isolates, respectively. This emergence of antimicrobial resistance in ICR Enterobacterales may pose a public health risk.

scholarly journals Erratum to: Mortality attributable to third-generation cephalosporin resistance in Gram-negative bloodstream infections in African hospitals: a multi-site retrospective study

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Angela Dramowski ◽  
Gerald Ong’ayo ◽  
Andrea M Rehman ◽  
Andrew Whitelaw ◽  
Appiah-Korang Labi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Bloodstream Infections ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Gram Negative ◽  
Cephalosporin Resistance

scholarly journals Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020

2020 ◽  
Vol 25 (46) ◽  
Author(s):  
Sybille Welker ◽  
Sébastien Boutin ◽  
Thomas Miethke ◽  
Klaus Heeg ◽  
Dennis Nurjadi
Keyword(s):  
Escherichia Coli ◽  
Carbapenem Resistance ◽  
Health Concern ◽  
Gram Negative Bacteria ◽  
Public Health Concern ◽  
Gram Negative ◽  
E Coli ◽  
Carbapenem Resistant ◽  
South West ◽  
Tertiary Hospitals

The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be under-reported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

Falls Among Older Adults: A Public Health Concern

2011 ◽  
Vol 1 (1) ◽  
pp. 13-18
Author(s):  
J. Handelsman
Keyword(s):  
Public Health ◽  
Older Adults ◽  
Health Concern ◽  
Public Health Concern
Sign in / Sign up

Export Citation Format

Share Document