Histological Changes in the Liver and Kidney of Clarias gariepinus Fed Chrysophyllum albidum Seedmeal as Maize Replacer

2014 ◽  
Vol 11 (1) ◽  
pp. 29-36 ◽  
Author(s):  
W.A. Jimoh ◽  
M.O. Sodamola ◽  
M.D. Adebayo ◽  
O.T. Banjo ◽  
A.A. Ayeloja ◽  
...  
Keyword(s):  
Clarias Gariepinus ◽  
Histological Changes ◽  
Liver And Kidney

scholarly journals Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus

2011 ◽  
Vol 3 (2) ◽  
pp. 329-339
Author(s):  
Animesh K. Mohapatra ◽  
Deepika Rai ◽  
Anika Tyagi
Keyword(s):  
Arsenic Trioxide ◽  
Mus Musculus ◽  
Seminiferous Tubules ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Hydropic Degeneration ◽  
Swiss Albino Mice ◽  
Cytoplasmic Vacuolization ◽  
Liver And Kidney ◽  
Albino Mice

The present study was carried out to investigate the effect of arsenic trioxide on the DNA and histomorphology of testis, liver and kidney of Swiss albino mice, Mus musculus. Oral administration of arsenic trioxide induced DNA damage in the testis, liver and kidney marked by light pink staining of nuclei after Feulgen’s reaction with reduced fine chromatin. Simultaneously severe histological changes were noted like distortion of seminiferous tubules, disorganization of spermatogonia, spermatocytes and spermatids with cytoplasmic vacuolization and nuclear pycnosis in testis. There was almost disappearance of sinusoids due to disruption of hepatic plates, inflammatory cellular infiltration around central veins and cytoplasmic vacuolization in hepatocytes with large irregular nuclei in liver of treated mice. Disorganized glomeruli with distorted Bowman’s capsules and mild to severe multifocal cloudy and hydropic degeneration with necrosis of tubules were observed in the kidney of treated mice. Inference drawn from the study indicated that arsenic induced both genotoxic histotoxic lesions.

scholarly journals Investigating the Histological Changes in Heart, Lung, Liver and Kidney of Male Albino Mice Treated with Ivabradine

2019 ◽  
Vol 16 (3(Suppl.)) ◽  
pp. 0719
Author(s):  
Hadeel Kamil Khaleel
Keyword(s):  
Pulmonary Congestion ◽  
Male Mice ◽  
Histological Changes ◽  
Cardiac Atrophy ◽  
Vascular Congestion ◽  
Myocardial Degeneration ◽  
Liver And Kidney ◽  
Tissue Changes ◽  
Myocardial Fibers ◽  
Hepatocyte Necrosis

            The present study aimed to investigate the histological changes of heart, lung, liver and kidney which caused by different concentrations (10, 20 and 40 mg/kg) of Ivabradine. Results of the study revealed some histological changes represented by aggregation of the lymphocytes around respiratory bronchioles of the lung. In the liver, the drug caused hepatocyte necrosis and infiltration of the lymphocytes. In Kidney, there are no histopathological modifications in the tissue after the animals treated with 10 mg\kg of Ivabradine. When the animals treated with Ivabradine drug at 20mg/kg of bw, dose showed vascular congestion between myocardial fibers of heart. Emphysematous changes of the alveoli and infiltration of lymphocytes around respiratory bronchioles of lung. In the liver there were dilated blood sinusoids. Also, there are vascular congestion and congestion of capillaries in the glomerular of kidney. Male mice treated with Ivabradine drug at 40 mg/kg of bw cause increase spaces between myocardial fibers, cardiac atrophy and myocardial degeneration in the heart. In addition, there are infiltration of lymphocytes around respiratory bronchioles, pulmonary congestion and emphysematous changes of the alveoli in lung. In the liver, the drug cause amyloid deposition and degeneration of hepatocytes. Furthermore, the drug caused vascular congestion in the kidney. Conclusion: From the current study, we conclude that the different concentrations of Ivabradine caused tissue changes in the heart, lung, liver and kidneys. The study should continue using different drugs and concentrations.

Effects of Androgens, Estrogens, and Cortisol on the Skin, Stomach, Liver, Pancreas, and Kidney in Gonadectomized Adult Sockeye Salmon (Oncorhynchus nerka)

1971 ◽  
Vol 28 (4) ◽  
pp. 485-490 ◽  
Author(s):  
J. R. McBride ◽  
A. P. van Overbeeke
Keyword(s):  
Islets Of Langerhans ◽  
Sockeye Salmon ◽  
Pacific Salmon ◽  
Oncorhynchus Nerka ◽  
Skin Atrophy ◽  
Histological Changes ◽  
Male And Female ◽  
Liver And Kidney ◽  
Marked Atrophy

A study was made of the histological changes occurring in the skin, stomach, liver, pancreas and kidney of adult gonadectomized male and female sockeye salmon in response to hormone treatments. The males received 11-ketotestosterone, 17α-methyltestosterone or cortisol for 4 or 7 weeks, and the females received estradiol, estradiol cypionate, or cortisol for 8 weeks.In the males, androgen injection evoked a highly significant increase in the thickness of the epidermis, a marked atrophy of the stomach, and a degeneration in the liver and kidney. In the pancreas, the exocrine portion showed characteristics of cytolysis in the acini, whereas the islets of Langerhans were hypertrophied. These changes were generally more pronounced after 7 weeks than after 4 but, in the skin, no further increase in the thickening of the epidermis was noted after the 4th week of treatment. No differences between responses of these tissues to 11-ketotestosterone and 17α-methyltestosterosne were detected.Estrogen administration in the females evoked similar, albeit weaker, responses in the skin, stomach, pancreas, and kidney than those recorded in the androgen-treated males. The liver of the females exhibited the characteristics of a hyperactive organ, which probably reflects estrogen-induced vitellogenesis.The effects of cortisol were similar in both sexes: little, if any, change was noted in the skin; atrophy or degeneration was observed in the stomach, liver, kidney, and in the exocrine portion of the pancreas, and the islets of Langerhans were hypertrophied. The cortisol-induced alterations were not, however, as pronounced as those noted in either the androgen- or estrogen-treated fish.These changes are discussed in relation to the changes observed in normal sexually maturing and reproducing Pacific salmon.

scholarly journals Comparative Effects of Phosphoenolpyruvate, a Glycolytic Intermediate, as an Organ Preservation Agent with Glucose and N-Acetylcysteine against Organ Damage during Cold Storage of Mouse Liver and Kidney

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Ishitsuka ◽  
Yusuke Fukumoto ◽  
Yuki Kondo ◽  
Mitsuru Irikura ◽  
Daisuke Kadowaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Organ Preservation ◽  
Mouse Liver ◽  
Organ Damage ◽  
Histological Changes ◽  
Glycolytic Intermediate ◽  
Cold Preservation ◽  
Oxidative Stress Parameters ◽  
Liver And Kidney ◽  
And Oxidative Stress

We evaluated the usefulness of phosphoenolpyruvate (PEP), a glycolytic intermediate with antioxidative and energy supplementation potentials, as an organ preservation agent. Using ex vivo mouse liver and kidney of a static cold storage model, we compared the effects of PEP against organ damage and oxidative stress during cold preservation with those of glucose or N-acetylcysteine (NAC). Lactate dehydrogenase (LDH) leakage, histological changes, and oxidative stress parameters (measured as thiobarbituric acid reactive substance and glutathione content) were determined. PEP (100 mM) significantly prevented an increase in LDH leakage, histological changes, such as tubulonecrosis and vacuolization, and changes in oxidative stress parameters during 72 h of cold preservation in mouse liver. Although glucose (100 mM) partly prevented LDH leakage and histological changes, no effects against oxidative stress were observed. By contrast, NAC inhibited oxidative stress in the liver and did not prevent LDH leakage or histological changes. PEP also significantly prevented kidney damage during cold preservation in a dose-dependent manner, and the protective effects were superior to those of glucose and NAC. We suggest that PEP, a functional carbohydrate with organ protective and antioxidative activities, may be useful as an organ preservation agent in clinical transplantation.

scholarly journals Bougainvillea spectabilisExhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes

2015 ◽  
Vol 21 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Pratibha Chauhan ◽  
Sunil Mahajan ◽  
Archana Kulshrestha ◽  
Sadhana Shrivastava ◽  
Bechan Sharma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Glycosylated Hemoglobin ◽  
Histological Changes ◽  
Liver And Kidney ◽  
Bougainvillea Spectabilis ◽  
Streptozotocin Induced Diabetes ◽  
Kidney Functions

The study investigates the effects of aqueous extract of Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and on DNA damage, if any, as well as on liver and kidney functions in streptozotocin-induced diabetes in Wistar rats. Daily administration of the aqueous extract of B spectabilis leaves for 28 days resulted in significant reduction in hyperglycemia and hyperlipidemia as evident from restoration of relevant biochemical markers following extract administration. The extract also exhibited significant antioxidant activity as evidenced from the enzymatic and nonenzymatic responses and DNA damage markers. The extract restored kidney and liver functions to normal and proved to be nontoxic. A marked improvement in the histological changes of tissues was also observed. The present study documented antihyperglycemic, antihyperlipidemic, and antioxidative potentials of the aqueous extract of B spectabilis leaves without any toxicity in streptozotocin-treated Wistar rats.

scholarly journals Anti-Leishmanial drug Pentostam induced histological changes to liver and kidney in male BALB/c wild mice

2021 ◽  
Vol 01 (02) ◽  
pp. 07-14
Author(s):  
Nouara Elazirg Elammari ◽  
Salem Ramadan Sariti
Keyword(s):  
Histological Changes ◽  
Wild Mice ◽  
Liver And Kidney

scholarly journals The effectiveness of Pectin in the reduction of histological changes caused by exposure to monosodium glutamate in female mice: مدى فعالية البكتين في الحد من التغيرات النسيجية التي يسببها تناول جلوتامات أحادي الصوديوم على إناث الفئران

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sarah Ibrahim Al Othman, Faten khalif Alanazi, Ghada Jaber S
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Monosodium Glutamate ◽  
Inflammatory Cells ◽  
Treated Group ◽  
Control Group ◽  
Central Vein ◽  
Histological Changes ◽  
Female Mice ◽  
Liver And Kidney

Monosodium glutamate (MSG) is widely used as a food additive. Excessive consumption of monosodium glutamate has also been shown to affect the liver and kidneys, causing damage to these tissues because of oxidative stress leading to increased production of reactive oxygen species (ROS). The purpose of the study described in this paper was to find out how the liver and kidney toxicity caused by monosodium glutamate can be mitigated using pectin. To this end, 30 albino mice females were divided into four groups. The animals were distributed in special cages. 12-15 weeks with an average body weight of 60 grams. The animals were divided into four groups: the experimental control group (1) comprising 5 female mice were given normal drinking water and the treated group (2) comprising 10 female mice were given monosodium glutamate at a dose of 3 g/kg body weight in drinking water. For three weeks, the treatment group (3) comprising 10 female mice was given pectin at a dose of 300 mg/70 kg body weight in drinking water immediately after the monosodium glutamate dose for three weeks and the pectin group (4) comprising 5 female mice were given Pectin at a dose of 300 mg/70 kg body weight in drinking water for three weeks. The mice were then anesthetized, dissected, and liver and kidney samples were taken from female mice and kept in a 10% neutral formalin solution to make tissue segments. The results showed many histological changes in the liver, such as congestion of the central vein, widening of the sinuses, and the appearance of signs of the death of most hepatocytes, infiltration of the central vein and an invasion of inflammatory cells around the central vein with the emergence of several gaps within the cells. Many of them cavity with the death of most of the tubule cells, the closure of some of them and the expansion and infiltration in others and bleeding inside the tissue. Pectin therapy has led to the disappearance of most of these changes and the emergence of a clear improvement in hepatic and renal tissue.

scholarly journals Histological changes, Micronuclei induction and Nuclear abnormalities in the peripheral erythrocytes of Clarias gariepinus (Burchell 1822) exposed to water sample from Apodu Reservoir

2020 ◽  
Vol 1 (1) ◽  
pp. 01-07 ◽  
Author(s):  
Abass Anifowoshe ◽  
Julia Oyebanji ◽  
Olayinka Oladipo ◽  
Fatai Oyeyemi ◽  
Moshood Abdulrahim ◽  
...  
Keyword(s):  
Water Sample ◽  
Micronucleus Test ◽  
Anthropogenic Activities ◽  
Clarias Gariepinus ◽  
Micronucleus Assay ◽  
Aquatic Organisms ◽  
Hepatic Tissue ◽  
Histopathological Analysis ◽  
Histological Changes ◽  
Nuclear Abnormalities

Pollution of water bodies in most developing countries is of grave concern since toxic pollutants interact with the genetic blueprints of aquatic organisms leading to a variety of illnesses. In this study, histological changes in the gills, liver and kidney as well as the genotoxic effect of water sample from Apodu reservoir, were investigated in the peripheral erythrocytes of cultured catfish (Clarias gariepinus) using micronucleus assay. They were exposed to the water sample for a period of 3, 7 and 14 days. The physico-chemical (pH, temperature, transparency) and heavy metals analysed (Ca>Mg>Fe>Zn>Mn>Cu>Ni=Pb=Cd=Cr) were all within the acceptable limit permissible. However, the micronucleus test shows statistically significant (p<0.05) induction of micronuclei and nuclear abnormalities as compared to the control (borehole water). The histopathological analysis shows some mild alterations in the organs such as distortion and infiltration of lymphocytic cells of the gills. We also reported mild distortion of hepatic tissue of the liver as well as abnormal nephron and glomeruli with congestion and vascular dilation of the kidney. These alterations might be due to anthropogenic activities that pollute the water body. Therefore, the influx of agricultural and domestic waste into the Apodu reservoir should be discouraged as part of remediating efforts.

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