Disease Interactome

2021 ◽  
pp. 69-84
Author(s):  
Suma Dawn ◽  
Nidhi Jain ◽  
Tulika Gangwar
Keyword(s):  
Quantitative Analysis ◽  
Hierarchical Clustering ◽  
Major Part ◽  
Visual Representation ◽  
Clustering Algorithms ◽  
Average Linkage ◽  
Co Morbidity ◽  
Gene Similarity ◽  
The Relationship ◽  
Secondary Diseases

The disease interactome is a network of genes that are related to each other through some attributes. These genes, being part of various diseases, show a high correlation among many diseases. Genes being a major part of the interactome thus can be used to determine the relationship between various diseases, their symptoms, clinical similarity, and co-morbidity. Subgraphs and similarity factors such as Jaccardian distance, cosine similarities, and others have been exploited to calculate the relationship between two or more diseases. Many diseases that did not show much resemblance on the basis of gene similarity or symptom similarity were seen to be closely related according to network interactome. The quantitative analysis between disease-disease was also done. Clustering algorithms like hierarchical clustering involving single, complete, and average linkage were applied to get a visual representation in the form of a dendrogram. Thus, disease-disease interactome was created, analyzed for finding related secondary diseases, and their basic nature was understood.

Handling WSD using Hierarchical Clustering Algorithm with sentences

2018 ◽  
pp. 83-88
Author(s):  
Mohana Priya K ◽  
Pooja Ragavi S ◽  
Krishna Priya G
Keyword(s):  
Hierarchical Clustering ◽  
Similarity Measure ◽  
Clustering Algorithm ◽  
Clustering Algorithms ◽  
Cosine Similarity Measure ◽  
Hierarchical Clustering Algorithm ◽  
Multiple Levels ◽  
Pos Tagger ◽  
Sentence Clustering ◽  
The Right

Clustering is the process of grouping objects into subsets that have meaning in the context of a particular problem. It does not rely on predefined classes. It is referred to as an unsupervised learning method because no information is provided about the "right answer" for any of the objects. Many clustering algorithms have been proposed and are used based on different applications. Sentence clustering is one of best clustering technique. Hierarchical Clustering Algorithm is applied for multiple levels for accuracy. For tagging purpose POS tagger, porter stemmer is used. WordNet dictionary is utilized for determining the similarity by invoking the Jiang Conrath and Cosine similarity measure. Grouping is performed with respect to the highest similarity measure value with a mean threshold. This paper incorporates many parameters for finding similarity between words. In order to identify the disambiguated words, the sense identification is performed for the adjectives and comparison is performed. semcor and machine learning datasets are employed. On comparing with previous results for WSD, our work has improvised a lot which gives a percentage of 91.2%

Peranan Whistleblowing Dalam Meningkatkan Integriti Anggota Polis Diraja Malaysia (Pdrm): Kajian Ke Atas Kontinjen Perak

Sains Insani ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 17-27
Author(s):  
Megat Ayop Megat Arifin ◽  
Abd. Halim Ahmad
Keyword(s):  
Quantitative Analysis ◽  
Demographic Factors ◽  
Positive Perception ◽  
External Threats ◽  
Positive Practices ◽  
The Impact ◽  
The Relationship

Whitsleblowing is one of the positive practices in organizations that are able to raise the level of integrity among the members of an organization. However, the roles of whistleblowing also inevitably invites a response, especially among members of the organization itself. This is because such practices are viewed as one factor that may be detrimental to the organization in addition to revealing the reporter (whistleblower) to some external threats and intimidation of discrimination within the organization. This paper is an attempt to examine the relationship between perceptions of members of the Royal Malaysian Police (RMP) Contingent of Perak through the role of whistleblowing practices to increase the perception of the integrity of the members. Next, identify the purpose of the whistleblowing and its effect on the integrity of the members of the organization. This study used a descriptive quantitative analysis to identify patterns of relationship that exists between the perception of whistleblowing practices with perceptions of increased integrity based on three basic variables of demographic factors, response to whistleblowing and the impact of making the report. The results showed that members of the Perak’s police have a positive perception of whistleblowing practices which are seen to be done in improving the integrity of the members.Keywords: whistleblowing, perception, RMP members, culture, integrity, organization, influence. ABSTRAK: Whitsleblowing merupakan salah satu amalan positif dalam organisasi yang mampu untuk meningkatkan tahap integriti ahli-ahli dalam sesebuah organisasi. Namun begitu, amalan whistleblowing juga turut tidak dapat mengelak daripada mengundang pelbagai respon khususnya dalam kalangan ahli organisasi itu sendiri. Amalan sebegini turut dilihat sebagai salah satu faktor yang boleh memudaratkan organisasi di samping mendedahkan pelapor (whistleblower) kepada beberapa bentuk ancaman ugutan dari luar dan diskriminasi dalam organisasi. Kertas ini merupakan satu upaya untuk melihat perkaitan antara persepsi anggota Polis Diraja Malaysia (PDRM) Kontinjen Perak melalui peranan amalan whistleblowing terhadap persepsi peningkatan integriti anggota. Seterusnya, mengenalpasti maksud whistleblowing dan pengaruhnya terhadap tahap integriti anggota dalam organisasi. Kajian ini menggunakan analisis kuantitatif berbentuk deskriptif bagi mengenalpasti corak hubungan yang wujud antara persepsi terhadap amalan whistleblowing dengan persepsi terhadap peningkatan integriti berdasarkan tiga pembolehubah asas iaitu faktor demografi, tanggapan terhadap whistleblowing dan kesan daripada tindakan membuat laporan. Dapatan kajian menunjukkan bahawa anggota PDRM Perak mempunyai persepsi yang positif terhadap whistleblowing yang mana ianya dilihat perlu dilaksanakan dalam meningkatkan integriti anggota.Kata kunci: whistleblowing, persepsi, amalan, anggota PDRM, budaya, integriti, organisasi, pengaruh.  

scholarly journals Geocomputing, New Technologies and Historical Analysis: Tools for a Changing Planet

Proceedings ◽  
2019 ◽  
Vol 30 (1) ◽  
pp. 9
Author(s):  
Sebastiano Trevisani
Keyword(s):  
Quantitative Analysis ◽  
Philosophy Of Science ◽  
New Technologies ◽  
Historical Analysis ◽  
Holistic Approach ◽  
Research Topic ◽  
The Other ◽  
Historical Records ◽  
The Earth ◽  
The Relationship

Modern Earth Scientists need also to interact with other disciplines, apparently far from the Earth Sciences and Engineering. Disciplines related to history and philosophy of science are emblematic from this perspective. From one side, the quantitative analysis of information extracted from historical records (documents, maps, paintings, etc.) represents an exciting research topic, requiring a truly holistic approach. On the other side, epistemological and philosophy of science considerations on the relationship between geoscience and society in history are of fundamental importance for understanding past, present and future geosphere-anthroposphere interlinked dynamics.

scholarly journals Hesitant Fuzzy Linguistic Agglomerative Hierarchical Clustering Algorithm and Its Application in Judicial Practice

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 370
Author(s):  
Shuangsheng Wu ◽  
Jie Lin ◽  
Zhenyu Zhang ◽  
Yushu Yang
Keyword(s):  
Hierarchical Clustering ◽  
Clustering Algorithm ◽  
Clustering Algorithms ◽  
Agglomerative Hierarchical Clustering ◽  
Research Gaps ◽  
Judicial Practice ◽  
Linguistic Term ◽  
Clustering Effect ◽  
Hierarchical Clustering Algorithm ◽  
Fuzzy Linguistic

The fuzzy clustering algorithm has become a research hotspot in many fields because of its better clustering effect and data expression ability. However, little research focuses on the clustering of hesitant fuzzy linguistic term sets (HFLTSs). To fill in the research gaps, we extend the data type of clustering to hesitant fuzzy linguistic information. A kind of hesitant fuzzy linguistic agglomerative hierarchical clustering algorithm is proposed. Furthermore, we propose a hesitant fuzzy linguistic Boole matrix clustering algorithm and compare the two clustering algorithms. The proposed clustering algorithms are applied in the field of judicial execution, which provides decision support for the executive judge to determine the focus of the investigation and the control. A clustering example verifies the clustering algorithm’s effectiveness in the context of hesitant fuzzy linguistic decision information.

Typing of unknown microorganisms based on quantitative analysis of fatty acids by mass spectrometry and hierarchical clustering

2011 ◽  
Vol 684 (1-2) ◽  
pp. 8-16 ◽  
Author(s):  
Tingting Li ◽  
Ling Dai ◽  
Lun Li ◽  
Xuejiao Hu ◽  
Linjie Dong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Quantitative Analysis ◽  
Hierarchical Clustering

Decreased glucagon binding and glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats

1989 ◽  
Vol 121 (5) ◽  
pp. 705-713 ◽  
Author(s):  
Nobuyuki Sato ◽  
Minoru Irie ◽  
Hiroshi Kajinuma ◽  
Kazuo Suzuki
Keyword(s):  
Quantitative Analysis ◽  
Cyclic Amp ◽  
Adrenergic Receptors ◽  
Marked Reduction ◽  
Diabetic Rats ◽  
Down Regulation ◽  
Streptozotocin Diabetic Rats ◽  
Β Adrenergic Receptors ◽  
Glucagon Receptors ◽  
The Relationship

Abstract. Adipocytes from streptozotocin-diabetic rats showed a markedly reduced lipolytic response to glucagon concomitant with a 90% or greater decrease in the number of glucagon receptors per cell. In contrast, β-adrenergic receptors assessed by [3H]dihydroalprenolol binding and lipolysis stimulated by isoproterenol, dibutyryl 3′5′-cyclic AMP and 3-isobutyl-1-methylxanthine were reduced by only 10–25% in diabetic rats compared with controls. Furthermore, quantitative analysis of the relationship between the amount of cell-bound glucagon and the hormone-stimulated lipolysis revealed that the function of the remaining 10% of glucagon receptors remained intact in cells from diabetic animals. These findings suggest that the lipolytic cascades, including β-adrenergic receptors, in adipocytes are not greatly impaired by diabetes, and therefore, the unresponsiveness of these cells to glucagon is mostly due to a marked reduction in the number of glucagon receptors, probably as a result of a down-regulation by postprandial hyperglucagonemia.

Persepsi Pengembangan Karir Ditinjau Dari Komitmen Organisasi Pada Karyawan Kontrak

2021 ◽  
Vol 15 (01) ◽  
pp. 21-34
Author(s):  
Zuraida Zuraida
Keyword(s):  
Quantitative Analysis ◽  
Organizational Commitment ◽  
Career Development ◽  
Significant Positive Correlation ◽  
Employee Commitment ◽  
Contract Employees ◽  
Analysis Technique ◽  
Negative Perceptions ◽  
The Relationship

Abstract : Contract employees are employees who work at the company with a certain time limit, and can be dismissed at any time, this affects employees' perceptions of career development at the company and also affects employee commitment to the company. This study aims to examine the relationship between perceptions of career development and organizational commitment for contract employees. Perceptions of career development variables and organizational commitment were measured using a scale. The subjects of this study were 48 contract employees, with the determination of the sample based on accidental sampling. The analysis technique used in this research is quantitative analysis using Karl Pearson's product moment with SPSS version 20 for Windows. Based on the research results, it is known that the perception of career development with organizational commitment on contract employees. There is a significant positive correlation (r.0.813 with sig <0.05) between the variable perceptions of career development and organizational commitment for contract employees, namely 0.000 and the significance value is below / less than 0.05, this means that the higher (positive) the perception of career development, the higher employee commitment to the company and vice versa, the lower (negative) perceptions of employee career development, the lower employee commitment to the company. On the perception of career development has the most categories at low (negative) with a contribution of 50% and organizational commitment at most has a low category with contributions 46%.   Keywords:   Contract Employees, Organizational Commitment, Perceptions of Career Development.   Abstrak : Karyawan kontrak merupakan karyawan yang bekerja di perusahaan dengan batasan waktu tertentu dan sewaktu-waktu dapat diberhentikan, hal ini mempengaruhi persepsi karyawan terhadap pengembangan karirnya pada perusahaan tersebut dan juga mempengaruhi komitmen karyawan pada perusahaannya. Penelitian ini bertujuan untuk menguji hubungan persepsi pengembangan karir terhadap komitmen organisasi pada karyawan kontrak. Variabel persepsi pengembangan karir dan komitmen organisasi diukur dengan menggunakan skala. Subjek penelitian ini berjumlah 48 karyawan kontrak , dengan penentuan sampel berdasarkan accidental sampling. Teknik analisis yang digunakan pada penelitian ini adalah analisis kuantitatif dengan menggunakan product moment karl pearson dengan program SPSS versi 20 for Windows. Berdasarkan hasil penelitian, diketahui bahwa persepsi pengembangan karir dengan komitmen organisasi pada karyawan kontrak, ada korelasi positif yang signifikan (r.0.813 dengan sig < 0.05) antara variabel persepsi pengembangan karir  dengan komitmen organisasi pada karyawan kontrak yaitu 0.000 dan nilai signifikansinya dibawah/lebih kecil 0.05, ini berarti bahwa semakin tinggi (positif) persepsi pengembangan karir maka semakin tinggi komitmen karyawan pada perusahaannya begitu sebaliknya semakin rendah (negatif) persepsi pengembangan karir karyawan maka semakin rendah komitmen karyawan pada perusahaannya. Pada persepsi pengembangan karir memiliki kategori paling banyak pada tingkat rendah (negatif) dengan kontribusi 50% dan komitmen organisasi paling banyak memiliki kategori rendah dengan kontribusi 46%.   Kata Kunci :  Karyawan Kontrak, Komitmen Organisasi, Persepsi Pengembangan Karir 

scholarly journals New Approach to Quantitative Analysis of Two-Component Polymer Systems by Infrared Spectroscopy

1996 ◽  
Vol 50 (6) ◽  
pp. 774-780 ◽  
Author(s):  
K. C. Cole ◽  
Y. Thomas ◽  
E. Pellerin ◽  
M. M. Dumoulin ◽  
R. M. Paroli
Keyword(s):  
Infrared Spectroscopy ◽  
Quantitative Analysis ◽  
Weight Fraction ◽  
Polymer Systems ◽  
Near Ir ◽  
Miscible Blends ◽  
Two Component ◽  
New Treatment ◽  
Two Peaks ◽  
The Relationship

A new treatment is proposed for quantitative analysis of two-component polymer systems by infrared spectroscopy. Like much previous work, it is based on a ratio involving two peaks in the same spectrum. The relationship between such a ratio and the concentration of a given polymer is inherently nonlinear. It is shown that this nonlinearity can be well described by a simple equation derived from the laws of optical transmission. This equation has the form χ1 = m1 + m2 R/(1 + m3 R), where χ1 is the weight fraction of polymer 1, the mi are adjustable coefficients, and the ratio R is equal to Aa/( Aa + Ab). The quantities Aa and Ab are the absorbances (peak heights or areas) at two frequencies a and b of which the first is associated mainly with polymer 1 and the second with polymer 2. This equation has been applied to various peak combinations in spectra of miscible blends of poly(phenylene ether) with polystyrene (both mid-IR and near-IR data) and immiscible blends of polypropylene with polyethylene (mid-IR data). It is shown that the equation is valid in all cases, covering the full concentration range from 0 to 100% even when the peaks used for the analysis involve absorption by both polymers. It is therefore believed to be of broad general usefulness for the analysis of polymer blends and copolymers.

Sign in / Sign up

Export Citation Format

Share Document