Corona

2021 ◽  
pp. 204-211
Author(s):  
Mansha Sharma ◽  
Ajay Kumar Sharma
Keyword(s):  
Developing Countries ◽  
Side Effects ◽  
Herd Immunity ◽  
The Body ◽  
New Normal ◽  
Social Wellbeing ◽  
The World ◽  
Different Shapes

Coronavirus has come up as the worst nightmare in the form of a pandemic for progressive sapiens in terms of health, wealth, prosperity, and social wellbeing. To date, coronavirus has mutated to seven different shapes evolving into various variants. The main deliberation of catching the disease is carelessness and negligence of the citizens, and in developing countries like India, population and illiteracy makes it even more difficult to control the disease. However, immunity can be the superhero in fighting against the virus that invades the host. Although a strong immunity is important to fight the disease, the symptoms show at a later stage by the body of a human with a stronger immunity and cases are getting critical in this case. After a long struggle, scientists have come up with vaccines that are 90% efficient and show some side effects. The world is expected to function only if ‘herd immunity' is achieved, but it is expected that wearing masks would be the new normal.

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

scholarly journals PENETAPAN KADAR KAFEIN PADA BUBUK TEH HITAM YANG BEREDAR DI PASAR DELI TUA MENGGUNAKAN SPEKTROFOTOMETRI UV

2020 ◽  
Vol 3 (1) ◽  
pp. 21-28
Author(s):  
DIAN IKA PERBINA MELIALA
Keyword(s):  
Side Effects ◽  
Sampling Method ◽  
Negative Impact ◽  
Black Tea ◽  
The Body ◽  
Test Results ◽  
Ultraviolet Spectrophotometry ◽  
The Public ◽  
Validation Test ◽  
The World

Tea is a drink that is very familiar in the world and is very common in everyday life. Tea is also the most consumed and favored beverage by the public after water. Besides being beneficial, tea also contains compounds that have a negative impact on the body, namely caffeine compounds. Caffeine is an alkaloid of the methylxanthine group which plays a role in increasing the work of psychomotor in the body, and side effects that can be caused are anxiety, irregular heartbeat, difficulty sleeping, tremors, diuresis and others. The purpose of this study was to determine the caffeine content in black tea powder circulating in the Old Deli market. This type of research is descriptive with a purposive sampling method. The analytical method used is qualitative with murexide and quantitative ultraviolet spectrophotometry with a wavelength of 267nm. The results of a qualitative analysis of all positive samples contained caffeine. The average quantitative yield of caffeine in brand A black tea powder was (4,82 ±0,0356)%, B brand black tea powder (4,89 ± 0,0173)% and C brand black tea powder (4,93 ± 0,0531)%. The validation test results obtained linearity r = 0,9984, LOD and LOQ is 0,8074 mcg/ml and 2,6914 mcg/ml ,% recovery = 100,07%, RSD = 0,33%. Based on the results of research conducted, it can be concluded that ultraviolet spectrophotometry can be used to determine caffeine levels in black tea powder.

scholarly journals THE ROLE OF MUSIC IN STRESS MANAGEMENT

2015 ◽  
Vol 3 (1SE) ◽  
pp. 1-39
Author(s):  
Anuradha Awasthi
Keyword(s):  
Side Effects ◽  
Stress Management ◽  
Human Mind ◽  
The Body ◽  
Negative Effects ◽  
Physiological Mechanisms ◽  
Happy Life ◽  
The World ◽  
Unique Power

Stress management refers to the development of certain psychological and physiological mechanisms that can be learned to reduce the side effects of human body and mind. According to Richard Lazarus and Susan Folk Men, when a person has few resources to reach a goal and the work to be done is too much, then he gets stressed. Research by Walter Cannon and Hans Salleay found that stress has negative effects on the body and mind. It is necessary for every human being to learn the techniques of stress management in order to live a satisfying, balanced and happy life. One of these techniques is the use of music. According to Jain Collingwood, music has such unique power that it reduces stress by affecting us emotionally. The melody of music makes the human mind happy, the lyrics of the song inspire the person and the heart likes the rhythm. Music affects all humans. The tradition of singing and dancing with different instruments in different languages ​​and dialects has been found in all the societies of the world, that is, music provides universal joy. तनाव प्रबंधन का अर्थ कुछ ऐसी मनेावैज्ञानिक और शारीरिक क्रियाआंे की प्रणाली विकसित करने से है जिन्हें सीख कर मनुष्य के शरीर और मन पर पडने वाले दुष्प्रभावोें को कम किया जा सकता है। रिचर्ड लज़ारस तथा सुसैन फोक मेन के अनुसार जब मनुष्य के पास किसी लक्ष्य तक पहुंचने के लिए संसाधन कम होते है और पूरे किये जाने वाले काम बहुत अधिक होते है तो उसे तनाव होता है। वाॅल्टर कैनन तथा हैन्स सेल्ये ने मनुष्यों तथा प्राणियों पर किये गये शोध मे पाया कि तनाव शरीर और मन पर नकारात्मक प्रभाव डालता है। प्रत्येक मनुष्य के लिए यह आवश्यक है कि वह संतोषप्रद, संतुलित और सुखी जीवन जीने के लिये तनाव प्रबंधन की तकनीके सीखे। इन्हीं तकनीको मे से एक है संगीत का उपयोग। जैन कालिंगवुड के अनुसार संगीत मे एैसी अनोखी शक्ति होती है जो कि हमें भावनात्मक रूप से प्रभावित कर तनाव को कम करती है। संगीत की स्वर लहरियाँ मनुष्य के मन को आनंदित करती हैं गीत के बोल व्यक्ति को प्रेरित करते हैं तथा लय मन को अच्छी लगती है। सभी मनुष्यों को संगीत प्रभावित करता है। विश्व के सभी समाजों मंे भिन्न - भिन्न भाषाओं और बोलियों में विभिन्न वाद्यों के साथ गाने तथा नृत्य करने की परंपरा पाई गई है अर्थात् संगीत सार्वभौमिक रूप से आनन्द प्रदान करता है।

A Conceptual Framework to improve the design of sustainable off-grid microgrid systems for remote communities in developing countries

2021 ◽  
Author(s):  
◽  
Abhi Chatterjee
Keyword(s):  
Developing Countries ◽  
Conceptual Framework ◽  
The Body ◽  
Research Centre ◽  
Research Approach ◽  
Remote Communities ◽  
Grid Systems ◽  
The World ◽  
Research Findings ◽  
Standard Framework

<p>From job creation to economic development, from security concerns to the full empowerment of women, energy lies at the heart of the Sustainable Development Goals (SDGs) - agreed to by the world’s leaders in September 2015 as part of the 2030 Agenda. In the words of former UN Secretary-General Ban Ki-moon, “Energy is the golden thread that connects economic growth, increased social equity, and an environment that allows the world to thrive." Approximately 1 billion people in the world today have no access to electricity, and the issues are dominating in the remote communities of the developing countries.  Decentralized systems have existed over a couple of decades to provide electricity provisions in the off-grid communities devoid of the necessary energy services. The literature, however, suggests that off-grid systems have failed in delivering the tasks set forth to curb the electricity crisis. The crisis has resulted in communities primarily residing in the remote/islanded areas having lower social and economic status compared to the urban areas with centralized grid connectivity. A further review of the literature points to a lack of a detailed standard framework for cross-sectional evaluation of sustainability and reliability of the off-grid systems, which results in non-uniformity of the universal electricity access.   Given this, the main objective of the thesis is to establish a conceptual framework to improve the design of remote off-grid microgrid systems through a Techno-Economic Assessment (TEA) approach, by implementing a mixed-research approach. The research strategy adopted to advance knowledge and for achieving the objective of the research follows the Technology and Policy Assessment (TPA) approach, developed by the UK Energy Research Centre (UKREC). The research evaluation design involves formative evaluations where questionnaires designed for investigating failure cases of remote microgrids are introduced, and a conceptual framework is developed, based on the lessons learned.   The conceptual framework comprising of modules incorporates essential features of improving the TEA of the remote microgrids and emphasizes on features like stakeholder assessments, sustainability aspects, energy management, and improving energy efficiency as well as overall system autonomy of the rural off-grid systems. Furthermore, following the TPA approach, the conceptual framework has been verified by involving a focus group. IEEE-Sustainable Energy Systems for Developing Communities (SESDC) was involved in the research verification process. The proposed conceptual framework was validated by incorporating a quantitative analysis to situate the research findings.  The research findings in the thesis contribute extensively to the body of knowledge by establishing a standard framework indicating the importance of energy-efficient approaches towards scaling up sustainable remote microgrids for solving energy crisis issues. As it were, the practical contribution of the thesis is critical in identifying and characterizing the dimensions of the Sustainable Developing Goal 7 for “affordable, reliable, sustainable and modern energy for all” and its impact on the other SDGs, thereby enabling progress towards the target 2030 of the United Nations.</p>

Covid-19 Vaccine Benefits and Concerns: Nigerian Perspectives

2021 ◽  
Author(s):  
Olorunfemi Ayeotan
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Mortality Rate ◽  
Herd Immunity ◽  
World Health ◽  
The Poor ◽  
The World ◽  
Poor Understanding ◽  
The Government ◽  
Health Organization

The World Health Organization reported 162,184,263 cases of COVID-19 and about 3,364,446 deaths globally with Nigeria statistics at 165,709 reported cases and 2,066 deaths as of May 16 2021. This increase in reported cases and deaths globally can be drastically reduced when significant number of the population of the world becomes vaccinated. Researchers have developed different COVID-19 vaccines in a bid to control the morbidity and mortality rate as well as mitigate disease severity. Popular concerns about the vaccine in Nigeria and Africa ranges from effectiveness and side effects, poor understanding of the virus, lack of trust in the government, fear of the vaccine being used as a bioweapon designed by advanced countries to reduce the population of the poor ones by causing infertility, and lack of appropriate infrastructure for safe storage of the vaccine. Howbeit, the vaccine has been proven to be safe and effective. Nationwide delivery and acceptance will confer herd immunity and curb the menace of drug resistance.

A Conceptual Framework to improve the design of sustainable off-grid microgrid systems for remote communities in developing countries

2021 ◽  
Author(s):  
◽  
Abhi Chatterjee
Keyword(s):  
Developing Countries ◽  
Conceptual Framework ◽  
The Body ◽  
Research Centre ◽  
Research Approach ◽  
Remote Communities ◽  
Grid Systems ◽  
The World ◽  
Research Findings ◽  
Standard Framework

<p>From job creation to economic development, from security concerns to the full empowerment of women, energy lies at the heart of the Sustainable Development Goals (SDGs) - agreed to by the world’s leaders in September 2015 as part of the 2030 Agenda. In the words of former UN Secretary-General Ban Ki-moon, “Energy is the golden thread that connects economic growth, increased social equity, and an environment that allows the world to thrive." Approximately 1 billion people in the world today have no access to electricity, and the issues are dominating in the remote communities of the developing countries.  Decentralized systems have existed over a couple of decades to provide electricity provisions in the off-grid communities devoid of the necessary energy services. The literature, however, suggests that off-grid systems have failed in delivering the tasks set forth to curb the electricity crisis. The crisis has resulted in communities primarily residing in the remote/islanded areas having lower social and economic status compared to the urban areas with centralized grid connectivity. A further review of the literature points to a lack of a detailed standard framework for cross-sectional evaluation of sustainability and reliability of the off-grid systems, which results in non-uniformity of the universal electricity access.   Given this, the main objective of the thesis is to establish a conceptual framework to improve the design of remote off-grid microgrid systems through a Techno-Economic Assessment (TEA) approach, by implementing a mixed-research approach. The research strategy adopted to advance knowledge and for achieving the objective of the research follows the Technology and Policy Assessment (TPA) approach, developed by the UK Energy Research Centre (UKREC). The research evaluation design involves formative evaluations where questionnaires designed for investigating failure cases of remote microgrids are introduced, and a conceptual framework is developed, based on the lessons learned.   The conceptual framework comprising of modules incorporates essential features of improving the TEA of the remote microgrids and emphasizes on features like stakeholder assessments, sustainability aspects, energy management, and improving energy efficiency as well as overall system autonomy of the rural off-grid systems. Furthermore, following the TPA approach, the conceptual framework has been verified by involving a focus group. IEEE-Sustainable Energy Systems for Developing Communities (SESDC) was involved in the research verification process. The proposed conceptual framework was validated by incorporating a quantitative analysis to situate the research findings.  The research findings in the thesis contribute extensively to the body of knowledge by establishing a standard framework indicating the importance of energy-efficient approaches towards scaling up sustainable remote microgrids for solving energy crisis issues. As it were, the practical contribution of the thesis is critical in identifying and characterizing the dimensions of the Sustainable Developing Goal 7 for “affordable, reliable, sustainable and modern energy for all” and its impact on the other SDGs, thereby enabling progress towards the target 2030 of the United Nations.</p>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

scholarly journals Comparison of Colorectal cancer prognosis between developed and developing countries: A literature review.

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Venkatesh Ramaswamy Naik
Keyword(s):  
Colorectal Cancer ◽  
Developing Countries ◽  
Developed Countries ◽  
The Body ◽  
Cancer Prognosis ◽  
Mortality And Morbidity ◽  
Factors Affecting ◽  
Treatment Practice ◽  
The World ◽  
Standardized Screening

Background: The cancer is caused when cells start dividing abnormally in the body. Age, genetics and lifestyle are major risk factors in developing cancer. The World Cancer Research Fund states that colorectal cancer incidence is globally ranked third in men and second in women. This highlights the need for effective screening and management of colorectal cancer to achieve better prognosis to prevent mortality and morbidity. Screening and management are not uniform all over the world, and it is affected by the economy of individual countries. In this context, we aimed to explore the prognosis of colorectal cancer in developed and developing countries and also to look for the factors affecting the prognosis.Material and Methods: A systematic search of the peer-reviewed journals from databases at Perdana University library which includes British Medical Journal, Up To Date, The Lancet, and Pubmed was done to answer the research questions. Results: We found that developed countries were in the west having a predominantly Caucasian population. The 5-year survival of patients with colorectal cancer (2008-13) was found to be least in Poland and the highest in Australia. In the developing countries it was found to have a broad representation from different ethnicities. The 5-year survival of colorectal cancer fwas ound to be least in Ghana and highest in Turkey.Conclusion: Looking at the results, the range of prognosis among developed countries is narrower than those in developing countries. This may be due to standardized screening and treatment practice in developed countries.

scholarly journals Attitudes on voluntary and mandatory vaccination against COVID-19: Evidence from Germany

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0248372
Author(s):  
Daniel Graeber ◽  
Christoph Schmidt-Petri ◽  
Carsten Schröder
Keyword(s):  
Side Effects ◽  
Real Time ◽  
Vaccination Coverage ◽  
Herd Immunity ◽  
Psychological Characteristics ◽  
Approval Rate ◽  
The World ◽  
The Individual ◽  
Mandatory Vaccination

Several vaccines against COVID-19 have now been developed and are already being rolled out around the world. The decision whether or not to get vaccinated has so far been left to the individual citizens. However, there are good reasons, both in theory as well as in practice, to believe that the willingness to get vaccinated might not be sufficiently high to achieve herd immunity. A policy of mandatory vaccination could ensure high levels of vaccination coverage, but its legitimacy is doubtful. We investigate the willingness to get vaccinated and the reasons for an acceptance (or rejection) of a policy of mandatory vaccination against COVID-19 in June and July 2020 in Germany based on a representative real time survey, a random sub-sample (SOEP-CoV) of the German Socio-Economic Panel (SOEP). Our results show that about 70 percent of adults in Germany would voluntarily get vaccinated against the coronavirus if a vaccine without side effects was available. About half of residents of Germany are in favor, and half against, a policy of mandatory vaccination. The approval rate for mandatory vaccination is significantly higher among those who would get vaccinated voluntarily (around 60 percent) than among those who would not get vaccinated voluntarily (27 percent). The individual willingness to get vaccinated and acceptance of a policy of mandatory vaccination correlates systematically with socio-demographic and psychological characteristics of the respondents. We conclude that as far as people’s declared intentions are concerned, herd immunity could be reached without a policy of mandatory vaccination, but that such a policy might be found acceptable too, were it to become necessary.

scholarly journals Preparation and investigation of the ayurvedic churna formulation for diabetes

2018 ◽  
Vol 8 (2) ◽  
pp. 9-12
Author(s):  
Chaitanya Kumar K ◽  
Mothilal K ◽  
Mahender K ◽  
Ravi D
Keyword(s):  
Side Effects ◽  
The Body ◽  
The Other ◽  
Antidiabetic Activity ◽  
200Mg Dose ◽  
100Mg Dose ◽  
Physiological Conditions ◽  
Synthetic Drugs ◽  
The World ◽  
Synthetic Drug

Out of most of the dreadful diseases in the world Diabetes, shortly known as DM, is the most dreadful. The primary cause of diabetes is the lack of insulin due to the insufficient secretion of insulin by the pancreas or the insensitivity of the body to reuptake the insulin. This results in the accumulation of the sugar or glucose in the blood, only thereby disturbing all the other physiological conditions in the body. Herbs, as we know, are devoid of or have very fewer side effects when compared to the antidiabetic synthetic drugs. There is evidence to show that the herbs are safer and the chemical leads that are isolated from the medicinal plants are potent in controlling diabetes. The antidiabetic activity of herbs was proven, and the mechanism of action of the drugs was also established in many pieces of research. The polyherbal churna was prepared using various herbs like Tinospora, Glycerrihiza etc. that are already proven for the antidiabetic activity. This formulation was investigated for the antidiabetic activity at two doses and was compared with a marketed formulation and also a standard synthetic drug in STZ induced DM method. The prepared churna formulation showed a better activity compared with the standard and the marketed churna. The prepared churna at 200mg dose showed better activity than the 100mg dose.

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