Nanoemulsion Applications

Prostate cancer (PCa) is a global issue with increasing rise in morbidity and mortality. PCa treatment has been a global challenge for many years because drugs designed to combat this disease might show low efficacy as a result of low solubility. Limitations of chemo-drugs for treating PCa give birth to the use of nanomedicine which helps to improve drug delivery systems. Nanoemulsions are particles that are pharmaceutically formulated and comprised within the range of a nanometer (10-200nm). Nanoemulsions are thermodynamically stable and made up of safe gradient agents. This chapter elucidates the physiological, biological, and molecular barriers affecting drug delivery in PCa. The authors discussed the importance of nanoemulsions as potential drug delivery mechanisms in PCa therapy. This chapter focuses on reviewing different ways by which nanoemulsion can bring solution to water-solubility problems and also target specific cancer cells. Limitations of nanoemulsions in the drug delivery field were also highlighted.

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Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

Current Drug Metabolism ◽

10.2174/1389200221999200820163337 ◽

2020 ◽

Vol 21 (11) ◽

pp. 902-909

Author(s):

Jingxin Zhang ◽

Weiyue Shi ◽

Gangqiang Xue ◽

Qiang Ma ◽

Haixin Cui ◽

...

Keyword(s):

Lung Cancer ◽

Drug Delivery ◽

Cancer Cells ◽

Targeted Delivery ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Lung Tumor ◽

A549 Cells ◽

Delivery Systems ◽

Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

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Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review

Current Drug Targets ◽

10.2174/1389450117666160613103705 ◽

2017 ◽

Vol 18 (11) ◽

Cited By ~ 4

Author(s):

Rohit R. Bhosale ◽

H. V. Gangadharappa ◽

Umme Hani ◽

Riyaz Ali M. Osmani ◽

Rudra Vaghela ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Novel Drug

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Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy

RSC Advances ◽

10.1039/c6ra07802h ◽

2016 ◽

Vol 6 (54) ◽

pp. 48294-48314 ◽

Cited By ~ 50

Author(s):

A. P. Subramanian ◽

S. K. Jaganathan ◽

A. Manikandan ◽

K. N. Pandiaraj ◽

Gomathi N ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Cells ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Free Form ◽

Remarkable Effect ◽

Efficient Delivery ◽

Recent Trends

The phytochemicals were found to become more soluble when delivered by the nanocarriers and exhibited a remarkable effect on the cancer cells compared to its free form.

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Nanoporous anodic titanium dioxide layers as potential drug delivery systems: Drug release kinetics and mechanism

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2016.03.073 ◽

2016 ◽

Vol 143 ◽

pp. 447-454 ◽

Cited By ~ 30

Author(s):

Magdalena Jarosz ◽

Anna Pawlik ◽

Michał Szuwarzyński ◽

Marian Jaskuła ◽

Grzegorz D. Sulka

Keyword(s):

Drug Delivery ◽

Titanium Dioxide ◽

Drug Release ◽

Drug Delivery Systems ◽

Release Kinetics ◽

Delivery Systems ◽

Kinetics And Mechanism ◽

Potential Drug ◽

Drug Release Kinetics

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Aptamer-modified polymer nanoparticles for targeted drug delivery

BioNanoMaterials ◽

10.1515/bnm-2015-0027 ◽

2016 ◽

Vol 17 (1-2) ◽

Cited By ~ 9

Author(s):

Julia Modrejewski ◽

Johanna-Gabriela Walter ◽

Imme Kretschmer ◽

Evren Kemal ◽

Mark Green ◽

...

Keyword(s):

Lung Cancer ◽

Drug Delivery ◽

Cancer Cells ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Mode Of Delivery ◽

Delivery Systems ◽

The Body ◽

Lung Cancer Cells ◽

Targeted Drug

AbstractThe purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting in unwarranted adverse effects. To circumvent this problem, there is an increasing demand for the development of intelligent drug delivery systems allowing a tissue-specific mode of delivery. Within this study, nanoparticles consisting of two biocompatible polymers are used. Because of their small size, nanoparticles are well-suited for effective drug delivery. The small size affects their movement through cell and tissue barriers. Their cellular uptake is easier when compared to larger drug delivery systems. Paclitaxel was encapsulated into the nanoparticles as a model drug, and to achieve specific targeting an aptamer directed against lung cancer cells was coupled to the nanoparticles surface. Nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and nanotracking analysis (NTA). Also their surface charge was characterized from ζ-potential measurements. Their preparation was optimized and subsequently specificity of drug-loaded and aptamer-functionalized nanoparticles was investigated using lung cancer cells.

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A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2021.14.4.1 ◽

2021 ◽

Vol 14 (4) ◽

pp. 5519-5228

Author(s):

Sunitha M Reddy ◽

Sravani Baskarla

Keyword(s):

Drug Delivery ◽

Dissolution Rate ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Water Solubility ◽

Drug Loading ◽

Aqueous Solubility ◽

Delivery Systems ◽

Particle Size Reduction

This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Oral route is the most convenient route for non-invasive administration. S-SNEDDS has more advantages when compared to the liquid self-emulsifying drug delivery system. Excipients were selected depends upon the drug compatibility oils, surfactants and co surfactants were selected to formulate Liquid SNEDDS these formulated liquid self-nano emulsifying drug delivery system converted into solid by the help of porous carriers, Melted binder or with the help of drying process. Conversion process of liquid to solid involves various techniques; they are spray drying; freeze drying and fluid bed coating technique; extrusion, melting granulation technique. Liquid SNEDDS has a high ability to improve dissolution and solubility of drugs but it also has disadvantages like incompatibility, decreased drug loading, shorter shelf life, ease of manufacturing and ability to deliver peptides that are prone to enzymatic hydrolysis.

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