Study on the Shear Structural Yield of Soft Soil Affected by Drainage Condition

2012 ◽  
Vol 256-259 ◽  
pp. 416-421 ◽  
Author(s):  
Ai Wu Yang ◽  
Ling Wei Kong ◽  
Li Qiang Lu
Keyword(s):  
Yield Stress ◽  
Internal Structure ◽  
Structural Properties ◽  
Structural Characteristics ◽  
Soft Soil ◽  
Undisturbed Soil ◽  
Soil Particles ◽  
Axial Shear ◽  
The Impact

Four kinds of tri-axial shear structural yield stress is studied by controlling the pre-test consolidate degree and draining condition during the test. The results showed that draining condition influenced the tri-axial shear structural yield stress. When under the UU condition, structural characteristics appeared not clearly; when consolidated before testing and un-drained during test, only the undisturbed soil performed the structural yield stress; when draining during testing, the undisturbed soil showed the increased structural yield stress while the remolded soil could form certain structure. The impact of the draining condition on the structural characteristics is incurred by the change of the internal structure, which means that the draining condition have changed the arrangement and connection of the soil particles, then changed the soil structural properties.

Experimental Study on Structural Properties Influencing on Compressibility of Soft Clay

2011 ◽  
Vol 261-263 ◽  
pp. 1767-1772
Author(s):  
Jiang Feng Wang ◽  
Yong Le Li ◽  
Yan Bin Gao ◽  
Zhi Quan Huang
Keyword(s):  
Yield Stress ◽  
Structural Properties ◽  
Soft Clay ◽  
Load Level ◽  
Horizontal Line ◽  
Undisturbed Soil ◽  
Straight Line ◽  
Undisturbed Samples ◽  
Reconstituted Soil ◽  
Compression Characteristics

Through the undisturbed samples and reconstituted samples for compression test, analyzed and got the characteristics of compression deformation and the influence law of structure properties on soft clay. The s-t curves deformation of reconstituted soil in small loads is the largest, as the load increases, tends gradually to horizontal line, but undisturbed soil deformation is the largest under the condition of a bigger load. Undisturbed soil due to structural exists, its s-lgt curves are divided into three categories according to load level. The e-lgp curve of soft clay is bounded by structure yield stress very clearly divided into two sections, but e-lgp curve of reconstituted soil is a straight line. Because structure of the reconstituted soil has been destroyed, its law of compression characteristics is comparative markedly. But due to the existence of undisturbed soil structural properties, near the structural yield stress, the compression parameters appear mutations. Research results show that influence of soft clay structural properties on its compression characteristics is not allowed to ignore.

scholarly journals The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction

2021 ◽  
Vol 22 (19) ◽  
pp. 10477
Author(s):  
Joana C. Pieretti ◽  
Jordan Beurton ◽  
Julián Munevar ◽  
Luiz C. C. M. Nagamine ◽  
Alain Le Faou ◽  
...  
Keyword(s):  
Structural Properties ◽  
Structural Characteristics ◽  
Engineered Nanoparticles ◽  
Blood Protein ◽  
Modified Chitosan ◽  
Biological Interface ◽  
Biological Fate ◽  
Silver Nps ◽  
Potential Applications ◽  
The Impact

In nanomedicine, hybrid nanomaterials stand out for providing new insights in both the diagnosis and treatment of several diseases. Once administered, engineered nanoparticles (NPs) interact with biological molecules, and the nature of this interaction might directly interfere with the biological fate and action of the NPs. In this work, we synthesized a hybrid magnetic nanostructure, with antibacterial and antitumoral potential applications, composed of a magnetite core covered by silver NPs, and coated with a modified chitosan polymer. As magnetite NPs readily oxidize to maghemite, we investigated the structural properties of the NPs after addition of the two successive layers using Mössbauer spectroscopy. Then, the structural characteristics of the NPs were correlated to their interaction with albumin, the major blood protein, to evidence the consequences of its binding on NP properties and protein retention. Thermodynamic parameters of the NPs–albumin interaction were determined. We observed that the more stable NPs (coated with modified chitosan) present a lower affinity for albumin in comparison to pure magnetite and magnetite/silver hybrid NPs. Surface properties were key players at the NP–biological interface. To the best of our knowledge, this is the first study that demonstrates a correlation between the structural properties of complex hybrid NPs and their interaction with albumin.

scholarly journals Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Zhihui Dou ◽  
Dapeng Zhao ◽  
Xiaohua Chen ◽  
Caipeng Xu ◽  
Xiaodong Jin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Structural Characteristics ◽  
Therapy Resistance ◽  
Regulatory Elements ◽  
Aberrant Splicing ◽  
Clinical Role ◽  
Splicing Isoforms ◽  
The Impact ◽  
Splicing Patterns

AbstractBcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development of multiple human diseases, especially cancers. Exploring the mechanism of Bcl-x splicing and regulation has provided insight into the development of drugs that could contribute to sensitivity of cancer cells to death. On this basis, we review the multiple splicing patterns and structural characteristics of Bcl-x. Additionally, we outline the cis-regulatory elements, trans-acting factors as well as epigenetic modifications involved in the splicing regulation of Bcl-x. Furthermore, this review highlights aberrant splicing of Bcl-x involved in apoptosis evade, autophagy, metastasis, and therapy resistance of various cancer cells. Last, emphasis is given to the clinical role of targeting Bcl-x splicing correction in human cancer based on the splice-switching oligonucleotides, small molecular modulators and BH3 mimetics. Thus, it is highlighting significance of aberrant splicing isoforms of Bcl-x as targets for cancer therapy.

scholarly journals DNA-Guided Assembly for Fibril Proteins

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 404
Author(s):  
Alexandru Amărioarei ◽  
Frankie Spencer ◽  
Gefry Barad ◽  
Ana-Maria Gheorghe ◽  
Corina Iţcuş ◽  
...  
Keyword(s):  
Computational Model ◽  
Structural Properties ◽  
Self Assembly ◽  
Structural Characteristics ◽  
Computational Modelling ◽  
Shape Reconstruction ◽  
Raw Material ◽  
Dna Assembly ◽  
Mesh Structure ◽  
Elementary Fibril

Current advances in computational modelling and simulation have led to the inclusion of computer scientists as partners in the process of engineering of new nanomaterials and nanodevices. This trend is now, more than ever, visible in the field of deoxyribonucleic acid (DNA)-based nanotechnology, as DNA’s intrinsic principle of self-assembly has been proven to be highly algorithmic and programmable. As a raw material, DNA is a rather unremarkable fabric. However, as a way to achieve patterns, dynamic behavior, or nano-shape reconstruction, DNA has been proven to be one of the most functional nanomaterials. It would thus be of great potential to pair up DNA’s highly functional assembly characteristics with the mechanic properties of other well-known bio-nanomaterials, such as graphene, cellulos, or fibroin. In the current study, we perform projections regarding the structural properties of a fibril mesh (or filter) for which assembly would be guided by the controlled aggregation of DNA scaffold subunits. The formation of such a 2D fibril mesh structure is ensured by the mechanistic assembly properties borrowed from the DNA assembly apparatus. For generating inexpensive pre-experimental assessments regarding the efficiency of various assembly strategies, we introduced in this study a computational model for the simulation of fibril mesh assembly dynamical systems. Our approach was based on providing solutions towards two main circumstances. First, we created a functional computational model that is restrictive enough to be able to numerically simulate the controlled aggregation of up to 1000s of elementary fibril elements yet rich enough to provide actionable insides on the structural characteristics for the generated assembly. Second, we used the provided numerical model in order to generate projections regarding effective ways of manipulating one of the the key structural properties of such generated filters, namely the average size of the openings (gaps) within these meshes, also known as the filter’s aperture. This work is a continuation of Amarioarei et al., 2018, where a preliminary version of this research was discussed.

scholarly journals Being a Gambler during the COVID-19 Pandemic: A Study with Italian Patients and the Effects of Reduced Exposition

2021 ◽  
Vol 18 (2) ◽  
pp. 424
Author(s):  
Maria Anna Donati ◽  
Silvia Cabrini ◽  
Daniela Capitanucci ◽  
Caterina Primi ◽  
Roberta Smaniotto ◽  
...  
Keyword(s):  
Structural Characteristics ◽  
Gambling Behavior ◽  
Online Gambling ◽  
Problem Gamblers ◽  
Electronic Gambling Machines ◽  
Electronic Gambling ◽  
Gambling Market ◽  
The Impact ◽  
Gambling Activities

The COVID-19 pandemic, with the consequent lockdown of about 3 months, can be viewed as an experimental model to observe the impact of the depletion of environmental factors that stimulate gambling, particularly electronic gambling machines (EGMs) that were set to zero. The effects of some structural characteristics of gambling activities that increase gambling behavior were studied among disordered gamblers in treatment in this unique scenario. In fact, studies investigating the effects of the lockdown on problem gamblers (PGs) under treatment are missing. The aims of this study were to analyze patients’ gambling behavior and craving during the lockdown and to conduct a comparison between gambling disorder (GD) symptoms at the beginning of the treatment and during lockdown. The study was conducted in Italy, the European country with the largest gambling market and the first to be affected by the virus. Data were collected through a semi-structured telephone interview conducted by healthcare professionals. Participants were 135 PGs under treatment (109 males, mean age = 50.07). Results showed that most PGs achieved a significant improvement in their quality of life, with less gambling behavior, GD symptoms, and lower craving. No shift toward online gambling and very limited shift towards other potential addictive and excessive behaviors occurred. The longer the treatment, the more monitoring is present and the better the results in terms of symptoms reduction. Individual and environmental characteristics during the lockdown favored the reduction in symptoms. Consideration for prevention and treatment are discussed.

Bending Strength and Fracture Behaviour of Metal-Ceramic Interpenetrating Phase Composites Manufactured by Using Semi-Solid Forming Technology

2022 ◽  
Vol 327 ◽  
pp. 111-116
Author(s):  
Laura Schomer ◽  
Kim Rouven Riedmüller ◽  
Mathias Liewald
Keyword(s):  
Bending Strength ◽  
Fracture Behaviour ◽  
Structural Characteristics ◽  
Process Window ◽  
Metallic Material ◽  
Forming Technology ◽  
Metal Ceramic ◽  
Semi Solid ◽  
The Impact ◽  
Interpenetrating Phase Composites

Interpenetrating Phase Composites (IPC) belong to a special category of composite materials, offering great potential in terms of material properties due to the continuous volume structure of both composite components. While manufacturing of metal-ceramic IPC via existing casting and infiltration processes leads to structural deficits, semi-solid forming represents a promising technology for producing IPC components without such defects. Thereby, a solid open pore body made of ceramic is infiltrated with a metallic material in the semi-solid state. Good structural characteristics of the microstructure as the integrity of the open-pore bodies after infiltration and an almost none residual porosity within the composites have already been proven for this manufacturing route within a certain process window. On this basis, the following paper focuses on the mechanical properties such as bending strength of metal-ceramic IPC produced by using semi-solid forming technology. Thereby, the impact of the significant process parameters on these properties is analysed within a suitable process window. Furthermore, a fractographic analysis is carried out by observing and interpreting the fracture behaviour during these tests and the fracture surface thereafter.

On the Impact Behavior of a Material With a Yield Point

1949 ◽  
Vol 16 (1) ◽  
pp. 39-52
Author(s):  
Merit P. White
Keyword(s):  
Yield Stress ◽  
Yield Point ◽  
Impact Behavior ◽  
Longitudinal Impact ◽  
Stress Strain ◽  
California Institute Of Technology ◽  
Static Yield ◽  
Institute Of Technology ◽  
Probable Nature ◽  
The Impact

Abstract An analysis of longitudinal impact tests that were made by Drs. D. S. Clark and P. E. Duwez at the California Institute of Technology on an iron and a steel with definite yield points is described. From this analysis is deduced the probable nature of the dynamic stress-strain relations for such materials. These appear to differ greatly from the static stress-strain relations, unlike the case for materials without yield points. As pointed out by Duwez and Clark, the upper yield stress for undeformed material is several times as great under impact as the static yield stress. The present analysis indicates that under impact, the material with a definite yield point is made harder at a given deformation, and ruptures at a higher (engineering) stress and smaller strain than when loaded statically. The critical impact velocity, defined as that at which nearly instantaneous failure occurs in tension, is discussed, and the factors upon which it depends are given.

FEATURES OF THE RUSSIAN SMALL BUSINESS MODEL AND THE CONSEQUENCES OF THE COVID-19 PANDEMIC

2021 ◽  
pp. 71-85
Author(s):  
Natal’ya E. Egorova ◽  
Keyword(s):  
Small Business ◽  
Business Model ◽  
Small Businesses ◽  
Structural Characteristics ◽  
Bank Lending ◽  
Structural Instability ◽  
Government Support ◽  
Negative Consequences ◽  
Development Levels ◽  
The Impact

The article analyzes the quantitative and structural stability of Russian small business and identifies the model features of its functioning. It investigates the dynamics of development of Russian small business is investigated and notes a downward trend in the number of small and medium-sized enterprises over the past two years. A conclusion is drawn that the quantitative indicators reflecting its functioning are highly sensitive to the negative effects of the macroeconomic environment. The author introduces a concept of the small business heterogeneity and brings up its structural characteristics, represented by various categories of small and medium-sized firms. Comparative analysis of the Russian small business model with foreign small business confirms its quantitative and structural instability. That makes the considered sector of the national economy vulnerable to shocks (externalities), including the COVID-19 pandemic. It is assumed that the negative consequences of the pandemic will affect Russian small businesses more than foreign ones, and the gap in their development levels will widen. An assessment of the impact of the COVID-19 pandemic on Russian small business and a forecast of its development are made in the context of limited government support and the absence of active bank lending.

scholarly journals Structural Properties of G,T-Parallel Duplexes

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Anna Aviñó ◽  
Elena Cubero ◽  
Raimundo Gargallo ◽  
Carlos González ◽  
Modesto Orozco ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Structural Properties ◽  
Theoretical Calculations ◽  
Md Simulations ◽  
Theoretical Studies ◽  
Duplex Structure ◽  
Strong Stabilization ◽  
The Stability ◽  
The Impact

The structure of G,T-parallel-stranded duplexes of DNA carrying similar amounts of adenine and guanine residues is studied by means of molecular dynamics (MD) simulations and UV- and CD spectroscopies. In addition the impact of the substitution of adenine by 8-aminoadenine and guanine by 8-aminoguanine is analyzed. The presence of 8-aminoadenine and 8-aminoguanine stabilizes the parallel duplex structure. Binding of these oligonucleotides to their target polypyrimidine sequences to form the corresponding G,T-parallel triplex was not observed. Instead, when unmodified parallel-stranded duplexes were mixed with their polypyrimidine target, an interstrand Watson-Crick duplex was formed. As predicted by theoretical calculations parallel-stranded duplexes carrying 8-aminopurines did not bind to their target. The preference for the parallel-duplex over the Watson-Crick antiparallel duplex is attributed to the strong stabilization of the parallel duplex produced by the 8-aminopurines. Theoretical studies show that the isomorphism of the triads is crucial for the stability of the parallel triplex.

scholarly journals The Influence of the Track Parameters on Vibration Characteristics of Subway Tunnel

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Wenbo Shi ◽  
Linchang Miao ◽  
Junhui Luo ◽  
Honglei Zhang
Keyword(s):  
Soft Soil ◽  
Power Level ◽  
Coupling Model ◽  
Calculation Model ◽  
Vertical Acceleration ◽  
Subway Tunnel ◽  
Ballastless Track ◽  
Train Operation ◽  
The Impact ◽  
Wheel Track

In soft soil areas, such as the Nanjing, it is very important to quantitatively analyze the dynamic behaviors of soft soils during the metro train operation. A nonlinear coupling model of wheel-track and a finite element calculation model of tunnel and soil were established based on the mechanical character of elastic supporting block ballastless track and the actual parameters of Nanjing soft soil. The time-variant vertical acceleration of the rail, the sleepers, and the surface of the tunnel can be calculated by the models, and the frequency dependence acceleration was verified by the fast Fourier transform algorithm. A modified vibration power level for human sensitivity was used to quantify the vibration energy of each part of the system, and the impact of the parameters in the model was evaluated. The results can be applied to the metro design and construction, which also can be the guidance during the tunnel construction.

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