Optimize the Structure of Air Sparger for Stirred Bioreactor

2010 ◽  
Vol 44-47 ◽  
pp. 213-217
Author(s):  
Zhi Wei Zhou ◽  
Bo Yan Song ◽  
Yu Kui Wang ◽  
Zun Tao Li ◽  
Yang Wang
Keyword(s):  
Influence Factors ◽  
Ring Structure ◽  
Ventilation Rate ◽  
Two Phase ◽  
Air Voids ◽  
Stirred Bioreactor ◽  
Whole Process ◽  
The One ◽  
Ventilation Velocity ◽  
Air Vent

During the whole process of cell culture, it needs enough air, especially oxygen supply. Therefore, the research about air sparger became significant. There are many influence factors of air sparger are important, including air sparger structure, installation location, ventilation rate. In order to solve these problems, the finite element numerical calculation is used to set a numerical model of air-liquid two-phase flow. This analysis makes clear that the distance between air vent and the bottom of bioreactor has little effect on the air voids, and the air voids is higher by adopting the structure of single air vent compared with the one of distribution ring structure. But the ventilation structure of big distribution ring avoids flooding effectively. The air voids of bioreactor increased with the velocity of ventilation is increased within limits. However, it causes air incomplete dispersion in bioreactor, overflowing from head top of the liquid, flooding and low air voids, if the ventilation velocity is over speed.

scholarly journals Two-phase CFD simulation of the monodyspersed suspension hydraulic behaviour in the tank apparatus from a circulatory pipe

2008 ◽  
Vol 10 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Roch Plewik ◽  
Piotr Synowiec ◽  
Janusz Wójcik
Keyword(s):  
Cfd Simulation ◽  
Fluidised Bed ◽  
Cfd Simulations ◽  
Two Phase ◽  
Hydraulic Behaviour ◽  
Hydraulic Conditions ◽  
The One ◽  
Cfd Method ◽  
Multi Phase ◽  
The Ideal

Two-phase CFD simulation of the monodyspersed suspension hydraulic behaviour in the tank apparatus from a circulatory pipe The hydrodynamics in fluidized-bed crystallizers is studied by CFD method. The simulations were performed by a commercial packet of computational fluid dynamics Fluent 6.x. For the one-phase modelling (15), a standard k-ε model was applied. In the case of the two-phase flows the Eulerian multi-phase model with a standard k-ε method, aided by the k-ε dispersed model for viscosity, has been used respectively. The collected data put a new light on the suspension flow behaviour in the annular zone of the fluidised bed crystallizer. From the presented here CFD simulations, it clearly issues that the real hydraulic conditions in the fluidised bed crystallizers are far from the ideal ones.

scholarly journals On the Two-phase Fractional Stefan Problem

2020 ◽  
Vol 20 (2) ◽  
pp. 437-458 ◽  
Author(s):  
Félix del Teso ◽  
Jørgen Endal ◽  
Juan Luis Vázquez
Keyword(s):  
Free Boundary ◽  
Stefan Problem ◽  
Free Boundary Problems ◽  
Classical Problem ◽  
Nonlocal Diffusion ◽  
Two Phase ◽  
Boundary Problems ◽  
Numerical Studies ◽  
The One ◽  
Evolution Type

AbstractThe classical Stefan problem is one of the most studied free boundary problems of evolution type. Recently, there has been interest in treating the corresponding free boundary problem with nonlocal diffusion. We start the paper by reviewing the main properties of the classical problem that are of interest to us. Then we introduce the fractional Stefan problem and develop the basic theory. After that we center our attention on selfsimilar solutions, their properties and consequences. We first discuss the results of the one-phase fractional Stefan problem, which have recently been studied by the authors. Finally, we address the theory of the two-phase fractional Stefan problem, which contains the main original contributions of this paper. Rigorous numerical studies support our results and claims.

Study of CFD Modeling of Performance for Classification

2012 ◽  
Vol 516-517 ◽  
pp. 784-789
Author(s):  
Wei Cao ◽  
Ying Fang ◽  
De Xiang Li
Keyword(s):  
Simulation Experiment ◽  
Particle Trajectory ◽  
Phase Particle ◽  
Theoretical Perspective ◽  
Cfd Modeling ◽  
Optimized Design ◽  
Two Phase ◽  
Ansys Cfx ◽  
The One ◽  
Classification Efficiency

The numerical simulation in the classification has been used in ANSYS CFX 10.0. We described the different flow fields within the classification in accordance with the one-phase simulation experiment, which provided a new theoretical perspective for optimized design on classification. At the same time, the classification efficiency was predicted by simulation for two phase particle trajectory. This will lay a foundation for improving classification efficiency.

scholarly journals Gallstone ileus resulting in strong intestinal obstruction

1995 ◽  
Vol 113 (1) ◽  
pp. 721-725
Author(s):  
Israel Szajnbok ◽  
Fernando Lorenzi ◽  
Aldo Junqueira Rodrigues Jr. ◽  
Luis Fernando Correa Zantut ◽  
Renato Sérgio Poggetti ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Gallstone Ileus ◽  
Ileocecal Valve ◽  
Mortality Rates ◽  
Degenerative Diseases ◽  
Two Phase ◽  
Therapy Decision ◽  
Biliary Calculus ◽  
The One ◽  
Elder People

Mechanic intestinal obstruction, caused by the passage of biliary calculus from vesicle to intestine, through fistulization, although not frequent, deserve study due to the morbi-mortality rates. Incidence in elder people explains the association with chronic degenerative diseases, increasing complexity in terms of therapy decision. Literature discusses the need and opportunity for the one or two-phase surgical attack of the cholecystenteric fistule, in front of the resolution on the obstructive urgency and makes reference to Gallstone Ileus as an exception for strong intestinal obstruction. The more frequent intestinal obstruction observed is when it occurs a Gallstone Ileus impacting in terms of ileocecal valve. The authors submit a Gallstone Ileus manifestation as causing strong intestinal obstruction, discussing aspects regarding diagnostic and treatment.

Two-Phase Boundary Layer Treatment for Subcooled Free-Convection Film Boiling Around a Body of Arbitrary Shape in a Porous Medium

1987 ◽  
Vol 109 (4) ◽  
pp. 997-1002 ◽  
Author(s):  
A. Nakayama ◽  
H. Koyama ◽  
F. Kuwahara
Keyword(s):  
Boundary Layer ◽  
Porous Medium ◽  
Free Convection ◽  
Phase Boundary ◽  
Flat Plate ◽  
Arbitrary Shape ◽  
Film Boiling ◽  
Two Phase ◽  
The One ◽  
Axisymmetric Bodies

The two-phase boundary layer theory was adopted to investigate subcooled free-convection film boiling over a body of arbitrary shape embedded in a porous medium. A general similarity variable which accounts for the geometric effect on the boundary layer length scale was introduced to treat the problem once for all possible two-dimensional and axisymmetric bodies. By virtue of this generalized transformation, the set of governing equations and boundary conditions for an arbitrary shape reduces into the one for a vertical flat plate already solved by Cheng and Verma. Thus, the numerical values furnished for a flat plate may readily be tranlsated for any particular body configuration of concern. Furthermore, an explicit Nusselt number expression in terms of the parameters associated with the degrees of subcooling and superheating has been established upon considering physical limiting conditions.

scholarly journals Extraction of tetracycline using the ionic liquid-based aqueous two phase systems: Single-stage versus multi-stage

2018 ◽  
Vol 24 (4) ◽  
pp. 387-397 ◽  
Author(s):  
Yi Liu ◽  
Li Chen ◽  
Jun Zhou ◽  
Zongcheng Yan
Keyword(s):  
Extraction Efficiency ◽  
Ph Value ◽  
Influence Factors ◽  
Volume Ratio ◽  
Line Length ◽  
Single Stage ◽  
Two Phase ◽  
Extraction Behavior ◽  
Multi Stage ◽  
Tie Line

Ionic liquids-based aqueous two-phase extraction (ILs-ATPE) offers an alternative approach to the extraction of tetracycline (TC) through their partitioning between two phases. Single-stage and multi-stage strategies have been evaluated and compared for the purification of TC using ATPE composed of 1-butyl-3-methylimidazolium halide ([Bmim]X(X=Cl,Br)) and K2HPO4. The influence factors on single-stage extraction behavior of TC were optimized systematically, including the pH value, tie line length, and volume ratio. The optimal extraction efficiency of TC could reach above 95% when the volume ratio is higher than 1.5 and the tie line length is 30.52%. The multi-stage ATPE was also investigated by simulating a three-stage crosscurrent operation in test tubes. According to the TC isotherm curve and respective McCabe?Thiele diagrams, a predicted optimized scheme of the countercurrent multi-stage ATPE was determined. TC can be purified in the IL-rich top phase with a final extraction efficiency of 99% and a final TC concentration of 0.25 mg/mL, if a three- -stage [Bmim]Cl-K2HPO4 ATPE with volume ratio of 0.5 and tie line length of 30.52% was employed. Thus, the multi-stage extraction with small volume ratio is necessary to achieve a higher recovery yield, resulting in the reduction of the IL consumption.

scholarly journals Productivity Influence Factors of Tight Sandstone Gas Reservoir with Water Produced

Geofluids ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yongchao Xue ◽  
Qingshuang Jin ◽  
Hua Tian
Keyword(s):  
Pressure Gradient ◽  
Relative Permeability ◽  
Gas Flow ◽  
Influence Factors ◽  
Stress Sensitivity ◽  
Consumption Pattern ◽  
Tight Sandstone ◽  
Gas Reservoir ◽  
Two Phase ◽  
Start Up

Finding ways to accelerate the effective development of tight sandstone gas reservoirs holds great strategic importance in regard to the improvement of consumption pattern of world energy. The pores and throats of the tight sandstone gas reservoir are small with abundant interstitial materials. Moreover, the mechanism of gas flow is highly complex. This paper is based on the research of a typical tight sandstone gas reservoir in Changqing Oilfield. A strong stress sensitivity in tight sandstone gas reservoir is indicated by the results, and it would be strengthened with the water production; at the same time, a rise to start-up pressure gradient would be given by the water producing process. With the increase in driving pressure gradient, the relative permeability of water also increases gradually, while that of gas decreases instead. Following these results, a model of gas-water two-phase flow has been built, keeping stress sensitivity, start-up pressure gradient, and the change of relative permeability in consideration. It is illustrated by the results of calculations that there is a reduction in the duration of plateau production period and the gas recovery factor during this period if the stress sensitivity and start-up pressure gradient are considered. In contrast to the start-up pressure gradient, stress sensitivity holds a greater influence on gas well productivity.

Modeling of Wall Friction for Multispecies Solid-Gas Flows

1986 ◽  
Vol 108 (4) ◽  
pp. 486-488 ◽  
Author(s):  
E. D. Doss ◽  
M. G. Srinivasan
Keyword(s):  
Shear Stress ◽  
Flow Model ◽  
Flow Characteristics ◽  
Wall Friction ◽  
Gas Flows ◽  
Two Phase ◽  
One Dimensional ◽  
Friction Models ◽  
Wall Interaction ◽  
The One

The empirical expressions for the equivalent friction factor to simulate the effect of particle-wall interaction with a single solid species have been extended to model the wall shear stress for multispecies solid-gas flows. Expressions representing the equivalent shear stress for solid-gas flows obtained from these wall friction models are included in the one-dimensional two-phase flow model and it can be used to study the effect of particle-wall interaction on the flow characteristics.

scholarly journals Patch-Recovery Filters for Curvature in Discontinuous Galerkin-Based Level-Set Methods

2016 ◽  
Vol 19 (2) ◽  
pp. 329-353 ◽  
Author(s):  
Florian Kummer ◽  
Tim Warburton
Keyword(s):  
Discontinuous Galerkin ◽  
Level Set ◽  
Numerical Study ◽  
Level Set Methods ◽  
Computational Cost ◽  
Pressure Jump ◽  
Two Phase ◽  
Two Fluids ◽  
Whole Process ◽  
Numerical Instabilities

AbstractIn two-phase flow simulations, a difficult issue is usually the treatment of surface tension effects. These cause a pressure jump that is proportional to the curvature of the interface separating the two fluids. Since the evaluation of the curvature incorporates second derivatives, it is prone to numerical instabilities. Within this work, the interface is described by a level-set method based on a discontinuous Galerkin discretization. In order to stabilize the evaluation of the curvature, a patch-recovery operation is employed. There are numerous ways in which this filtering operation can be applied in the whole process of curvature computation. Therefore, an extensive numerical study is performed to identify optimal settings for the patch-recovery operations with respect to computational cost and accuracy.

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