The Synthesis of Cephalosporin Intermediates THZ
Keyword(s):
Starting from Penicillin G,the THZ was synthesized through three main steps:esterification,oxidation and ring-opening. The effects of various reaction temperature,reaction time and ratio of reactants on the ring-opening reaction were investigated.The yields of its three step reaction are 91%,95.8% and 77.3%,respectively.The products were characterized by FT-IR,HNMR,Elemental analysis and MS. At 90~95°C and 0.04~0.05Mpa, the yield of THZ was 77.3%.
2013 ◽
Vol 690-693
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pp. 1599-1603
2013 ◽
Vol 734-737
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pp. 2532-2535
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2014 ◽
Vol 915-916
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pp. 713-716
2011 ◽
Vol 239-242
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pp. 1118-1122
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2014 ◽
Vol 672-674
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pp. 172-176
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2013 ◽
Vol 813
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pp. 255-258
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