Inclusion Complex of Docetaxel with Sulfobutyl Ether β-Cyclodextrin: Preparation, In Vitro Cytotoxicity and In Vivo Safety

Docetaxel (DTX), as a first-line anti-tumor drug, has been studied for decades for its diverse bioactivities. However, DTX presents poor solubility in water, low bioavailability and serious toxic side effects which has hindered its application in the clinic. To address these problems, docetaxel-sulfobutyl ether-β-cyclodextrin inclusion complex (DTX-SBE-β-CD) was prepared successfully by saturated aqueous solution method. Sulfobutyl ether β-cyclodetrin (SBE-β-CD) is used as delivery material. For this study, the inclusion complex of docetaxel with sulfobutyl ether β-cyclodetrin (DTX-SBE-β-CD) was prepared and optimized its properties to enhance the cytotoxicity of cancer cells. A large number of physical characterization results showed that DTX-SBE-β-CD inclusion complex was successfully prepared by saturated aqueous solution method. DTX-SBE-β-CD inclusion complex was optimized by Central Composite Design. DTX-SBE-β-CD had an inhibitory effect on the in vitro determination of MCF-7 and HepG2 cells by MTT assay. Pharmacokinetic studies were carried out on male Sprague–Dawley rats by tail injection, including the distribution, metabolism and elimination of DTX-SBE-β-CD in vivo. In the experimental study of inhibition of cancer cells, DTX and DTX-SBE-β-CD showed apparent concentration-dependent inhibitory actions on tumor cells and the inhibition of DTX-SBE-β-CD group was more obvious.

Photocatalytic Degradation of Tetracycline by ZnO/γ-Fe2O3 Paramagnetic Nanocomposite Material

In recent years, the presence of numerous xenobiotic substances, such as antibiotics, has been detected in water environments. They can be considered as environmental contaminants, even if their effect on human health has yet to be totally understood. Several approaches have been studied for the removal of these kinds of pollutants. Among these compounds, tetracycline (TC), a broad-spectrum antibiotic, is one of the most commonly found in water due to its widespread use. In the context of reducing the presence of TC in aqueous solution, in this contribution, a composite catalyst based on zinc oxide (ZnO) and iron oxide (γ-Fe2O3) was developed and its photocatalytic properties were investigated. The catalytic materials were synthesized by a microwave-assisted aqueous solution method and characterized by Field Emission Scanning Electron Microscope (FESEM), X-Ray Fluorescence (XRF) and Brunauer−Emmett−Teller (BET) analysis. The TC concentration was evaluated by spectrophotometer measurements at specific time intervals. The performed photocatalytic experiments clearly demonstrated that the ZnO/γ-Fe2O3 composite catalyst presents significant photocatalytic activity, indeed a TC degradation efficiency of 88.52% was registered after 150 min. The presence of iron oxide in the structure of the catalyst enhances both the surface area and the pore volume, facilitating the adsorption of the analyte on the surface of nanostructures, a fundamental phase to optimize a photodegradation process. Moreover, ZnO was found to play the key role in the photocatalytic process assisted by γ-Fe2O3 which enhanced the TC degradation efficiency by 20%.

Facile synthesis of cesium trithiocyanurate with high ionic conductivity and large birefringence properties

A new trithiocyanurate with enhanced proton conductivity and large birefringence has been synthesized by a facile aqueous solution method.

PHOTODEGRADATION OF RhB UNDER VISIBLE LIGHT BY PT/TIO2 NANOPARTICLES PREPARED THROUGH PHOTOREDUCTIVE DEPOSITION PROCESS

Pt/TiO2 nanoparticles were prepared by a simple two-step aqueous solution method, which consists of a low temperature hydrothermal step and a photoreduction deposition step. The as-prepared samples were characterized by XRD, TEM, XPS, UV-vis, and BET techniques. The as-prepared samples exhibited enhanced photocatalytic activity towards the degradation of rhodamine B (RhB) under visible light irradiation. With increasing Pt content from 0.25 to 1 wt.%, the band gap energies shift from 2.32 to 1.64 eV. The 0.75 wt.% Pt/TiO2 sample showed the best photocatalytic activity, which could be ascribed to the formation of a Schottky barrier and the localized surface plasmon resonance effect of Pt nanoparticles. And the as-prepared samples also displayed excellent stability and reusability in multiple experimental cycles.

Morphology transformation and self-selective etching of ZnO nanostructures under centralized polarization field

The morphology of ZnO nanostructures has great influence on its performance in device applications. In this paper, ZnO nanoflowers composed of nanorods have been synthesized by introducing a centralized polarization field in aqueous solution method. Meanwhile, with the decrease of precursor solution, obvious self-selective etching has been observed on ZnO (002) planes and the nanorods gradually transform to nanotubes. The room-temperature photoluminescence spectra show the UV emission, as well as the visible emissions which indicate the defects in the samples. Moreover, based on the SEM and XRD analysis, the possible growth mechanisms of different ZnO nanostructures were proposed.

An aqueous solution method towards Sb2S3 thin films for photoanodes

An aqueous solution approach, integrating atomic layer deposition and chemical vapor deposition, is proposed to grow high-quality Sb2S3 thin films.