The Effect and Mechanism of Apoptosis on Hela Cells Induced by Bufotalin
2013 ◽
Vol 834-836
◽
pp. 568-572
Keyword(s):
Cytotoxic activity of Bufotalin was determined by MTT assay at various concentrations ranging from 0.002 to 0.008 μmol/ml on Hela cells. The Apoptosis and its mechanism induced by Bufotalin was also studied. The results showed Bufotalin displayed the marked inhibition effect to Hela cells and the IC50 value is 0.0045 μmol/ml for 24 hour. The procaspase-3,-8 and-9 decreased and their active cleaved forms increased treated with Bufotalin at concentrations from 0.002 to 0.006 μmol/ml. These data suggest that the pro-apoptotic effect of Bufotalin is mediated through activation of caspases and mitochondria in Hela cells.
2021 ◽
Vol 12
(2)
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pp. 1624-1631
Keyword(s):
2013 ◽
Vol 395-396
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pp. 587-590
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Keyword(s):
2010 ◽
Vol 10
(1)
◽
2021 ◽
Vol 6
(1)
◽
pp. 49-58
Keyword(s):
2019 ◽
Vol 10
(2)
◽
pp. 51
◽
Keyword(s):
Keyword(s):