Blood Compatibility of Organic-Inorganic Biomedical Materials

2005 ◽  
Vol 284-286 ◽  
pp. 713-716
Author(s):  
Akiyoshi Osaka ◽  
Tomohiko Yoshioka ◽  
Takeshi Yabuta ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa
Keyword(s):  
Stainless Steel ◽  
Fourier Transform ◽  
Infrared Spectra ◽  
Partial Thromboplastin Time ◽  
Blood Clotting ◽  
Blood Compatibility ◽  
Thin Layers ◽  
Active Partial Thromboplastin Time ◽  
Hybrid Layers ◽  
Fibrinogen Adsorption

Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L)substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and prothrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Blood Compatibility of Stainless-Steel and Titanium Immobilized with Alginic Acid Layers

2002 ◽  
Vol 734 ◽  
Author(s):  
Tomohiko Yoshioka ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka
Keyword(s):  
Stainless Steel ◽  
Photoelectron Spectroscopy ◽  
Blood Clotting ◽  
Alginic Acid ◽  
Blood Compatibility ◽  
Adhesion Assay ◽  
Clotting Factors ◽  
Titanium Substrates ◽  
Blood Clotting Factors

ABSTRACTγ-Aminopropyltriethoxysilane (γ-APS) was grafted on stainless-steel and titanium substrates, and subsequently alginic acid layer was immobilized on them. Their surfaces were characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Blood compatibility of thus obtained substrates was evaluated in terms of both the number of the adhered platelets and blood clotting factors for plasma contacted with the substrates such as active partial thromboplastin time (PTT), prothrombin time (PT), and amount of fibrinogen (Fib). The steel and titanium substrates with alginic acid layer did not affect blood clotting factors. In vitro platelet adhesion assay indicated that those substrates adhered less number of platelets than non-treated substrates. Hence the alginic acid immobilization leads to blood compatible surfaces.

Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation

2007 ◽  
Vol 342-343 ◽  
pp. 317-320
Author(s):  
Jin Wang ◽  
Jia Ju Tang ◽  
Ling Ren ◽  
Chang Jiang Pan ◽  
Nan Huang
Keyword(s):  
Cell Proliferation ◽  
Stainless Steel ◽  
Fourier Transform ◽  
Platelet Adhesion ◽  
Blood Compatibility ◽  
Activated Partial Thromboplastin Time ◽  
Alamar Blue ◽  
Casting Method ◽  
Activated Platelets

Rapamycin/curcumin co-loaded and rapamycin-loaded poly(lactide-co-glycolide)(PLGA) films were prepared by a casting method. The components of different drug-loaded films were analyzed by Fourier transform infrared spectroscopy (FTIR), and the major peaks of rapacymin and curcumin were both observed in these films. Compared to the rapamycin-loaded film, the results of in vitro platelet adhesion tests show that the number of adhered platelets reduce, and few aggregated and activated platelets are observed. The APTTs (activated partial thromboplastin time) of rapamycin/curcumin co-loaded films is nearly 6 seconds longer than for the rapamycin-loaded PLGA films. All results indicate that curcumin may suppress thrombosis activated by rapamycinloaded film, and improve the anticoagulative property. The results of alamar blue indicate that the rapamycin/curcumin co-loaded film has better antiproliferation effect than 316 stainless steel (SS).

Synthesis, characterization, and their some chemical and biological properties of PVA/PAA/nPS hydrogel nanocomposites: Hydrogel and wound dressing

2020 ◽  
Vol 35 (3) ◽  
pp. 203-215
Author(s):  
Mehmet Emin Diken ◽  
Berna Koçer Kizilduman ◽  
Begümhan Yilmaz Kardaş ◽  
Enes Emre Doğan ◽  
Mehmet Doğan ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Acrylic Acid ◽  
Infrared Spectra ◽  
Vinyl Alcohol ◽  
Fourier Transform Infrared ◽  
Poly Vinyl Alcohol ◽  
Seed Particles ◽  
Fourier Transform Infrared Spectra ◽  
Hydrogel Nanocomposites ◽  
Poly Acrylic Acid

The nanocomposite hydrogels were prepared by dispersing of the nanopomegranate seed particles into poly(vinyl alcohol)/poly(acrylic acid) blend matrix in an aqueous medium by the solvent casting method. These hydrogels were characterized using scanning electron microscopy, Fourier transform infrared spectra, differential scanning calorimetry, and optical contact angle instruments. The nanopomegranate seed, blend, and hydrogel nanocomposites were tested for microbial activity. In addition, cytocompatibilities of these blend and hydrogel nanocomposites/composites were tested on human lymphocyte with in vitro MTS cell viability assays. Fourier transform infrared spectra revealed that esterification reaction took place among functional groups in the structure of poly(vinyl alcohol) and poly(acrylic acid). The hydrophilic properties of all hydrogels decreased with increasing nanopomegranate seed content. The mean diameters of the nanopomegranate seed particles were about 88 nm. Nanopomegranate seed particles demonstrated antibacterial properties against gram-positive bacteria, Staphylococcus aureus, and gram-negative bacteria, Escherichia coli. The lymphocyte viabilities increased after addition of nanopomegranate seeds into the polymer blend. The swelling behavior of blend and hydrogels was dependent on the cross-linking density created by the reaction between poly(vinyl alcohol)/poly(acrylic acid) blend and nanopomegranate seed. Scanning electron microscopy images were highly consistent with Fourier transform infrared spectra, differential scanning calorimetry, and antibacterial activity results.

scholarly journals Functional Antimicrobial Surface Coatings Deposited onto Nanostructured 316L Food-Grade Stainless Steel

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1055
Author(s):  
Gonzalez A. S. ◽  
Riego Á. ◽  
Vega V. ◽  
García J. ◽  
Galié S. ◽  
...  
Keyword(s):  
Stainless Steel ◽  
316L Stainless Steel ◽  
Electrochemical Techniques ◽  
Functional Materials ◽  
Atomic Layer ◽  
Thin Layers ◽  
Nanoporous Structure ◽  
Stainless Steel Surface ◽  
Functional Coatings ◽  
Food Grade

In our study, we demonstrated the performance of antimicrobial coatings on properly functionalized and nanostructured 316L food-grade stainless steel pipelines. For the fabrication of these functional coatings, we employed facile and low-cost electrochemical techniques and surface modification processes. The development of a nanoporous structure on the 316L stainless steel surface was performed by following an electropolishing process in an electrolytic bath, at a constant anodic voltage of 40 V for 10 min, while the temperature was maintained between 0 and 10 °C. Subsequently, we incorporated on this nanostructure additional coatings with antimicrobial and bactericide properties, such as Ag nanoparticles, Ag films, or TiO2 thin layers. These functional coatings were grown on the nanostructured substrate by following electroless process, electrochemical deposition, and atomic layer deposition (ALD) techniques. Then, we analyzed the antimicrobial efficiency of these functionalized materials against different biofilms types (Candida parapsilosis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis). The results of the present study demonstrate that the nanostructuring and surface functionalization processes constitute a promising route to fabricate novel functional materials exhibiting highly efficient antimicrobial features. In fact, we have shown that our use of an appropriated association of TiO2 layer and Ag nanoparticle coatings over the nanostructured 316L stainless steel exhibited an excellent antimicrobial behavior for all biofilms examined.

scholarly journals Poly(Vinylamine) Derived N-Doped C-Dots with Antimicrobial and Antibiofilm Activities

2021 ◽  
Vol 7 (2) ◽  
pp. 40
Author(s):  
Semiha Duygu Sutekin ◽  
Mehtap Sahiner ◽  
Selin Sagbas Suner ◽  
Sahin Demirci ◽  
Olgun Güven ◽  
...  
Keyword(s):  
Blood Clotting ◽  
Minimum Bactericidal Concentration ◽  
Blood Compatibility ◽  
Weight Ratio ◽  
Gram Negative Bacteria ◽  
Biofilm Inhibition ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

Nitrogen-doped carbon dots (N-doped C-dots) was synthesized by using poly(vinyl amine) (PVAm) as a nitrogen source and citric acid (CA) as a carbon source via the hydrothermal method. Various weight ratios of CA and PVAm (CA:PVAm) were used to synthesize N-doped C-dots. The N-doped C-dots revealed emission at 440 nm with excitation at 360 nm and were found to increase the fluorescence intensity with an increase in the amount of PVAm. The blood compatibility studies revealed no significant hemolysis for N-doped C-dots that were prepared at different ratios of CA:PVAm for up to 500 μg/mL concentration with the hemolysis ratio of 1.96% and the minimum blood clotting index of 88.9%. N-doped C-dots were found to be more effective against Gram-positive bacteria than Gram-negative bacteria, with the highest potency on Bacillus subtilis (B. subtilis). The increase in the weight ratio of PVAm in feed during C-dots preparation from 1 to 3 leads to a decrease of the minimum bactericidal concentration (MBC) value from 6.25 to 0.75 mg/mL for B. subtilis. Antibiofilm ability of N-doped C-dots prepared by 1:3 ratio of CA:PVAm was found to reduce %biofilm inhibition and eradication- by more than half, at 0.78 mg/mL for E. coli and B. subtilis generated biofilms and almost destroyed at 25 mg/mL concentrations.

A Practical Real-Time Fourier Transform Infrared Detector for Liquid Chromatography

1978 ◽  
Vol 32 (5) ◽  
pp. 502-506 ◽  
Author(s):  
D. Warren Vidrine ◽  
David R. Mattson
Keyword(s):  
Fourier Transform ◽  
Liquid Chromatography ◽  
Real Time ◽  
Infrared Spectra ◽  
Infrared Detector ◽  
Fourier Transform Infrared ◽  
Paraffin Oil ◽  
Chromatographic Detection ◽  
Liquid Chromatographic ◽  
System Capability

A practical Fourier transform infrared system for real-time liquid chromatographic detection is described. Simple flowcell detection with automatic solvent subtraction is used, and detection of 500 ng of injected paraffin oil is demonstrated. Results from several chromatographic runs illustrate the system capability to serve as a real time infrared detector and simultaneously acquire infrared spectra.

Photometric Precision in Infrared Spectra Measured by Fourier Transform Spectroscopy

1975 ◽  
Vol 29 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Peter R. Griffiths
Keyword(s):  
Fourier Transform ◽  
Infrared Spectra ◽  
Fourier Transform Spectroscopy ◽  
Truncation Function

Digitally recorded spectra containing lines of width less than or equal to the resolution at which the measurement has been made are observed to show some photometric In spectra measured by Fourier transform spectroscopy, this error may be substantially reduced if the interferogram is zero-filled. To prevent the generation of artifacts in the spectrum (of a similar origin to the sine x side-lobes formed when a non-zero-filled spectrum is computed with a box-car truncation function), the zero-filled interferogram must be suitably apodized.

Fourier-Transform Infrared Spectroscopy of Environmentally Weathered Textile Fabrics for Enhanced Microplastic Identification

2021 ◽  
Author(s):  
Shreyas Patankar ◽  
Ekaterina Vassilenko ◽  
Mathew Watkins ◽  
Anna Posacka ◽  
Peter Ross
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Infrared Spectra ◽  
Environmental Fate ◽  
Uv Light ◽  
Natural Fibers ◽  
Fourier Transform Infrared ◽  
Ambient Conditions ◽  
Selection Of

<p>Microplastic pollution in oceans is among the global environmental concerns of our time. Emerging research on ocean environments indicates that microfibers, such as those originating from textiles, are some of the most commonly occurring type of microplastic contaminants. While Fourier-transform infrared spectroscopy (FTIR) is commonly used to identify and characterize pollutant samples obtained from the environment, this identification is challenging because infrared spectra of materials can be modified by exposure to the ocean, air, UV light, and other ambient conditions, in a process referred to as “weathering”. We report preliminary efforts in improving FTIR characterization of microplastics by building a library of infrared spectra of common textile fibers weathered under a selection of ambient conditions. Consumer textile materials including polyester, nylon, cotton, and other, were exposed to a selection of ambient conditions: ocean, air, and wastewater treatment stages, in a controlled weathering experiment. Infrared spectra were monitored for up to 52 weeks, with the resulting data illuminating on the environmental fate and longevity of synthetic and natural fibers. Spectral changes caused by weathering were found to depend strongly on both the composition of the material and the specific ambient conditions. This library of weathered material spectra is useful not only in easier identification of environmental microfibers, but also in helping us estimate the duration and manner of weathering that a given environmental microfiber may have experienced.</p>

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