Bioinspired Synthesis of Cross-Linking of Dopamine-Containing Block Copolymers to Form Thermosensitive Covalent Hydrogels

2012 ◽  
Vol 531-532 ◽  
pp. 238-241 ◽  
Author(s):  
Kui Huang ◽  
Jin San Chen ◽  
Yang Liu
Keyword(s):  
Sol Gel ◽  
Coupling Efficiency ◽  
Pluronic F127 ◽  
Cross Linking ◽  
Inversion Method ◽  
Sustained Drug Delivery ◽  
Vis Spectroscopy ◽  
Marine Mussels ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Marine mussels secrete remarkable mussel adhesive proteins (MAPs) for adherence to the substrates upon which they reside. Inspired by the intermolecular cross-linking characteristics of MAPs, we report the synthesis of thermosensitive dopamine modified Pluronic copolymer (PluF127-Dopa) with high coupling efficiency. Under certain temperature and concentration, PluF127-Dopa copolymers in aqueous solution self-assemble into micelles and are able to rapidly form a more stable hydrogels upon addition of oxidizing reagents such as NaIO4, resulting from oxidative cross-linking of dopamine. UV-vis spectroscopy was utilized to identify the reaction intermediates. The sol-gel transition curves of cross-linked PluF127-Dopa hydrogels (CL-PluF127-Dopa) were determined by a vial inversion method. The critical gelation concentration of CL-PluF127-Dopa hydrogels was significantly lower than those for PluF127-Dopa and unmodified Pluronic F127. The apparent mechanical strength of CL-PluF127-Dopa hydrogels was dramatically enhanced compared to those unmodified Pluronic copolymer hydrogels, suitable for sustained drug delivery. These new biomimetic materials are expected to have potential uses in biomedical applications.

pH-Induced Cross-Linking of Dopamine-Containing Block Copolymers with Fe3+ to Form Self-Healing Hydrogels

2012 ◽  
Vol 569 ◽  
pp. 11-14 ◽  
Author(s):  
Kui Huang ◽  
Yu Niu ◽  
Long Jiang Wang ◽  
Yang Liu ◽  
Jin San Chen ◽  
...  
Keyword(s):  
Coupling Efficiency ◽  
Ph Control ◽  
Side Chain ◽  
Cross Linking ◽  
Self Healing ◽  
Complex Species ◽  
Mussel Adhesive Proteins ◽  
Mussel Adhesive ◽  
Adhesive Proteins ◽  
Catechol Moiety

The unusual amino acid 3,4-dihydroxyphenylalanine with a catechol side chain is believed to impart both adhesive and cohesive characteristics of mussel adhesive proteins. Inspired by the pH-tunable coordination between catechol moiety and Fe3+, responsible for the high extensibility and self-healing properties of the cuticle of mussel byssal threads, we report the synthesis of a dopamine modified Pluronic F68 block copolymer (PluF68-Dopa) with high coupling efficiency and utilization of catechol-Fe3+interactions to yield cross-linking hydrogels with enhanced mechanical strength and self-healing properties. Ultraviolet-visible spectroscopy was used to identify PluF68-Dopa-Fe3+complex species via pH control in dilution solution. At lower pH, concentrated PluF68-Dopa-Fe3+mixture remained a fluid, whereas at higher pH an elastomeric gel immediately formed. PluF68-Dopa-Fe3+cross-linked hydrogels are not only pH-responsive but also possess self-healing properties due to the reversible bond interactions between catechol moiety and Fe3+. These new biomimetic materials are expected to have potential biomedical and engineering applications.

scholarly journals Hypoxia weakens mussel attachment by interrupting DOPA cross-linking during adhesive plaque curing

2018 ◽  
Vol 15 (147) ◽  
pp. 20180489 ◽  
Author(s):  
Matthew N. George ◽  
Benjamin Pedigo ◽  
Emily Carrington
Keyword(s):  
Adhesion Strength ◽  
Seawater Temperature ◽  
Compositional Analysis ◽  
Cross Linking ◽  
Force Microscopy ◽  
Seawater Ph ◽  
Marine Mussels ◽  
Synthetic Adhesives ◽  
Seawater Environment ◽  
Adhesive Proteins

Marine mussels ( Mytilus spp.) attach to a wide variety of surfaces underwater using a network of byssal threads, each tipped with a protein-based adhesive plaque that uses the surrounding seawater environment as a curing agent. Plaques undergo environmental post-processing, requiring a basic seawater pH be maintained for up to 8 days for the adhesive to strengthen completely. Given the sensitivity of plaques to local pH conditions long after deposition, we investigated the effect of other aspects of the seawater environment that are known to vary in nearshore habitats on plaque curing. The effect of seawater temperature, salinity and dissolved oxygen concentration were investigated using tensile testing, atomic force microscopy and amino acid compositional analysis. High temperature (30°C) and hyposalinity (1 PSU) had no effect on adhesion strength, while incubation in hypoxia (0.9 mg l −1 ) caused plaques to have a mottled coloration and prematurely peel from substrates, leading to a 51% decrease in adhesion strength. AFM imaging of the plaque cuticle found that plaques cured in hypoxia had regions of lower stiffness throughout, indicative of reductions in DOPA cross-linking between adhesive proteins. A better understanding of the dynamics of plaque curing could aid in the design of better synthetic adhesives, particularly in medicine where adhesion must take place within wet body cavities.

scholarly journals Effect of Oxidation Rate on Cross-Linking of Mussel Adhesive Proteins

2003 ◽  
Vol 4 (4) ◽  
pp. 1098-1098 ◽  
Author(s):  
Sander Haemers ◽  
Ger J. M. Koper ◽  
Gert Frens
Keyword(s):  
Oxidation Rate ◽  
Cross Linking ◽  
Mussel Adhesive Proteins ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Surface Modification for Protein Resistance Using a Biomimetic Approach

2003 ◽  
Vol 774 ◽  
Author(s):  
Jeffrey L. Dalsin ◽  
Phillip B. Messersmith
Keyword(s):  
High Concentration ◽  
Protein Resistance ◽  
Mussel Adhesive Proteins ◽  
Gold Substrates ◽  
Marine Mussels ◽  
Protein Adhesion ◽  
Biomimetic Approach ◽  
Mussel Adhesive ◽  
Poly Ethylene ◽  
Adhesive Proteins

AbstractIn recent years the immobilization of poly(ethylene glycol) (PEG) on surfaces has proved to be one of the most attractive methods to prevent biological fouling of surfaces. We have developed a paradoxical biomimetic PEGylation strategy that exploits the adhesive characteristics of proteins secreted by marine mussels—one of nature's most notorious foulers. Linear PEGs were coupled to peptides containing 3,4-dihydroxyphenylalanine (DOPA), an unusual amino acid which is found in high concentration in these so-called mussel adhesive proteins. Using surface plasmon resonance, we have demonstrated enhanced resistance to protein adhesion on gold substrates modified with the DOPA-containing PEGs.

Cross-Linking and Multilayer Adsorption of Mussel Adhesive Proteins

Langmuir ◽  
2002 ◽  
Vol 18 (12) ◽  
pp. 4903-4907 ◽  
Author(s):  
Sander Haemers ◽  
Mieke C. van der Leeden ◽  
Ger J. M. Koper ◽  
Gert Frens
Keyword(s):  
Cross Linking ◽  
Multilayer Adsorption ◽  
Mussel Adhesive Proteins ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Thin films of polymer mimics of cross-linking mussel adhesive proteins deposited by matrix assisted pulsed laser evaporation

2009 ◽  
Vol 255 (10) ◽  
pp. 5496-5498 ◽  
Author(s):  
R. Cristescu ◽  
I.N. Mihailescu ◽  
I. Stamatin ◽  
A. Doraiswamy ◽  
R.J. Narayan ◽  
...  
Keyword(s):  
Thin Films ◽  
Pulsed Laser ◽  
Laser Evaporation ◽  
Cross Linking ◽  
Mussel Adhesive Proteins ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Density Functional Theory Study on the Cross-Linking of Mussel Adhesive Proteins

2015 ◽  
Vol 119 (17) ◽  
pp. 5496-5504 ◽  
Author(s):  
Mohammad A. Matin ◽  
Ramesh Kumar Chitumalla ◽  
Manho Lim ◽  
Xingfa Gao ◽  
Joonkyung Jang
Keyword(s):  
Density Functional Theory ◽  
Density Functional ◽  
Cross Linking ◽  
Density Functional Theory Study ◽  
Functional Theory ◽  
Mussel Adhesive Proteins ◽  
The Cross ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Effect of Oxidation Rate on Cross-Linking of Mussel Adhesive Proteins

2003 ◽  
Vol 4 (3) ◽  
pp. 632-640 ◽  
Author(s):  
Sander Haemers ◽  
Ger J. M. Koper ◽  
Gert Frens
Keyword(s):  
Oxidation Rate ◽  
Cross Linking ◽  
Mussel Adhesive Proteins ◽  
Mussel Adhesive ◽  
Adhesive Proteins

Exploring the characteristics of the nickel oxide nanoparticles via Sol - gel method

2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Jothi M ◽  
Sowmiya K
Keyword(s):  
Nickel Oxide ◽  
Ph Value ◽  
Lattice Structure ◽  
Sol Gel ◽  
Systematic Change ◽  
Average Crystalline Size ◽  
Nio Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
X Ray ◽  
Vis Spectroscopy

Nickel Oxide (NiO) is an important transition metal oxide with cubic lattice structure. NiO is thermally stable that is suitable for tremendous applications in the field of optic, ceramic,glass, electro-chromic coatings, plastics, textiles, nanowires, nanofibers, electronics,energy technology, bio-medicine, magnetism and so on. In this present study, NiO nanoparticles were successfully synthesized by sol-gel technique. Nano-sols were prepared by dissolving Nickel-Chloride [NiCl2.6H2O] in NaOH solvent and were converted into nano structured gel on precipitation. A systematic change in preparation parameters like calcination temperature, time, pH value has been noticed in order to predict the influence on crystallite size. Then the prepared samples were characterized by the X-ray Diffraction Spectroscopic (XRD), UV-VIS Spectroscopy, Fourier Transform Infra-Red Spectroscopy (FTIR), Energy Dispersive X-ray Spectroscopy (EDX), Scanning Electron Microscopy (SEM) and Particle Size Analyzer (PSA). From XRD, the average crystalline-size has been calculated by Debye-Scherrer Equation and it was found to be 12.17 nm and the band gap energy of Nickel oxide (NiO) from UV studies reveals around 3.85 eV. Further, EDX and FTIR studies, confirm the presences of NiO nanoparticles. The SEM study exhibits the spherical like morphology of Nickel oxide (NiO). Further from PSA, the mean value of NiO nanoparticles has been determined.

scholarly journals Photocatalytic activity of Pr-modified TiO2 for the degradation of bisphenol A

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Denise S. Cordeiro ◽  
Fernando L. Cassio ◽  
Larissa Ciccotti ◽  
Thiago L. R. Hewer ◽  
Paola Corio ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Bisphenol A ◽  
Pore Diameter ◽  
Sol Gel ◽  
Bandgap Energy ◽  
Photocatalytic Efficiency ◽  
Average Pore ◽  
X Ray ◽  
Vis Spectroscopy ◽  
Adsorption Desorption

AbstractPraseodymium doped TiO2 nanoparticles were successfully prepared by the sol–gel method and characterized by X-ray powder diffraction, N2 adsorption–desorption isotherm, and UV–vis spectroscopy. The effects of the dopant on the crystallite size, specific surface area, average pore diameter, pore volume, and bandgap energy were investigated. The photocatalytic activity of the catalysts was evaluated by bisphenol A degradation and mineralization, which is a representative endocrine disruptor. Furthermore, under visible light irradiation the Pr-modified TiO2 photocatalysts exhibited higher photocatalytic efficiency than unmodified TiO2. When praseodymium was loaded (1.0–5.0%) onto the surface of TiO2, the rates of degradation and mineralization were increased 3–5 times.

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