Loading of Fluvastatin onto Gelatin-Coated Titanium Implants

2018 ◽  
Vol 782 ◽  
pp. 233-237
Author(s):  
Shinji Takemoto ◽  
Kaori Sasaki ◽  
Shiho Sugawara ◽  
Setsuo Saitoh ◽  
Tomofumi Sawada ◽  
...  
Keyword(s):  
Dental Implants ◽  
Alkaline Treatment ◽  
Titanium Implants ◽  
Xps Analysis ◽  
Optimal Loading ◽  
Gelatin Layer ◽  
Pre Treatment ◽  
Titanium Dental Implants

We aimed to investigate the effects of alumina blasting and alkaline treatment on the immobilization of gelatin-fluvastatin complexes on titanium disks. Blasted titanium disks were submicron-sized porous while the alkaline treated disks were submicron-and nanoporous. XPS analysis revealed homogeneous coverage of titanium disks with a gelatin layer on top of an intermediate polydopamine treatment. The highest amount of fluvastatin immobilization was observed on top of alkaline treated titanium as compared to the blasted disk. A combination of alkaline pre-treatment followed by polydopamine-assisted immobilization of gelatin facilitated optimal loading of fluvastatin onto titanium dental implants.

scholarly journals Direct Metal Laser Sintering Titanium Dental Implants: A Review of the Current Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
F. Mangano ◽  
L. Chambrone ◽  
R. van Noort ◽  
C. Miller ◽  
P. Hatton ◽  
...  
Keyword(s):  
Dental Implants ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Three Dimensional ◽  
Laser Sintering ◽  
Titanium Implants ◽  
Human Studies ◽  
Direct Metal Laser Sintering ◽  
Titanium Dental Implants

Statement of Problem. Direct metal laser sintering (DMLS) is a technology that allows fabrication of complex-shaped objects from powder-based materials, according to a three-dimensional (3D) computer model. With DMLS, it is possible to fabricate titanium dental implants with an inherently porous surface, a key property required of implantation devices.Objective. The aim of this review was to evaluate the evidence for the reliability of DMLS titanium dental implants and their clinical and histologic/histomorphometric outcomes, as well as their mechanical properties.Materials and Methods. Electronic database searches were performed. Inclusion criteria were clinical and radiographic studies, histologic/histomorphometric studies in humans and animals, mechanical evaluations, andin vitrocell culture studies on DMLS titanium implants. Meta-analysis could be performed only for randomized controlled trials (RCTs); to evaluate the methodological quality of observational human studies, the Newcastle-Ottawa scale (NOS) was used.Results. Twenty-seven studies were included in this review. No RCTs were found, and meta-analysis could not be performed. The outcomes of observational human studies were assessed using the NOS: these studies showed medium methodological quality.Conclusions. Several studies have demonstrated the potential for the use of DMLS titanium implants. However, further studies that demonstrate the benefits of DMLS implants over conventional implants are needed.

Histomorphometric Evaluation of Bone Response to Different Titanium Implant Surfaces

2007 ◽  
Vol 361-363 ◽  
pp. 613-616
Author(s):  
Laurent Le Guenhennec ◽  
Eric Goyenvalle ◽  
Marco A. Lopez-Heredia ◽  
Pierre Weiss ◽  
Yves Amouriq ◽  
...  
Keyword(s):  
Dental Implants ◽  
Calcium Phosphates ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Bone Response ◽  
Bone To Implant Contact ◽  
Coated Surfaces ◽  
Titanium Dental Implants

Titanium dental implants presenting different blasted surfaces and an OCP coated surfaces have been implanted in the femoral epiphysis of rabbits. A comparable osseointegration has been observed for the titanium implants blasted either with alumina or biphasic calcium phosphates particles whatever the delay of implantation (2 or 8 weeks). A higher bone to implant contact has been observed for the SLA and OCP coated implants as compared to the grit-blasted groups.

Surface Modification of Ti Dental Implants by Grit-Blasting and Micro-Arc Oxidation

2008 ◽  
Vol 47-50 ◽  
pp. 467-470 ◽  
Author(s):  
Yeon Wook Kim
Keyword(s):  
Surface Roughness ◽  
Dental Implants ◽  
High Surface ◽  
Titanium Implants ◽  
Osteoblastic Cell ◽  
Implant Surface ◽  
Oxidation Treatment ◽  
Grit Blasting ◽  
Micro Arc Oxidation ◽  
Titanium Dental Implants

The osseointegration capability of titanium dental implants is related to their chemical composition and surface roughness. In this study, the combination of grit-blasting and micro-arc oxidation had been used for producing the improved implant surfaces. The ceramic particles were projected to titanium dental implants through a nozzle at high velocity by means of compressed air to get high surface roughness. Then the surface of titanium implants was modified by micro-arc oxidation treatment. The current density, frequency and duty were 50-300 mA/cm2, 100 Hz, and 50%, respectively. A porous TiO2 layer was formed on the surface after the oxidation treatment. The surface structure of oxidized implants exhibited nanometer-sized pores with an average diameter of 0.2 µm. The TiO2 passive layer of the implant surface can attribute to the excellent biocompatibility. The high roughness (Ra=0.182 µm) formed by grit-blasting maximizes the interlocking between mineralized bone and the surface of the implant. Surface roughness in the manometer range formed by micro-arc oxidation treatment would play an important role in the adsorption of proteins, adhesion of osteoblastic cell and thus the rate of osseointegration.

The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study

2020 ◽  
Vol 46 (5) ◽  
pp. 475-479
Author(s):  
Levent Cigerim ◽  
Volkan Kaplan
Keyword(s):  
Bone Resorption ◽  
Dental Implants ◽  
Titanium Implants ◽  
Biological Aging ◽  
Implant Survival ◽  
Convenience Sample ◽  
Radiographic Measurements ◽  
Significant Difference ◽  
The Mean ◽  
Titanium Dental Implants

It has been demonstrated that the osteoconductivity, hydrophilicity, and biological capacity of titanium decreases over time, and this phenomenon was described as the biological aging of titanium. The aim of this study was to evaluate whether the age of sand-blasted and acid-etched (SLA) titanium dental implants (duration from the production date until the date of dental implant surgery) affects marginal bone resorption and implant survival. This nonrandom convenience-sample retrospective pilot study was carried out in 200 implants of 64 patients. Radiographic measurements were performed on intraoral periapical radiographs. Implants were divided into 2 age groups; group 1 = 0–3 months and group 2 = 36–41 months. A P value < .05 was considered statistically significant. Of the implants, 41% (n = 82) were between 0 and 3 months old, and 59% (n = 118) were between 36 and 41 months old. All (n = 200) of the implants survived and maintained their function. The mean mesial marginal resorption measurement was 0.60 ± 0.65 mm, and the mean distal marginal resorption was 0.77 ± 1.07 mm. There was no statistically significant difference between the amount of mesial and distal marginal bone resorption according to implant age (P > .05). In SLA surface titanium implants with adequate initial primary stability and a 3-month osseointegration period before loading, biological aging of titanium did not affect implant survival and marginal bone resorption.

scholarly journals Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants

2019 ◽  
Vol 8 (9) ◽  
pp. 1368 ◽  
Author(s):  
José Joaquín Merino ◽  
María Eugenia Cabaña-Muñoz ◽  
Adolfo Toledano Gasca ◽  
Alba Garcimartín ◽  
Juana Benedí ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Materials ◽  
Study Groups ◽  
Dental Amalgam ◽  
Titanium Implants ◽  
Monocyte Chemoattractant Protein 1 ◽  
Proinflammatory Mediators ◽  
Dental Amalgam Fillings ◽  
Titanium Dental Implants

Titanium is the mean biocompatible metal found in dental titanium alloys (Ti-6Al-4V). The safety of certain dental biomaterial amalgams has been questioned in patients. The levels of several systemic cytokines (interleukin (IL)-1 beta, IL-4: pg/mL) and chemokines (monocyte chemoattractant protein-1 (MCP-1), soluble fractalkine (CX3CL1: pg/mL) were determined using ELISA and compared between these study groups. The study included 30 controls without dental materials (cont), 57 patients with long-term titanium dental implants plus amalgams (A + I group) as well as 55 patients with long-term dental amalgam alone (A group). All patients (except controls) have had dental titanium implants (Ti-6Al-4V) and/or amalgams for at least 10 years (average: 15 years). We evaluated whether systemic levels of cytokines/chemokines, kyn/L-trp ratio and aromatic amino acid levels (HPLC: mM/L, Phe, L-Trp, His, Treo) could be altered in patients with long-term dental titanium and/or amalgams. These systemic markers were evaluated in 142 patients. The A + I group had higher L-Kynurenine/L-Tryptophan ratios than patients with long-term dental amalgam fillings alone (A). In addition, levels of IL-1 Beta cytokine, CX3CL1 and MCP-1 chemokines were higher in the A + I group than in the A group (A). The increased L-kyn/L-trp ratio and MCP-1 and fractalkine receptor (CX3CR1) elevations could suggest enhanced chemotactic responses by these chemokines in the A + I group.

scholarly journals Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Mo/Hg2+, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams

2019 ◽  
Vol 8 (1) ◽  
pp. 86 ◽  
Author(s):  
María Cabaña-Muñoz ◽  
José Parmigiani-Izquierdo ◽  
Fabio Camacho Alonso ◽  
José Merino
Keyword(s):  
Oxidative Stress ◽  
Dental Implants ◽  
Dental Materials ◽  
Dental Amalgam ◽  
Titanium Implants ◽  
Systemic Oxidative Stress ◽  
Hair Samples ◽  
Dental Amalgams ◽  
Titanium Dental Implants

Introduction: the biological safety of dental biomaterials has been questioned in human studies. Material and Methods: Several heavy metals/oligoelements were compared by Inductive Coupled Mass Spectrometry (ICP-MS) in hair samples from 130 patients (n = 54 patients with long-term titanium dental implants and amalgams (A + I group), 51 patients with long-term dental amalgam alone (A group), as well as controls (n = 25: without dental materials) of similar age. All patients (except controls) had had titanium dental implants and/or dental amalgams for at least 10 years (average: 17). We evaluated whether A + I patients could present higher systemic malondialdehyde levels (MDA) as compared to the A group. Results: The A + I group have lower molybdenum levels (A + I) and reduced Mo/Co and Mo/Fe2+ ratios, which could predispose them to oxidative stress by raising MDA levels as compared to the A group alone; our findings suggest that higher Co levels could enhance oxidative stress in the A + I group. However, there were no differences on metals from titanium alloy (Ti-6Al), Cr from crowns or Hg2+, Sn, Zn2+, Cu2+ levels between the A + I and A groups. Conclusion: patients with long-term dental titanium and amalgams have systemic oxidative stress due to rising MDA levels and lower Mo/Co and Mo/Fe2+ ratios than those with amalgams alone.

scholarly journals Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Ali Hafezeqoran ◽  
Roodabeh Koodaryan
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Meta Analysis ◽  
Titanium Implants ◽  
Removal Torque ◽  
Significant Difference ◽  
Modified Surface ◽  
Bone To Implant Contact ◽  
Titanium Dental Implants ◽  
Zirconia Implants

Background. The information available about osseointegration and the bone to implant interaction of zirconia implants with various surface modifications is still far from sufficient.Objective. The purpose of this systematic review and meta-analysis was to evaluate and compare zirconia dental implants with different surface topographies, with a focus on bone to implant contact and removal torque.Methods. The systematic review of the extracted publications was performed to compare the bone to implant contact (BIC) with removal torque (RT) values of titanium dental implants and machined and surfaced modified zirconia implants.Results. A total of fifteen articles on BIC and RT values were included in the quantitative analysis. No significant difference in the BIC values was observed between titanium and machined zirconia implants (p=0.373; 95% CI:-0.166 to 0.443). However, a significantly better BIC values were observed for acid etched zirconia implants compared with those of titanium implants (p=0.032; 95% CI: 0.068 to 1.461). Unmodified zirconia implants showed favorable BIC values compared to modified-surface zirconia implants (p=0.021; 95% CI:-0.973 to-0.080).Conclusion. Acid etched zirconia implants may serve as a possible substitute for successful osseointegration.

scholarly journals Zirconia vs. Titanium Dental Implants: Primary Stability In-Vitro Analysis

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7886
Author(s):  
Nerea Arlucea ◽  
Aritza Brizuela-Velasco ◽  
Markel Dieguez-Pereira ◽  
Miquel Punset ◽  
Meritxell Molmeneu ◽  
...  
Keyword(s):  
Dental Implants ◽  
Primary Stability ◽  
Titanium Implants ◽  
Insertion Torque ◽  
Static Compression ◽  
Compression Load ◽  
Vitro Analysis ◽  
Titanium Dental Implants ◽  
Zirconia Implants

The present experimental trial uses two types of dental implants, one made of titanium (Ti6Al4V) and the other one of zirconia (ZrO2), but both of identical design, to compare their stability and micro-movements values under load. One of each type of implant (n = 42) was placed into 21 cow ribs, recording the insertion torque and the resonance frequency using a specific transducer. Subsequently, a prosthetic crown made of PMMA was screwed onto each of the implants in the sample. They were then subjected to a static compression load on the vestibular cusp of the crown. The resulting micromovements were measured. The zirconia implants obtained a higher mean of both IT and RFA when compared with those of titanium, with statistically significant differences in both cases (p = 0.0483 and p = 0.0296). However, the micromovement values when load was applied were very similar for both types, with the differences between them (p = 0.3867) not found to be statistically significant. The results show that zirconia implants have higher implant stability values than titanium implants. However, the fact that there are no differences in micromobility values implies that caution should be exercised when applying clinical protocols for zirconia based on RFA, which only has evidence for titanium.

Zirconia Dental Implants: A Literature Review

2011 ◽  
Vol 37 (3) ◽  
pp. 367-376 ◽  
Author(s):  
Zeynep Özkurt ◽  
Ender Kazazoğlu
Keyword(s):  
Mechanical Properties ◽  
Literature Review ◽  
Dental Implants ◽  
Titanium Implants ◽  
Research Articles ◽  
Clinical Use ◽  
Success Rates ◽  
Novel Technologies ◽  
Titanium Dental Implants ◽  
Zirconia Implants

Abstract Titanium and titanium alloys are widely used for fabrication of dental implants. Because of potential immunologic and possible esthetic compromises with titanium implants, novel implant technologies are being developed. However, these novel technologies must maintain the characteristics that provide titanium implants with their high success rates. Zirconia implants were introduced into dental implantology as an alternative to titanium implants. Zirconia seems to be a suitable implant material because of its toothlike color, mechanical properties, biocompatibility, and low plaque affinity. The aim of this study is to review clinical and research articles conducted on zirconia dental implants, compare them with titanium dental implants, and provide information on zirconia dental implant osseointegration and mechanical strength. Zirconia dental implants have the potential to become alternative dental implants to titanium dental implants, but they are not yet in routine clinical use.

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