scholarly journals Cabled Ocean Observatory Systems

2004 ◽  
Vol 38 (2) ◽  
pp. 30-43 ◽  
Author(s):  
Alan D. Chave ◽  
Gary Waterworth ◽  
Andrew R. Maffei ◽  
Gene Massion
Keyword(s):  
Fiber Optic ◽  
High Reliability ◽  
Power Grid ◽  
System Engineering ◽  
Power Cable ◽  
Future Studies ◽  
Control Instrument ◽  
Engineering Environment ◽  
And Control

Future studies of episodic processes in the ocean and earth will require new tools to complement traditional, ship-based, expeditionary science. This will be enabled through the construction of innovative facilities called ocean observatories which provide unprecedented amounts of power and two-way bandwidth to access and control instrument networks in the oceans. The most capable ocean observatories are designed around a submarine fiber optic/power cable connecting one or more seafloor science nodes to the terrestrial power grid and communications backhaul. This paper defines the top level requirements that drive cabled observatory design and the system engineering environment within which a scientifically-capable infrastructure can be implemented. Commercial high reliability submarine telecommunication technologies which will be crucial in the design of long term cabled observatories are then reviewed. The top level architecture of a generic cabled observatory, describing the main subsystems comprising the whole and defining technological approaches to their engineering, is then described, along with some example design choices and tradeoff studies

scholarly journals Piezo drive tunable optic filter

2021 ◽  
Author(s):  
Wen Zu
Keyword(s):  
High Performance ◽  
Tuning Range ◽  
Fiber Optic ◽  
High Reliability ◽  
Axial Strain ◽  
Reaction Force ◽  
Fine Tuning ◽  
Element Analysis ◽  
Compensation Design

Tunable fiber optic filter has extensive applications in telecommunications, spectroscopy, and fiber optic sensing. Many research attempts have been devoted to develop a filter with a wide tuning range, a fast tuning speed, a fine tuning resolution, and high reliability. Despite of the progress made so far, a tunable fiber optic filter that combines all these qualities is still a subject of intensive research. This thesis describes the design, fabrication and test results of a high performance tunable fiber optic filter. The filter is piezo-driven using a flexural hinge structure for displacement magnification and an axial strain of a fiber Bragg grating. Finite element analysis was used to design the mechanical structure to achieve the required displacement magnification and reaction force for grating compression. A passive thermal compensation design was implemented with two spacers of different coefficients of thermal expansion to compensate the thermal-induced wavelength drift. A feedback control system with a linear variable differential transformer was employed to control the displacement and to achieve the designed tuning accuracy. A tuning range of 13.7 nm, a maximum closed loop switching time of 17.3 ms, and a wavelength drift of 1.4 pm/C were achieved. The flexural-hinge structure, that offers noise-free motion, no need of lubricants and no wear, ensures its long-term reliability.

scholarly journals Piezo drive tunable optic filter

2021 ◽  
Author(s):  
Wen Zu
Keyword(s):  
High Performance ◽  
Tuning Range ◽  
Fiber Optic ◽  
High Reliability ◽  
Axial Strain ◽  
Reaction Force ◽  
Fine Tuning ◽  
Element Analysis ◽  
Compensation Design

Tunable fiber optic filter has extensive applications in telecommunications, spectroscopy, and fiber optic sensing. Many research attempts have been devoted to develop a filter with a wide tuning range, a fast tuning speed, a fine tuning resolution, and high reliability. Despite of the progress made so far, a tunable fiber optic filter that combines all these qualities is still a subject of intensive research. This thesis describes the design, fabrication and test results of a high performance tunable fiber optic filter. The filter is piezo-driven using a flexural hinge structure for displacement magnification and an axial strain of a fiber Bragg grating. Finite element analysis was used to design the mechanical structure to achieve the required displacement magnification and reaction force for grating compression. A passive thermal compensation design was implemented with two spacers of different coefficients of thermal expansion to compensate the thermal-induced wavelength drift. A feedback control system with a linear variable differential transformer was employed to control the displacement and to achieve the designed tuning accuracy. A tuning range of 13.7 nm, a maximum closed loop switching time of 17.3 ms, and a wavelength drift of 1.4 pm/C were achieved. The flexural-hinge structure, that offers noise-free motion, no need of lubricants and no wear, ensures its long-term reliability.

Automatic Control Instrument of γ-Ray Non-Destructive Testing Equipment

2011 ◽  
Vol 271-273 ◽  
pp. 945-948
Author(s):  
Yi Luo ◽  
Ying Li ◽  
Zai Xiu Chen ◽  
Kai Wang ◽  
Yong Han
Keyword(s):  
High Reliability ◽  
Working Environment ◽  
Motor Drive ◽  
Non Destructive Testing ◽  
Destructive Testing ◽  
Optical Encoder ◽  
Control Instrument ◽  
Location Parameters ◽  
And Control ◽  
Non Destructive

With the NDT radioactive isotope widely used in engineering, it puts forward higher requirements for NDT. As the complexity of the device working environment and high reliability requirements, system reliability and security is the focus of the entire design. This NDT uses PT and PLC to operate and control machine and optical encoder to achieve the collection of the source location parameters, DC torque motor drive to ensure jitter-free, long locked rotor, uniform speed drive performance to ensure machine security and stability.

Suppressed, but Not Forgotten

2011 ◽  
Vol 70 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Beat Meier ◽  
Anja König ◽  
Samuel Parak ◽  
Katharina Henke
Keyword(s):  
Memory Trace ◽  
Thought Suppression ◽  
Test Phase ◽  
Indirect Test ◽  
Final Test ◽  
Test Experiment ◽  
And Control ◽  
Cue Words ◽  
The Impact

This study investigates the impact of thought suppression over a 1-week interval. In two experiments with 80 university students each, we used the think/no-think paradigm in which participants initially learn a list of word pairs (cue-target associations). Then they were presented with some of the cue words again and should either respond with the target word or avoid thinking about it. In the final test phase, their memory for the initially learned cue-target pairs was tested. In Experiment 1, type of memory test was manipulated (i.e., direct vs. indirect). In Experiment 2, type of no-think instructions was manipulated (i.e., suppress vs. substitute). Overall, our results showed poorer memory for no-think and control items compared to think items across all experiments and conditions. Critically, however, more no-think than control items were remembered after the 1-week interval in the direct, but not in the indirect test (Experiment 1) and with thought suppression, but not thought substitution instructions (Experiment 2). We suggest that during thought suppression a brief reactivation of the learned association may lead to reconsolidation of the memory trace and hence to better retrieval of suppressed than control items in the long term.

Strengthening of occupational health promotion by the German Prevention Health Care Act

2019 ◽  
pp. 188-190
Author(s):  
Diana Hart
Keyword(s):  
Public Health ◽  
Health Care ◽  
Health Promotion ◽  
Primary Prevention ◽  
Occupational Health ◽  
Life Expectancy ◽  
Prevention And Control ◽  
Occupational Health Promotion ◽  
And Control

All countries are faced with the problem of the prevention and control of non-communicable diseases (NCD): implement prevention strategies eff ectively, keep up the momentum with long term benefi ts at the individual and the population level, at the same time tackling hea lth inequalities. Th e aff ordability of therapy and care including innovative therapies is going to be one of the key public health priorities in the years to come. Germany has taken in the prevention and control of NCDs. Germany’s health system has a long history of guaranteeing access to high-quality treatment through universal health care coverage. Th r ough their membership people are entitled to prevention and care services maintaining and restoring their health as well as long term follow-up. Like in many other countries general life expectancy has been increasing steadily in Germany. Currently, the average life expectancy is 83 and 79 years in women and men, respectively. Th e other side of the coin is that population aging is strongly associated with a growing burden of disease from NCDs. Already over 70 percent of all deaths in Germany are caused by four disease entities: cardiovascular disease, cancer, chronic respiratory disease and diabetes. Th ese diseases all share four common risk factors: smoking, alcohol abuse, lack of physical activity and overweight. At the same time, more and more people become long term survivors of disease due to improved therapy and care. Th e German Government and public health decision makers are aware of the need for action and have responded by initiating and implementing a wide spectrum of activities. One instrument by strengthening primary prevention is the Prevention Health Care Act. Its overarching aim is to prevent NCDs before they can manifest themselves by strengthening primary prevention and health promotion in diff erent sett ings. One of the main emphasis of the Prevention Health Care Act is the occupational health promotion at the workplace.

Cognitive Treatment for OCD

2012 ◽  
Author(s):  
Maureen L. Whittal ◽  
Melisa Robichaud
Keyword(s):  
Term Treatment ◽  
Future Directions ◽  
Cognitive Treatment ◽  
Long Term Treatment ◽  
Inflated Responsibility ◽  
And Control ◽  
The Relationship ◽  
Control Of Thoughts

The cornerstone of cognitive treatment (CT) for OCD is based upon the knowledge that unwanted intrusions are essentially a universal experience. As such, it is not the presence of the intrusion that is problematic but rather the associated meaning or interpretation. Treatment is flexible, depending upon the nature of the appraisals and beliefs, but can include strategies focused on inflated responsibility and overestimation of threat, importance and control of thoughts, and the need for perfectionism and certainty. The role of concealment and the relationship to personal values are important maintaining and etiological factors. The short-term and long-term treatment outcome is reviewed, along with predictors of treatment response and mechanisms of action, and the chapter concludes with future directions regarding CT for OCD.

scholarly journals The Anti-PD-1/PD-L1 Immunotherapy for Gastric Esophageal Cancer: A Systematic Review and Meta-Analysis and Literature Review

2021 ◽  
Vol 28 ◽  
pp. 107327482199743
Author(s):  
Ke Chen ◽  
Xiao Wang ◽  
Liu Yang ◽  
Zheling Chen
Keyword(s):  
Overall Survival ◽  
Esophageal Cancer ◽  
Survival Rate ◽  
Meta Analysis ◽  
Response Rates ◽  
Control Group ◽  
Term Survival ◽  
Long Term Survival ◽  
And Control

Background: Treatment options for advanced gastric esophageal cancer are quite limited. Chemotherapy is unavoidable at certain stages, and research on targeted therapies has mostly failed. The advent of immunotherapy has brought hope for the treatment of advanced gastric esophageal cancer. The aim of the study was to analyze the safety of anti-PD-1/PD-L1 immunotherapy and the long-term survival of patients who were diagnosed as gastric esophageal cancer and received anti-PD-1/PD-L1 immunotherapy. Method: Studies on anti-PD-1/PD-L1 immunotherapy of advanced gastric esophageal cancer published before February 1, 2020 were searched online. The survival (e.g. 6-month overall survival, 12-month overall survival (OS), progression-free survival (PFS), objective response rates (ORR)) and adverse effects of immunotherapy were compared to that of control therapy (physician’s choice of therapy). Results: After screening 185 studies, 4 comparative cohort studies which reported the long-term survival of patients receiving immunotherapy were included. Compared to control group, the 12-month survival (OR = 1.67, 95% CI: 1.31 to 2.12, P < 0.0001) and 18-month survival (OR = 1.98, 95% CI: 1.39 to 2.81, P = 0.0001) were significantly longer in immunotherapy group. The 3-month survival rate (OR = 1.05, 95% CI: 0.36 to 3.06, P = 0.92) and 18-month survival rate (OR = 1.44, 95% CI: 0.98 to 2.12, P = 0.07) were not significantly different between immunotherapy group and control group. The ORR were not significantly different between immunotherapy group and control group (OR = 1.54, 95% CI: 0.65 to 3.66, P = 0.01). Meta-analysis pointed out that in the PD-L1 CPS ≥10 sub group population, the immunotherapy could obviously benefit the patients in tumor response rates (OR = 3.80, 95% CI: 1.89 to 7.61, P = 0.0002). Conclusion: For the treatment of advanced gastric esophageal cancer, the therapeutic efficacy of anti-PD-1/PD-L1 immunotherapy was superior to that of chemotherapy or palliative care.

scholarly journals Pseudogymnoascus destructans growth in wood, soil and guano substrates

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jenny Urbina ◽  
Tara Chestnut ◽  
Jennifer M. Allen ◽  
Taal Levi
Keyword(s):  
Dna Extraction ◽  
Emerging Infectious Diseases ◽  
Transmission Risk ◽  
Pseudogymnoascus Destructans ◽  
White Nose Syndrome ◽  
Management Interventions ◽  
Pathogen Persistence ◽  
Tenfold Increase ◽  
And Control

AbstractUnderstanding how a pathogen can grow on different substrates and how this growth impacts its dispersal are critical to understanding the risks and control of emerging infectious diseases. Pseudogymnoascus destructans (Pd) causes white-nose syndrome (WNS) in many bat species and can persist in, and transmit from, the environment. We experimentally evaluated Pd growth on common substrates to better understand mechanisms of pathogen persistence, transmission and viability. We inoculated autoclaved guano, fresh guano, soil, and wood with live Pd fungus and evaluated (1) whether Pd grows or persists on each (2) if spores of the fungus remain viable 4 months after inoculation on each substrate, and (3) whether detection and quantitation of Pd on swabs is sensitive to the choice to two commonly used DNA extraction kits. After inoculating each substrate with 460,000 Pd spores, we collected ~ 0.20 g of guano and soil, and swabs from wood every 16 days for 64 days to quantify pathogen load through time using real-time qPCR. We detected Pd on all substrates over the course of the experiment. We observed a tenfold increase in pathogen loads on autoclaved guano and persistence but not growth in fresh guano. Pathogen loads increased marginally on wood but declined ~ 60-fold in soil. After four months, apparently viable spores were harvested from all substrates but germination did not occur from fresh guano. We additionally found that detection and quantitation of Pd from swabs of wood surfaces is sensitive to the DNA extraction method. The commonly used PrepMan Ultra Reagent protocol yielded substantially less DNA than did the QIAGEN DNeasy Blood and Tissue Kit. Notably the PrepMan Ultra Reagent failed to detect Pd in many wood swabs that were detected by QIAGEN and were subsequently found to contain substantial live conidia. Our results indicate that Pd can persist or even grow on common environmental substrates with results dependent on whether microbial competitors have been eliminated. Although we observed clear rapid declines in Pd on soil, viable spores were harvested four months after inoculation. These results suggest that environmental substrates and guano can in general serve as infectious environmental reservoirs due to long-term persistence, and even growth, of live Pd. This should inform management interventions to sanitize or modify structures to reduce transmission risk as well early detection rapid response (EDRR) planning.

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