Effects of Far Infrared Rays Irradiated from Ceramic Material (BIOCERAMIC) on Psychological Stress-Conditioned Elevated Heart Rate, Blood Pressure, and Oxidative Stress-Suppressed Cardiac Contractility

2012 ◽  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Heart Rate ◽  
Ceramic Material ◽  
Psychological Stress ◽  
Cardiac Contractility ◽  
Far Infrared ◽  
Infrared Rays ◽  
And Oxidative Stress ◽  
Elevated Heart Rate

scholarly journals Autonomic impairment and oxidative stress: Relationship in PCOS patients

2020 ◽  
Vol 14 (2) ◽  
pp. 82-88
Author(s):  
Musfika Mostafa ◽  
Sultana Ferdousi ◽  
Shamima Sultana ◽  
Ayesha Akhter
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Heart Rate ◽  
Standard Deviation ◽  
Polycystic Ovary ◽  
Digital Data ◽  
Autonomic Nerve ◽  
Cardiovascular Risks ◽  
Rr Intervals ◽  
And Oxidative Stress

Background: Polycystic ovary syndrome (PCOS) is one of the most common, heterogeneous endocrine disorder of reproductive aged women. Association of autonomic impairment and elevated oxidative stress may predispose these patients to increased cardiovascular risks. Objective: To evaluate the relationship between cardiac autonomic nerve function (CANF) and oxidative stress in patients with PCOS. Methods: This cross sectional study was conducted in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from September, 2018 to August, 2019. For this study, 30 newly diagnosed PCOS patients aged 20-35 years were recruited and similar age, body mass index (BMI) 30 apparently healthy, regularly menstruating women were enrolled as control. CANF was assessed by analyzing time domain measures of Heart Rate Variability (HRV). HRV data were recorded by a digital data acquisition device, Powerlab 8/35 (AD instruments, Australia). For evaluation of oxidative stress, plasma catalase and plasma Malondialdehyde (MDA) levels were measured. Statistical analysis was done by unpaired “t” test and Pearson’s correlation test as applicable. Results: In this study, resting pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly higher (p<0.001, p<0.01, p<0.01 respectively) and standard deviation of the RR intervals (SDRR) (p<0.01), mean R-R interval, standard deviation of the difference between successive RR intervals (SDSD), square root of mean squared differences of successive RR intervals (RMSSD), proportion of RR interval with duration >50 ms (pRR50%) were significantly lower (p<0.001) in PCOS than healthy controls. In addition, plasma catalase was significantly lower (p<0.01) and plasma MDA was significantly higher (p<0.001) in PCOS patients compared to controls. On correlation analysis, mean heart rate, SDRR, SDSD, RMSSD and pRR50% showed negative correlation with plasma catalase and plasma MDA (p<0.05) in PCOS patients but these were not significant. Conclusion: The present study reveals that reduced parasympathetic activity in PCOS patients may be related to oxidative stress. J Bangladesh Soc Physiol. 2019, December; 14(2): 82-88

scholarly journals Novel Soy Germ Pasta Improves Endothelial Function, Blood Pressure, and Oxidative Stress in Patients With Type 2 Diabetes: Figure 1

Diabetes Care ◽  
2011 ◽  
Vol 34 (9) ◽  
pp. 1946-1948 ◽  
Author(s):  
Carlo Clerici ◽  
Elisabetta Nardi ◽  
Pier Maria Battezzati ◽  
Stefania Asciutti ◽  
Danilo Castellani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Endothelial Function ◽  
And Oxidative Stress

Febuxostat Attenuates the Progression of Periodontitis in Rats

Pharmacology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Naseratun Nessa ◽  
Miyuki Kobara ◽  
Hiroe Toba ◽  
Tetsuya Adachi ◽  
Toshiro Yamamoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Bone Resorption ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Gingival Tissue ◽  
Systemic Effects ◽  
Rt Pcr ◽  
Tnf Α ◽  
And Oxidative Stress

Introduction: Periodontitis is a lifestyle-related disease that is characterized by chronic inflammation in gingival tissue. Febuxostat, a xanthine oxidase inhibitor, exerts anti-inflammatory and antioxidant effects. Objective: The present study investigated the effects of febuxostat on periodontitis in a rat model. Methods: Male Wistar rats were divided into 3 groups: control, periodontitis, and febuxostat-treated periodontitis groups. Periodontitis was induced by placing a ligature wire around the 2nd maxillary molar and the administration of febuxostat (5 mg/kg/day) was then initiated. After 4 weeks, alveolar bone loss was assessed by micro-computed tomography and methylene blue staining. The expression of osteoprotegerin (OPG), a bone resorption inhibitor, was detected by quantitative RT-PCR and immunological staining, and the number of osteoclasts in gingival tissue was assessed by tartrate-resistant acid phosphatase staining. The mRNA and protein expression levels of the proinflammatory cytokines, tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β), in gingival tissue were measured using quantitative RT-PCR and immunological staining. Oxidative stress in gingival tissue was evaluated by the expression of 4-hydroxy-2-nonenal (4-HNE), and 8-hydroxy-2-deoxyguanosine (8-OHdG). To clarify the systemic effects of periodontitis, blood pressure and glucose tolerance were examined. Results: In rats with periodontitis, alveolar bone resorption was associated with reductions in OPG and increases in osteoclast numbers. The gingival expression of TNF-α, IL-1β, 4-HNE, and 8-OHdG was up-regulated in rats with periodontitis. Febuxostat significantly reduced alveolar bone loss, proinflammatory cytokine levels, and oxidative stress. It also attenuated periodontitis-induced glucose intolerance and blood pressure elevations. Conclusion: Febuxostat prevented the progression of periodontitis and associated systemic effects by inhibiting proinflammatory mediators and oxidative stress.

Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children

2021 ◽  
Vol 195 ◽  
pp. 110870
Author(s):  
Jennifer K. Mann ◽  
Liza Lutzker ◽  
Stephanie M. Holm ◽  
Helene G. Margolis ◽  
Andreas M. Neophytou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Air Pollution ◽  
Glucose Dysregulation ◽  
And Oxidative Stress

Abstract 16443: Effects of Dietary Salt Intakes on Blood Pressure, Renal Function and Oxidative Stress in Rats Treated With Candesartan

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Gangyi Zhu ◽  
Yanting Yu ◽  
Xiaoyan Wang
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Renal Function ◽  
Kidney Diseases ◽  
Sprague Dawley ◽  
Dietary Salt ◽  
Salt Restriction ◽  
Low Salt ◽  
Receptor Blockers ◽  
And Oxidative Stress

Candesartan is one of angiotensin II type1 receptor blockers(ARB) and commonly used as first-line antihypertensive treatment. Low salt diet is often recommended by clinicians to the patients with hypertension and kidney diseases. However,it is not clear whether salt restriction is beneficial to the patients taking ARB. In order to explore this problem, the impacts of different salt diets on blood pressure (BP),renal function and oxidative stress were determined in 2-3 months old male Sprague Dawley rats treated with candesartan. The rats were randomly divided into 4 groups fed agar-gelled food rationally with NaCl content at 0.01%, 0.8%, 2% and 4% respectively(4-7 rats/group) while all rats were intraperitoneally injected with candesartan at 1mg / kg / day for 7 days. SBP started to decline on day 2 in all except 4% NaCl groups relative to day 0 (recorded 5-6 hrs before the first injection). On day 6, systolic BP (mmHg, tail-cuff, Softron,BP-98A) was lower in 0.8% (103.7+2.3) & 0.01% (101.6+3) groups than 2% (113.5+4.1) & 4% (129.9+4.6) groups (one way ANOVA,LSD test, P<0.05) and correlated positively with food NaCl intakes (R 2 =0.9832). DBP was changed in a similar pattern as SBP. Serum creatinine (μmol/L) was higher in 0.01% group (225+39) than groups of 0.8% (1328+350), 2% (2095+242) and 4% (1576+703) while creatinine clearance (ml/day) was lower in 0.01% group (69.3+9) than groups of 0.8% (43.7+9), 2%(27.7+2) and 4%(29+0.6). In order to determine whether oxidative stress plays any role in the BP regulation and renal function maintenance, we also checked renal protein expression of ROS components. Relative to 0.8% group, renal NOXs were not altered in 0.01% group while NOX1 (145+18,% of 0.8% group), NOX2 (240+54) and NOX4 (197+41) was higher in 2% group than other groups. Mn-SOD (77+7.8), not Cu-Zn SOD, was decreased while HO1 (170+16), not HO2, was increased in 0.01% group. Renal abundance of nitrotyrosine was lower in 0.01% than other groups indicating a decreased oxidative stress, possibly caused by increase in HO1. We concluded that salt restriction with candesartan is beneficial to antihypertensive effect of AT1R blockade but disadvantage to maintenance of renal function. Thus, cautions to choice of low salt intakes are necessary when taking ARB agents.

scholarly journals Aqueous extract of Pterocarpus santalinoides DC stem bark prevents L-NAME-induced hypertension in rat

2021 ◽  
Vol 10 (3) ◽  
pp. 166-172
Author(s):  
Chinte Yamjom Ramatou ◽  
◽  
Ngo Lemba Thom Esther ◽  
Florence Tsofack Ngueguim ◽  
Yannick Bekono Fouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Hdl Cholesterol ◽  
Experimental Period ◽  
Stem Bark ◽  
Renal Markers ◽  
Induced Hypertension ◽  
And Oxidative Stress ◽  
Pterocarpus Santalinoides

Background: Pterocarpus santalinoides stem bark is commonly used in Cameroonian medicine to treat many diseases including hypertension. Thus, this study was aimed to evaluate preventive effects of aqueous extract of Pterocarpus santalinoides (AEPS) stem bark on NG-Nitro-L-arginine-methyl ester (LNAME)-induced hypertension in rat. Methods: Normotensive rats received L-NAME (25 mg/kg intraperitoneally) concomitantly with AEPS (50, 100 and 200 mg/kg) or captopril (20 mg/kg) orally during 3 weeks. At the end of experimental period, arterial pressure and heart rate were recorded by invasive method. After sacrifice, blood, aorta and heart were harvested for biochemical analysis on homogenate. Results: Intraperitoneal injection of L-NAME induced in rat a significant increase (p < 0.001; p < 0.01; p < 0.05) of blood pressure, heart rate, malondialdehyde, total cholesterol, triglycerides, LDL-cholesterol, hepatic and renal markers functions. L-NAME also decreased significantly (p < 0.001; p < 0.01; p < 0.05) the levels of HDL-cholesterol, nitrites, glutathione, superoxide dismutase and catalase activities as compared to control rats. The AEPS prevented significantly the increase (p < 0.001) of hemodynamic parameters induced by L-NAME and various modifications of biochemical parameters (lipid profile, hepatic and renal markers functions) and oxidative stress markers evaluated. Conclusion: This study shows that the aqueous extract of Pterocarpus santalinoides prevents hypertension, dyslipidemia and oxidative stress induced by L-NAME in rat by attenuating endothelial dysfunction, liver and kidney’s damages

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