Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study

Purpose: In this study, we compared the effects of three agents frequently used in daily life for medical expulsive therapy. Materials and methods: A total of 143 patients meeting the criteria were included in the study. Patients were divided into three homogeneous drug groups which were tamsulosin group (n:48), alfuzosin group (n:47) and silodosin group (n:48). The time of stone expulsion, analgesic needs, side effects of the medicine and endoscopic intervention needs of the patients were recorded. Results: The rate of stone expulsion was 70.8% (n:34) in tamsulosin group, 70.2% (n:33) in alfuzosin group, and 75% (n:36) in silodosin group. No significant difference was observed among the rates of stone expulsion in three groups, and the rates of stone expulsion were similar (p = 0.778). The duration of stone expulsion was significantly different in the groups (p = 0.012): the time of stone expulsion for tamsulosin was 2.33 ± 0.78 days longer than for Silodosin, indicating a significant difference. There was no significant difference between tamsulosin-alfuzosin and silodosin-alfuzosin (respectively p = 0.147, p = 0.925). Conclusions: The results of this study showed that medical expulsive therapy by using alpha blocker agents is safe and efficacious. This option must be kept in mind for patients who do not ask for surgery as the first-step treatment for eligible patients.

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Clinical and Paraclinical Characteristics of 57 Deceased COVID-19 Patients in Tehran, Iran: A Retrospective Observational Study

International Journal of Medical Laboratory ◽

10.18502/ijml.v8i1.5667 ◽

2021 ◽

Author(s):

Niayesh Mohebbi ◽

Sara Pakzad Karamad ◽

Keyvan Gohari Moghadam ◽

Mohamadreza Jafary ◽

Poorya Rajabi ◽

...

Keyword(s):

Observational Study ◽

Retrospective Observational Study ◽

Polymerase Chain Reaction Test ◽

Ct Scans ◽

Ground Glass ◽

Positive Real ◽

Significant Difference ◽

Polymerase Chain ◽

Novel Coronavirus ◽

Chain Reaction Test

Background and Aims: In 2019, a novel coronavirus called SARS-COV-2 spread throughout the world, causing a pandemic a few months later. As the virus is not well-known and highly contagious, it is important to observe patients for all possible symptoms and comorbidities. This study aimed to demonstrate some demographic, clinical, and paraclinical features of the deceased patients with COVID-19 in Iran. Materials and Methods: A retrospective observational study was designed to demonstrate the clinical and paraclinical features of deceased patients who had a positive real time-polymerase chain reaction test result for COVID-19. The study included all COVID-19 patients who visited Shariati Hospital, Tehran, Iran, from February 20th until May 20th, 2020. All data were analyzed using IBM SPSS version 21 (Mann-Whitney or Fisher’s test). Results: The patients had a mean age of 63.86 ± 16.428, and most were males (59.65%). Diabetes and hypertension were the most frequent comorbidities. The most common symptoms among the patients were dyspnea (64.91%), weakness (61.40%), fever (60.71%), and having ground-glass opacities in the CT scans (85.96%). There was also a rise in lactate dehydrogenase, serum ferritin, D-dimer, and procalcitonin. Conclusions: Older COVID-19 patients are more likely to get more severe forms of the disease. Most of the deceased COVID-19 patients had ground-glass opacities in their CT scans. Dyspnea, fatigue, and fever were the most frequent symptoms. Hypertension and diabetes were the most important comorbidities. There was almost no significant difference between the two genders regarding clinical and paraclinical symptoms.

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Ketamine Infusion in Post-Surgical Pain Management after Head and Neck Surgery: A Retrospective Observational Study

The Open Anesthesia Journal ◽

10.2174/2589645801913010132 ◽

2019 ◽

Vol 13 (1) ◽

pp. 132-138

Author(s):

Vincenzo Pota ◽

Maria B. Passavanti ◽

Caterina Aurilio ◽

Manlio Barbarisi ◽

Luca G. Giaccari ◽

...

Keyword(s):

Observational Study ◽

Head And Neck ◽

Pain Control ◽

Neck Surgery ◽

Retrospective Observational Study ◽

Ketamine Infusion ◽

Surgical Pain ◽

Significant Difference ◽

Before And After ◽

Remifentanil Group

Background: Head and neck cancer affects approximately 382,000 new patients per year worldwide with a significant portion undergoing surgical treatment. During postoperative period key elements in the Intensive Care Unit (ICU) are airway management and pain control. Objective: We evaluated the average change of inpatient pain control using a Numerical Rating Score (NRS). We also evaluated the time of extubation after ICU admission recording the incidence of desaturation and the necessity of re-intubation. Secondary outcomes were the incidence of postoperative complications, included those narcotics-related, and the use of rescue analgesics. Methods: In this retrospective observational study, we analyzed data of registry before and after we have changed our postoperative analgesic protocol from remifentanil infusion to ketamine infusion. Results: Medical records of 20 patients were examined. 10 patients received 0.5 mg/kg ketamine bolus at the end of surgery, followed by a continuous infusion of 0.25 mg/kg/h. All patients presented a significant decrease in pain intensity from the 4th to 48th postoperative hour (p < 0.05), but statically not a significant difference in NRS score was recorded between the two groups. Time to extubation was shorter in ketamine group compared to the remifentanil group (112.30 min ± 16.78 vs. 78 min ± 14.17; p < 0.05). Desaturation rate was 10% in the remifentanil group, while no case was recorded in the ketamine group. Conclusion: The level of analgesia provided by ketamine and remifentanil was comparable. Ketamine was superior in ventilatory management of the patient with more rapid extubation and with no case of desaturation.

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Pharmacological interaction and side effects in oncohaematology: a retrospective observational study.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.e18235 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. e18235-e18235

Author(s):

Elena Tenti ◽

Andrea Casadei Gardini ◽

Cristina Papayannidis ◽

Giovanni Marconi ◽

Giorgia Simonetti ◽

...

Keyword(s):

Side Effects ◽

Observational Study ◽

Retrospective Observational Study ◽

Pharmacological Interaction

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The Potential Impact of Recreational Cannabis Legalization on the Prevalence of Cannabis Use Disorder and Psychotic Disorders: A Retrospective Observational Study: L’effet potentiel de la légalisation du cannabis récréatif sur la prévalence du trouble d’utilisation du cannabis et des troubles psychotiques : une étude observationnelle rétrospective

The Canadian Journal of Psychiatry ◽

10.1177/0706743720984684 ◽

2021 ◽

pp. 070674372098468

Author(s):

Catherine Vignault ◽

Amélie Massé ◽

David Gouron ◽

Jacques Quintin ◽

Khashayar Djahanbakhsh Asli ◽

...

Keyword(s):

Observational Study ◽

Psychotic Disorders ◽

Mixed Model ◽

Linear Mixed Model ◽

Cannabis Use ◽

University Hospital ◽

Retrospective Observational Study ◽

Cannabis Use Disorder ◽

Centre Hospitalier Universitaire ◽

Significant Difference

Objectives: The principal objective of our study was to document the short-term impact of the legalization of recreational cannabis on active cannabis use, cannabis use disorder, and various psychotic disorders. Methods: We carried out a retrospective observational study of patients who were at least 12 years old and who had visited a psychiatrist in the emergency unit of the Centre hospitalier universitaire de Sherbrooke (CHUS). We included all the consultations of this type over a 5-month period, immediately following the legalization of recreational cannabis in Canada. We then divided our population into an adult (over 18) and teenager group (12 to 17) compared the data to the data from consultations made 2 years earlier, using a generalized linear mixed model. Results: We examined consultations in patients over 18 years old in prelegalization ( n = 1,247) and postlegalization ( n = 1,368) groups. We observed a statistically significant increase in the use of cannabis (28.0% to 37.1%; odds ratio [ OR] = 1.81 [1.34 to 2.44], P = 0.00011) as well as an increase in diagnoses of active cannabis use disorder (17.7% to 24.3%; OR = 1.53 [1.13 to 2.08], P = 0.0064). The increase in cannabis use disorder was more prominent among patients between 18 and 24 years old (17.3% to 25.9%; OR = 2.27 [1.17 to 4.40], P = 0.015). We observed no statistically significant difference in terms of psychotic disorder diagnoses (27.4% to 29.2%; OR = 1.17 [0.84 to 1.63], P = 0.35)]. Conversely, we identified a greater proportion of patients who had a personality disorder diagnosis in the postlegalization period (39.6% to 44.9%; OR = 1.35 [1.02 to 1.80], P = 0.038). Examination of pediatric (under 18 years old) consultations revealed no statistically significant differences. Conclusion: Although an affirmative conclusion is tentative, the current findings suggest a first link between the legalization of cannabis in Canada and increased diagnoses of cannabis use disorder, as well as cannabis use in general among patients in a university hospital psychiatric emergency department.

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Side-effects related to adjuvant CAPOX treatment for colorectal cancer are associated with intermuscular fat area, not with total skeletal muscle or fat, a retrospective observational study.

JCSM Clinical Reports ◽

10.17987/jcsm-cr.v3i1.46 ◽

2018 ◽

Vol 3 (1) ◽

Cited By ~ 1

Author(s):

Rogier Leendert Charles Plas ◽

Klaske Van Norren ◽

Harm Van Baar ◽

Carla Van Aller ◽

Maarten De Bakker ◽

...

Keyword(s):

Colorectal Cancer ◽

Skeletal Muscle ◽

Body Composition ◽

Adipose Tissue ◽

Side Effects ◽

Linear Regression ◽

Observational Study ◽

Cox Regression ◽

Muscle Quality ◽

Retrospective Observational Study

AbstractBackground: Chemotherapeutic treatment is regularly accompanied by side-effects. Hydrophilic chemotherapeutics such as capecitabine and oxaliplatin (CAPOX), often used in colorectal cancer treatment, predominantly accumulate in non-adipose tissues. From this we hypothesized that body composition and fat infiltration in the muscle (muscle attenuation and intermuscular-adipose-tissue [IMAT] content) are associated with chemotherapy-induced toxicities.Methods: In this retrospective observational study, we collected data from 115 colorectal cancer patients receiving adjuvant CAPOX chemotherapy between 2006 and 2015. Information on cancer characteristics were obtained from the Netherlands Cancer Registry. Diagnostic CT scans were retrieved to assess cross-sectional areas of skeletal muscle and adipose tissue at the third lumbar vertebrae. Information on dose-limiting toxicity [DLT] and relative administered dose (as % of BSA-based-planned-dose) were retrieved from medical charts. Associations between body composition, muscle quality and chemotherapy-induced toxicities were determined using Cox-regression and linear-regression analyses.Results: We found that DLT incidence was 90% in our cohort: 50% had their dose reduced, 30% their next cycle postponed, 4% a full treatment stop and 6% was hospitalized at their first DLT. Most common were reductions in oxaliplatin dose whilst keeping the capecitabine dose constant. Cox regression analysis indicated no association between body composition or muscle quality and DLT during the first treatment cycle or time to the first DLT. Multiple linear regression showed that higher IMAT-index and IMAT muscle percentage were associated with a lower relative administered dose of oxaliplatin.Conclusions: In conclusion; only IMAT, not skeletal or fat area was associated with dose-limiting toxicities among these CRC patients who received CAPOX treatment.

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Role of Intravenous immunoglobulin in Non-Immunocompromised children With Severe Adenovirus Pneumonia: A Retrospective Observational Study

10.21203/rs.3.rs-88010/v1 ◽

2020 ◽

Author(s):

Huifeng Fan ◽

Chen Chen ◽

Xuehua Xu ◽

Senqiang Zeng ◽

Genquan Yin ◽

...

Keyword(s):

Observational Study ◽

Intravenous Immunoglobulin ◽

Life Support ◽

Advanced Life Support ◽

Retrospective Observational Study ◽

Ivig Treatment ◽

Dosage Group ◽

Ivig Infusion ◽

Significant Difference ◽

Adenovirus Pneumonia

Abstract Background: Adenovirus pneumonia is a pulmonary infectious disease commonly occurring in children, and severe cases can lead to death and sequelae. Here, we aimed to observe the therapeutic timing and dosage of intravenous immunoglobulin(IVIg) in non-immunocompromised children with severe adenovirus pneumonia.Methods: This retrospective observational study investigated severe adenovirus pneumonia treated with IVIg in non-immunocompromised pediatric patients at a tertiary hospital in 2019. Participants were classified as early presenters (5-10 days of illness course) and later presenters (11-15 days) according to the timing of IVIg treatment. Patients’ clinical data were then analyzed in terms of different dosages of IVIg administration. Results: Among 202 patients enrolled, 128 were early presenters and 74 were later presenters during the study period. The later presenters had longer fever duration, more incidences of fungal coinfections, more demands for mechanical ventilation, and higher incidence of bronchiectasis than early presenters (P<0.05). For early presenters, no statistically significant differences in demands for advanced life support, outcomes and sequelae were observed between the two different dosage groups (P>0.05). For later presenters, shorter fever duration and lower usage of extracorporeal membrane oxygenation (ECMO) were observed in the high-dosage group than that in the low-dosage group (P<0.05). The incidence of post-infectious bronchiolitis obliterans (PIBO) and bronchiectasis was not significantly different between the two groups (P>0.05). The incidence of adverse events was 6.62% during IVIg infusion, showing no significant difference between the two groups (P>0.05).Conclusions: Early medical care and treatment with IVIg are very important to improve the prognosis of non-immunocompromised children with severe adenovirus pneumonia. For later presenters, children with severe conditions may benefit from a high IVIg dosage.

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Relationship between ABO blood group phenotypes and nCOVID-19 susceptibility: A retrospective observational study

SCRIPTA MEDICA ◽

10.5937/scriptamed51-29692 ◽

2020 ◽

Vol 51 (4) ◽

pp. 217-239

Author(s):

Sudhir Bhandari ◽

Ajit Shaktawat ◽

Amit Tak ◽

Jyotsna Shukla ◽

Jitentdra Gupta ◽

...

Keyword(s):

Observational Study ◽

Blood Group ◽

Demographic Data ◽

Blood Groups ◽

Retrospective Observational Study ◽

Partition Analysis ◽

Institutional Ethics ◽

Significant Difference ◽

Chi Squared ◽

Group A

Background: Since the outbreak of coronavirus disease-19 (COVID-19) research has been continued to explore multiple facets of the disease. The objective of the present study was to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility. Methods: In this retrospective observational study 132 hospitalised COVID-19 patients were enrolled from the Swai Man Singh (SMS) Medical Hospital in Jaipur, India after receiving approval from the Institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of 'A', 'B', 'AB', 'O', 'Rh' and 'Kell' blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson's Chi-squared test and partition analysis. Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group 'A' phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups 'AB', 'B', 'O' and 'Rh' showed no significant difference for susceptibility to COVID-19. Conclusion: The study shows a relationship between ABO, Rh and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

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Trends of human influenza infection in Chhattisgarh: a retrospective observational study

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20192191 ◽

2019 ◽

Vol 8 (6) ◽

pp. 1288

Author(s):

Raj Sharma ◽

Rupendra K. Bharti ◽

Sanat Sharma ◽

Mahendra K. Jaiswal

Keyword(s):

Influenza Virus ◽

Observational Study ◽

Influenza A ◽

Influenza Infection ◽

World Health ◽

Retrospective Observational Study ◽

Human Influenza ◽

Sample Collection ◽

Human Influenza Virus ◽

Significant Difference

Background: Human influenza virus was recognized as a pandemic in 2009 by the World Health Organization (WHO). Since then many newer incidences was recognized in India, but there was no sufficient data from all state of India. This study will provide data from the Chhattisgarh state of India.Methods: It was a retrospective observational study from December 2015 to November 2017. All patient samples with suspected influenza infection were collected and analysed by Real-time reverse polymerase chain reaction (RT-PCR).Results: 341 patients’ sample was collected and analysed; among these samples, 07.9% of patients have all three serotype of influenza positive. Raipur district has the highest incidence of influenza A followed by Durg and Raigarh district of Chhattisgarh. There was no significant difference between male and female who was affected by the influenza virus.Conclusions: The incidence of Human influenza virus is lesser in Chhattisgarh as compare to the average states of India and the state capital has a higher rate of sample collection as well as positive influenza infection.

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Relationship Between ABO Blood group Phenotypes and nCOVID-19 Susceptibility – A Retrospective Observational Study

10.21203/rs.3.rs-39611/v2 ◽

2021 ◽

Author(s):

Sudhir Bhandari ◽

Ajeet Singh Shaktawat ◽

Amit Tak ◽

Bhoopendra Patel ◽

Jyotsna Shukla ◽

...

Keyword(s):

Observational Study ◽

Blood Group ◽

Demographic Data ◽

Blood Groups ◽

Retrospective Observational Study ◽

Partition Analysis ◽

Institutional Ethics ◽

Significant Difference ◽

Chi Squared ◽

Group A

Abstract Background: Since the outbreak of coronavirus disease-19 research has been continued to explore multiple facets of the disease. The objective of the present study is to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility.Methods: In this hospital based, retrospective observational study 132 COVID-19 patients were enrolled from SMS Medical Hospital in Jaipur, India after receiving approval from the institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of ‘A’ , ‘B’, ‘AB’, ‘O’, ‘Rh’, and ‘Kell’ blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson’s chi-squared test and partition analysis.Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group ‘A’ phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups ‘AB’, ‘B’, ‘O’, and ‘Rh’ showed no significant difference for susceptibility to COVID-19.Conclusion: The study shows a relationship between ABO, Rh, and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

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Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

Hämostaseologie ◽

10.1055/s-0037-1619773 ◽

2012 ◽

Vol 32 (S 01) ◽

pp. S39-S42 ◽

Cited By ~ 1

Author(s):

S. Kocher ◽

G. Asmelash ◽

V. Makki ◽

S. Müller ◽

S. Krekeler ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Observational Study ◽

Retrospective Observational Study ◽

Frequent Change ◽

Patient Age ◽

Treatment Regimens ◽

Patient Âgé ◽

The Relationship ◽

Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

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