scholarly journals Considering the hypothesis of the pathophysiology of cellulite in its treatment

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
José Maria Pereira de Godoy ◽  
Ana Carolina Pereira de Godoy ◽  
Maria de Fatima Guerreiro Godoy
Keyword(s):  
Clinical Trial ◽  
Medical Records ◽  
Ethics Committee ◽  
Clinical Treatment ◽  
P Value ◽  
Lymph Drainage ◽  
The Mean ◽  
Cervical Stimulation ◽  
Alpha Error ◽  
Paired T Test

The aim of this study was to evaluate perimetric reductions in the clinical treatment of cellulite (aesthetics) using the Godoy method in a randomized retrospective clinical trial. The medical records of 150 patients treated for cellulite in the period from 2006 to 2011 in the Clinica Godoy were revisited. Treatment comprised manual and mechanical lymph drainage and cervical stimulation for one hour per day over 10 days. The paired t-test was used for statistical analysis, with an alpha error of 5% (P-value <0.05) being considered acceptable. This study was started after being approved by the Research Ethics Committee of the Medicine School in São José do Rio Preto (FAMERP - no. 395- 2010), Brazil and after being registered as a clinical trial. The mean reduction of the 150 patients was 3.81±2.76 g (P-value <0.0001; 95% confidence interval: 3.408-4.223). A significant reduction in size was seen with the clinical treatment of cellulite giving an improvement in the physical appearance. Pathophysiological mechanisms such as regional skin lymphostasis seem to be involved in the formation of cellulite.

scholarly journals Intensive Treatment of Cellulite Based on Physiopathological Principles

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
José Maria Pereira de Godoy ◽  
Mayra Yara Groggia ◽  
Lucilene Ferro Laks ◽  
Maria de Fátima Guerreiro de Godoy
Keyword(s):  
Statistical Analysis ◽  
Lymphatic System ◽  
Intensive Therapy ◽  
Treatment Session ◽  
Lymph Drainage ◽  
The Mean ◽  
Cervical Stimulation ◽  
New Hypothesis ◽  
Alpha Error ◽  
Gluteal Fold

Aim. The aim of this paper is to report a novel intensive therapy of gynoid lipodystrophy (cellulite) based on a new hypothesis.Methods. Were evaluated in 10 patients with ages ranging between 25 and 59 years (mean 35.6 years) grade IV cellulite identified by clinical evaluation. Before initiating treatment, perimetry was performed at 5 cm intervals along both thighs, at the gluteal fold, 5, 10, and 15 cm above the gluteal fold, at the navel, and 5 cm above the navel. The patients were submitted to a 4-hour daily treatment session that consisted of manual and mechanical lymph drainage and cervical stimulation by the Godoy & Godoy technique adapted for the treatment of cellulite. After 10 sessions over two weeks, the patients were again evaluated. The pairedt-test was utilized for statistical analysis with an alpha error of 5% (Pvalue < 0.05). A reduction was identified at all of the measurement points (pairedt-test;Pvalue < 0.0001).Results. The mean reductions varied between 4.0 and 5.7 cm at the measurement points but reductions of more than 10 cm in perimeter were achieved in some patients.Conclusion. This technique involving lymphatic system stimulation is efficacious in the treatment of cellulite.

Abstract P42: Active Compression Decompression-CPR in an Infant Manikin Model Using a Novel Adhesive Glove Device

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Sharda Udassi ◽  
Jai P Udassi ◽  
Melissa Lamb ◽  
Doug Theriaque ◽  
Arno L Zaritsky ◽  
...  
Keyword(s):  
Healthcare Providers ◽  
Crossover Design ◽  
P Value ◽  
Compression Pressure ◽  
Compression Depth ◽  
Significant Difference ◽  
The Mean ◽  
Chest Decompression ◽  
Acd Cpr ◽  
Paired T Test

Introduction: In animals Active Compression-Decompression(ACD)-CPR improves hemodynamics compared with standard CPR (S-CPR). We evaluated the feasibility of achieving ACD-CPR with a novel, simple and inexpensive Adhesive Glove Device (AGD) in an infant manikin model using two thumb (TT) chest compression. Hypothesis: AGD-ACD CPR provides better chest decompression compared to S-CPR in an infant manikin model without excessive rescuer fatigue. Methods: Laerdal ™ Baby ALS Trainer manikin was modified to digitally record compression pressure (CP), compression depth (CD) and decompression depth (DD). The thumb portion of two oven mitts were sewn together and a Velcro adhesive patch was stitched on the underside with an encircling adjustable strap for proper fit to create the AGD. An interlocking Velcro patch was glued to the manikin chest wall. Sixteen BLS or PALS certified healthcare providers were prospectively randomized to perform either two-thumb S-CPR or AGD-ACD-CPR for 5 minutes with a 30:2 compression:ventilation ratio using a crossover design. During AGD-ACD-CPR subjects were asked to pull up during chest decompression. Rescuer heart rate (HR), respiratory rate (RR), recovery time (RT) for HR/RR to return to baseline and actual compressions delivered per minute were recorded. Subjects were blinded to data recordings. Data (mean±SEM) was analyzed using 2 sided paired t-test; p-value ≤0.05 was considered significant. Results: Chest decompression was greater with AGD-ACD-CPR; the mean DD difference was 0.11±0.02 inches, p=<0.001. Compressions given per minute were 102±21 in S-CPR group vs. 96±16 in AGD-ACD-CPR group, p=0.04. In AGD-CPR 75% and in S-CPR only 12% of subjects achieved complete recoil to or beyond baseline. There was no significant difference in CD, CP, HR, RR and RT between the groups. Conclusions: Active decompression and improved recoil was achievable with the use of our simple, inexpensive AGD in this infant CPR model. Use of our device did not result in excessive rescuer fatigue compared to S-CPR. The clinical significance of 6 less compressions/minute in the AGD-CPR group needs to be determined.

scholarly journals COMPARISON OF THE EFFECTIVENESS OF TWO LEVELS OF SUCTION PRESSURE ON OXYGEN SATURATION IN PATIENTS WITH ENDOTRACHEAL TUBE

2017 ◽  
Vol 3 (6) ◽  
pp. 693-696
Author(s):  
Muhaji Muhaji ◽  
Bedjo Santoso ◽  
Putrono Putrono
Keyword(s):  
Oxygen Saturation ◽  
T Test ◽  
Mean Difference ◽  
P Value ◽  
Pressure Group ◽  
Endotracheal Suctioning ◽  
Consecutive Sampling ◽  
The Common ◽  
The Mean ◽  
Paired T Test

Background: Endotracheal suctioning is one of the common supportive measures in intensive care units (ICU), which may be related to complications such as hypoxia. However, a questionable efficacy is still identified to choose suctioning pressure between 130 mmHg and 140 mmHg that is effective for patients with endotracheal tube.Objective: To compare the effectiveness of 130 mmHg and 140 mmHg suctioning pressure on oxygen saturation in patients with endotracheal tube.Methods: This research used a quasy experimental design with pretest and posttest group. The study was conducted from 31 January to 1 March 2017 in the Hospital of Panti Wilasa Citarum and Hospital of Roemani Muhammadiyah Semarang. There were 30 samples recruited using consecutive sampling, with 15 assigned in the 130 mmHg and 140 mmHg suctioning pressure group. Pulse oximetry was used to measure oxygen saturation. Paired t-test and Independent t-test were used for data analysis.Results: Findings showed that there was a statistically significant effect of 130 and 140 mmHg suctioning pressure on oxygen saturation in patients with ETT with p-value <0.05. There was a significant mean difference of oxygen saturation between 130 mmHg and 140 mmHg suctioning pressure group with p-value 0.004 (<0.05). The mean difference of oxygen saturation between both groups was 13.157.Conclusion: The 140 mmHg suctioning pressure is more effective compared with 130 mmHg suctioning pressure in increasing oxygen saturation in patients with ETT.

Rapid rituximab infusion is safe and well tolerated in malignant and benign disease

2020 ◽  
pp. 107815522097845
Author(s):  
Sorana G Ursu ◽  
Derek L Rinchuse ◽  
John Lister
Keyword(s):  
Medical Records ◽  
Malignant Disease ◽  
Benign Disease ◽  
P Value ◽  
Infusion Time ◽  
Benign Diseases ◽  
Secondary Objective ◽  
The Mean ◽  
The One ◽  
Related Reaction

Introduction Although the safety and feasibility of rapid rituximab administration has been demonstrated for B-cell malignancies, there is scant data in the literature to support its use in patients with benign diseases. Objective To identify the incidence of infusion-related reaction with rapid rituximab administration in malignant and benign disease. Secondary objective was to determine the infusion time saved between standard administration and rapid rituximab administration. Methods A retrospective cohort study was conducted by reviewing electronic medical records from December 2018 to April 2020. Adult patients who received at least one dose of rapid rituximab were included. Results A total of 63 patents were included. The incidence of an infusion-related reaction with rapid rituximab was 1.6%. The one patient who reacted had a diagnosis of neuromyelitis optica. The mean infusion time saved was 2.9 hours (95% CI: 2.7-3.1; P-value <0.001). Conclusion The use of the rapid rituximab administration is safe and well tolerated in both benign and malignant disease.

scholarly journals Severe Perinatal Asphyxia and Risk of Neonatal Jaundice at a Tertiary Hospital in Northern Nigeria

2021 ◽  
pp. 17-22
Author(s):  
I. A. Imoudu ◽  
M. O. Yusuf ◽  
A. T. Aro ◽  
P. E. Akpabio ◽  
Z. M. Waziri
Keyword(s):  
Medical Records ◽  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Perinatal Asphyxia ◽  
Tertiary Hospital ◽  
P Value ◽  
Community Based ◽  
Special Care Baby Unit ◽  
The Mean ◽  
The Relationship

Background: The risk factors of neonatal jaundice are largely known, yet there is little agreement on the association between it and perinatal asphyxia. Aim: To investigate the association between severe perinatal asphyxia (SPA) and the risk of clinical jaundice (NNJ) among neonates managed at the Federal Medical Centre, Azare, Nigeria. Methodology: Case control design was employed. Medical records of 315 babies managed at the special care baby unit from 1st January, 2011 to 31st December, 2018 were analysed. The exposure of interest was SPA and the outcome was jaundice. Logistic regression was applied to demonstrate the relationship between neonatal jaundice and SPA. Relative risk was provided as odds ratio and 95% confidence interval. Results: Sixty-three cases and 252 controls were enrolled in the study. The mean age of the cases (4.39) and that of the controls (4.95 ) did not differ significantly (t= -0.52, P= 0.30). One hundred and fifty-six (61.9%) of the controls were males while 34 (54.0%) of the cases were females. For 59 (93.7%) of the cases treatment for jaundice was done with phototherapy and 1.6% required exchange blood transfusion. SPA significantly reduced the risk of developing NNJ (adjusted OR = 0.27, P-value ˂ 0.01).                                                                           Conclusion: We demonstrated a significantly reduced risk of developing neonatal jaundice with prior exposure to severe perinatal asphyxia. Prospective multicenter and community based studies correlated with serum bilirubin levels are recommended.   

scholarly journals ROLE OF GINKGO BILOBA IN TINNITUS BASED ON TINNITUS HANDICAP INVENTORY

2021 ◽  
Vol Volume 9 (upjohns/volume9/Issue2) ◽  
pp. 32-36
Author(s):  
Monica Manhas
Keyword(s):  
Informed Consent ◽  
Ginkgo Biloba ◽  
Ethics Committee ◽  
P Value ◽  
Inclusion Criteria ◽  
Tinnitus Handicap Inventory ◽  
Institutional Ethics ◽  
The Mean ◽  
Pre Treatment

ABSTRACT AIMS AND OBJECTIVES To evaluate whether there is role of Ginkgo biloba in treatment of tinnitus or not, using Tinnitus Handicap Inventory MATERIAL METHODS: The present prospective study, after approval by Institutional Ethics Committee, was conducted in Department of ENT, GMC Jammu from January 2019 to January 2020 on 90 patients with primary complaint of tinnitus. Inclusion criteria- Age: 20 years or above, Duration of tinnitus > 3 months. Informed consent was taken and all patients were asked to complete the THI-Tinnitus Handicap Inventory. All patients were given 50mg of Ginkgo biloba standardized extract LI 1370 (containing 25% flavonoids, 3% ginkgolides and 5% bilobalides). Patients were advised to take three tablets daily for 12 weeks. RESULTS The mean pre-treatment THI score was 43.6 and mean post-treatment THI score (at 12 weeks) was 39.4; the mean change in THI score was 4.2, the result being statistically insignificant (p-value= 0.43). Out of 90 patients, 51 reported unchanged severity of tinnitus, 27 patients reported improvement in severity of tinnitus and 12 patients reported worsening of condition. CONCLUSION According to our study, Ginkgo biloba has no significant therapeutic role in tinnitus. However, the aetiology of tinnitus is multifactorial and Ginkgo biloba could benefit patients with ischemic aetiology. KEYWORDS Ginkgo, biloba, handicap, inventory, tinnitus

RADIOLOGIC- PATHOLOGIC CORRELATION OF DEPTH OF INVASION IN TONGUE CARCINOMA

2021 ◽  
pp. 27-28
Author(s):  
Pranay Bhandari ◽  
Ashwin Rangole ◽  
Tanuj Shrivastava ◽  
Ameya Bihani ◽  
Pratiksha Pawar
Keyword(s):  
Basement Membrane ◽  
Normal Mucosa ◽  
P Value ◽  
Depth Of Invasion ◽  
Tongue Carcinoma ◽  
Adjacent Normal Mucosa ◽  
Dence Interval ◽  
The Mean ◽  
Group 2 ◽  
Paired T Test

Introduction: th In tongue carcinoma according to AJCC 8 guidelines depth of invasion is included in staging, therefore there is need of imaging which can accurately assess the pretreatment stage of tumor. The objective of this study was to correlate the depth of invasion reporting by MRI and postoperative HPR. Methods: In MRI DOI was measured by drawing perpendicular lines from the reference line to the point of maximal tumor projection in the tongue medially, histologically DOI was measured from the level of the basement membrane of the closest adjacent normal mucosa. Results: Paired t test was done on the DOI of MRI and HPR. The two tailed P value is less than 0.0001. This difference is considered to be extremely statistically signicant. The mean of group one (DOI-MRI) minus Group 2 (DOI-HPR) equals 6.860. 95% condence interval of this difference is from 5.200 to 8.520. Conclusion: In our study we nd there is statiscally signicant difference between DOI reports in MRI and postoperative HPR.

scholarly journals The Effect of the Emotional Demonstration Method of Mealing Schedule on the Knowledge of Mothers to Children in Posyandu V Mulyorejo Surabaya

2021 ◽  
Vol 2 (1) ◽  
pp. 17-21
Author(s):  
Nidya Comdeca Nurvitriana ◽  
Setiana Andarwulan
Keyword(s):  
Health Workers ◽  
Sampling Technique ◽  
Mean Value ◽  
T Test ◽  
P Value ◽  
Children Under Five ◽  
Under Five ◽  
Post Test ◽  
The Mean ◽  
Paired T Test

Background of research on mother's knowledge of toddlers in providing feeding schedules, especially snacks. Giving snacks that are not right on schedule will have an influence on the growth and development of infants. Through the Emotional Demontration method, eating schedule for snacking can be controlled. Emotional Demonstration is the provision of education not only through lectures but also through games so that the key messages conveyed can be remembered by mothers of toddlers in Posyandu V Mulyorejo Surabaya. The Emo Demo method is one solution to reduce the stunting rate. In 2017 the stunting rate in Indonesia reached 22.2%. Based on the results of the survey conducted through interviews with nutritionists, it was explained that there were 16 stunting toddlers in Posyandu V Surabaya. Quantitative Research Methodology, a quasi-experimental research design method with one group pretest posttest approach. The population in this study were all mothers of children under five in Posyandu V Mulyorejo Surabaya as many as 36 people, samples as many as 36 mothers of toddlers. With a total sampling technique. Analyze data with Paired T-test. The results showed the mean value of the pre test was 6.06, the mean value after the post test reached 8.16. While the significance value of p value = 0,000 with α = 0.05 through the Paired T-test. The conclusion is that there are differences in the knowledge of pre and post test among mothers of children under five in Posyandu V Mulyorejo Surabaya, p value = 0,000 with α = 0.05. Suggestions for health workers to continue to make improvements in practicing emotional demonstration to participants because it is very useful in increasing knowledge to prevent increased stunting rates.

scholarly journals Terapi pada Pasien Kanker Payudara Stadium Lanjut Menurunkan Kadar C- Reaktif Protein dan Meningkatkan Kadar Albumin

2019 ◽  
Vol 11 (2) ◽  
pp. 116
Author(s):  
Arya Wawolumaja ◽  
Victor Pontoh ◽  
Marselus Merung
Keyword(s):  
Breast Cancer ◽  
Serum Albumin ◽  
Late Stage ◽  
T Test ◽  
Nutrition Status ◽  
P Value ◽  
Female Patients ◽  
The Mean ◽  
Serum Crp ◽  
Paired T Test

Abstract: Breast cancer is one of the malignancies that has a high prevalence and can occur in both sexes. Albeit, more than 70% of these patients were detected at late stage. Inflammation could accelerate the tumor growth, invasion, angiogenesis, and metastasis. Increased serum CRP indicates uncontrolled infection or pathological process. Meanwhile, serum albumin is used to evaluate the nutrition status, the severity of disease, and prognosis. This study was aimed to evaluate the influence of serum CRP and albumin levels in female patients with breast cancer after treatment. This was an interventional analytical study with a cross sectional design. This study was conducted at Prof. Dr. R. D. Kandou Hosppital Manado. Subjects were all female patients with breast cancer from May to August 2018. The results showed that there were 43 patients of late stage breast cancer, mean age of 52.16 years. After treatment there was a decrease in the mean serum CRP level from 17.05 mg/dL to 6.40 mg/dL and the paired t test obtained a t value of 3.269 and a P value of 0.001. Moreover, there was an increase in the mean serum albumin level from 3.59 mg/L to 3.76 mg/L and the paired t test obtained a t value of -2,896 and a P value of =0.003. Conclusion: Chemotherapy and or surgery performed on female patients with breast cancer could decrease the serum CRP level and increase the serum albumin level.Keywords: breast cancer, serum CRP, serum albuminAbstrak: Kanker payudara merupakan salah satu jenis keganasan yang memiliki prevalensi cukup tinggi dan dapat terjadi baik pada laki-laki maupun perempuan. Lebih dari 70% penderita kanker payudara ditemukan pada stadium lanjut. Keadaan inflamasi dapat mempercepat pertumbuhan tumor, invasi, angiogenesis, dan metastasis. Hadirnya CRP serum yang meningkat mengindikasikan adanya infeksi atau proses patologik yang tidak teratasi. Albumin serum secara umum digunakan untuk menilai status nutrisi, derajat keparahan penyakit, perkembangan penyakit, dan prognosisnya. Penelitian ini bertujuan untuk menilai pengaruh kadar CRP dan albumin serum pada pasien perempuan dengan kanker payudara stadium lanjut setelah terapi. Jenis penelitian ialah intervensional analitik dengan desain potong lintang Penelitian dilakukan di RSUP Prof. Dr. R. D. Kandou Manado. Subjek penelitian ini ialah semua penderita kanker payudara berjenis kelamin perempuan pada periode Mei 2018 s/d Agustus 2018. Hasil penelitian mendapatkan 43 pasien dengan kanker payudara stadium lanjut dengan usia rerata 52,16 tahun. Setelah terapi terjadi penurunan rerata kadar CRP serum dari 17,05 mg/dL menjadi 6,40 mg/dL dan uji t berpasangan menunjukkan nilai t=3,269 dengan P=0,001. Selain itu, terjadi peningkatan rerata kadar albumin serum dari 3,59 mg/L menjadi 3,76 mg/L dan uji t berpasangan menunjukkan nilai t=-2,896 dengan P=0,003. Simpulan: Modalitas kemoterapi dan/atau operasi pada pasien kanker payudara stadium lanjut secara bermankna menurunkan kadar CRP serum tetapi meningkatkan kadar albumin serum.Kata kunci: kanker payudara, CRP serum, albumin serum

scholarly journals Comparison of combined intraarticular (IA) and intravenous (IV) administration of tranexamic acid with IA and IV alone in patients undergoing total knee arthroplasty without drainage catheter: a clinical trial study

2021 ◽  
Author(s):  
Nima Bagheri ◽  
Mohammad Amin Amini ◽  
Arezu Pourahmad ◽  
Farzad Vosughi ◽  
Alireza Moharrami ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Blood Loss ◽  
The Other ◽  
P Value ◽  
Drainage Catheter ◽  
Total Knee ◽  
Matched Case ◽  
The Mean ◽  
Double Blinded ◽  
Hemoglobin Drop

Abstract Purpose we aim to determine the most effective route for TXA administration (among IA, IV, combined IA/IV) for TKA surgeries using tourniquet without drainage catheters Methods We performed a double-blinded clinical trial on a total of 147 TKA candidates. The amount of blood loss and hemoglobin drop were evaluated in three matched case groups administered TXA during the TKA either via IV, IA or IV plus IA route. Drainage catheter was used for none of the cases. Results The combined group showed an average blood loss of 630 ± 252 ml which was significantly lower than the IV group (878 ± 268 ml, P-value < 0.01) and the IA group (774 ± 288 ml, P-value = 0.03). Besides, the mean hemoglobin and hematocrit drop was significantly lower in the combined group compared to the other two groups, 48 and 72 hours postoperatively (P value < 0.05). Conclusions The TXA administration via IV plus IA route had 28% and 19% reduction of blood loss in comparison with using the TXA via IV alone and IA alone methods respectively. Therefore, given the surgery is performed with tourniquet application, TXA usage via IV plus IA route may be a more effective way for reducing the perioperative blood loss in TKA cases in patients undergoing TKA without drain placement.

Sign in / Sign up

Export Citation Format

Share Document