scholarly journals Surgery results in low relapse and progression rates in extramedullary plasmacytoma of the head and neck: A case cohort and review of the literature

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Matevz Skerget ◽  
Tadej Dovsak ◽  
Gregor Kos ◽  
Samo Zver
Keyword(s):  
Multiple Myeloma ◽  
Local Recurrence ◽  
Head And Neck ◽  
Treatment Option ◽  
Local Control ◽  
Extramedullary Plasmacytoma ◽  
Initial Evaluation ◽  
Review Of The Literature

Extramedullary plasmacytoma of the head and neck is a rare indolent neoplasm. Radiotherapy is often the preferred treatment option with excellent local control and survival. The risk of local recurrence or transformation to multiple myeloma is 10- 30%. In our case-cohort, thorough, sensitive initial evaluation for disseminated clonal disease and the incorporation of surgery led to excellent results with no recurrences or systemic progression.

scholarly journals Head and Neck Solitary Extramedullary Plasmacytoma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Bijan Khademi ◽  
Zohreh Zandifar ◽  
Mohammad Mohammadianpanah ◽  
Sayed Hasan Hamedi ◽  
Samira Razzaghi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Literature Review ◽  
Head And Neck ◽  
Survival Rates ◽  
Extramedullary Plasmacytoma ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Long Term Follow Up ◽  
Radiotherapy Alone

Introduction. This study aimed to report the characteristics and treatment outcome of 13 patients with solitary extramedullary plasmacytomas of the head and neck and analytical literature review. Materials and Methods. Nine patients (69%) were treated with gross surgical resection followed by radiotherapy, three (23%) were primarily treated with radiotherapy alone, and one (8%) was treated with surgery alone. Results. There were 3 women and 10 men with the median age of 52 years. Nasal cavity (46%) and paranasal sinuses (23%) were the most common primary sites. After a median follow-up of 28 months, 10 patients are alive and free of disease, one is alive with multiple myeloma, and two died of multiple myeloma. In the literature review the median age was 58 years and male/female ratio was 2.7. Sinonasal tract was the most common primary site. Ten-year local control and progression to multiple myeloma rates were 88% and 23%, respectively. The 5- and the 10-year overall survival rates were 71 and 69%, respectively. Conclusion. Radiation therapy with or without surgery is an effective treatment for patients with head and neck extramedullary plasmacytoma. However, long-term follow-up for detection of local recurrence and progression to multiple myeloma is essential.

scholarly journals Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy

2022 ◽  
Author(s):  
Xavier León ◽  
Jacinto García ◽  
Albert Pujol ◽  
Julia de Juan ◽  
Rosselin Vásquez ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Head And Neck ◽  
Local Control ◽  
Squamous Cell ◽  
Integration Site ◽  
Leukemia Virus ◽  
Transcriptional Expression ◽  
Proviral Integration Site ◽  
Increased Risk ◽  
Elevated Expression

Abstract Purpose Proviral integration site for Moloney murine leukemia virus (PIMs) are proto-oncogenes encoding serine/threonine kinases that phosphorylate a variety of substrates involved in the regulation of cellular processes. Elevated expression of PIM-1 has been associated with poor prognosis in several types of cancer. There are no studies that have analyzed the response to radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) according to the expression of PIM-1. The aim of our study was to analyze the relationship between the transcriptional expression of PIM-1 and local response to radiotherapy in HNSCC patients. Methods We determined the transcriptional expression of PIM-1 in 135 HNSCC patients treated with radiotherapy, including patients treated with chemoradiotherapy (n = 65) and bioradiotherapy (n = 15). Results During the follow-up, 48 patients (35.6%) had a local recurrence of the tumor. Patients with local recurrence had a higher level of PIM-1 expression than those who achieved local control of the disease (P = 0.017). Five-year local recurrence-free survival for patients with a high expression of PIM-1 (n = 43) was 44.6% (95% CI 29.2–60.0%), and for patients with low expression (n = 92) it was 71.9% (95% CI 62.5–81.3%) (P = 0.007). According to the results of multivariate analysis, patients with a high PIM-1 expression had a 2.2-fold increased risk of local recurrence (95% CI 1.22–4.10, P = 0.009). Conclusion Patients with elevated transcriptional expression levels of PIM-1 had a significantly higher risk of local recurrence after radiotherapy.

scholarly journals Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
A. Romano ◽  
M. S. Marescalco ◽  
Chiara Liardo ◽  
L. Villari ◽  
C. Vetro ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Hematological Malignancy ◽  
Case Reports ◽  
Oral Lesion ◽  
Extramedullary Plasmacytoma ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Multistage Process ◽  
Solitary Bone Plasmacytoma ◽  
Magnetic Resonance Imaging Mri

Extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites.

Triple manifestation of extramedullary plasmacytoma in the upper airway: an unusual clinical entity

2011 ◽  
Vol 125 (9) ◽  
pp. 970-972 ◽  
Author(s):  
I Morariu ◽  
P Burns ◽  
P Roche ◽  
S Hone
Keyword(s):  
Multiple Myeloma ◽  
Rare Case ◽  
Unusual Case ◽  
English Literature ◽  
Upper Airway ◽  
Extramedullary Plasmacytoma ◽  
Review Of The Literature ◽  
Close Cooperation ◽  
Disease Free ◽  
Extramedullary Plasmacytomas

AbstractObjective:We report an extremely rare case of extramedullary plasmacytoma.Method:Case report and review of the English-literature concerning extramedullary plasmacytoma and multiple myeloma.Result:We present an unusual case of multiple extramedullary plasmacytomas, which, over a protracted course of 30 years, presented on different occasions at three separate sites in the head and neck. The patient was managed surgically on all occasions, and was disease-free at the time of writing.Conclusion:Following review of the literature, we believe this to be the only case with this extremely unusual presentation. This case is noteworthy, not only because of the rarity of extramedullary plasmacytoma, but also because it highlights a number of important clinical issues. The diagnosis and management of extramedullary plasmacytoma require close cooperation between multiple disciplines.

Extramedullary Plasmacytomas of the Head and Neck

1993 ◽  
Vol 109 (5) ◽  
pp. 877-885 ◽  
Author(s):  
Mark K. Wax ◽  
K. John Yun ◽  
Rawhi A. Omar
Keyword(s):  
Multiple Myeloma ◽  
Head And Neck ◽  
Surgical Excision ◽  
Middle Cranial Fossa ◽  
Extramedullary Plasmacytoma ◽  
Cervical Region ◽  
Immunoperoxidase Staining ◽  
Upper Respiratory Tract ◽  
University Hospitals ◽  
Extramedullary Plasmacytomas

Extramedullary plasmacytomas are solitary tumors consisting of neoplastic plasma cell proliferations that occur in locations other than bone. On initial presentation they must be differentiated from multiple myeloma. This may prove to be difficult because a varying percentage may be associated at a later date with the development of multiple myeloma. Solitary extramedullary plasmacytomas represent up to 4% of nonepithelial lesions of the upper respiratory tract. From 1970 to 1990, at West Virginia University Hospitals, seven patients with solitary extramedullary plasmacytoma were identified. In four of these patients the tumor was located in the head and neck, with one tumor located in each of the following sites: temporoparietal scalp, maxillary sinus, nasopharynx, and cervical region. One patient had extensive destruction of the temporal bone, with extension intracranially to the middle cranial fossa. No patient had multiple myeloma, nor did any develop. Diagnosis was based on a combination of histology along with special immunoperoxidase staining for Ig lambda and kappa light chains. This will be demonstrated and discussed. Treatment consisted of radiotherapy in three cases, with doses ranging from 3175 to 6000 rad. One patient, treated with surgical excision, experienced a relapse at a distant site 6 years later. All patients have maintained local control and have been followed for a minimum of 1 1/2 years, with an average of 3 years. We describe our experience with these tumors and present a pertinent review of the literature. While these tumors may present as aggressive locally destructive lesions, their management should be as organ-sparing as possible because excellent control can be achieved in the majority of cases. Patients should be followed for life because multiple myeloma may develop in a significant number.

Plasma Cell Tumors of the Head and Neck

1983 ◽  
Vol 92 (3) ◽  
pp. 311-313 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Multiple Myeloma ◽  
Head And Neck ◽  
Plasma Cell ◽  
Extramedullary Plasmacytoma ◽  
Plasma Cell Granuloma ◽  
Solitary Plasmacytoma ◽  
Disseminated Disease ◽  
Local Significance

In order of frequency, the plasma cell lesions affecting the head and neck are multiple myeloma, extramedullary plasmacytoma, plasma cell granuloma, and solitary plasmacytoma of bone. All except plasma cell granuloma are neoplastic and they are interrelated. The solitary plasmacytoma of bone is regarded as a form of multiple myeloma. The extramedullary plasmacytoma may be a lesion of local significance only or may terminate in a disseminated disease, myelomatosis, that differs clinically and prognostically from multiple myeloma.

scholarly journals Retrobulbar secondary plasmacytoma: a case report and systematic review of the literature

2018 ◽  
Vol 5 (9) ◽  
pp. 2703-2707 ◽  
Author(s):  
Mehrdad Payandeh ◽  
Noorodin Karami ◽  
Soode Enayati ◽  
Afshin Karami ◽  
Mehrnoush Aeinfar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Multiple Myeloma ◽  
Case Report ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Therapeutic Options ◽  
Review Of The Literature ◽  
Orbital Involvement ◽  
Therapeutic Measures ◽  
Uncommon Case

Multiple myeloma is described by the proliferation of malignant plasma cells, in which orbital involvement is rare. In this report, we collected all cases with orbital multiple myeloma from 2009 to 2018 and investigated the characteristics such as sex, age, common orbital symptoms, unilateral or bilateral and different therapeutic options. Also, we reported an uncommon case of multiple myeloma that has been developed into plasmacytoma. Our patient had been initially diagnosed with multiple myeloma, but after a few months, the disease had progressed to secondary extramedullary plasmacytoma in the retrobulbar. Therapeutic measures, such as surgery to prevent its development in the patient's eye, were successful.

scholarly journals Recurrence of Isolated Multiple Myeloma in the Skull Base: A Case Report and Review of the Literature

2007 ◽  
Vol 86 (9) ◽  
pp. 555-560 ◽  
Author(s):  
Omar F. Husein ◽  
Abraham Jacob ◽  
Douglas D. Massick ◽  
D. Bradley Welling
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Skull Base ◽  
Scientific Literature ◽  
Clinical Course ◽  
Extramedullary Plasmacytoma ◽  
Review Of The Literature ◽  
Systemic Involvement

Extramedullary plasmacytoma involving the skull base is rare. We describe what we believe is the first reported case of recurrent multiple myeloma presenting as an isolated lesion in the central skull base in a patient with no evidence of systemic involvement. We discuss the patient's presentation, clinical course, and treatment, and we review the relevant scientific literature.

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