COVID-19 and blood groups: A six-months observational study in Ferrara, Italy

The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care - IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p=0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p=0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.

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Prevalence of ABO and Rh blood groups and their association with Transfusion-Transmissible Infections (TTIs) among Blood Donors in Islamabad, Pakistan

BioScientific Review ◽

10.32350/bsr.0304.02 ◽

2021 ◽

Vol 3 (4) ◽

Author(s):

Muhammad Yousaf Khan ◽

Farwa Sijjeel ◽

Ahmareen Khalid ◽

Rukhshan Khurshid ◽

Umm E Habiba ◽

...

Keyword(s):

Viral Infection ◽

Blood Group ◽

Blood Donors ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Syphilis Infection ◽

Group System ◽

Group A ◽

Group B

Certain Rh positive blood groups showed a link between the ABO blood grouping and susceptibility to some infectious ailments. Study was carried out to find the association of ABO Blood Group System / Rh type with different viral infection. A retrospective observational study was carried in 7631 blood donors to find the association of ABO Blood Group System / Rh type with viral infection due to hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Syphilis. Data of the study indicateF that the highest incidence of blood group in blood donor was B followed by O, A and AB. The incidence of HBsAg +ve, HCV Ab +ve and infection of Syphilis was also highest in donor with blood group B followed by O, A and AB. Blood group A were more susceptible to HIV Ab +ve followed by blood group B, O and AB. The group B donors had the greatest risk of viral infection with HBV, HCV, HIV, and Syphilis; followed by the groups O, A, and AB. Donors in group AB had the lowest incidence rate of all viral infection. The study revealed that blood group B is most prevalent among donors, followed by blood groups O, A, and AB. On the other side, the rate of HBV, HCV, HIV, and Syphilis infection was greatest among group B donors, followed by group O, group A, and group AB. Copyright(c) The Authors

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ABO blood group system and occurrence of ischemic stroke

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x-anp-2020-0219 ◽

2021 ◽

Author(s):

Rafaella Chiodini LOTZ ◽

Carolina da Silveira WELTER ◽

Silvia Aparecida RAMOS ◽

Leslie Ecker FERREIRA ◽

Norberto Luiz CABRAL ◽

...

Keyword(s):

Ischemic Stroke ◽

Blood Group ◽

Cerebrovascular Diseases ◽

Blood Groups ◽

Blood Type ◽

Control Group ◽

Abo Blood Group ◽

Blood Group System ◽

Abo Blood Groups ◽

Group System

ABSTRACT Background: Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved that there is a link between the ABO blood group system and the occurrence of thrombotic events. Nonetheless, its association with IS is not well established. Objective: For that reason, the purpose hereof was to investigate the relation between the ABO blood groups and the occurrence of IS in a Brazilian cohort of cerebrovascular diseases. Methods: Five hundred and twenty-nine subjects were included over 12 months, from which 275 presented an IS episode and 254 composed the control group. Blood samples were drawn for direct and reverse serotyping. The control and IS groups were compared regarding the traditional risk factors and the distribution of the ABO blood groups. Results: The IS group presented a higher prevalence of systemic arterial hypertension (SAH), diabetes mellitus, smoking habits, family history, cardiopathy, and sedentary lifestyle in comparison with the control group. The AB blood type prevailed among the patients (5.1 vs. 1.6%; p<0.05) and this group had more SAH cases in comparison with the O type group (92.9 vs. 67.3%; p<0.05). Conclusions: Our results suggest that the occurrence of IS is more frequent among patients of the AB blood type.

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Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality

10.1101/2021.04.19.21255738 ◽

2021 ◽

Author(s):

Uzma Ishaq ◽

Asmara Malik ◽

Jahanzeb Malik ◽

Asad Mehmood ◽

Azhar Qureshi ◽

...

Keyword(s):

Logistic Regression ◽

Blood Group ◽

Cox Regression ◽

Survival Function ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Acute Phase Reactants ◽

Blood Group A ◽

Group A

AbstractBackground and objectiveThe ABO blood group system has been associated with infectious and noninfectious disease, including dengue, hepatitis B virus (HBV), and severe respiratory syndrome coronavirus (SARS), etc. Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood group in South-East Asian population needs to be explored.MethodsIt was a retrospective study of patients with real time polymerase chain reaction (RT-PCR) diagnosis of COVID-19 at Advanced Diagnostics and Liver Center between April 2020 to January 2021. Blood group A, B, O, and AB were identified in every participant, irrespective of their RH type and allotted groups 1, 2,3, and 4, respectively. Cox regression and logistic regression were used for inferential statistics.ResultsThe cohort included 1067 patients: 521 (48.8%) of blood group O, 295 (27.6%) of blood group B, 202 (18.9%) of blood group A, and 49 (4.5%) of blood group AB. The majority of the patients were males 712 (66.7%) with an average body mass index (BMI) of 27.45 ± 3.53. Patients with AB blood group stayed a median (IQR) of 14 (5, 27) days while A blood group cohort stayed 13 (6,27) days and overall 10.6% COVID-19-related mortality was observed at our center, with 13.9% in blood group A as the majority of COVID-19 deaths. Regarding severity of COVID-19 disease, there was a trend towards critical disease in blood group A and O (n=83, 41.1%; n=183, 35.1%; OR, 11.34 (95% CI, 46.79-53.22); p<0.001). Logistic regression demonstrates blood group O and AB as predictors for severe COVID-19 disease (O: OR: 0.438 (95% CI: 0.168-1.139) p=0.090; AB: OR: 0.415 (95% CI: 0.165-1.046) p=0.062) and cause-specific hazards ratio (HR) for survival function was 3.206 (p=0.361) among all blood groups.ConclusionAlthough the prevalence of blood group O was higher in this cohort, hospital stay, severity of disease, and mortality were associated with blood group A. Further studies are needed for understanding the underlying mechanism behind the association of blood groups with COVID-19.

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The ABO Blood Group System and Plasmodium Infection in Iran: A Comprehensive Study

Iranian Journal Of Health Sciences ◽

10.18502/jhs.v7i3.1533 ◽

2019 ◽

Author(s):

Farshid Karami ◽

Mozhdeh Mohammadian ◽

Seif Ali Mahdavi ◽

Mohammad Taghi Rahimi

Keyword(s):

Blood Group ◽

Geographical Distribution ◽

Significant Relationship ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Plasmodium Infection ◽

Group System ◽

Group Distribution ◽

Comprehensive Study

Background: Geographical distribution of ABO blood groups affects by race, ethnicity, migration and some infectious agents, such as Plasmodium species. P. falciparum is the major causative agent of death in malaria that can affect ABO blood group distribution in different populations. Therefore, the objective of the current study was to determine the effect of p. falciparum on ABO blood group distribution in Iran. Materials & Methods The present study was conducted on the database of Iranian Blood Transfusion Organization (IBTO) in 30 provinces of the country about ABO and Rh blood groups of the people who referred to health centers from June 2011 to August 2012. Results: A total number of 2124560 individuals were referred to IBTO in 30 provinces. The highest and lowest rates of O blood group were observed in Sistan & Baluchestan (64.6%) and Lorestan (37.7%), respectively. P. falciparum was the most common species of malaria in Sistan & Baluchestan (53215) and the rarest infection agent in Semnan province (20). The results showed statistically significant relationship (p < 0.05) between prevalence of P. falciparum with O blood group, while this relationship for a blood group was not significant (p > 0.05). Conclusion: Our results revealed a significant relationship between prevalence of P. falciparum and geographical distribution of ABO blood. There was also found more susceptibility and risk to malaria infection and cerebral malaria in a blood group compared to other groups. In addition, this was the first comprehensive study on the ABO blood group system and Plasmodium infection in Iran.

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Evaluation of blood groups in patients with anti TPO positive

Asian Journal of Medical Sciences ◽

10.3126/ajms.v10i6.25878 ◽

2019 ◽

Vol 10 (6) ◽

pp. 67-70 ◽

Cited By ~ 1

Author(s):

Eşref Araç ◽

İhsan Solmaz

Keyword(s):

Diabetes Mellitus ◽

Blood Group ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Negative Group ◽

Positive Group ◽

Group System ◽

The Relationship ◽

B Blood Group

Background: In studies, ABO blood group system has been shown to be associated with type 2 diabetes mellitus, chronic renal failure, gestational diabetes mellitus, postpartum depression, coronary artery disease, Crohn’s disease as well as various cancer types such as stomach, breast, skin cancers and rheumatologic diseases. Aims and Objective: The relationship between anti TPO positivity and ABO blood group system is aimed to be investigated by using blood groups which are the product of genetic structure and easy to identify by considering the relationship between anti TPO positivity and blood group. Materials and Methods: 4312 patients with determined blood groups were included among the patients, who were admitted to the internal medicine outpatient clinics of our hospital between January 2, 2017 and May 28, 2019 and were screeened for thyroid antibodies with thyroiditis susceptibility. Results: The most common blood group was A in both anti TPO positive and anti TPO negative patient groups.The rate of those with O blood group was 2.65% higher in anti TPO positive group than anti TPO negative group. B blood group was found to be 4.87% higher in anti TPO negative group than anti TPO positive group (p:0.148). Conclusion: In conclusion, it was found that O blood group may be a risk factor for anti TPO positivity and B blood group is much lower in anti TPO positive ones. However, it is obvious that more comprehensive prospective multicentered clinical and experimental studies are needed to establish the relationship between blood groups and autoimmune diseases, especially autoimmune thyroiditis.

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An Insight into the General Trend of Blood Group Dissemination among Local Population of Muzaffarabad

Asian Journal of Allied Health Sciences (AJAHS) ◽

10.52229/ajahs.v3i3.345 ◽

2020 ◽

pp. 39-43

Author(s):

OJS Admin

Keyword(s):

Blood Group ◽

Disease Susceptibility ◽

General Trend ◽

Local Population ◽

Blood Groups ◽

Blood Group System ◽

Group System ◽

Insight Into

Blood groups ABO and Rhesus, constituting the most principal blood group system, are of key signicance for clinical and transfusion practices and are moreover, thought to be associated with disease susceptibility.

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ABO blood group system and risk of brain tumors: A retrospective case–control study in Northeast of China

Translational Surgery ◽

10.4103/ts.ts_24_17 ◽

2018 ◽

Vol 3 (3) ◽

pp. 49

Author(s):

Chuanlu Jiang ◽

Liang Chang ◽

Shihong Zhao ◽

Zhou Dan ◽

Guofu Li ◽

...

Keyword(s):

Brain Tumors ◽

Blood Group ◽

Case Control Study ◽

Case Control ◽

Abo Blood Group ◽

Blood Group System ◽

Retrospective Case ◽

Group System ◽

Northeast Of China ◽

Control Study

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The Lebanese COVID-19 Cohort; A Challenge for the ABO Blood Group System

Frontiers in Medicine ◽

10.3389/fmed.2020.585341 ◽

2020 ◽

Vol 7 ◽

Author(s):

Athar Khalil ◽

Rita Feghali ◽

Mahmoud Hassoun

Keyword(s):

Blood Group ◽

Severe Form ◽

Abo Blood Group ◽

Blood Group System ◽

Retrospective Case ◽

Genetic Characteristics ◽

Group System ◽

Different Populations ◽

Control Study

A sudden outbreak of pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly spread all over the world facilitating the declaration of the resultant disease as a pandemic on March 2020. Predisposing factors for acquiring COVID-19 and for developing a severe form of this disease were postulated to be related to the epidemiological, clinical, and genetic characteristics of the patients. Biological markers such as the ABO blood group system were amongst these factors that were proposed to be linked to the variability in the disease course and/or the prevalence of the infection among different groups. Herein, we conducted the first retrospective case-control study from the Middle East and North Africa that tackles the association between the blood group types and the susceptibility to, as well as the severity of, SARS-CoV-2 infection. Contrary to the most acknowledged hypothesis, our results challenged the significance of this association and questioned the role of the ABO blood group system in dictating the severity of this disease. For future similar studies, we endorsed analyzing larger cohorts among different populations and we encouraged implementing more rigorous approaches to diminish the potential confounding effect of some underlying comorbidities and genetic variants that are known to be associated with the ABO blood group system.

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