scholarly journals Utilizzo di staminali da tessuto adiposo nelle lesioni cutanee croniche: esperienza clinica/Use of adipose tissue stem cells in chronic skin lesions: clinical experience

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Fabrizio Moffa ◽  
Alberico Balbiano da Colcavagno ◽  
Elia Ricci
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Chronic Wound ◽  
Wound Care ◽  
Local Treatment ◽  
Skin Lesions ◽  
Complex Process ◽  
Number Of Patients ◽  
Global Vision ◽  
Chronic Skin

La guarigione di una ferita cronica è un processo articolato e complesso, che richiede una visione clinica globale del paziente. Tuttavia, il trattamento locale del letto della ferita riveste un’importanza fondamentale. Sempre più ormai si parla di medicina rigenerativa di tipo induttivo come mezzo per stimolare le cellule senescenti all’interno di una lesione cutanea cronica, in particolare mediante l’utilizzo delle cellule staminali mesenchimali. Il tessuto adiposo autologo rappresenta una fonte di cellule staminali e la tecnologia Lipogems® ne rende possibile la sua applicazione clinica. In questo studio vengono analizzati i risultati ottenuti con tale metodica che, seppur con i limiti di un numero ancora non consistente di pazienti, sono comunque incoraggianti nel proseguire lungo questa strada, considerata da molti come l’ultima frontiera nel wound care. The healing of a chronic wound is an articulated and complex process, requiring a patient’s clinical global vision. However, local treatment of the wound bed is of fundamental importance. More and more now we talk about regenerative medicine as a means to stimulate senescent cells in a chronic skin lesion, particularly through the use of mesenchymal stem cells. Autologous adipose tissue is a source of stem cells and Lipogems® technology makes it possible for its clinical application. In this study we analyze the results obtained with this method that, even with the limits of a not yet substantial number of patients, they are still in encouraging continue along this road, considered by many as the last frontier in wound care.

scholarly journals Antlerogenic stem cells extract accelerate chronic wound healing: a preliminary study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Janusz Kmiecik ◽  
Michał Jerzy Kulus ◽  
Jarosław Popiel ◽  
Agnieszka Cekiera ◽  
Marek Cegielski
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Small Population ◽  
Area Ratio ◽  
Wound Treatment ◽  
Ki 67 ◽  
Pressure Therapy

Abstract Background Chronic wounds constitute a significant medical and social problem. Chronic wound treatment may be supported by various techniques, such as negative pressure therapy, phototherapy or stem cells therapy, yet most of those supporting therapies need more evidence to be used for standard wound care. Current study covers the use of sonicated Antlerogenic Stem Cells (ASC) extract on chronic wounds. Methods Study was performed on 20 dermatological patients with venous leg ulcers, divided into two groups – treated with and without ASC extract respectively. The area and circumference of the wounds during the follow-up visits were measured on the wound imprint. Dynamics of wound healing was determined and compared between control and study group; statistics includes changes in absolute values (wound area, circumference), as well as relative (percentage of wound decrease, circumference/area ratio) and their change in time. For the purpose of Ki-67 immunohistochemical staining, sections were sampled from the wound edge at distinct check-points during therapy. Results of both groups were compared with Student test or Mann-Whitney test, depending on results distribution. Results Besides Ki-67 expression, all tested wound healing parameters (including relative and absolute wound decrease and changes in circumference/area ratio) were statistically significant more favorable in experimental group. Conclusion ASC extract significantly supported standard chronic wound treatment. Due to small population of study the results should be considered preliminary, yet promising for further research.

scholarly journals Instillation-TIME (iTIME) as a rationale amendment for TIME conception. Is there enough evidence for the efficiency of negative pressure wound therapy with instillation (iNPWT) to announce a breakthrough idea for wound treatment?

2019 ◽  
Vol 6 (2) ◽  
pp. 7-8
Author(s):  
Adam Bobkiewicz ◽  
Adam Studniarek ◽  
Łukasz Krokowicz ◽  
Michał Drews ◽  
Tomasz Banasiewicz
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Care Management ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wound ◽  
Wound Care ◽  
Wound Treatment ◽  
Wound Therapy ◽  
Number Of Patients ◽  
Moisture Balance

An increased number of patients developing difficult-to-heal wounds results in billions spending for chronic wound care management. Introduction of TIME conception has been a breakthrough idea for wound healing based on phase-adapted wound therapy that interacts and influence each other and included: T – tissue management, I - infection control, M - moisture balance, E - edge of the wound. Negative pressure wound therapy (NPWT) revolutionized the management of wound healing. Moreover, recently NPWT with instillation (iNPWT) has gained the popularity of optimizing wound healing. In the context of acceleration of wound healing, iNPWT meets the criteria of the TIME conception. All individual components of TIME strategy are found in iNPWT providing “all in one” conception. Such management is easy to apply, monitor and it is well- tolerated by patients. Based on the current studies, iNPWT is found to be an important alternative for other methods of wound healing. It is believed that iNPWT will evolve and gain popularity as an innovative treatment for TIME conception.

scholarly journals Survey on issues concerning eHealth and telemedicine in Wound Care

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Ciro Falasconi ◽  
Vincenzo Amalfi ◽  
Patrizia Baroni ◽  
Giovanni Vito Corona ◽  
Corrado Maria Durante ◽  
...  
Keyword(s):  
Wound Care ◽  
Skin Lesions ◽  
Daily Basis ◽  
Standards Of Care ◽  
The Internet ◽  
Modern Information Technology ◽  
The World ◽  
Use Of The Internet ◽  
Chronic Skin ◽  
New Generation

In the three months period between March and June 2016 we launched a survey on the AUIC website, open to the contribution of all members, to evaluate the dissemination and use of modern information technology in the treatment of Chronic Skin Lesions (CSL). The now ubiquitous diffusion of desktop and portable computers and mobile devices such as smartphones and tablets has confirmed the World Wide Web (“the Internet”) as a tool for communication and sharing of information and knowledge. With the current daily use of the Internet and the advent of social media there are no longer any limits to communication in all social and employment contexts. In our view, it is clear that the world of wound care could, or rather should, use these important tools in order to improve the standards of care offered to patients on a daily basis. In addition, the entry of a new generation of “digital natives” in the labor market will make the use of these technologies no longer an exception, but the most absolute normality.

scholarly journals Quality of life study in Wound Care. Final report

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Giuseppe Nebbioso ◽  
C. Albanese ◽  
F. Bonat ◽  
A. Botta ◽  
Giovanni Vito Corona ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Determinants ◽  
Wound Care ◽  
Skin Lesions ◽  
Subjective Perception ◽  
Final Report ◽  
Life Study ◽  
Broad Concept ◽  
Chronic Skin

In recent decades the aging of the population has led to an increase in chronic conditions responsible for various complications such as chronic skin lesions (CSL). The data provided in the literature indicate an incidence of CSL up to 3% but, in fact, little is known about the real impact of the different types of ulcers and we know even less about the quality of life and social status of the affected citizens. By quality of life we refer to the subjective perception that an individual has of their physical and psychologicalemotional health, of the position they have in life in the context of the environment within which they live and in relation to their expectations and concerns. It is a very broad concept that includes physical and psychological health, degree of independence, social relationships, personal beliefs and their relationship to the principal characteristics of their environment. Their health status is therefore influenced by so-called social determinants and their understanding and evaluation is critical to the development of new social and healthcare policies. In order to evaluate the influence of social determinants on the genesis of CSL and the role that lesions have in the physical-psychological condition of patients, in January 2014 the AIUC (Italian Association of Skin Ulcers) and Simitu (Association for the rights of patients with chronic skin lesions) launched the study “Quality of life study in wound care”, a survey on the quality of life of patients suffering from CSL, whose final results are presented in this publication.

Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®)

2022 ◽  
Author(s):  
Dirk Debus ◽  
Semra Genç ◽  
Philipp Kurz ◽  
Martin Holzer ◽  
Kurt Bauer ◽  
...  
Keyword(s):  
Case Report ◽  
Local Treatment ◽  
Local Therapy ◽  
Skin Lesions ◽  
Lower Leg ◽  
Sodium Chlorite ◽  
Leishmania Tropica ◽  
Skin Ulcers ◽  
Chronic Skin

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

scholarly journals TELEDERMATOLOGY: CONCEPTS AND APPLICATIONS IN MEDICINE

2015 ◽  
Vol 62 (2) ◽  
pp. 99-104
Author(s):  
Maria-Magdalena Constantin ◽  
◽  
Anca Răducan ◽  
Elena Poenaru ◽  
Traian Constantin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Chronic Wound ◽  
Wound Care ◽  
Skin Cancers ◽  
Acne Rosacea ◽  
Therapeutic Algorithm ◽  
Chronic Skin ◽  
Store And Forward ◽  
Chronic Skin Disease

Objectives. To assess the concepts of teledermatology (TD), a subspecialty of dermatology and one of the most common applications of telemedicine. Material and methods. This systematic review, totaling 32 works, is aimed to evaluate the advantages and limitations of teledermatology, which can be delivered in two ways: real-time (synchronous), using videoconference technology, and store-and-forward (SAF) methods (aynchronous), using digital images via internet, a cheaper and more convenient modality for the health care provider. Results. So far, teledermatology has been implemented in dermoscopy, dermatopathology and chronic wound care. However, other chronic skin disease, such as psoriasis, dermatitis, acne, rosacea and skin cancers can be evaluated and monitored using store-and-forward methods. Conclusions. In order to develop a teledermatology platform, Romanian dermatology requires specific protocols and equipment for taking and sending photographs. A dermatologist would then review the data using store-and forward method and respond with a diagnosis and therapeutic algorithm.

scholarly journals Mechanical micronization of lipoaspirates for treatment of bleomycin-induced scleroderma in nude mice

2020 ◽  
Author(s):  
Wenqing Jiang ◽  
Jing Wang ◽  
Jiayan Lin ◽  
Shenglu Jiang ◽  
Yuping Quan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Nude Mice ◽  
Stromal Vascular Fraction ◽  
Skin Lesions ◽  
Post Transplantation ◽  
Treatment Groups ◽  
Dermal Thickness ◽  
Cytokine Levels ◽  
Anti Inflammatory

Abstract Background Scleroderma is a chronic autoimmune disease that causes hardening of the skin. Adipose tissue is used as a regenerative treatment for scleroderma, and mechanical micronization of adipose tissue can concentrate stem cells, improving its therapeutic efficacy. Stromal vascular fraction gel (SVF gel) is produced by subjecting lipoaspirates to a series of mechanical processes. The present study aimed to assess the therapeutic effect of SVF gel on dermal scleroderma. Methods Scleroderma was induced in nude mice by daily subcutaneous injections of bleomycin (BLM) for 4 weeks. SVF gel, cell-enriched lipoaspirates (CAL), or Coleman fat (CF) (0.1 mL) was injected subcutaneously into local sclerosis lesions. Histological analyses, TUNEL assay, and qRT-PCR were conducted 4 weeks post-transplantation. Results SVF gel, CAL, and CV decreased dermal thickness in the scleroderma model (P < 0.05), and sclerosis was significantly decreased in the SVF gel and CAL groups. SVF gel and CAL decreased macrophage infiltration, pro-inflammatory cytokine levels, and fibrosis in transferred fat and/or skin lesions (P < 0.05). This revealed anti-inflammatory and anti-fibrotic effects of adipose-derived stem cells (ASCs) therapy in scleroderma (P < 0.05). SVF gel exhibited the most potent anti-inflammatory and anti-fibrotic effects among treatment groups (P < 0.05). Conclusion SVF gel and CAL significantly reversed dermal sclerosis, and were more effective than CF. The SVF gel group exhibited the lowest inflammation both in transferred fat and in skin lesions, and also the lowest fibrosis among the three groups. This study suggested that SVF gel was a more suitable adipose-based therapy for topical treatment of scleroderma patients.

scholarly journals Management and antisepsis in wound care: The experience of an Italian region (Liguria) in the treatment of older people affected by chronic ulcers

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Aurora Parodi ◽  
Valeria Maria Messina ◽  
Teresa Cannavale ◽  
Stefania Sorbara ◽  
Andrea Francesco Pestarino ◽  
...  
Keyword(s):  
Older People ◽  
Elderly People ◽  
Wound Care ◽  
Healing Process ◽  
Skin Lesions ◽  
Wound Management ◽  
Italian Regions ◽  
Chronic Ulcers ◽  
Chronic Skin ◽  
The Impact

Liguria is one of the Italian regions with the highest percentage of elderly people. The European Union declared the region as a “reference site”, for experimenting cutting-edge solutions and assistance models in health management of elderly people. Chronic ulcers become a problem of considerable importance looking at the number of involved elderly patients and of the necessary resources for their care, as well for the impact on the patient’s quality of life, due to the painful and limiting nature of the pathology. This study aims to evaluate the appropriate wound management in older people affected by chronic ulcers. A group of wound care experts operating in the Liguria region met with the aim of reviewing the epidemiology of chronic skin lesions, analyzing the diagnostic/therapeutic approach currently in use, focusing on the importance of the antisepsis in wound management. In Liguria region general practitioners reported a 3.9% prevalence of chronic skin lesions in 2018, and up to 7.35% in women over 85 years; about 90% of the lesions managed at home were pressure lesions. An overall assessment of the patient and the lesion, appropriate cleansing and antisepsis phases and a multidisciplinary management are essential to facilitate the wound’s healing process among the elderly.

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