Trends in Cardiovascular Complications and Mortality among Patients with Diabetes in South Korea

Elevation of the arterial stiffness is one of the important pathogenic factors associated with a high risk of cardiovascular complications and mortality rate in patients with diabetes and metabolic syndrome. Correction of the arterial stiffness has a great value for decrease of the risk of atherosclerosis progress and organ protection. Therapy with ACE inhibitor ramipril provides not only high antihypertensive effect but also significant improvement of parameters of the arterial stiffness which indicates an additional vasoprotective effect of the drug.

Download Full-text

Glycemic variability and cardiovascular disease in patients with type 2 diabetes

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-002032 ◽

2021 ◽

Vol 9 (1) ◽

pp. e002032

Author(s):

Marcela Martinez ◽

Jimena Santamarina ◽

Adrian Pavesi ◽

Carla Musso ◽

Guillermo E Umpierrez

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

Glycated Hemoglobin ◽

Glucose Monitoring ◽

Glycemic Variability ◽

Cardiovascular Complications ◽

Glucose Levels ◽

Increased Risk ◽

Patients With Diabetes

Glycated hemoglobin is currently the gold standard for assessment of long-term glycemic control and response to medical treatment in patients with diabetes. Glycated hemoglobin, however, does not address fluctuations in blood glucose. Glycemic variability (GV) refers to fluctuations in blood glucose levels. Recent clinical data indicate that GV is associated with increased risk of hypoglycemia, microvascular and macrovascular complications, and mortality in patients with diabetes, independently of glycated hemoglobin level. The use of continuous glucose monitoring devices has markedly improved the assessment of GV in clinical practice and facilitated the assessment of GV as well as hypoglycemia and hyperglycemia events in patients with diabetes. We review current concepts on the definition and assessment of GV and its association with cardiovascular complications in patients with type 2 diabetes.

Download Full-text

Comment on Shah et al. Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients: A Population-Based Cohort Study. Diabetes Care 2013;36:2670–2676

Diabetes Care ◽

10.2337/dc13-2490 ◽

2014 ◽

Vol 37 (4) ◽

pp. e78-e79 ◽

Cited By ~ 1

Author(s):

Therese Tillin ◽

Naveed Sattar ◽

Nita Forouhi ◽

Alun D. Hughes ◽

Nish Chaturvedi

Keyword(s):

Cohort Study ◽

South Asian ◽

Diabetes Care ◽

Cardiovascular Complications ◽

Population Based ◽

Chinese Patients ◽

Diabetes Diagnosis ◽

Complications And Mortality

Download Full-text

DYSLIPIDEMIA – TYPE2 DIABETES AND NON DIABETES POPULATION IN AND AROUND ERODE DISTRICT, TAMILNADU

10.36106/ijar/4900437 ◽

2021 ◽

pp. 8-9

Author(s):

Murugesan Thinakaran ◽

Thangadurai Chitra

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Complications ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Lipid Status ◽

Type2 Diabetes ◽

Patients With Diabetes ◽

Tertiary Hospitals ◽

Low Hdl

Background and objects: Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid status. Dyslipidemia is common in diabetes mellitus and is associated with cardiovascular complications. Early diagnosis and treatment is the main cornerstone in the prevention of its multiple complications. The aim of the study was to determine the prevalence of abnormal lipid prole levels. Materials and Method: The study population was made up of Eighty-ve (85) already diagnosed type 2 diabetic patients and Ninety-two (92) with an age range of 28 to 70 years, who come from routine health, follow up at various tertiary hospitals in Erode. The samples were analyzed using the chemical analyzer COBAS INTEGRA 400. Results and Conclusion: Dyslipidemia was found in 63.52% in type2 diabetes patients and 43.47% in non-diabetic patients. High TG, high LDL-C, high TC and low HDL-C exhibited an increasing trend in the proportion of patients with dyslipidemia. The following risk factors namely female sex, age above 50- years, BMI (overweight and obese), poor glycemic control, central obesity and physical inactivity were associated with diabetic dyslipidemia. This study presents some interesting and novel ndings which may be very important in the care and management of patients with type-2 diabetes.

Download Full-text

Response to Comment on Shah et al. Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients: A Population-Based Cohort Study. Diabetes Care 2013;36:2670–2676

Diabetes Care ◽

10.2337/dc13-2836 ◽

2014 ◽

Vol 37 (4) ◽

pp. e80-e80

Author(s):

Baiju R. Shah ◽

J. Charles Victor ◽

Maria Chiu ◽

Jack V. Tu ◽

Sonia S. Anand ◽

...

Keyword(s):

Cohort Study ◽

South Asian ◽

Diabetes Care ◽

Cardiovascular Complications ◽

Population Based ◽

Chinese Patients ◽

Diabetes Diagnosis ◽

Complications And Mortality

Download Full-text

Outcomes after surgery in patients with diabetes who used metformin: a retrospective cohort study based on a real-world database

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-001351 ◽

2020 ◽

Vol 8 (2) ◽

pp. e001351

Author(s):

Chao-Shun Lin ◽

Chuen-Chau Chang ◽

Chun-Chieh Yeh ◽

Yi-Cheng Chang ◽

Ta-Liang Chen ◽

...

Keyword(s):

Cohort Study ◽

Real World ◽

Lower Risk ◽

Randomized Clinical Trials ◽

Medical Condition ◽

Perioperative Outcomes ◽

Major Surgery ◽

Postoperative Intensive Care ◽

Patients With Diabetes ◽

Complications And Mortality

IntroductionLimited information was available regarding the perioperative outcomes in patients with and without use of metformin. This study aims to evaluate the complications and mortality after major surgery in patients with diabetes who use metformin.Research design and methodsUsing a real-world database of Taiwan’s National Health Insurance from 2008 to 2013, we conducted a matched cohort study of 91 356 patients with diabetes aged >20 years who used metformin and later underwent major surgery. Using a propensity score-matching technique adjusted for sociodemographic characteristics, medical condition, surgery type, and anesthesia type, 91 356 controls who underwent surgery but did not use metformin were selected. Logistic regression was used to calculate the ORs with 95% CIs for postoperative complications and 30-day mortality associated with metformin use.ResultsPatients who used metformin had a lower risk of postoperative septicemia (OR 0.94, 95% CI 0.90 to 0.98), acute renal failure (OR 0.87, 95% CI 0.79 to 0.96), and 30-day mortality (OR 0.79, 95% CI 0.71 to 0.88) compared with patients who did not use metformin, in both sexes and in every age group. Metformin users who underwent surgery also had a decreased risk of postoperative intensive care unit admission (OR 0.60, 95% CI 0.59 to 0.62) and lower medical expenditures (p<0.0001) than non-use controls.ConclusionsAmong patients with diabetes, those who used metformin and underwent major surgery had a lower risk of complications and mortality compared with non-users. Further randomized clinical trials are needed to show direct evidence of how metformin improves perioperative outcomes.

Download Full-text

The structural and functional changes of blood cells and molecular components in diabetes mellitus

Biological Chemistry ◽

10.1515/hsz-2016-0196 ◽

2017 ◽

Vol 398 (4) ◽

pp. 411-423 ◽

Cited By ~ 12

Author(s):

Leszek Szablewski ◽

Anna Sulima

Keyword(s):

Diabetes Mellitus ◽

Red Blood Cells ◽

Blood Cells ◽

White Blood Cells ◽

Neutrophil Function ◽

Cardiovascular Complications ◽

Oxygen Binding ◽

Functional Changes ◽

Coronary Syndrome ◽

Patients With Diabetes

Abstract It is known fact that diabetes mellitus (DM) affects blood cells. Changes in the erythrocyte membrane, disorder in hemoglobin oxygen-binding and modification in mechanical characteristics, are effects of hyperglycemia on red blood cells. Altered susceptibility infection of patients with diabetes has been ascribed to a depression in the function of polymorphonuclear leukocytes. Neutrophil function in patients with diabetes with good glucose control is slightly different than in healthy ones. DM causes significant changes in lymphocytes metabolism and their functions. Patients with diabetes, presenting with acute coronary syndrome, are at higher risk of cardiovascular complications and recurrent ischemic events in comparison to non-diabetic counterparts. Various mechanisms, including endothelial dysfunction, platelet hyperactivity, and abnormalities in coagulation and fibrynolysis have been implicated for this increased atherothrombotic risk. There are many other alterations of blood cells due to DM. In the present review we focused on modifications of blood cells due to DM. Then, as a second point, we explored how the changes affect functions of red blood cells, white blood cells and platelets.

Download Full-text