scholarly journals A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future

2021 ◽  
Vol 45 (5) ◽  
pp. 629-640
Author(s):  
Seung-Hwan Lee ◽  
Kun-Ho Yoon

The year 2021 marks the 100th anniversary of the discovery of insulin, which has greatly changed the lives of people with diabetes and become a cornerstone of advances in medical science. A rapid bench-to-bedside application of the lifesaving pancreatic extract and its immediate commercialization was the result of a promising idea, positive drive, perseverance, and collaboration of Banting and colleagues. As one of the very few proteins isolated in a pure form at that time, insulin also played a key role in the development of important methodologies and in the beginning of various fields of modern science. Since its discovery, insulin has evolved continuously to optimize the care of people with diabetes. Since the 1980s, recombinant DNA technology has been employed to engineer insulin analogs by modifying their amino acid sequence, which has resulted in the production of insulins with various profiles that are currently used. However, unmet needs in insulin treatment still exist, and several forms of future insulins are under development. In this review, we discuss the past, present, and future of insulin, including a history of ceaseless innovations and collective intelligence. We believe that this story will be a solid foundation and an unerring guide for the future.

2021 ◽  
Vol 30 (9) ◽  
pp. 2-3
Author(s):  
Jaichan LEE

It is 100 years when we think about the history of ferroelectricity. We, who study ferroelectricity, are honored and pleased to share the 100-year anniversary of ferroelectricity and recall its history. At this great moment, we look back to the brief history on the verge of ferroelectricity. Our hope is that ferroelectricity studied as an early collective phenomenon will be coupled with quantum behavior, the essence of modern science, to become a new age in the history of science and technology.


1982 ◽  
Vol 15 (1) ◽  
pp. 3-25 ◽  
Author(s):  
David C. Lindberg

Roger Bacon has often been victimized by his friends, who have exaggerated and distorted his place in the history of mathematics. He has too often been viewed as the first, or one of the first, to grasp the possibilities and promote the cause of modern mathematical physics. Even those who have noticed that Bacon was more given to the praise than to the practice of mathematics have seen in his programmatic statements an anticipation of seventeenth-century achievements. But if we judge Bacon by twentieth-century criteria and pronounce him an anticipator of modern science, we will fail totally to understand his true contributions; for Bacon was not looking to the future, but responding to the past; he was grappling with ancient traditions and attempting to apply the truth thus gained to the needs of thirteenth-century Christendom. If we wish to understand Bacon, therefore, we must take a backward, rather than a forward, look; we must view him in relation to his predecessors and contemporaries rather than his successors; we must consider not his influence, but his sources and the use to which he put them.


2018 ◽  
Vol 73 (2) ◽  
pp. 135-140
Author(s):  
I. E. Esaulenko ◽  
A. V. Nikitin ◽  
L. V. Vasilieva ◽  
E. V. Gosteva ◽  
I. A. Starodubtseva ◽  
...  

The article concerns the 100th anniversary of the Department of Propaedeutics of Internal Diseases at the NN Burdenko Voronezh State Medical University. There are several important stages in the formation of the department. The history of the development of the department of propaedeutics of internal diseases is inextricably linked with the formation of the Voronezh Medical University from the day of its foundation. During the last century, the department was headed by famous scientists-clinicians: Philosophov P.I., Kurshakov N.A., Gerke A.A., Ravich-Shcherbo V.A., and others. The national medicine owes to their work in the field of diagnosis and treatment of tuberculosis diseases of the lungs and pleura, the clinical course of adhesive pericarditis. During the postwar periods, the department was headed by professors Tumanovsky M.N., Kobyzev A.S., Safonov Yu.D. Their contribution to the development of medical science is difficult to overestimate. The doctrine of Professor Safonov Yu.D. on the bio-hydraulic mechanism of origin of heart sounds found resonance all over the world. Since 1987 to the present time the department of propaedeutics of internal diseases is headed by Professor Nikitin A.V. known as the founder of a new scientific direction in the field of non-drug treatment methods for diseases of internal organs. For his scientific contribution, Anatoly Vladimirovich was awarded the USSR Council of Ministers Prize, and was given an Honorary title «Honored Worker of the Higher School of the Russian Federation». Professor Nikitin A.V. is a famous scientist, a clinician, and a teacher who advised on 50 candidate and 5 doctoral dissertations defended afterward.


1988 ◽  
Vol 3 (2-3) ◽  
pp. 63-68 ◽  
Author(s):  
Marjorie A. Hoy

AbstractBiological control of arthropod pests has a long history of useful practical application. Parasites, predators, and pathogens have been employed in many cases to control pest arthropods in an efficient, cost-effective, and permanent manner. The traditional tactics used in biological control (classical, augmentation, and conservation) remain vital and valuable tools in the biological control of pests for agricultural crops, range lands, forests, and glasshouses. New technologies offer promise. One emerging technique involves the genetic improvement of natural enemies of arthropods through selection, hybridization, or recombinant DNA technology.


2020 ◽  
Vol 7 (1) ◽  
pp. 104-112
Author(s):  
S. B. Filimonov

The work is dedicated to the 100th anniversary of the end of the Civil War inCrimea, which ended in the fall of 1920 with the Russian Exodus. The source significance of the newspapers published in the “white”Crimeain 1917–1920 is characterized and which became the result of the red terror of 1920–1921, when they were threatened with execution by bibliographic rarity, for the history of the domestic intelligentsia, science and culture. The presence in these newspapers of a significant number of publications of prominent and prominent Russian writers and scholars who are not listed in published bibliographic directories and therefore remained little known. The articles of Professor N. K. Gudzia, remaining little-known, “The End of Ukrainian Independence” and the writer S. Ya. Yelpatievsky, “Looking into the Future,” published in 1919–1920, before the formation of theUSSRin 1922, and devoted to thoughts on the future ofRussia, are being published. andUkraine. After the collapse of theUSSRin 1991, these articles again acquired extraordinary relevance.


Author(s):  
Andrew Jong ◽  
Melody Moh ◽  
Teng-Sheng Moh

This chapter elaborates on using generative adversarial networks (GAN) for virtual try-on applications. It presents the first comprehensive survey on this topic. Virtual try-on represents a practical application of GANs and pixel translation, which improves on the techniques of virtual try-on prior to these new discoveries. This survey details the importance of virtual try-on systems and the history of virtual try-on; shows how GANs, pixel translation, and perceptual losses have influenced the field; and summarizes the latest research in creating virtual try-on systems. Additionally, the authors present the future directions of research to improve virtual try-on systems by making them usable, faster, more effective. By walking through the steps of virtual try-on from start to finish, the chapter aims to expose readers to key concepts shared by many GAN applications and to give readers a solid foundation to pursue further topics in GANs.


2018 ◽  
Vol 48 (1) ◽  
pp. 1-23 ◽  
Author(s):  
Matthew Holmes

Somatic hybridization is the particle collider of the biological world: where plant cells stripped of their cell wall are fused to create interspecific crosses containing a huge range of genetic information. This paper charts the origins of somatic hybridization and its rise and fall as a plant breeding technique. During the 1960s and 1970s, the creation of somatic hybrids through cell fusion promised a new era of crop improvement. Yet the promises of somatic hybridization were instead fulfilled by advances in recombinant DNA technology. Rather than cast somatic hybridization as a failed research program, this paper argues that a number of factors significantly slowed, but did not halt, developments in somatic hybridization research from the 1960s; the technique should therefore be considered a dormant biotechnology. Reconstructing the history of somatic hybridization reveals a new history of modern biotechnology beyond genetic modification, dominated by plant physiologists.


Author(s):  
С.В. ТЕРЕБОВА ◽  
Н.И. АБРАМОВА ◽  
И.В. ГУСАРОВ ◽  
В.В. ВАХРУШЕВА

Сельскохозяйственное производство страны определяет условия поддержания жизнедеятельности общества и потому имеет особое значение. При этом обеспечение продовольственной безопасности страны невозможно без внедрения в отрасли достижений научно-технического прогресса. Огромная роль в этом принадлежит профильным научным учреждениям, в числе которых Северо-Западный научно-исследовательский институт молочного и лугопастбищного хозяйства — обособленное подразделение ФГБУН «Вологодский научный центр РАН». В 2021 году институт отмечает 100-летний юбилей. Цель статьи — показать вклад и значение аграрных исследований института в развитие отечественной сельскохозяйственной науки и совершенствование технологий сельскохозяйственного производства. В публикации представлен ретроспективный взгляд на становление аграрных исследований в СЗНИИМЛПХ, основы которых были заложены в начале ХХ века и продолжают совершенствоваться по сегодняшний день. Дано краткое описание основных исторических этапов формирования и преобразований института. Показан вклад выдающихся ученых в его становление, ключевая роль среди которых принадлежит Алексею Степановичу Емельянову, руководившему институтом почти 50 лет. Дана информация об основных направлениях исследований СЗНИИМЛПХ. Раскрываются перспективы развития его в современных условиях. Изложены наиболее значимые достижения сотрудников. National agricultural production defines the conditions for the society to maintain its existence and therefore is especially important. However, the providing of national food security is dependent on advances in agriculture brought by scientific progress and technological change. A crucial role in this process is played by sectoral scientific institutions including the Northwestern Dairy Farming and Grassland Management Research Institute — Detached Unit of FSBIS «Vologodskiy Scientific Center of the RAS». In 2021 the institute celebrates its 100th anniversary. The aim of the article is to demonstrate the contribution and the significance of the institute's agricultural studies to the development of the national agricultural science and the improvement of agricultural production technologies. The paper presents a retrospective view on the formation of the agricultural studies at NWDFGMRI. Their framework was established in the beginning of the 20th century, and even today it still continues improving. The authors briefly describe the milestones of the history of the institute in respect of its creation and transformations. They also demonstrate the contribution of the eminent scientists to its formation and the key role of Alexey Stepanovich Yemelyanov who was the head of the institute for almost 50 years. In addition, the article describes the main research directions of NWDFGMRI, discusses the  prospects of its development in the modern conditions and reports the most significant achievements of the researchers.


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