Ketosteroid standardized Cissus quadrangularis L. extract and its anabolic activity: Time to look beyond ketosteroid?

Abstract Objective To analyze the application of concept nursing of accelerated rehabilitation surgery in orthopedic postoperative recovery. Methods A total of 120 patients who received orthopedic surgery were divided into the control group undergoing routine orthopedic nursing and the observation group undergoing the concept of accelerated rehabilitation surgery nursing. Results Patients in the observation group had shorter in-bed activity time and out-of-bed activity time, average time of hospital stay, and lower total treatment costs. The incidence of incision infection, respiratory system infection, digestive tract infection, urinary tract infection, deep vein thrombosis, and other complications in the observation group was much lower. The recovery scores of joint function in the observation group at 1, 3, 6, and 12 months after the operation were all better, and the recovery rate of joint function within 1 year after the operation was higher. Conclusion Following the concept of accelerated rehabilitation surgery nursing during the perioperative period can improve the quality of postoperative orthopedic recovery.

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Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial

Scientific Reports ◽

10.1038/s41598-021-81606-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Saimai Chatree ◽

Chantacha Sitticharoon ◽

Pailin Maikaew ◽

Kitchaya Pongwattanapakin ◽

Issarawan Keadkraichaiwat ◽

...

Keyword(s):

Treated Group ◽

Dependent Manner ◽

Hip Circumference ◽

White Adipocyte ◽

Ppar Γ ◽

White Adipocytes ◽

Cissus Quadrangularis ◽

Baseline Values ◽

Dose Dependent ◽

Vehicle Treated Group

AbstractObesity is associated with the growth and expansion of adipocytes which could be decreased via several mechanisms. Cissus Quadrangularis (CQ) extract has been shown to reduce obesity in humans; however, its effect on human white adipocytes (hWA) has not been elucidated. This study aimed to investigate the effects of CQ on obesity, lipolysis, and browning of hWA. CQ treatment in obese humans significantly decreased waist circumference at week 4 and week 8 when compared with the baseline values (p < 0.05 all) and significantly decreased hip circumference at week 8 when compared with the baseline and week 4 values (p < 0.05 all). Serum leptin levels of the CQ-treated group were significantly higher at week 8 compared to baseline levels (p < 0.05). In hWA, glycerol release was reduced in the CQ-treated group when compared with the vehicle-treated group. In the browning experiment, pioglitazone, the PPAR-γ agonist, increased UCP1 mRNA when compared to vehicle (p < 0.01). Interestingly, 10, 100, and 1000 ng/ml CQ extract treatment on hWA significantly enhanced UCP1 expression in a dose-dependent manner when compared to pioglitazone treatment (p < 0.001 all). In conclusion, CQ decreased waist and hip circumferences in obese humans and enhanced UCP1 mRNA in hWA suggestive of its action via browning of hWA.

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The Relationship Between Hippocampal Volume and Activity Diversity

Innovation in Aging ◽

10.1093/geroni/igaa057.2249 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 652-653

Author(s):

Emily Urban-Wojcik ◽

Soomi Lee ◽

Susan Charles ◽

David Almeida ◽

Richard Davidson ◽

...

Keyword(s):

Brain Volume ◽

Daily Diary ◽

Brain Structures ◽

Total Activity ◽

The United States ◽

Hippocampal Volume ◽

Daily Activities ◽

Activity Time ◽

Left And Right ◽

The Relationship

Abstract The hippocampus, implicated in learning, memory, and spatial navigation, is one of the few brain structures that demonstrates neurogenesis across the lifespan. Hippocampal volume (HV), then, may be a marker of exposure to and engagement with novel events and environments, which may in turn be related to cognitive functioning. The present study examined the relationship between HV and activity diversity (AD), which characterizes the range and evenness of participation in daily activities. In 52 participants who completed the daily-diary and neuroscience projects of the Midlife in the United States Refresher study, greater levels of AD across an 8-day period were related to greater HV averaged across the left and right hemispheres when adjusting for overall brain volume, total activity time, time between projects, and relevant sociodemographic variables, b=1128mm3, t(43)=2.54, p=.015. These findings may point to a mechanism through which AD has been related to better cognitive and mental health outcomes.

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