scholarly journals Seroprevalence of transfusion transmitted infections in healthy blood donors: A 5-year tertiary care hospital experience

2017 ◽  
Vol 9 (04) ◽  
pp. 283-287 ◽  
Author(s):  
Sushama A. Chandekar ◽  
Gaythri P. Amonkar ◽  
Heena M. Desai ◽  
Nitin Valvi ◽  
Gururaj V. Puranik
Keyword(s):  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Venereal Disease ◽  
Tertiary Care ◽  
Screening Tests ◽  
Care Hospital ◽  
Serum Samples ◽  
Healthy Donors ◽  
Immunodeficiency Virus ◽  
Testing Technology

Abstract INTRODUCTION: Transfusion transmitted infections (TTIs) can cause threat to bloody safety as blood transfusion is an important mode of transmission of TTI to the recipient, hence, to prevent transmission of these diseases, screening tests on blood bags is an important step for blood safety. AIM: This study was undertaken with the aim of determining the seroprevalence of TTI in healthy blood donors in a tertiary care blood bank. MATERIALS AND METHODS: A retrospective study was carried out over a period of 5 years from January 2007 to December 2011. Serum samples were screened for hepatitis B surface antigen (HBsAg), antibodies to human immunodeficiency virus (HIV) Type 1 and 2, hepatitis c virus (HCV) and syphilis using enzyme-linked immunosorbent assays with the third generation kits and venereal disease research laboratory test, respectively. RESULTS: A total of 76,653 healthy donors were included out of which majority of donors were male (91.79%). The overall seroprevalence of HIV, HBsAg, HCV, and syphilis were 0.26%, 1.30%, 0.25%, and 0.28%, respectively. CONCLUSION: Methods to ensure a safety blood supply should be encouraged. For that, screening with a better selection of donors and use of sensitive screening tests including nucleic acid testing technology should be implemented.

SERO PREVALENCE OF TRANSFUSION TRANSMITTED INFECTIONS (TTI) IN VOLUNTARY BLOOD DONORS IN A TERTIARY CARE HOSPITAL AT SRINAGAR

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Nadia Shafi Chickan ◽  
Altaf Hussain Mir ◽  
Masaratt-ul Gani ◽  
Shazia Handoo ◽  
Farooq Ahmad Ganie
Keyword(s):  
Health Care ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Care Facility ◽  
Health Care Facility ◽  
Care Hospital ◽  
Serum Samples

Introduction: Blood transfusion plays an vital role in patients management and is live saving in my instances. it plays a pivotal role as a specialized modality of treatment and saves millions of lives worldwide each year and reduces morbidity. Stringent screening of blood not only ensure safe supply of blood and blood products, but also gives us idea about prevalence of ttis among general population Objective: to determine the serroperavalance of tti among blood donors in lalded hospital Materials and methods: A retrospective study was carried out over a period of 3 years from January 2017 to December 2019.serum samples were screened for hepatitis B surface antigen ,antibodies to human immunodeficiency virus Type 1 and 2 ,hepatitis c virus and syphilis in department of transfusion medicine was carried out Result: The result shows that 55 (3.72%) of the blood donors had TTIs. The prevalence of Hepatitis B, Hepatitis C, Malaria, Syphilis and Human immunodeficiency viruses (HIV), was found to be 31(0.21%), 23 (0.15%), 01 (0.0.006%), 01 (0.006%) and 02 (0.0.23%) respectively. None were positive for malaria. Conclusion: Transfusion Transmittable Infections pose a threat to patients admitted in any health care facility and if not carefully screened for will cause significant morbidity. Careful screening of all donor blood units in the blood bank of a hospital is absolutely necessary to prevent any untoward incidence of TTI in patients admitted to a health care facility Keywords: Transfusion, Sero-Prevalence, Donors, Transfusion Transmissible Infections.

scholarly journals Seroprevalence of markers of transfusion transmissible infections among blood donors at a tertiary care hospital blood bank: a 5 year retrospective study

2019 ◽  
Vol 7 (8) ◽  
pp. 2976
Author(s):  
Irm Yasmeen ◽  
Supinder Kour ◽  
Imran Khurshid ◽  
Aasifa Malik
Keyword(s):  
Blood Donors ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Blood Bank ◽  
Care Hospital ◽  
Serum Samples ◽  
Tertiary Care Centre ◽  
Healthy Donors ◽  
Hiv 1 ◽  
Apparently Healthy

 Background: Transfusion transmitted infections (TTIs) can be caused by various microorganisms present in the blood of apparently healthy donors. The recipient may get infected after being transfused with the unsafe blood. It is mandatory to screen the blood for HIV 1 and 2, HBV, HCV, Syphilis and Malaria. This study was undertaken to investigate the seroprevalance of Transfusion transmitted infections among blood donors at our tertiary care centre and to compare our study with other studies conducted at different hospitals of the country as well as outside.Methods: A retrospective review of blood donor records was made over a period of 5 years with effect from January 2014 to December 2018 at blood bank, department of Blood Transfusion and Immunohaematology, SKIMS, Soura, Srinagar. Both voluntary and replacement blood donors were selected after taking proper history and examination were included in the study. Serum samples were screened for HIV 1 & 2, HBV (HBsAg) and HCV using ELISA with 3rd generation kits.Results: A total of 56325 blood donors were screened. Out of total 55346 (98.2%) were males and 979 (1.73%) were females. Among them 38969 (69.1%) were replacement donors and 17356 (30.8%) were voluntary donors. The seroprevalance of HBV (HBsAg), HCV and HIV 1and 2 was 0.24%, 0.17% and 0.01% respectively and overall seroprevalance of TTIs was 0.43%.Conclusions: Continuous improvement and implementation of newer techniques like NAT and chemilumenescence for testing of blood for TTIs will reduce the risk of acquiring these infections.lance

scholarly journals Frequency of Transfusion Transmitted Infection Among Blood Donors at Specialized Tertiary Care Hospital in Bangladesh

2015 ◽  
Vol 1 (1) ◽  
pp. 12-14
Author(s):  
Ferdous Ara ◽  
Zubaida Nasreen ◽  
Md Aminul Islam ◽  
Md Abdullah Yusuf ◽  
Mohammad Syaeed Hassan ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Venereal Disease ◽  
Tertiary Care ◽  
Malarial Parasite ◽  
Care Hospital ◽  
Transmitted Infection ◽  
Major Health Problem ◽  
The Status

Background: Blood transfusion is associated with a number of complications. Transfusion transmitted infections (TTI) are one of the major health problem in Bangladesh.Objective: The objective of the present study was to assess the status of transfusion transmitted infections among the apparently healthy donors.Methods: This study we carried out among 585 blood donors in the transfusion medicine department from April 2013 to March 2014 at National Institute of Neurosciences (NINS) and Hospital in Dhaka, Bangladesh. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria to see the prevalence of TTI.Results: Prevalence of hepatitis B virus (HBV), HCV, and syphilis were 1.20, 0.68 and 0.34% respectively. No blood donor tested showed positivity for malarial parasite and HIV.Conclusion: Mandatory screening of donated blood and use of sensitive screening test should be done to reduce TTI in Bangladesh.J. Natl Inst. Neurosci Bangladesh 2015;1(1):12-14

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

scholarly journals Evaluation of positive serological screening test rates in blood donors with ABO and Rh type blood groups

2019 ◽  
Vol 6 (09) ◽  
pp. 4592-4595
Author(s):  
Canan Eren
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Blood Groups ◽  
Pathogen Transmission ◽  
Screening Tests ◽  
Serum Samples ◽  
Serological Screening ◽  
Significant Difference ◽  
Anti Hiv

Background: Blood transfusion is a life-saving method in emergencies. However, it also carries the risk of pathogen transmission, which is called transfusion transmitted infections (TTIs). All donated blood samples were screened for hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibody (anti-HCV), anti-human immunodeficiency virus antigens (anti-HIV½) and syphilis using Venereal Disease Research Laboratory (VDRL) test. This study was designed and carried out to determine the seroprevalences of TTIs among blood donors with different ABO and Rh blood groups. Identification of a relation between different blood groups and TTIs was anticipated. Methods: All blood donors data obtained from the Blood Center of Marmara University Pendik Training and Research Hospital between January 2013 and October 2018 are analyzed retrospectively. Serum samples were examined for HBsAg, anti-HCV, anti-HIV½, and VDRL. Results: HBsAg and anti-HIV½ positivity positivity rates were not statistically different according to ABO blood groups (p>0.05). Anti-HCV positivity rates are partially statistically significant (p<0.05). While the incidence of anti-HCV in patients with AB Rh (+) cases was significantly higher than that of 0 Rh (+), A Rh (+) and AB Rh (+) groups, no significant difference was found for the other analyzed blood groups (p>0.05). VDRL positivity rates did not differ significantly (p>0.05). Seropositive cases, as reported by Rh type blood group; HBsAg, anti-HCV, anti-HIV½, and VDRL positivity rates were not statistically significant (p>0.05). Conclusions: No significant relationship was found among TTIs and ABO and Rh type blood groups. For blood transfusion safety, screening tests should always and carefully be performed.

The seroprevalence of HIV, hepatitis B, hepatitis C and venereal disease research laboratory test seropositivity in blood donors: a 5-year retrospective comparative study at tertiary care hospital in Mumbai, Maharashtra, India

2017 ◽  
Vol 5 (6) ◽  
pp. 2662
Author(s):  
Khaneta Parveen ◽  
Abdul Faheem Khan ◽  
Abdul Salim Khan
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Venereal Disease ◽  
Tertiary Care ◽  
Seroprevalence Rate ◽  
Care Hospital ◽  
Total Blood ◽  
Retrospective Comparative Study

Background: The high seroprevalence of transfusion-transmitted infectious (TTI) diseases such as HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in India affects the safety of blood for recipients. This study was undertaken with the aim to screen the blood donor’s demographic profile and to estimate seroprevalence of HIV, HBV, HCV and VDRL transmissible by blood transfusion in voluntary and replacement male and female blood donors during the last 5 year period.Methods: The present study was conducted over a period of 5 years (2001-2005) and involved 1,53,020 blood donors including both (voluntary, replacement males and females) who were thoroughly screened and selected for blood donation in blood bank at Departments of Pathology, Seth GS Medical College and KEM hospital, Mumbai, Maharashtra, India.Results: Total five years seropositivity for all four disease marker in all blood donors was 9150 (5.97%). The incidence of HIV seropositivity was 1995 (1.30%), the seroprevalence of HBV in total blood donor was 4673 (3.05%), HCV consist of 1599 (1.04%), and VDRL seropositivity was least, i.e. 883 (0.57%). Out of total 9150 (5.97%) seropositive blood donors, 24 (0.26%) blood donors showed concomitant seropositivity for more than one of the blood transmissible diseases.Conclusions: Seroprevalence rate of all the four blood transmissible diseases was higher in replacement donors, and lower in voluntary group of donors. Therefore, it has been evaluated that the voluntary blood donation is safer and promoted for safe blood donation in comparison to replacement blood donation.

scholarly journals Seroprevalence of human immunodeficiency virus, hepatitis B and hepatitis C among blood donors at a tertiary care hospital in North India

2020 ◽  
Vol 9 (11) ◽  
pp. 1671
Author(s):  
Kanwaljit Kaur ◽  
Ramneek Locham ◽  
Smriti Kaur Aulakh ◽  
Rajni Bassi ◽  
Jiteshwar Singh Pannu
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Donor Pool ◽  
Immunodeficiency Virus ◽  
First Time

Background: The prevalence of transfusion transmitted infections (TTIs), in blood transfusion services are a major problem across blood banks and hospitals in the world. In, India, the effort to provide safe transfusion to patients is a heightened problem for various reasons. In this study, seroprevalence of Transfusion transmitted infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a pool of blood donors.Methods: The data collection was carried out for a period of two years from, January 2017 to December 2018, and total sample size of donors was 38,142. We studied the frequency, gender wise distribution, donor (first time vs repeat) wise distribution and yearly trend of seroprevalence of TTIs in blood units donated at our hospital.Results: A total of 37,457 (98.2%) males and 685 (1.79%) females donated blood during the study period. The results suggest that among the blood donors, the prevalence of HCV was highest (0.77%) followed by HBV (0.46%) and HIV (0.13%). Seropositivity was found to be more in first-time donors (0.83%) as compared to repeat-donors (0.52%). Seropositivity was found to be more among males (1.35%) than females (0.01%). The discussion suggests underlying reasons for the results along-with future direction of research.Conclusions: The need of the hour is to encourage repeat voluntary blood donors in order to maintain safe supply of blood and its components to donors. Efforts should be made to include females in the blood donor pool by increasing awareness and through dedicated efforts to improve female health and nutrition.

scholarly journals Screening of viral markers for HIV HBV and HCV infections in blood donors in France and residual risk of viral transmission by blood transfusion

1998 ◽  
Vol 3 (7) ◽  
pp. 76-9 ◽  
Author(s):  
J Pillonel ◽  
C Saura ◽  
A M Couroucé
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Viral Transmission ◽  
Screening Tests ◽  
Immunodeficiency Virus

The first part of this article presents the results of screening tests for antibodies to human immunodeficiency virus (HIV) and hepatitis C virus (HCV) and for hepatitis B surface antigen (HBsAg) from 1986 to 1996. The second part presents the most recent

Sign in / Sign up

Export Citation Format

Share Document