scholarly journals Evaluation of positive serological screening test rates in blood donors with ABO and Rh type blood groups

2019 ◽  
Vol 6 (09) ◽  
pp. 4592-4595
Author(s):  
Canan Eren
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Blood Groups ◽  
Pathogen Transmission ◽  
Screening Tests ◽  
Serum Samples ◽  
Serological Screening ◽  
Significant Difference ◽  
Anti Hiv

Background: Blood transfusion is a life-saving method in emergencies. However, it also carries the risk of pathogen transmission, which is called transfusion transmitted infections (TTIs). All donated blood samples were screened for hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibody (anti-HCV), anti-human immunodeficiency virus antigens (anti-HIV½) and syphilis using Venereal Disease Research Laboratory (VDRL) test. This study was designed and carried out to determine the seroprevalences of TTIs among blood donors with different ABO and Rh blood groups. Identification of a relation between different blood groups and TTIs was anticipated. Methods: All blood donors data obtained from the Blood Center of Marmara University Pendik Training and Research Hospital between January 2013 and October 2018 are analyzed retrospectively. Serum samples were examined for HBsAg, anti-HCV, anti-HIV½, and VDRL. Results: HBsAg and anti-HIV½ positivity positivity rates were not statistically different according to ABO blood groups (p>0.05). Anti-HCV positivity rates are partially statistically significant (p<0.05). While the incidence of anti-HCV in patients with AB Rh (+) cases was significantly higher than that of 0 Rh (+), A Rh (+) and AB Rh (+) groups, no significant difference was found for the other analyzed blood groups (p>0.05). VDRL positivity rates did not differ significantly (p>0.05). Seropositive cases, as reported by Rh type blood group; HBsAg, anti-HCV, anti-HIV½, and VDRL positivity rates were not statistically significant (p>0.05). Conclusions: No significant relationship was found among TTIs and ABO and Rh type blood groups. For blood transfusion safety, screening tests should always and carefully be performed.

scholarly journals Seroprevalence of transfusion transmitted infections in healthy blood donors: A 5-year tertiary care hospital experience

2017 ◽  
Vol 9 (04) ◽  
pp. 283-287 ◽  
Author(s):  
Sushama A. Chandekar ◽  
Gaythri P. Amonkar ◽  
Heena M. Desai ◽  
Nitin Valvi ◽  
Gururaj V. Puranik
Keyword(s):  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Venereal Disease ◽  
Tertiary Care ◽  
Screening Tests ◽  
Care Hospital ◽  
Serum Samples ◽  
Healthy Donors ◽  
Immunodeficiency Virus ◽  
Testing Technology

Abstract INTRODUCTION: Transfusion transmitted infections (TTIs) can cause threat to bloody safety as blood transfusion is an important mode of transmission of TTI to the recipient, hence, to prevent transmission of these diseases, screening tests on blood bags is an important step for blood safety. AIM: This study was undertaken with the aim of determining the seroprevalence of TTI in healthy blood donors in a tertiary care blood bank. MATERIALS AND METHODS: A retrospective study was carried out over a period of 5 years from January 2007 to December 2011. Serum samples were screened for hepatitis B surface antigen (HBsAg), antibodies to human immunodeficiency virus (HIV) Type 1 and 2, hepatitis c virus (HCV) and syphilis using enzyme-linked immunosorbent assays with the third generation kits and venereal disease research laboratory test, respectively. RESULTS: A total of 76,653 healthy donors were included out of which majority of donors were male (91.79%). The overall seroprevalence of HIV, HBsAg, HCV, and syphilis were 0.26%, 1.30%, 0.25%, and 0.28%, respectively. CONCLUSION: Methods to ensure a safety blood supply should be encouraged. For that, screening with a better selection of donors and use of sensitive screening tests including nucleic acid testing technology should be implemented.

scholarly journals Screening of viral markers for HIV HBV and HCV infections in blood donors in France and residual risk of viral transmission by blood transfusion

1998 ◽  
Vol 3 (7) ◽  
pp. 76-9 ◽  
Author(s):  
J Pillonel ◽  
C Saura ◽  
A M Couroucé
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Viral Transmission ◽  
Screening Tests ◽  
Immunodeficiency Virus

The first part of this article presents the results of screening tests for antibodies to human immunodeficiency virus (HIV) and hepatitis C virus (HCV) and for hepatitis B surface antigen (HBsAg) from 1986 to 1996. The second part presents the most recent

Seroprevalence of the hepatitis E virus antibodies among blood donors in the Qassim region, Saudi Arabia

2021 ◽  
Author(s):  
Bader Y Alhatlani ◽  
Waleed A Aljabr ◽  
Mohammed S Almarzouqi ◽  
Sami M Alhatlani ◽  
Rayan N Alzunaydi ◽  
...  
Keyword(s):  
Public Health ◽  
Saudi Arabia ◽  
Blood Transfusion ◽  
Hepatitis E Virus ◽  
Blood Donors ◽  
Indirect Elisa ◽  
Hepatitis E ◽  
Public Health Issue ◽  
Serum Samples ◽  
Major Public Health Issue

Aim: Hepatitis E virus (HEV) transmission through blood transfusion is a major public health issue worldwide. We aimed to determine the seroprevalence of HEV in blood donors in the Qassim region of Saudi Arabia. Materials & methods: Serum samples (n = 1078) were collected from volunteer blood donors and tested for the presence of anti-HEV IgG and IgM by indirect ELISA. Results: The seroprevalence of anti-HEV IgG among the blood donors was 5.7% overall. Anti-HEV IgG and IgM seropositivity were significantly higher in non-Saudi donors than in Saudi donors (22.1 vs 3 and 7.8 vs 0.2% for anti-HEV IgG and IgM, respectively). Conclusion: The seroprevalence of HEV among blood donors in the Qassim region was lower than previous estimates for other regions of the country and neighboring countries.

scholarly journals Seroprevalence rates of transfusion-transmitted infections among blood donors in Jordan

2016 ◽  
Vol 10 (04) ◽  
pp. 377-383 ◽  
Author(s):  
Lina Souan ◽  
Faten Tout ◽  
Mahmoud Siag ◽  
Maher A. Sughayer
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Cancer Center ◽  
Type I ◽  
Human T Cell ◽  
Healthy Donors ◽  
Elisa Technique ◽  
Anti Hiv

Introduction: Statistics on the prevalence of donor screening for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (anti-HCV) in Jordan are outdated. There are no studies on the prevalence of anti-HIV I/II, anti-human T-cell lymphotropic virus type I and II (anti-HTLV-I/II), or anti-syphilis. Data are also lacking on the prevalence and significance of using anti-HBc screening in Jordan. This study aimed to evaluate the prevalence of transfusion-transmissible infections (TTI) among donors at King Hussein Cancer Center and compare it with neighboring countries and to evaluate the significance of screening for anti-HB core total (anti-HBc) antibodies. Methodology: A retrospective analysis covering the period from 2009 to 2013 was conducted on records of healthy donors. The number of donors was 10,101, 12,694, 13,387, 14,256, and 12,495, respectively. Donors were screened for HBsAg, anti-HBc, anti-HIV I/II, anti-HCV, and anti-HTLV-I/II using ELISA technique, while syphilis antibodies were detected using rapid chromatographic immunoassay. Results: Among 62,933 donors, the prevalence of HBsAg was 0.52%, of anti-HBc was 6.04%, and of anti-HCV was 0.16%. None of the donors were positive for anti-HIV I/II, anti-HTLV I/II, or anti-TP. Conclusions: This study demonstrates that the seroprevalence for HBsAg, anti-HBc, and anti-HCV in Jordan was low compared to neighboring countries. None of the donors were confirmed positive for anti-HIV I/II, anti-HTLV I/II, or anti-TP during the studied period. This study demonstrates the importance of screening for anti-HBc to improve blood and platelet safety and stresses the need to complement it with an algorithm that qualifies reentry of anti-HBc false-positive donors.

How Many Bloods will a ‘HIVCHEK’ Check? Multiple Tests for HIV Antibody for a Single Screening Kit

1992 ◽  
Vol 22 (4) ◽  
pp. 151-154 ◽  
Author(s):  
G J Wannan ◽  
M J Cranefield ◽  
W A M Cutting ◽  
P R Fischer ◽  
F D Hargreaves ◽  
...  
Keyword(s):  
Blood Donors ◽  
Screening Tests ◽  
Serum Samples ◽  
Hiv Seroprevalence ◽  
Multiple Tests ◽  
Test Kit ◽  
Highly Sensitive ◽  
Multiple Sample ◽  
Sample Method ◽  
Hiv 1

Detection of HIV infection in blood donors or populations is usually by testing sera for antibodies to HIV-1 and HIV-2. Screening tests are now highly sensitive and specific, but still expensive and scarce in Africa. We tested the commercially available kits ‘HIVCHEK 1 + 2′ in two field laboratories, on specimens from blood donors and antenatal women in rural Zaire. We describe a method of using one test kit for up to five serum samples, saving money and time. In 491 antenatal mothers in Eastern Zaire, among whom the HIV seroprevalence was 3.3%, we compared ‘HIVCHEK’ results with results obtained by ELISA and Western blot. The ‘HIVCHEK’ multiple-sample method had a sensitivity of 82% and a specificity of 99.6%. In an area with an HIV seroprevalence of <4%, using ‘HIVCHEK’ by the multiple sample method would lead to a saving of about £2400 for every 1000 individuals tested.

scholarly journals Risk factors associated with hepatitis C virus infection in Taiwanese government employees

2001 ◽  
Vol 126 (2) ◽  
pp. 291-299 ◽  
Author(s):  
H. C. CHANG ◽  
M. W. YU ◽  
C. F. LU ◽  
Y. H. CHIU ◽  
C. J. CHEN
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B Surface Antigen ◽  
Individual Characteristics ◽  
Hcv Infection ◽  
Serum Samples ◽  
Educational Levels ◽  
Previous Blood Transfusion ◽  
Positive Rate

This study evaluated the roles of multiple factors in hepatitis C virus (HCV) infection, with emphasis on the modification of various individual characteristics on the risk associated with percutaneous exposure to blood. Serum samples taken from 4869 men in Taiwan within a cohort study were tested for HCV antibody. The overall positive rate of anti-HCV was 1·6 %. In a logistic regression, factors positively associated with anti-HCV positivity were previous blood transfusion (odds ratio [OR] = 7·28; 95 % confidence interval [CI] = 4·26–12·45), a history of surgery (OR = 2·06; 95 % CI = 1·23–3·46), and lower educational levels (OR = 1·94; 95 % CI = 1·14–3·32). The anti-HCV positive rate was significantly lower in hepatitis B surface antigen (HBsAg) carriers than in non-carriers (OR = 0·60; 95 % CI = 0·37–0·95). Ageing, lower educational levels, O blood group, and Taiwanese ethnicity enhanced the likelihood of HCV infection through blood transfusion/surgery, whereas HBsAg status, cigarette smoking, and habitual alcohol drinking reduced it.

scholarly journals Seroprevalence of the hepatitis E virus among blood donors in the Qassim Region, Saudi Arabia

2020 ◽  
Author(s):  
Bader Alhatlani ◽  
Waleed Aljabr ◽  
Mohammed Almarzouqi ◽  
Sami Alhatlani ◽  
Rayan Alzunaydi ◽  
...  
Keyword(s):  
Public Health ◽  
Saudi Arabia ◽  
Blood Transfusion ◽  
Hepatitis E Virus ◽  
Blood Donors ◽  
Geographical Area ◽  
Hepatitis E ◽  
Public Health Issue ◽  
Serum Samples ◽  
Major Public Health Issue

Abstract Objectives The aim of this study was to evaluate the seroprevalence of hepatitis E virus (HEV), a major public health issue worldwide with the potential for transmission via blood transfusion, in blood donors in the Qassim Region, Saudi Arabia. Serum samples (n = 1,078) were collected from volunteer blood donors from January to April 2019 and tested for the presence of anti-HEV IgG and IgM by indirect enzyme-linked immunosorbent assays. Results Overall, the seroprevalence of anti-HEV IgG and IgM among blood donors was 5.7% and 1.3%, respectively. Additionally, the seropositive rates of anti-HEV IgG and IgM were significantly higher in non-Saudi donors (22.1% and 7.8%) than in Saudi donors (3% and 0.2%). The seroprevalence of anti-HEV IgG increased with age; however, there was no correlation between gender and anti-HEV IgG and/or IgM. The seroprevalence of HEV among blood donors in the Qassim Region was lower than previous estimates for other regions of the country. Further studies covering a wider geographical area are needed to validate and expand the findings and to determine the importance of HEV screening in the region.

scholarly journals HEPATITIS B, C & HIV

2006 ◽  
Vol 13 (04) ◽  
pp. 632-636
Author(s):  
MOHAMMAD FAYYAZ ◽  
Muhammad Ayub Khan ◽  
MASROOR ALI QAZI ◽  
Ghulam Mohyud Din `Chaudhary ◽  
GULZAR AHMED
Keyword(s):  
Blood Transfusion ◽  
Hepatitis B ◽  
Past History ◽  
Hepatitis B Surface Antigen ◽  
Immunosorbant Assay ◽  
Human Immuno Deficiency Virus ◽  
History Of ◽  
Enzyme Linked Immunosorbant Assay ◽  
Age Range ◽  
Anti Hiv

Objective: To determine the prevalence of HBV, HCV and HIV in healthyblood donors in Blood Transfusion Services, Bahawal Victoria Hospital, Bahawalpur. Design: Prospective observationalstudy. Setting: Blood Transfusion Services, Bahawal Victoria Hospital (BVH), affiliated with Quaid-e-Azam medicalCollege Bahawalpur. Period: From 1 January t st o 31st December 2005. Methods and Materials: All the personscoming for blood donations , at the BVH facility, were included. Clinically anaemic, ill, past history of jaundice and ageof less than 18 or more than 50 years were excluded. All the donors (27938) from various areas of Bahawalpur,Bahawalnagar, Lodhran, Vehari and Rahim Yar Khan districts, were screened for hepatitis B surface antigen (HBs)Antigen, hepatitis C antibody (Anti HCV) & Human Immuno-deficiency Virus Antibody (Anti-HIV)on sera by one StepTest Device. All the positives cases were confirmed by Enzyme Linked Immunosorbant Assay. Results: Out of total27938, 25420(91%) were male. Mean age was 28 years with age range 18-50. No HIV positive case was detected.HBV was 2.69%, slightly more than HCV, 2.52%. Males were significantly (p<0.02) more infected than females.Conclusion: Risk of transmission of viral hepatitis is a major problem of blood transfusion. Frequency of viral hepatitisin blood donors is higher in our area as compared to rest of the world. HIV infection is very low. Preventive strategiesinclude good blood transfusion services along with safe sex and other measures.

scholarly journals Distribution of ABO, Rhesus D and Subgroups of ABO among Blood Donors in Sokoto, North Western Nigeria

2020 ◽  
pp. 6-13
Author(s):  
A. B. Ibrahim ◽  
H. Attahiru ◽  
O. Erhabor ◽  
P. F. Udomah ◽  
A. Yakubu ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Blood Groups ◽  
Blood Group A ◽  
Significant Difference ◽  
Tile Method ◽  
Group A ◽  
The Common ◽  
Group B ◽  
North Western

ABO, Rhesus D and subgroups of ABO are highly immunogenic and are the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction and maternal alloimmunization. The aim of this study was to determine the occurrence of ABO, Rh D and subgroups of ABO among blood donors attending Specialist Hospital Sokoto, Nigeria. ABO, Rhesus D and subgroups of ABO antigen status of 176 blood donors with mean age of 30.44 ± 8.210 years attending Specialist Hospital Sokoto were determined using tile method for ABO and Rh D and conventional tube method for anti- A1, anti- H reagents for ABO subgroups respectively. Among the 176 subjects tested, blood group O+ was the most frequent group with 93 (52.8%), 39 (22.2%) were blood group B+, 37(21.0%) were blood group A+, 5 (2.8%) were blood group AB+, 2 (1.1%) were blood group O-. No data was obtained for A-, B- and AB- blood groups.  Out of 37 A blood groups obtained, 31 (83.8%) had A1 antigens and 6 (16.2%) had A2 antigens. Out of the 5 AB blood groups, all had A1B antigens. The study also shows that there was statistically significant difference between blood group A and ethnic groups (Hausa, Fulani and Yoruba) (p<0.05). Blood group O was found to be the most frequent followed by B, A and AB except among Hausa which revealed a pattern of O> A> B> AB. ABO, subgroups shows majority had A1 followed by A2 and A1B respectively.

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