Abstract P059: Prevalence And Correlates Of Co-occurring Metabolic Syndrome And Chronic Kidney Disease: Findings From The Hispanic Community Health Study/study Of Latinos (hchs/sol)

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Celestin Missikpode ◽  
Sylvia E Rosas ◽  
Ana Ricardo ◽  
James Lash ◽  
Unab I Khan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
High Sensitivity ◽  
Health Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hispanic Community

Introduction: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are highly prevalent among Hispanics/Latinos, yet data on co-occurring MetS and CKD are not available. Understanding the prevalence and correlates of MetS-CKD overlap may inform intervention programs for such subgroups. Methods: Data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Visit 1 (2008-2011) was used. MetS was defined as the presence of three or more of the following risk factors: abdominal obesity, high triglyceride, low high-density lipoprotein cholesterol level, elevated blood pressure, and elevated glucose level. CKD was defined as eGFR <60 mL/min per 1.73 m 2 or the presence of albuminuria (urine albumin-creatinine ratio ≥17 mg/g in men and ≥25 mg/g in women). Of 16,415 HCHS/SOL participants, data from 14,527 persons with complete information on kidney function measures and covariates were analyzed using logistic regression. Potential correlates included age, sex, Hispanic/Latino background, acculturation, education, income, physical activity, alcohol use, cigarette smoking, cardiovascular disease, hemoglobin, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance (HOMA-IR). Analyses accounted for complex sampling design. Results: Average age was 41 years, 52% were women, 33% had prevalent MetS, and 14% had prevalent CKD. MetS and CKD co-occurred in 7.8% of the study population, 8.5% in men and 7.2% in women. The prevalence of co-occurring MetS and CKD was 10.4% in Puerto Rican, 9.2% in Cuban, 7.2% in Central American, 7.2% in Mexican, 6.5% in Dominican, and 5.3% in South American. Factors independently related to those co-occurring conditions were age, sex, physical activity levels, cardiovascular disease, high-sensitivity C-reactive protein, and HOMA-IR ( Table ). Conclusions: Targeted prevention efforts that address key modifiable overlapping risk factors may be especially effective in reducing metabolic syndrome and improving kidney health.

Management of non-conventional risk factors

2020 ◽  
pp. 111-116
Author(s):  
Roberto Pedretti
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
High Sensitivity ◽  
Controlled Trials ◽  
Reactive Protein ◽  
Prognostic Implications ◽  
Hs Crp ◽  
Worse Prognosis ◽  
Conventional Risk Factors

Evidence supports the association of some non-conventional or yet to be established risk factors (RFs), such as serum uric acid (UA) or high-sensitivity C-reactive protein (hs-CRP), with the risk of arterial hypertension (HTN), metabolic syndrome, and chronic kidney disease and a worse prognosis in patients with known coronary vascular disease (CVD). However, there is no evidence from randomized controlled trials to support their use in guiding therapy. In the secondary prevention setting, detection of peripheral vascular damage and kidney dysfunction may provide significant additional prognostic implications.

scholarly journals The prevalence of metabolic syndrome increases with serum high sensitivity C-reactive protein concentration in individuals without a history of cardiovascular disease: a report from a large Persian cohort

2017 ◽  
Vol 54 (6) ◽  
pp. 644-648 ◽  
Author(s):  
Seyyed MR Kazemi-Bajestani ◽  
Maryam Tayefi ◽  
Mahmoud Ebrahimi ◽  
Ali R Heidari-Bakavoli ◽  
Mohsen Moohebati ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Protein Concentration ◽  
International Diabetes Federation ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
Fourth Quartile

Background Metabolic syndrome is defined by a clustering of cardiovascular risk factors and is associated with a heightened inflammatory state. A raised serum high-sensitivity C-reactive protein, a marker of inflammation, is also known to associate with cardiovascular risk. We have investigated the relationship between the presence of metabolic syndrome and serum high-sensitivity C-reactive protein concentration in a large representative Persian population cohort without a history of cardiovascular disease. Methods The MASHAD study population cohort comprised 9778 subjects, who were recruited from the city of Mashhad, Iran, between 2007 and 2008. Several cardiovascular risk factors were measured in this population without cardiovascular disease. Individuals were categorized into quartiles of serum high-sensitivity C-reactive protein concentration: first quartile – 0.72 (0.59–0.85) (median [range]) mg/L, second quartile – 1.30 (1.14–1.4) mg/L, third quartile – 2.29 (1.92–2.81) mg/L and fourth quartile – 6.63 (4.61–11.95) mg/L, respectively. The prevalence of metabolic syndrome in each quartile was determined using either International Diabetes Federation or Adult Treatment Panel III criteria. Results The prevalence of metabolic syndrome was highest in the fourth quartile for serum high-sensitivity C-reactive protein (1220 subjects [50.0%]), and significantly higher than that in the first quartile (reference group) (634 subjects [25.9%]) ( P < 0.001). A positive smoking habit (OR, 1.47 [1.26–1.70], P < 0.001) and the presence of either metabolic syndrome-International Diabetes Federation (OR, 1.35 [1.18–1.55], P < 0.001) or metabolic syndrome-ATPIII (OR, 1.40 [1.18–1.50], P < 0.001) were strong predictors of a fourth quartile for serum high-sensitivity C-reactive protein concentration. Conclusions There was a significant association between high concentrations of serum high-sensitivity C-reactive protein and the presence of metabolic syndrome among individuals without a history of cardiovascular disease in our Persian cohort.

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