The role of vitamin D levels in early onset sepsis development in term neonates

2018 ◽  
Vol 08 ◽  
Author(s):  
Ahmed Shara
Keyword(s):  
Vitamin D ◽  
Early Onset ◽  
Term Neonates ◽  
Early Onset Sepsis ◽  
Vitamin D Levels

scholarly journals Association of vitamin D deficiency with early onset sepsis in term neonates

2019 ◽  
Vol 6 (2) ◽  
pp. 440 ◽  
Author(s):  
Ashwani Kumar ◽  
Gursharan Singh Narang ◽  
Gurmeet Singh ◽  
Navneet Virk
Keyword(s):  
Vitamin D ◽  
Early Onset ◽  
Clinical Laboratory ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Study Group ◽  
Laboratory Findings ◽  
Term Neonates ◽  
Early Onset Sepsis ◽  
Vitamin D Levels

Background: Vitamin D is a fat-soluble steroid hormone. Vitamin D also has immunomodulatory effects on immune function. Early onset sepsis (EOS) is characterized by signs and symptoms of infection with or without accompanying bacteremia in the first three days of life. The objective of the study was to determine the possible association between neonatal vitamin D levels and EOS in term neonates.Methods: 100 term neonates with clinical and laboratory findings of EOS (study group) and 100 healthy infants with no signs of clinical/laboratory infection (control group) were enrolled. Sera was drawn during first 3 postnatal days of life in both groups for measurement of 25-hydroxyvitamin D (25-OHD) levels.Results: Neonatal 25-OHD levels (17.4ng/dL) in the study group were significantly lower than those of the control group (26.8 ng/dL) (p=0.001). In present study negative correlation was found between vitamin D level and CRP.Conclusions: Lower neonatal 25-OHD levels are associated with EOS. Adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.

scholarly journals Impact of serum level of vitamin D on term neonates with early onset sepsis

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yasmine Soliman ◽  
Magdy Sakr ◽  
Tarek Emran ◽  
Mohamed El Samanoudy
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Early Onset ◽  
Term Neonates ◽  
Early Onset Sepsis

Vitamin D Levels and Early Onset Sepsis in Newborns

2021 ◽  
Vol 35 (2) ◽  
pp. 64-69
Author(s):  
Balveer Jeengar ◽  
Sunil Gothwal ◽  
Kailash Kumar Meena ◽  
Vijendra Kumar Garg ◽  
Vivek Athwani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Onset ◽  
Care Center ◽  
Tertiary Care ◽  
Area Under The Curve ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Maternal Vitamin ◽  
Early Onset Sepsis ◽  
Vitamin D Levels

Aim: To find out association between vitamin D level and early onset neonatal sepsis (EONS). Methods: This case control study was conducted at a tertiary care center in Northern India during June 2018 to May 2019. Neonates with culture-proven EONS were included as case and neonates without EONS were enrolled as control. 25OH-D levels were evaluated with other routine blood samples. Statistical analysis was done by using unpaired t test and chi-square test. Results: Sixty-two infants were enrolled in each group; baseline characteristics were comparable in both groups. Risk of EONS increased 8 times in neonates with 25OH-D level <30 ng/mL (odds ratio = 8.2; 95% confidence interval [CI]: 3.08-21.82; P = .000). The 25OH-D level was significantly lower in EONS group than control group. Optimal cut-off for 25OH-D was 25 ng/mL to predict EONS with a sensitivity and specificity of 88.7% and 79%, respectively (area under the curve: 0.84; 95% CI: 0.76-0.92; P = .000). Conclusions: Vitamin D insufficiency is significantly associated with EONS. Vitamin D deficiency significantly increases risk of EONS. Maternal vitamin D supplementation may improve neonatal vitamin D levels and may decreases risk of EONS. Further studies including maternal vitamin D level are required for implementation.

scholarly journals The Role of Vitamin D as a Biomarker in Alzheimer’s Disease

2021 ◽  
Vol 11 (3) ◽  
pp. 334
Author(s):  
Giulia Bivona ◽  
Bruna Lo Sasso ◽  
Caterina Maria Gambino ◽  
Rosaria Vincenza Giglio ◽  
Concetta Scazzone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Cognitive Decline ◽  
Immune Cell ◽  
Response To Treatment ◽  
Cellular Processes ◽  
Vitamin D Levels ◽  
The Brain ◽  
Key Questions

Vitamin D and cognition is a popular association, which led to a remarkable body of literature data in the past 50 years. The brain can synthesize, catabolize, and receive Vitamin D, which has been proved to regulate many cellular processes in neurons and microglia. Vitamin D helps synaptic plasticity and neurotransmission in dopaminergic neural circuits and exerts anti-inflammatory and neuroprotective activities within the brain by reducing the synthesis of pro-inflammatory cytokines and the oxidative stress load. Further, Vitamin D action in the brain has been related to the clearance of amyloid plaques, which represent a feature of Alzheimer Disease (AD), by the immune cell. Based on these considerations, many studies have investigated the role of circulating Vitamin D levels in patients affected by a cognitive decline to assess Vitamin D’s eventual role as a biomarker or a risk factor in AD. An association between low Vitamin D levels and the onset and progression of AD has been reported, and some interventional studies to evaluate the role of Vitamin D in preventing AD onset have been performed. However, many pitfalls affected the studies available, including substantial discrepancies in the methods used and the lack of standardized data. Despite many studies, it remains unclear whether Vitamin D can have a role in cognitive decline and AD. This narrative review aims to answer two key questions: whether Vitamin D can be used as a reliable tool for diagnosing, predicting prognosis and response to treatment in AD patients, and whether it is a modifiable risk factor for preventing AD onset.

scholarly journals Role of Vitamin D in the Prevention of Pancreatic Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Pubudu Bulathsinghala ◽  
Kostas N. Syrigos ◽  
Muhammad W. Saif
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Dietary Intake ◽  
Sun Exposure ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Advanced Stages

Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake.

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