scholarly journals Extended approach or usage of nasoseptal flap is a risk factor for olfactory dysfunction after endoscopic anterior skullbase surgery: results from 928 patients in a single tertiary center

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
M.Y. Seo ◽  
D-H. Nam ◽  
D-S. Kong ◽  
Y. Noh ◽  
Y.G. Yung ◽  
...  
Keyword(s):  
Risk Factor ◽  
Olfactory Dysfunction ◽  
Nasoseptal Flap ◽  
Extended Approach ◽  
Tertiary Center

scholarly journals Olfactory and Gustatory Dysfunctions as a Clinical Manifestation of Coronavirus Disease 2019 in a Malaysian Tertiary Center

2020 ◽  
pp. 000348942096316 ◽  
Author(s):  
Kuganathan Ramasamy ◽  
Jeyasakthy Saniasiaya ◽  
Norhaslinda Abdul Gani
Keyword(s):  
Nasal Obstruction ◽  
Telephone Interview ◽  
Complete Recovery ◽  
Sudden Onset ◽  
Olfactory Dysfunction ◽  
Rt Pcr ◽  
Younger Age ◽  
Tertiary Center ◽  
The Mean ◽  
Polymerase Chain

Objective: To investigate the prevalence of olfactory and gustatory dysfunction among patients with COVID-19 infection and the recovery rate. Methods: Adult patients (≥18 years) tested positive for COVID-19 via reverse transcription-polymerase chain reaction (RT-PCR) and admitted in Hospital Tuanku Ja’afar Seremban, Malaysia, were recruited in this study. Patients completed a questionnaire via telephone interview comprising the following details: age, sex, ethnicity, comorbidities, general and otorhinolaryngological symptoms, onset and duration of olfactory and gustatory dysfunction. Patients with persistent olfactory and gustatory dysfunction at the time of the initial interview were followed-up every 3 to 5 days till resolution. Results: A total of 145 patients were included in our study. The mean age of patients was 43.0 ± 17.7 (range: 18-86). Fever (44.1%) and cough (39.3%) were the most prevalent general symptoms. Thirty-one patients (21.4%) reported olfactory dysfunction and 34 (23.4%) reported dysgeusia. There was a significant association between both olfactory and gustatory dysfunction ( P < .001). Altered sense of smell or taste occurred before other symptoms in 7 (15.9%); concomitant in 16 (36.4%) and after in 15 (34.1%). Six patients (13.6%) reported isolated sudden-onset anosmia. The median duration of olfactory and gustatory dysfunctions was 7 days. Complete recovery was achieved for 70.5% of the patients within 7 days of symptom onset. Only 6 (19.4%) of the 31 patients with olfactory dysfunction experienced nasal obstruction or rhinorrhea. Olfactory dysfunction was not significantly associated with nasal obstruction or rhinorrhea. Olfactory dysfunction was significantly associated with younger age ( P = .002), female ( P = .011), and hyperlipidemia ( P = .012). Gustatory dysfunction was significantly associated with fever ( P = .019) and cough ( P = .039). Conclusion: Olfactory and gustatory dysfunction is a pertinent manifestation of COVID-19. Most of the affected patients achieve rapid and complete recovery. Sudden onset of olfactory and gustatory dysfunction should be recognized as a major symptom of COVID-19 as we implore to contain this pandemic.

Malignancy following lung transplantation.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e12019-e12019
Author(s):  
Ammar Khanshour ◽  
Raed Abu Awwad ◽  
Robert Chapman ◽  
Alan Betensley
Keyword(s):  
Risk Factor ◽  
Skin Cancer ◽  
Lung Transplantation ◽  
Lung Transplant ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Chi Square ◽  
Post Transplant ◽  
Transplant Patients ◽  
Tertiary Center

e12019 Background: Malignancy has been shown to be a frequent complication of solid organ transplantation. It has been reported more commonly in lung transplant patients compared to other solid organ transplant recipients presumably due to the greater degree of immunosuppression required for these patients; the International Society for Heart and Lung Transplantation (ISHLT) reported that malignancies account for 15% of all deaths of lung transplant patients between 5 and 10 years after transplant. The aim of this study is to describe malignancies observed in patients who underwent lung transplantation in a single, large tertiary center. Methods: A retrospective analysis of the medical records of all adult recipients of lung allografts transplanted at Henry Ford Hospital between 1994 and 2010 was performed. Main variables included age at transplant, type of transplant, smoking status and type of malignancy. Study end point was development of malignancy. Patients surviving less than 3 months were excluded from the final analysis. T-test and Chi-square tests were used in the statistical analysis. Results: 145 patients received lung transplants with 136 patients surviving at least 3 months. Of the 136 cases included; 31 (23%) patients developed post-transplant malignancy as follows: skin cancer in 17, lung cancer (in the native lung) in 10, colon cancer in 3, cervical cancer in 3, renal cell carcinoma in 2, post transplant lymphoproliferative disorder (PTLD) in 2, head and neck cancer in 2, bladder cancer in 1 and vulvar cancer in 1. Eight patients developed more than one malignancy. 83% of those who developed malignancy were smokers while 67% of those who did not develop malignancy were smokers (Chi-square is 3.41, P>0.05). Patients who developed malignancy were older at time of transplantation (mean ± SD, 58.0±7.5 vs. 55.6±9.0 years; P= 0.04). Conclusions: Malignancy is a common complication after lung transplantation, with skin cancer being the most common. Age at transplantation seems to be a risk factor for development of malignancy. Smoking as a risk factor did not reach statistical significance in the studied population.

scholarly journals Risk factor for Heart failure admissions in adults with congenital heart disease in monocentric tertiary center

2016 ◽  
Vol 8 (5) ◽  
pp. 10
Author(s):  
N. Ben Moussa ◽  
F. Pontnau ◽  
V. Salles ◽  
Y. Boudjemline ◽  
A. Legendre ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Congenital Heart ◽  
Tertiary Center

scholarly journals The significance of post-traumatic amnesia as a risk factor in the development of olfactory dysfunction following head injury

2006 ◽  
Vol 23 (8) ◽  
pp. 618-621 ◽  
Author(s):  
I J Swann ◽  
B Bauza-Rodriguez ◽  
R Currans ◽  
J Riley ◽  
V Shukla
Keyword(s):  
Risk Factor ◽  
Head Injury ◽  
Olfactory Dysfunction ◽  
Traumatic Amnesia ◽  
Post Traumatic

scholarly journals Evaluation of suicidal ideation in adult people with epilepsy and caregivers in a tertiary center

2021 ◽  
Author(s):  
Rafael Batista João ◽  
Mateus Henrique Nogueira ◽  
Lucas Scárdua Silva ◽  
Ricardo Brioschi ◽  
Gabriel Ferri Baltazar ◽  
...  
Keyword(s):  
Risk Factor ◽  
Suicidal Ideation ◽  
Adverse Effects ◽  
Adverse Events ◽  
Regression Analyses ◽  
Epidemiological Factors ◽  
Younger Age ◽  
Tertiary Center ◽  
Profile Score ◽  
Item Scores

Background: Epilepsy is a risk factor for suicidal ideation (SI). SI still poorly investigated in caregivers of people with epilepsy (PWE). Aim: We aimed to analyze the prevalence and predictors of SI in adults PWE and caregivers. Methods: We analyzed 548 consecutive PWE (60% women; median age 41 [18-83]) and 191 caregivers (72% women; median age 47 [18-82]) followed at Outpatients’ epilepsy clinics from a tertiary center. We used “item nine” (item scores ≥1) of the BDI-II to determine the SI presence. The presence of symptoms of anxiety (with BAI) and depression (with BDI-II) was defined with scores ≥14 (for both PWE and caregivers). The presence of anti-seizure drugs (ASDs) adverse effects was defined with the “Liverpool Adverse Events Profile” score≥46. Epidemiological factors and anxiety were investigated as predictors of SI in caregivers and PWE (along with seizure frequency, epilepsy-type, and ASDs’ adverse events). Results: Depression was present in 41% of the PWE and 32% of the caregivers (p=0.04). Anxiety was observed in 37% of PWE and 33% of caregivers (p=0.32). The SI frequency was higher in PWE (19%) compared to the caregivers (11%; p=0.02). Logistic regression analyses were performed for both groups separately. For the PWE (model accounted for 17%-27%), the most significant predictors were anxiety (OR 4.4, p<0.001), presence of ASDs’ adverse effects (OR 2, p=0.021), recurrent seizures (OR 3, p<0.004), and younger age (OR 0.98, p<0.037). For the caregivers (model accounted for 18-37%), only anxiety (OR 43, p<0.001) predicted SI. Conclusion: Identifying SI predictors is equally necessary for PWE and caregivers.

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