scholarly journals The natural history of community-acquired common colds symptoms assessed over 4-years

2015 ◽  
Vol 53 (1) ◽  
pp. 81-88
Author(s):  
Theodore J. Witek ◽  
David L. Ramsey ◽  
Andrew N. Carr ◽  
Donald K. Riker
Keyword(s):  
Sore Throat ◽  
Common Cold ◽  
Nasal Congestion ◽  
Runny Nose ◽  
Symptom Evaluation ◽  
Symptom Frequency ◽  
Bothersome Symptom ◽  
History Of ◽  
The Common ◽  
Pain Symptoms

Background: The common cold is the most frequently experienced infection among humans, but limited data exist to characterize the onset, duration, severity and intersection of symptoms in community-acquired colds. A more complete understanding of the symptom frequency and burden in naturally occurring colds is needed. Methodology: We characterized common cold symptoms from 226 cold episodes experienced by 104 male or female subjects. Subjects were enrolled in the work environment in an attempt to start symptom evaluation (frequency and severity) at the earliest sign of their cold. We also assessed the symptom that had the greatest impact on the subject by asking them to identify their single most bothersome symptom. Results: Symptom reporting started within 24 hours of cold onset for most subjects. Sore throat was a harbinger of the illness but was accompanied by multiple symptoms, including nasal congestion, runny nose and headache. Cough was not usually the most frequent symptom, but was present throughout the cold, becoming most bothersome later in the cold. Nasal congestion, pain (eg, sore throat, headache, muscle pains) or feverishness and secretory symptoms (eg, runny nose, sneezing), and even cough, were simultaneously experienced with high incidence over the first 4 days of illness. The single most bothersome symptom was sore throat on day 1, followed by nasal congestion on days 2-5 and cough on days 6 and 7. Conclusion: There is substantial overlap in the appearance of common cold symptoms over the first several days of the common cold. Nasal congestion, secretory and pain symptoms frequently occur together, with cough being somewhat less prominent, but quite bothersome when present. These data establish the typical symptomatology of a common cold and provide a foundation for the rational treatment of cold symptoms typically experienced by cold sufferers.

scholarly journals Clinical Analysis of 9 Cases of Neonatal Influenza A

2021 ◽  
Author(s):  
Yanlan Zhang ◽  
Lin Xu ◽  
Caiying Wang ◽  
Lin Pang
Keyword(s):  
Influenza A ◽  
Nasal Congestion ◽  
Antiviral Treatment ◽  
Clinical Analysis ◽  
Runny Nose ◽  
Reactive Protein ◽  
Cell Counts ◽  
History Of ◽  
White Blood Cell Counts ◽  
Medical University

Abstract Background: The population is generally susceptible to influenza A, while neonatal cases are relatively rare. The study aims to explore the clinical characteristics, diagnosis, treatment, and prognosis of neonates with influenza A.Methods: The clinical data from neonates with influenza A who were treated in the neonatal department of Beijing Ditan Hospital affiliated with Capital Medical University from November 2017 to January 2019 were retrospectively analyzed.Results: A total of 9 neonates with influenza A were admitted and treated, with a distribution of 7 males and 2 females. The onset was 1.44 ± 1.46 days (mean ± SD), and age at diagnosis was 21.44 ±6. 53 days. All cases had a history of exposure to febrile patients, The main symptoms are fever, nasal congestion, runny nose, sneezing, coughing, other respiratory symptoms and digestive symptoms such as vomiting milk, choking milk, less milk, diarrhea. Laboratory tests showed 7 cases of decreased white blood cell counts, 3 cases of increased plasma C-reactive protein concentrations. All cases were administered antiviral therapy on the day of admission. Eight neonates reverted to a normal temperature within 48 hours after hospitalization, one neonate’s temperature returned to normal after 48 hours of hospitalization, and all cases' symptoms gradually improved.Conclusion: The symptoms of influenza A in neonates are atypical, once a diagnosis is confirmed, the prognosis is likely to be favorable as long as antiviral treatment with antiviral is initiated as soon as possible.

scholarly journals Distinguishing between COVID-19 and the common cold in a primary care setting - comparison of patients with positive and negative SARS-CoV-2 PCR results

2020 ◽  
Author(s):  
Johannes Just ◽  
Marie-Therese Puth ◽  
Felix Regenold ◽  
Klaus Weckbecker ◽  
Markus Bleckwenn
Keyword(s):  
Primary Care ◽  
Sore Throat ◽  
Common Cold ◽  
First Grade ◽  
Infected Person ◽  
Cross Sectional ◽  
Policy Makers ◽  
Primary Care Patients ◽  
The Common ◽  
Predictive Risk

BackgroundCombating the COVID-19 pandemic is a major challenge for health systems, citizens and policy makers worldwide. Early detection of affected patients within the huge population of patients with common cold symptoms is an important element of this effort but often hindered by limited testing resources. We aimed to identify predictive risk profiles for a positive PCR result in primary care.MethodsMulti-center cross-sectional cohort study on predictive characteristics over a period of 4 weeks in primary care patients in Germany. We evaluated age, sex, reason for testing, risk factors, symptoms, and expected PCR result for their impact on the test 46 result.ResultsIn total, 374 patients in 14 primary care centers received SARS-CoV-2 PCR swab testing and were included in this analysis. A fraction of 10.7% (n=40) tested positive for COVID-19. Patients who reported anosmia had a higher odds ratio (OR: 4.54; 95%-CI: 1.51–13.67) for a positive test result while patients with a sore throat had a lower OR (OR: 0.33; 95%-CI: 0.11–0.97). Patients who had a first grade contact with an infected persons and showed symptoms themselves also had an increased OR for positive testing (OR: 5.16; 95% CI: 1.72–15.51). This correlation was also present when they themselves were still asymptomatic (OR: 12.55; 95% CI: 3.97–39.67).ConclusionThe reported contact to an infected person is the most important factor for a positive PCR result, independent of any symptoms of illness in the tested patient. Those persons with contact to an infected person should always get a PCR test. If no contact is reported and testing material is scarce, anosmia should increase the likelihood of performing a test, while a sore throat should decrease it.

A short history of the common cold

Commond Cold ◽  
2009 ◽  
pp. 1-21 ◽  
Author(s):  
Isabel Atzl ◽  
Roland Helms
Keyword(s):  
Common Cold ◽  
Short History ◽  
History Of ◽  
The Common

scholarly journals Análise da Revisão Cochrane: Antihistamínicos para a Constipação. Cochrane Database Syst Rev. 2015;11:CD009345.

2016 ◽  
Vol 29 (3) ◽  
pp. 164
Author(s):  
Carmel Sterrantino ◽  
Gonçalo Duarte ◽  
João Costa ◽  
António Vaz-Carneiro
Keyword(s):  
Beneficial Effect ◽  
Common Cold ◽  
Randomized Clinical Trials ◽  
Nasal Congestion ◽  
Cochrane Review ◽  
Adult Patients ◽  
Upper Airways ◽  
Runny Nose ◽  
Increased Risk ◽  
The Individual

The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component.

THE NATURAL HISTORY OF THE COMMON COLD

The Lancet ◽  
1949 ◽  
Vol 253 (6541) ◽  
pp. 71-75 ◽  
Author(s):  
C.H. Andrewes
Keyword(s):  
Natural History ◽  
Common Cold ◽  
History Of ◽  
The Common

scholarly journals Otolaryngology-Specific Symptoms May Be Highly Observed in Patients With a History of Covid-19 Infection After Inactivated Coronavirus Vaccination

2021 ◽  
pp. 014556132110284
Author(s):  
Hakan Avcı ◽  
Burak Karabulut ◽  
Hazal Duygu Eken ◽  
Abdussamet Faraşoğlu ◽  
Tolga Çakil ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sore Throat ◽  
Health Care Workers ◽  
Nasal Congestion ◽  
Care Workers ◽  
History Of ◽  
Study Population ◽  
The Mean ◽  
Specific Symptoms ◽  
Smell Loss

Objective: To evaluate the otolaryngology-specific symptoms that occur after receiving the Covid-19 vaccine and its possible side effects in patients who had Covid-19 infection in the last 6 months before the vaccination. Patients and Methods: The study comprised 3383 health care workers who were vaccinated against Covid 19. After excluding, the study was conducted with 1710 (51%) participants who agreed to answer the study questions. The participants were divided into 2 groups according to the history of Covid-19 positivity in the last 6 months before vaccination. The presence of symptoms related to otolaryngology practice, including cough, nasal congestion, rhinorrhea, sore throat, hearing loss, dizziness, loss of smell, loss of taste, ear pressure, and facial paralysis was recorded. Results: The mean age of the study population was 35.79 ± 10.2 (19-71) years and 1454 (85%) of the patients had a history of Covid-19 infection in the last 6 months. Regarding otolaryngology-related symptoms, the most common complaints were rhinorrhea (4.4%), sore throat (3.2%), and nasal congestion (2.9%). The presence of smell and taste loss, nasal congestion, rhinorrhea, sore throat, and hearing loss was significantly more common in patients with a history of Covid-19 infection. Conclusions: The patients with a history of Covid-19 disease might have otolaryngology-specific symptoms more commonly than those without a history of Covid-19 disease in the last 6 months before vaccination.

scholarly journals Pseudoephedrine—Benefits and Risks

2021 ◽  
Vol 22 (10) ◽  
pp. 5146
Author(s):  
Krystyna Głowacka ◽  
Anna Wiela-Hojeńska
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Common Cold ◽  
Structural Similarity ◽  
Doping Agent ◽  
History Of ◽  
The Common ◽  
Legal Restrictions ◽  
Cns Stimulant

Pseudoephedrine (PSE) is a drug with a long history of medical use; it is helpful in treating symptoms of the common cold and flu, sinusitis, asthma, and bronchitis. Due to its central nervous system (CNS) stimulant properties and structural similarity to amphetamine, it is also used for non-medical purposes. The substance is taken as an appetite reducer, an agent which eliminates drowsiness and fatigue, to improve concentration and as a doping agent. Due to its easier availability, it is sometimes used as a substitute for amphetamine or methamphetamine. Pseudoephedrine is also a substrate (precursor) used in the production of these drugs. Time will tell whether legal restrictions on the sale of this drug will reduce the scale of the problem associated with its misuse.

scholarly journals Otolaryglogical Manifestations of Patients with Confirmed Covid-19 Infection

2021 ◽  
Vol 17 (1) ◽  
pp. 31-34
Author(s):  
Ahmed Abbas Mousa ◽  
Khalid Dahham Radi Al-Assal ◽  
Jawad Abdulkadhum Beden Thuhabat
Keyword(s):  
Sore Throat ◽  
Nasal Congestion ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
Upper Respiratory Tract ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Upper Respiratory ◽  
The Impact

Background: the coronavirus leads to upper respiratory tract-associated manifestations like nasal congestion, sore throat, and smell disorder Objectives: To reveal the impact of COVID-19 pandemic on otolaryngology symptoms using our daily medical practice. Subject and Methods: A cross-sectional study that was carried on in the isolation wards at Al-Kindy and Al-Nu’man Teaching Hospitals during three months from the 1st of Jun. till the end of Aug. 2020. It included 1270 patients who were diagnosed with COVID-19 infection seen in the ENT consultation clinic and admitted to the isolation wards. Results: Otolaryngological manifestations were shown as 15.7% complained of sore throat, the headache was presented in 11%. Non-otolaryngological manifestations were more common than otolaryngological manifestations as fever presented in 63% of cases and cough in 56.1%. Conclusion: Otolaryngological symptoms are not uncommon but less than fever or cough. Otolaryngological manifestation with a history of contact with COVID-19 patients should be considered in the diagnosis.

scholarly journals The emergence of COVID-19 in Indonesia: analysis of predictors of infection and mortality using independent and clustered data approaches

2020 ◽  
Author(s):  
Erlina Burhan ◽  
Ari Fahrial Syam ◽  
Ahmad Jabir Rahyussalim ◽  
Prasenohadi ◽  
Navy G Lolong Wulung ◽  
...  
Keyword(s):  
Sore Throat ◽  
Principal Component ◽  
Hierarchical Cluster ◽  
International Travel ◽  
Risk Of Infection ◽  
Runny Nose ◽  
Increased Risk ◽  
Increase Risk ◽  
History Of ◽  
Univariate Analyses

AbstractBackgroundAnalyses of correlates of SARS-CoV-2 infection or mortality have usually assessed individual predictors. This study aimed to determine if patterns of combined predictors may better identify risk of infection and mortalityMethodsFor the period of March 2nd to 10th 2020, the first 9 days of the COVID-19 pandemic in Indonesia, we selected all 18 confirmed cases, of which 6 died, and all 60 suspected cases, of which 1 died; and 28 putatively negative patients with pneumonia and no travel history. We recorded data for travel, contact history, symptoms, haematology, comorbidities, and chest x-ray. Hierarchical cluster analyses (HCA) and principal component analyses (PCA) identified cluster and covariance patterns for symptoms or haematology which were analysed with other predictors of infection or mortality using logistic regression.ResultsFor univariate analyses, no significant association with infection was seen for fever, cough, dyspnoea, headache, runny nose, sore throat, gastrointestinal complaints (GIC), or haematology. A PCA symptom component for fever, cough, and GIC tended to increase risk of infection (OR 3.41; 95% CI 1.06-14; p=0.06), and a haematology component with elevated monocytes decreased risk (OR 0.26; 0.07-0.79; 0.027). Multivariate analysis revealed that an HCA cluster of 3-5 symptoms, typically fever, cough, headache, runny nose, sore throat but little dyspnoea and no GIC tended to reduce risk (aOR 0.048; <0.001–0.52; 0.056). In univariate analyses for death, an HCA cluster of cough, fever and dyspnoea had increased risk (OR 5.75; 1.06 − 31.3, 0.043), but no other individual predictor, cluster or component was associated. Other significant predictors of infection were age ≥ 45, international travel, contact with COVID-19 patient, and pneumonia. Diabetes and history of contact were associated with higher mortality.ConclusionsCluster groups and co-variance patterns may be stronger correlates of SARS-CoV-2 infection than individual predictors. Comorbidities may warrant careful attention as would COVID-19 exposure levels.

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