Frequency of Low Vitamin D3 Levels in Subjects with Parkinson’s Disease. A Study Conducted at PMCH, a Tertiary Care Hospital, Nawabshah

Objectives. To determine the frequency of depression in patients with idiopathic parkinsonism presenting to a tertiary care Hospital in Karachi. Material and methods. This case study was conducted at the neurology department Jinnah Postgraduate Medical Centre, Karachi (JPMC). The duration of the study was six months from 22nd January 2019 to 2nd June 2019. A total of 114 patients of parkinsonism (idiopathic Parkinson’s disease) were included in this study. Patients were assured of confidentiality. They were given questionnaire with Beck depression inventory while waiting in the neurology outpatient clinic. Questionnaire was taken back after 25 minutes. Patient score more than 9 was diagnosed as depression. The identified depressed patient was offered treatment. Results. Frequency of depression in patients with idiopathic Parkinson’s disease was observed in 48.25% (55/114) cases. Conclusions. It is concluded that our study indicates the burden of depression in Parkinson disease (PD) patients. However, even with stable or mild deficit in motor function, the wide prevalence of depression indicates that it should be suspected and treated. Over the past several years, systematic studies of depression and its treatment have contributed significantly to this most challenging psychiatric problem in PD. Hence, there is a need of policy for screening and prompt treatment of such patients so they could lead to enhance quality of life.

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A clinico-epidemiological profile of Parkinson’s disease patients attending the tertiary care hospital of hilly state of North India: a hospital based cross-sectional study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213088 ◽

2021 ◽

Vol 9 (8) ◽

pp. 2397

Author(s):

Amethyst Bamon ◽

Rajiv Raina ◽

Sudhir Sharma ◽

Nidhi Chauhan

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Tertiary Care Hospital ◽

Neurodegenerative Disorder ◽

Tertiary Care ◽

Cross Sectional Study ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Epidemiological Profile

Background: Parkinson's disease (PD) is a neurodegenerative disorder, with male preponderance. It is associated with both motor and non-motor symptoms, which affect quality of life in elderly people. Due to paucity of studies on its epidemiology and prevalence, this disease needs assiduity and further exploration.Methods: A hospital based cross-sectional study was conducted in the tertiary care hospital, among 45 patients diagnosed with PD.Results: The mean age of the participants was 61.17±12.30 years, with male to female ratio was 2:1. The average age of onset of PD was 57.4±12.30 years. Tremor was the most common initial symptom (68.88%) followed by rigidity (20%) and bradykinesia. Most of the patients (86.66%) had progressive symptoms, and 69% had unilateral involvement of limbs.Conclusions: The profile of patients with PD in Himachal Pradesh is similar to that from other populations in India and other developing countries. However, the dearth of studies and data pertaining to PD, invigorate the need to explore this neurodegenerative disorder to comprehend its clinic-epidemiological profile in our state.

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Socio-demographic Characteristics of Parkinson’s Disease Patients attended at a Tertiary Care Hospital in Dhaka City

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v6i2.42982 ◽

2019 ◽

Vol 6 (2) ◽

pp. 106-110

Author(s):

Md Enayet Ul Islam ◽

Afzal Momin ◽

Farzana Sharmin ◽

Provat Kumar Sarkar ◽

Md Azharul Hoque

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Demographic Characteristics ◽

Care Hospital ◽

Dhaka City ◽

Female Ratio ◽

Medical College ◽

Patient Department

Background: Parkinson’s disease occurs in different socio-demographic characteristic people. Objective: The Purpose of the present study was to see the socio-demographic characteristics of Parkinson’s disease patients attended at a tertiary care hospital in Dhaka city. Methodology: This cross-sectional study was carried out in the in-patient and out-patient Department of Medicine and Neurology of Sir Salimullah Medical College and Mitford Hospital, Dhaka from July 2012 to December 2013 for a period of one and half year. All patients with Parkinson’s disease who were admitted under department of Medicine and Neurology and also who visited out-patient department of Medicine and Neurology of Sir Salimullah Medical College and Mitford Hospital, Dhaka were taken as study population. Patients who were diagnosed as Parkinson’s disease according to Brain Bank clinical criteria for diagnosis of Parkinson’s disease were included in this study. The demographic and socio-economic characteristics were recorded in a semi-structured questionnaire. Result: A total number of 40 Parkinson’s patients were recruited for this study. The mean age was 69.15±10.08 years. The male female ratio was found 1.22:1. The majority patients were businessman which was 13(32.5%) cases. The majority of 15(37.5%) patients came from rural area. However, 12(30.0%) patients were in primary level. Furthermore, 21(52.5%) patients came from lower class. Conclusion: In conclusion elder male rural dwellers are mostly suffering from Parkinson’s disease Journal of Current and Advance Medical Research 2019;6(2):106-110

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Prevalence of Depression in Patients of Parkinson’s Disease Presenting to a Tertiary Care Hospital at Karachi

Journal of Neurology & Stroke ◽

10.15406/jnsk.2016.04.00138 ◽

2016 ◽

Vol 4 (4) ◽

Author(s):

Haresh Kumar

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Prevalence Of Depression

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Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v44i1.36799 ◽

2018 ◽

Vol 44 (1) ◽

pp. 9-14

Author(s):

Mohammad Ibrahim Khalil ◽

Md Ridwanur Rahman ◽

Serajoom Munira ◽

Mohmood Uz Jahan

Keyword(s):

Risk Factors ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Depressive Disorder ◽

Sleep Disturbance ◽

Brain Mri ◽

Univariate Analysis ◽

Tertiary Care ◽

Significant Proportion ◽

Care Hospital

Depression in idiopathic Parkinson’s disease is highly prevalent that can significantly impair the quality of life. Its exact mechanism of development is still poorly understood. It is well studied in western population but data from Asia especially in the South Asian region is limited. Considering this, to identify the potential risk factors of depression,a cross-sectional study was conducted among Parkinson’s disease patients attending a tertiary care hospital in Bangladesh between July 2013-June 2014, in the Department of Neurology, ShaheedSuhrawardy Medical College and Hospital in Dhaka, Bangladesh. One hundred thirtyseven cases of Parkinson’s disease were enrolled, based on UK Parkinson's Disease Society Brain Bank criteria. Brain MRI was done in all cases, and patients with aphasia, significant cognitive deficits, secondary Parkinsonism were excluded. The overall prevalence of depression in the study population was 42%. There were no significant differences in gender, residence, education, smoking and marital status. In univariate analysis, age≥70 years, un-employed, right side predominantly involved, disease duration ≥5 years, sleep disturbance, postural instability, dose of levodopa ≥500 mg/day, Hoehn and Yahrstage ≥III and moderate to severe disability were significantly associated with depressive disorder. Whereas in multivariate linear stepwise regression model, age ≥70 years), p=0.044), right side predominant involvement (p<0.001); sleep disturbance (p=0.006) and dose of levodopa ≥500 mg/day (p<0.001) were the major risk factors for depressive disorder. A significant proportion of Parkinson’s disease patients suffer from depression. It was identified that depression in Parkinson’s disease was significantly associated with advancing age, predominate right side involvement, sleep disturbance and higher daily dose of levodopa.Bangladesh Med Res Counc Bull 2018; 44(1):9-14

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Study of Role of Vitamin D3 Supplementation in Patients Suffering from Dry Eye Syndrome (DES) Attending in Tertiary Care Hospital, at S.K.M.C.H. Muzaffarpur, Bihar

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i11.13 ◽

2019 ◽

Vol 7 (11) ◽

Author(s):

Dr Rajiv Kumar Singh ◽

Keyword(s):

Dry Eye ◽

Vitamin D3 ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Dry Eye Syndrome ◽

Care Hospital ◽

Vitamin D3 Supplementation

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Demographic and Non-Motor Clinical Profiles of Parkinson’s Disease Patients attended at a Tertiary Care Hospital in Bangladesh

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v4i2.38927 ◽

2018 ◽

Vol 4 (2) ◽

pp. 123-128

Author(s):

Md Mahmudur Rahman ◽

Md Tauhidul Islam Chowdhury ◽

Mohammad Selim Shahi ◽

Md Jalal Uddin

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Sleep Disorder ◽

Psychiatric Symptoms ◽

Tertiary Care ◽

Care Hospital ◽

Elderly Male ◽

Excessive Sweating ◽

Oral Dryness ◽

Clinical Profiles

Background: Parkinson’s disease can be presented as non-motor clinical features.Objective: The purpose of the present study was to observe the demographic and non-motor clinical profiles of Parkinson’s disease patients.Methodology: This descriptive cross-sectional study was carried out in the Department of Neurology at Mymensingh Medical College, Mymensingh, Bangladesh from January 2009 to December 2010 for a period of two(02) years. PD patient presents with both motor and non-motor symptoms. NMS has variable presentations like sensory, autonomic, psychiatric and sleep disorder. Parkinson’s disease patients were diagnosed clinically. Each patient was assessed by a standard questionnaire, including sensory, autonomic, psychiatric and sleep disorder symptoms.Result: A total number of51 Parkinson’s disease patients were recruited for this study. Mean (±SD) age of male and female were 57.51±7.1 years and 60.00±10.2 years. Out of the 51 patients, 58.8% patients had sensory, 72.5% patients had autonomic, 47.1% patients had neuro-psychiatric and 66.7% patients had sleep disturbance symptoms. The most frequent sensory symptoms were akathisia 47.1%, diffuse pain 37.3%,and tightening sensation 27.5%. The most frequent autonomic symptoms were excessive sweating 54.9%, palpitation 35.3%, oral dryness 33.3%. The most frequentneuro-psychiatric symptoms were fatigue 56.8%, anxiety 45.1%, and depression 23.5%. The most frequent sleep disorders were insomnia 54.9%, day time sleepiness 11.8% and restless leg syndrome 9.8%.Conclusion: In conclusion elderly male rural people are commonly presented with PD presented with akathisia, diffuse pain, excessive sweating, palpitation, oral dryness, fatigue, anxiety and depressionJournal of National Institute of Neurosciences Bangladesh, 2018;4(2): 123-128

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Prospective, randomized, open label comparative study of efficacy of atorvastatin versus atorvastatin with vitamin D3 in patients with dyslipidemia attending tertiary care hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20213228 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1076

Author(s):

Motakatla Usha Rani ◽

Chitra Karuppiah ◽

Novaladi Kiruthiga ◽

Vivek Rayavarapu

Keyword(s):

Vitamin D ◽

Cardiovascular Diseases ◽

Lipid Profile ◽

Vitamin D3 ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Open Label ◽

Group A ◽

Group B

Background: Cardiovascular diseases are one of the most important group of diseases causing premature mortality and morbidity. Dyslipidemia is an independent risk factor for cardiovascular diseases and is a disorder of lipoprotein metabolism. Various research studies support role of vitamin D against dyslipidemia. Vitamin D concentration positively correlates with HDL cholesterol and negatively with serum LDL and triglyceride levels. Vitamin D supplementation to Atorvastatin appeared to have increased cholesterol lowering activity more than either substance did alone.Methods: The study was conducted in an outpatient department of general medicine for a duration of 12 weeks in a tertiary care hospital. Total of 100 patients with dyslipidemia were selected based on measurement of lipid profile. Out of 100 patients, 50 patients under group A were treated with atorvastatin 10mg and balance 50 patients under group B treated with atorvastatin and Vitamin D3 1000 IU/day orally. Patients were followed up monthly for 3 months and lipid profile was assessed at baseline and at the end of study. The baseline characteristics were similar in both study groups.Results: On comparing groups at the end of 12 weeks mean LDL, triglycerides and VLDL were significantly reduced in group B than group A with p<0.001. The mean HDL level too increased in group B than group A with p<0.001.Conclusions: Fasting plasma lipid profile improvement was higher in the atorvastatin with vitamin D3 group compared to atorvastatin group.

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