Lipid Profile of Coronary Heart Disease Patients: A Prospective Observational Study

Abstract Background This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD). Methods The PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model. Results Twenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels. Conclusions The results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.

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Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.06.672 ◽

2018 ◽

Vol 275 ◽

pp. e215

Author(s):

S. Kutkiene ◽

Z. Petrulioniene ◽

A. Laucevicius ◽

U. Gargalskaite ◽

A. Saulyte ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Lipid Profile ◽

Serum Lipid ◽

Serum Lipid Profile ◽

Middle Aged ◽

History Of

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Lipoprotein particles and size, total and high molecular weight adiponectin, and leptin in relation to incident coronary heart disease among severely obese postmenopausal women: The Women's Health Initiative Observational Study

BBA Clinical ◽

10.1016/j.bbacli.2015.03.005 ◽

2015 ◽

Vol 3 ◽

pp. 243-250 ◽

Cited By ~ 10

Author(s):

Rachel H. Mackey ◽

Kathleen M. McTigue ◽

Yuefang F. Chang ◽

Emma Barinas-Mitchell ◽

Rhobert W. Evans ◽

...

Keyword(s):

Molecular Weight ◽

Coronary Heart Disease ◽

Heart Disease ◽

Observational Study ◽

Postmenopausal Women ◽

High Molecular Weight ◽

High Molecular Weight Adiponectin ◽

Incident Coronary Heart Disease ◽

Health Initiative ◽

Severely Obese

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Age-dependence of the magnitude of lipid profile variables resemblance between first degree relatives in families of patients with early coronary heart disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.07.245 ◽

2016 ◽

Vol 252 ◽

pp. e4

Author(s):

M. Konnov ◽

A. Deev ◽

N. Gratsiansky

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Lipid Profile ◽

Age Dependence ◽

First Degree Relatives

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Lipid profile in patients with alcohol dependence syndrome

Annals of Clinical Chemistry and Laboratory Medicine ◽

10.3126/acclm.v1i1.12312 ◽

2015 ◽

Vol 1 (1) ◽

pp. 29-32

Author(s):

Mithileshwer Raut ◽

Prashant Regmi ◽

Saroj Prasad Ojha ◽

Bharat Jha

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Lipid Metabolism ◽

Alcohol Use ◽

Alcohol Dependence ◽

Lipid Profile ◽

Consumption Pattern ◽

Cholesterol Levels ◽

Alcohol Dependence Syndrome ◽

The Mean

BACKGROUND: Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on lipid metabolism is well recognized. Investigations had been carried out in the earlier period on abnormal lipid profile as a risk factor for Coronary Heart disease (CHD). Patients of alcohol dependence usually have a consumption pattern of more heavy use. Therefore it is useful to study the lipid profile in patients of alcohol dependence, to understand the effects of increasing levels of consumption. METHODS: This cross-sectional study was conducted in TU Teaching Hospital. ADS patients were screened by the consultant psychiatrist using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire. A total of 89 patients scored positive on the AUDIT as having alcohol-related problems and were included in the study. 89 ADS patients and 89 healthy controls both male and female were enrolled as participants. Blood Pressure and other anthropometric parameters were measured while fasting blood samples were analyzed for serum lipid profile. SPSS program was used to analyze data, t-test & Spearman's correlation coefficient was used to find correlation. RESULTS: Among the ADS cases 95% were current smokers. Mean age of cases and controls was 35.42±5.6 & 34.53±3.5 years respectively. The mean total cholesterol levels were found to be higher in cases (5.41±0.70) than controls (3.79±0.74) with a strong statistical significance (p<0.001). Also, Mean triglyceride (TG) levels (2.09±0.72), along with the mean HDL-cholesterol (1.66±0.40) and LDL-cholesterol levels (2.79±0.81) were also elevated in cases when compared to the control samples (p<0.001). CONCLUSION: This study has demonstrated definitive lipid profile changes in patients of alcohol dependence, with some correlation to the liver dysfunction. Alcohol causes alteration in various parameters of lipid metabolism including those which predispose to CHD. Low to moderate alcohol use over prolonged periods has been linked to have protective influence for development of coronary heart disease (CHD), through increase in high density lipoprotein cholesterol (HDL-C) levels. DOI: http://dx.doi.org/10.3126/acclm.v1i1.12312 Ann. Clin. Chem. & Lab. Med. 1(1) 2015: 29-32

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