Accuracy of Tri-ponderal Mass Index and Body Mass Index in Estimating Insulin Resistance, Hyperlipidemia, Impaired Liver Enzymes or Thyroid Hormone Function and Vitamin D Levels in Children and Adolescents

Introduction: Body weight gain in children and teenagers is one of the major challenges that cause undesirable health outcomes. Simultaneously with the prevalence of overweight and obesity, children and adolescents are diagnosed with 25-hydroxyvitamin D (25(OH)D) deficiency in different sides of the world. The present study aimed to assess 25(OH)D status among Iranian volunteers aged 1-16 years and find the correlation between 25(OH)D status and body mass index (BMI) subjects. Material and Methods: The total volunteers included 807 Iranian children aged 1 to 16 referred to the general and endocrinology clinics in Babol city, Mazandaran Province. A trained physician determined anthropometric characteristics. Serum levels of calcium (Ca), phosphate (P), creatinine (Cr), urea, thyroxine (T4), thyroid-stimulating hormone (TSH), and 25(OH)D were assessed in all children. Results: 25.27% of the children were 25(OH)D deficient, and 59.1% were insufficient. There was no significant difference in serum 25(OH)D level between girls and boys (P=0.13). A significant negative correlation was found in serum 25(OH)D level with weight (P=0.000, r=-0.12), BMI (P=0.000, r=-0.13), and age (P=0.000, r=-0.13). Conclusion: These data displayed that 25(OH)D insufficiency is highly prevalent among children in the north of Iran. Serum 25(OH)D levels are affected by age and BMI value. Improving vitamin D deficiency helps to maintain the health of children and adolescents during this critical period.

Download Full-text

Vitamin D status and its relation to insulin resistance in a Mexican pediatric population

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0510 ◽

2020 ◽

Vol 33 (4) ◽

pp. 481-486

Author(s):

Yunue Flores Ruelas ◽

Mario Del Toro Equihua ◽

Norma Alejandra Jiménez Solís ◽

Luz Margarita Baltazar Rodríguez ◽

Ivan Delgado Enciso ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Children And Adolescents ◽

Serum Vitamin ◽

World Health ◽

Model Assessment ◽

Inverse Association ◽

Insulin Levels ◽

Vitamin D Levels ◽

The Mean

AbstractBackgroundObesity in children and adolescents has increased alarmingly, placing them at a higher risk for impaired glucose tolerance and type 2 diabetes. The prevalence of vitamin D deficiency has increased as well. Vitamin D is critical for glucose homeostasis and insulin secretion. Studies on adults have reported an inverse association between vitamin D levels and insulin resistance (IR), but the results in children are inconsistent. The aim of our study was to determine the association between IR and serum vitamin D levels in obese Mexican children and adolescents.MethodsA cross-sectional study was performed on 227 children and adolescents between 6 and 19 years of age. Obesity was diagnosed through body mass index (BMI) for age, according to the World Health Organization (WHO) criteria (2007). 25-Hydroxyvitamin D (25[OH]D) was measured using an immunoassay technique and the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the Matthews equation. Student’s t-test was carried out.ResultsThe mean serum 25(OH)D level was 35.80 ng/mL, and 55.1% of the subjects had levels classified as sufficient, 33.5% as insufficient, and 11.5% as deficient. The mean level of HOMA-IR was 3.16, and 70% of the subjects were diagnosed with IR. Fasting insulin levels and HOMA-IR were significantly different in adolescents with hypovitaminosis, compared with adolescents in the vitamin D sufficiency group (p = 0.01 and p = 0.03, respectively).ConclusionsThe insulin levels and HOMA-IR were higher in adolescents with hypovitaminosis. The girls presented higher levels of insulin and HOMA-IR than the boys.

Download Full-text

Asthma control status in pregnancy, body mass index, and maternal vitamin D levels

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2017.03.053 ◽

2017 ◽

Vol 140 (5) ◽

pp. 1453-1456.e7 ◽

Cited By ~ 10

Author(s):

Hooman Mirzakhani ◽

George O'Connor ◽

Leonard B. Bacharier ◽

Robert S. Zeiger ◽

Michael X. Schatz ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Asthma Control ◽

Body Mass ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

In Pregnancy

Download Full-text

Body mass index determines sunbathing habits: implications on vitamin D levels

Internal Medicine Journal ◽

10.1111/j.1445-5994.2009.01900.x ◽

2009 ◽

Vol 39 (4) ◽

pp. 256-258 ◽

Cited By ~ 66

Author(s):

M. Kull ◽

R. Kallikorm ◽

M. Lember

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Vitamin D Levels

Download Full-text

Bone mineral density, vitamin D levels, body mass index and exocrine pancreatic function in patients with chronic pancreatitis

Pancreatology ◽

10.1016/j.pan.2017.08.015 ◽

2017 ◽

Vol 17 (5) ◽

pp. S2

Author(s):

A.D. Polanco Jiménez ◽

A. López Serrano ◽

P. Latorre Año ◽

A. Pascual Romero ◽

M.J. Suárez Dávalos ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Vitamin D ◽

Chronic Pancreatitis ◽

Body Mass ◽

Bone Mineral ◽

Exocrine Pancreatic Function ◽

Pancreatic Function ◽

Mineral Density ◽

Vitamin D Levels

Download Full-text

Correlation of Vitamin D and Body Mass Index in Term Normotensive and Pre -Eclamptic Women

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v3i4.24263 ◽

2015 ◽

Vol 3 (4) ◽

pp. 21-25

Author(s):

Taru Gupta ◽

Nupur Gupta ◽

Leena Wadhwa ◽

Sarika Arora ◽

Jyoti Bagla ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Serum Alkaline Phosphatase ◽

Vitamin D Supplementation ◽

Control Group ◽

Maternal Body Mass Index ◽

Study Group ◽

Percentage Body Fat ◽

Vitamin D Levels

INTRODUCTION: Obesity is associated with alteration in the vitamin D levels and has been related to vitamin D status. Lower vitamin D levels in higher BMI individuals may be secondary to an alteration in tissue distribution resulting from an increase in adipose mass. Therefore women with higher BMI need higher vitamin D supplementation as compared to women with BMI within normal range. MATERIAL AND METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each). Control group had women with singleton uncomplicated term normotensive pregnant women in labour while the study group comprised of term preeclamptic women in labour.In all the patients their BMI was analysed .Blood samples for vitamin D, serum calcium, serum phosphorus, serum parathormone, serum alkaline phosphatase levels were drawn and subsequently their levels were evaluated in cord blood; correlation studied between vitamin D & BMI. RESULTS: The mean BMI was relatively higher in the study group (26.34 ± 4.12)kg/m2 than in the control group ( 24.24 ± 3.13)kg/m2. Thus in our study a prevalence of higher BMI was seen in patients of preeclampsia. When all the 100 women are being considered, median vitamin D levels were found to be higher (6.6ng/ml) in normal BMI patients (n=55) as compared to levels (5.6ng/ml) in patients with higher BMI(n=45). CONCLUSION: Vitamin D levels are related to maternal body mass index. Individuals with higher percentage body fat may require higher vitamin D intake to attain optimal 25(OH) D levels, compared with lean individuals and thereby may prevent pregnancy complications like Pre eclampsia.

Download Full-text

Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

10.53350/pjmhs211561231 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1231-1233

Author(s):

A. W. Khan ◽

H. T. Hussain ◽

Z.U. Mustafa ◽

M. A. Qamar ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Body Mass ◽

Morbidity And Mortality ◽

P Value ◽

Mortality And Morbidity ◽

Severe Vitamin ◽

Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

Download Full-text