scholarly journals Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

2011 ◽  
Vol 2 (6) ◽  
pp. 93 ◽  
Author(s):  
Tsutomu Nishida
Keyword(s):  
Treatment Strategy ◽  
Intraepithelial Neoplasia ◽  
Endoscopic Biopsy ◽  
Non Invasive

scholarly journals Comparative analysis of differences between preoperative endoscopic biopsy and postoperative pathological examination for diagnosis of gastric intraepithelial neoplasia

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199492
Author(s):  
Yangqing Wu ◽  
Jianzhong Sang ◽  
Jianbo Zhou ◽  
Ying Fang
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Intraepithelial Neoplasia ◽  
Endoscopic Biopsy ◽  
Pathological Examination ◽  
Low Grade ◽  
High Grade ◽  
Original Diagnosis ◽  
Submucosal Dissection ◽  
Low Grade Dysplasia ◽  
Pathological Tissues

Objective This study was performed to compare the differences between preoperative endoscopic biopsy (PEB) and postoperative pathological examination (PPE) for diagnosis of gastric intraepithelial neoplasia (GIN). Methods From September 2016 to July 2019, 188 consecutive patients with GIN at Yuyao People’s Hospital were retrospectively analyzed. The 188 patients had 218 GIN lesions. All patients underwent PEB and either endoscopic submucosal dissection or surgical treatment. PPE was performed on pathological tissues that had been surgically removed. Results Among 138 cases of low-grade dysplasia (LGD) diagnosed by PEB, 46 were upgraded to high-grade dysplasia (HGD), 20 were upgraded to early gastric cancer (EGC), and 2 were downgraded to inflammation after PPE. Among 42 cases of HGD, 23 were upgraded to EGC, 2 were downgraded to LGD, and 2 were downgraded to inflammation after PPE. Among 38 cases of EGC, 1 was downgraded to HGD and 2 were downgraded to LGD after PPE. The original diagnosis was maintained after the operation in 120 cases of GIN. Conclusion Biopsy did not fully reflect the lesions of GIN. Biopsy review should be actively performed, and the lesions should be clarified by endoscopic submucosal dissection or surgery.

scholarly journals Focused Ultrasound Surgery Applications in Treating Vulvar Non-neoplastic Epithelial Disorders

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Felix Wu Shun Wong ◽  
Chengzhi Li
Keyword(s):  
Skin Lesion ◽  
Alternative Treatment ◽  
Focused Ultrasound ◽  
Intraepithelial Neoplasia ◽  
Vulvar Intraepithelial Neoplasia ◽  
Preparation Technique ◽  
Ultrasound Surgery ◽  
Non Invasive ◽  
Focused Ultrasound Surgery ◽  
Surgical Treatments

: Vulvar intraepithelial neoplasia is a premalignant skin lesion of the vulva that often presents with severe vulvar pruritus, pain, and psychosexual disorders. The technology of non-invasive focused ultrasound surgery has improved over the years. Today its potential to treat these irritating diseases noninvasively is a relatively new area of clinical research interest. Increasing studies in China revealed that FUS treatment is effective and safe. This paper describes the preparation, technique, postoperative care, and results of this focused ultrasound surgery for treating vulvar non-neoplastic epithelial disease. Therefore it could be a future alternative treatment for benign vulvar diseases, replacing many invasive surgical treatments.

scholarly journals The diagnostic accuracy of conventional forceps biopsy compared to ESD

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 261-265
Author(s):  
Shimin Wu ◽  
Xinjian Zhu ◽  
Lijuan Xiang ◽  
Jianqiang Chen ◽  
Chunxiao Chen
Keyword(s):  
Diagnostic Accuracy ◽  
Endoscopic Submucosal Dissection ◽  
Active Treatment ◽  
Intraepithelial Neoplasia ◽  
Endoscopic Biopsy ◽  
Low Grade ◽  
High Grade ◽  
Forceps Biopsy ◽  
Gastric Epithelial Neoplasia ◽  
Treatment Measures

AbstractObjectiveconventional forceps biopsy (CFB) is the most popular way to screen for gastric epithelial neoplasia (GEN). Our study aimed to compare the diagnostic accuracy between conventional forceps biopsy and endoscopic submucosal dissection (ESD).Methods105 patients diagnosed GEN finally undertook ESD in our hospital were enrolled. We retrospectively assessed the characteristics of pathological results of CFB and ESD.ResultsThe overall pathologic concordance rate between the CFB and ESD specimens was 68.57%. 55 cases of CFB maintained low-grade intraepithelial neoplasia (LGIN) under ESD,18 cases (23.1%) diagnosis for high-grade intraepithelial neoplasia (HGIN), 5 cases (6.4%) diagnosis for cancer. Moreover, 10 cases of CFB maintained HGIN under ESD. Lesions with surface hyperemia (44.4% vs. 27.54%) or surface ulcer (57.14% vs.26.76%) were more likely to cancerate (P<0.05).Conclusionendoscopic biopsy in the diagnosis of low-grade intraepithelial neoplasia, may exist or progression to high-grade intraepithelial neoplasia, some may have cancer, should take active treatment measures.

scholarly journals Diagnosis of the pancreatic cancer

2021 ◽  
Vol 11 (9) ◽  
pp. 67-73
Author(s):  
Przemysław Raczkiewicz ◽  
Maria Kalicka ◽  
Tomasz Korzec ◽  
Konrad Kania ◽  
Katarzyna Cyboran
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Cyst ◽  
Precancerous Lesions ◽  
Gene Mutations ◽  
Intraepithelial Neoplasia ◽  
Key Words Pancreatic Cancer ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Cystic Neoplasms ◽  
Non Invasive ◽  
Mucinous Neoplasms

Introduction: The pancreatic cancer arises from non-invasive precursor lesions and develops through the accumulation of characteristic gene mutations. The recent scientific reports based on genetic tests state that the approximate time between cancerous initiation and the development of cancer with metastasisis15 years. We candistinguish three main precancerous lesions leading to the pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). The imaging tests used for the diagnostics and observation of precancerous pancreas lesions are MR, MRC, CT and EUS. Method: review of the recent literature based on PubMEd, Google scholar research based onthe following key words: pancreatic cancer, precancer of the pancreas, pancreatic cyst, tuber of the pancreas, medical imaging of the pancreasPurpose of the work: systematizing information about precancers of the pancreatic cancer based on the latest research and findings

Bacteria-induced nasal necrosis with negative cultures

2020 ◽  
Vol 13 (8) ◽  
pp. e235778
Author(s):  
Ashwini Milind Tilak ◽  
Jessica Bishop ◽  
Harishanker Jeyarajan ◽  
Jessica Grayson
Keyword(s):  
Staphylococcus Epidermidis ◽  
Acute Inflammation ◽  
Squamous Epithelium ◽  
Inferior Turbinate ◽  
Endoscopic Biopsy ◽  
Surrounding Tissue ◽  
Non Invasive ◽  
Initial Culture ◽  
History Of ◽  
A Current

A 79-year-old man with liver failure, hypertension and hyperlipidemia presented with a 1.5-month history of progressive nasal crusting and pain on the inside of the nose, advancing into a necrotic columella and philtrum. On rigid endoscopy, debris extended to middle and inferior turbinate to midway posteriorly. Initial culture swabs and CT were negative. The patient underwent endoscopic biopsy of the lesion, with histopathological findings revealing abundant acute inflammation and minute fragments of atypical squamous epithelium, favouring reactive atypia. Non-invasive fungal hyphae were identified. Bacterial cultures revealed Staphylococcus epidermidis, Corynebacterium accolens, Curvularia species and Pseudomonas putida. A current literature search failed to find other published cases of P. putida nasal infections. P. putida is generally difficult to isolate on swab culture as the surrounding tissue is necrosed; this case highlights the importance of reconsidering bacterial infection and obtaining a tissue biopsy in the case of non-healing necrotic-appearing tissue with negative culture swab and CT without evidence of mass.

scholarly journals Safety and Ethics in Endoscopic Studies in Children: Evidence From the BEECH Study in Zambia

2020 ◽  
Author(s):  
Kanta Chandwe ◽  
Beatrice Amadi ◽  
Miyoba Chipunza ◽  
Masuzyo Zyambo ◽  
Paul Kelly
Keyword(s):  
Clinical Benefit ◽  
Endoscopic Biopsy ◽  
Intestinal Biopsy ◽  
Upper Gastrointestinal Endoscopy ◽  
Serious Adverse Events ◽  
Nutritional Interventions ◽  
Non Invasive ◽  
Environmental Enteropathy ◽  
Life Saving ◽  
And Function

Abstract Background Environmental enteropathy is an example of a poorly-understood intestinal disorder affecting millions of children worldwide, characterized by malabsorption and stunting. Although there is increasing interest in non-invasive means of assessing intestinal structure and function, the potential value of intestinal biopsy for histology, immunostaining, RNA sequencing and epigenetic work means that endoscopic biopsy remains extremely valuable. We here report our experience in the BEECH (Biomarkers of Environmental Enteropathy in CHildren) study of stunting in Zambia, in the belief that it may help address the knowledge gap regarding the safety of endoscopic biopsy in vulnerable young children. Methods We report our experience of safety in 119 children undergoing endoscopic biopsy in the BEECH study in Lusaka Children’s Hospital, Lusaka, and discuss ethical considerations in this light. Results Upper gastrointestinal endoscopy was performed on children with stunting (length-for-age z score -2 or less) not responsive to nutritional interventions. Conscious sedation was provided by anaesthetists. Of 119 children, 5 (4%) developed transient desaturation, but no serious adverse events were experienced; no clinical, demographic or anaesthetic characteristics were identified as predictive of desaturation. Two children derived clinically useful information from the endoscopy, one life-saving. Of 105 lactase tests, 59 (54%) showed hypolactasia. Discussion Children with stunting underwent endoscopy safely, and some derived clinical benefit. Safety and the possibility of clinical benefit are usually felt to be preconditions for the ethical justification for endoscopy for research in children, and we believe that these conditions were met in this study.

scholarly journals Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology

2021 ◽  
Vol 11 (23) ◽  
pp. 11238
Author(s):  
Felix Ruoff ◽  
Melanie Henes ◽  
Markus Templin ◽  
Markus Enderle ◽  
Hans Bösmüller ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Protein Profiling ◽  
Treatment Needs ◽  
Non Invasive ◽  
Minimal Sample ◽  
Cervical Cells ◽  
Tissue Sparing

Non-invasive physical plasma (NIPP) is a novel therapeutic tool, currently being evaluated for the treatment of cancer and precancerous lesions in gynecology and other disciplines. Additionally, patients with cervical intraepithelial neoplasia (CIN) may benefit from NIPP treatment due to its non-invasive, side-effect-free, and tissue-sparing character. However, the molecular impact of in vivo NIPP treatment needs to be further investigated. For this purpose, usually only very small tissue biopsies are available after NIPP treatment. Here, we adapted DigiWest technology, a high-throughput bead-based Western blot, for the analysis of formalin-fixed paraffin-embedded (FFPE) cervical punch biopsies with a minimal sample amount. We investigated the molecular effects of NIPP treatment directly after (0 h) and 24 h after in vivo application. Results were compared to in vitro NIPP-treated human malignant cervical cells. NIPP effects were primarily based on an inhibitory impact on the cell cycle and cell growth factors. DigiWest technology was suitable for detailed protein profiling of small, primary FFPE biopsies.

scholarly journals Case Report: Noninvasive Clinical Intervention of REBACIN® on Histologic Regression of High Grade Cervical Intraepithelial Neoplasia

2021 ◽  
Vol 8 ◽  
Author(s):  
Fan Wang ◽  
Rong Liu ◽  
Yan Ma ◽  
Dai-Fei Wu ◽  
Liu-Hong Deng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Clinical Intervention ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Non Invasive ◽  
Future Fertility ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

High-risk human papillomavirus (hrHPV) persistent infection is the major cause of cervical cancer. Clinical intervention of hrHPV-associated high-grade squamous intraepithelial lesion (HSIL) is critical to prevent cervical cancer, and current treatment is surgery (an invasive therapy). However, some patients refuse to do so for an afraid of potential adverse effects on future fertility or other concerns which creates a critical need for development of non-invasive therapeutic strategies. Here, we report for the first time the cases of non-invasive intervention with REBACIN®, a proprietary antiviral biologics, in clinical treatment of HSIL. From 12,958 visiting patients assessed for eligibility, 18 HSIL-patients with cervical intraepithelial neoplasia-grade 2, positive of both diffused overexpression of p16 and high-risk HPV were enrolled in this non-invasive clinical intervention mainly due to concerns of future fertility. REBACIN® was administered intravaginally every other day for 3 months (one-course) except during menstrual period, and were followed up for 6-36 months for the examination of high-risk HPV DNA, cervical cytology, and histopathology. After one to three course treatments, most cases (16/18) displayed both the regression from HSIL (CIN2) to normal cervical cytology and clearance of high-risk HPV infection. Further studies demonstrated REBACIN® significantly suppressed HPV16 E7 oncoprotein expression in a human cervical cancer cell line, which is consistent with previous finding that REBACIN® inhibits the growth of tumors induced by expression of E6/E7 oncogenes of either HPV16 or HPV18. This report indicates REBACIN® as a novel effective non-invasive clinical intervention for HSIL-patients as well for high-risk HPV persistent infection, providing a new clinical option for the non-invasive treatment of hrHPV-associated high-grade squamous intraepithelial lesion, which is worthy of further research on clinical validation and application.

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