scholarly journals The prevalence of Gasterophilus intestinalis (Diptera: Oestridae) in donkeys (Equus asinus) in Egypt with special reference to larvicidal effects of neem seed oil extract (Azadirachta indica) on third stage larvae

2018 ◽  
Vol 8 (4) ◽  
pp. 423 ◽  
Author(s):  
Marwa M. Attia ◽  
Marwa M. Khalifa ◽  
Olfat A. Mahdy
Keyword(s):  
Special Reference ◽  
Azadirachta Indica ◽  
Seed Oil ◽  
Neem Seed ◽  
Equus Asinus ◽  
Third Stage ◽  
Neem Seed Oil ◽  
Oil Extract

Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats

2014 ◽  
Vol 1 (3) ◽  
pp. 66 ◽  
Author(s):  
ManasRanjan Naik ◽  
Divya Agrawal ◽  
Rasmirekha Behera ◽  
Ayon Bhattacharya ◽  
Suhasini Dehury ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Seed Oil ◽  
Albino Rats ◽  
Neem Seed ◽  
Neem Seed Oil ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals CHARACTERIZATION OF PHYSICOCHEMICAL PROPERTIES AND BIOACTIVE COMPOUNDS OF OIL FROM NASCENT SEEDS OF AZADIRACHTA INDICA

2020 ◽  
Vol 8 (9) ◽  
pp. 1436-1441
Author(s):  
Samuel Atabo ◽  
◽  
Zara Muhammad ◽  
Kurmi Ann Pyeng ◽  
◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Bioactive Compounds ◽  
Iodine Value ◽  
Azadirachta Indica ◽  
Seed Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Neem Seed ◽  
Saponification Value ◽  
Neem Seed Oil ◽  
Pharmaceutical Industries

Depending on composition, fatty acids of plant sources are explicitly useful in food, chemical and pharmaceutical industries. The present study characterizes Soxhlet extracted neem seed oil by determination of physicochemical properties and bioactive compounds. Extraction involved the use of solvent semi-continuous extraction method for 6 hours with N-hexane. Percentage Oil yield was at 39. Saponification value (50.490mgKOH/g), Iodine value (50.28g/100g), Acid value (5.610mgKOH/g), Free fatty acid (2.805w/w), Peroxide value (62.75meq/kg) and Specific gravity (0.948) were determined. Density at 250C, Flash point, boiling point, melting point, colour and Odour provided supportive information to the major physicochemical properties analyzed. Gas Chromatography - Mass Spectrometry (GC-MS) of the Soxhlet extracted Neem Seed oil showed different peak values of industrially essential compounds such as 7-Pentadecyne, Glycidyl palmitate, Oleic Acid, 9,12-Octadecadienoic acid and methyl ester (Omega-6 acid). Saponification value was found to be high, suggesting the presence of FFA with low molecular weight, which brands the oil as essential in cosmetic and food industries. Low Iodine value and low total acidity seems to consolidate the usefulness of neem seed oil in cosmetic industries. Conversely, the high peroxide level makes it unsuitable for cooking. It may therefore be inferred that Soxhlet extracted Azadirachta indica seed may be industrially viable but less suitable for consumption.

Removal of free fatty acid in Azadirachta indica (Neem) seed oil using phosphoric acid modified mordenite for biodiesel production

2010 ◽  
Vol 101 (15) ◽  
pp. 5897-5902 ◽  
Author(s):  
Vasanthakumar SathyaSelvabala ◽  
Thiruvengadaravi Kadathur Varathachary ◽  
Dinesh Kirupha Selvaraj ◽  
Vijayalakshmi Ponnusamy ◽  
Sivanesan Subramanian
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Phosphoric Acid ◽  
Azadirachta Indica ◽  
Seed Oil ◽  
Biodiesel Production ◽  
Neem Seed ◽  
Neem Seed Oil

scholarly journals Protective effects of neem (Azadirachta indica A. Juss) seed oil on carbon tetrachloride-induced hepatotoxicity in Wistar rats

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
MacDonald Idu ◽  
Oghale Ovuakporie-Uvo ◽  
Suzan O. Okojie
Keyword(s):  
Carbon Tetrachloride ◽  
Azadirachta Indica ◽  
Wistar Rats ◽  
Seed Oil ◽  
Hepatoprotective Effect ◽  
Fatty Tissue ◽  
Neem Seed ◽  
Animal Body ◽  
Neem Seed Oil ◽  
Dose Dependent

Background: Azadirachta indica (neem) seed oil was evaluated for its hepatoprotective effect. Liver damage was induced using carbon tetrachloride (CCl4) while silymarin served as a positive control.Aim: This study is aimed at testing the hepatoprotective potentials of A. indica seed oil on Wistar rats.Method: Hepatotoxicity was induced by the administration of 1.0 mL/kg of CCl4 subcutaneously to 72 healthy Wistar rats of both sexes (weight range: 145 g – 315 g). The seed oil of A. indica was orally administered daily in various doses of 0.25 mL/kg, 0.5 mL/kg and 1.0 mL/kg for 14 days. Animal body and organ weights were recorded, while blood and liver tissues were collected for biochemical, haematological and histological analyses.Results: Treatment with neem seed oil lowered the aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels significantly (P < 0.05) in a dose-dependent manner compared to the control. The haematological parameters, organ weight index and animal body weight showed no significant difference (P > 0.05) when compared with the control. Histology assessment was in agreement with the biochemical result as tissues of CCl4 exhibited significant fatty tissue accumulation, as opposed to that of 0.25 mL/kg neem treatment, which showed only moderate accumulation of fatty tissues, while higher doses, 0.5 mL/kg and 1.0 mL/kg, showed a healthy liver as compared with the control.Conclusion: The result of this study revealed that neem seed oil had a dose-dependent hepatoprotective effect on the experimental rats.

scholarly journals Physicochemical, Druggable, ADMET Pharmacoinformatics and Therapeutic Potentials of Azadirachtin - a Prenol Lipid (Triterpenoid) from Seed Oil Extracts of Azadirachta indica A. Juss.

2021 ◽  
Vol 11 (5) ◽  
pp. 33-46
Author(s):  
T. Loganathan ◽  
A. Barathinivas ◽  
C. Soorya ◽  
S. Balamurugan ◽  
T. G. Nagajothi ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Seed Oil ◽  
Stem Bark ◽  
Pharmacological Properties ◽  
Plant Parts ◽  
Plant Seeds ◽  
Neem Seed Oil ◽  
Oil Extract ◽  
Bioactive Secondary Metabolite ◽  
Different Parts

Azadirachtin (AZA) is the most abundant bioactive secondary metabolite (BASM) in neem seed oil extract (NSOE) of Azadirachta indica A. Juss. AZA is localised in different parts of the plant (seeds, fruits, flowers, leaves, stem, bark and root) however, with varying degree of concentration. It has been documented that maximum concentration of AZA is present to the tune of 48000 μg g-1 in the seeds. It has been established that the environmental conditions determines the overall content and composition of BASM in different parts of the plant. Neem plant parts are most commonly used as therapeutic agents in remote villages in India for its ethnomedicinal therapeutic potentials; however, its physicochemical, druggable and pharmacological properties inadequately described. In the present study an attempt has been made to evaluate the physicochemical, druggable and pharmacological properties of Azadirachtin in NSOE of A. indica from ADMET perspectives. Keywords: NEEM; Azadirachta indica; Azadirachtin; Pharmacoinformatics; ADMET; Drug-Likeness; Toxicology

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