scholarly journals Effect of Ethanol Leaf Extract of Newboulda Laevis on Blood Glucose Levels of Diabetic Rats

2011 ◽  
Vol 10 (3) ◽  
Author(s):  
OJ Owolabi ◽  
FC Amaechina ◽  
M Okoro
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT EFFECTS OF ETHANOLIC LEAF EXTRACT OF ERYTHRINA ABBYSINICA LAM, EX DC

2018 ◽  
Vol 11 (8) ◽  
pp. 300
Author(s):  
Kamadyaapa Davie Rexon ◽  
Gondwe Mavuto Masopera ◽  
Shauli Mathulo ◽  
Sewani Rusike Constance ◽  
Nkeh Chungag Benedicta
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Antioxidant Properties ◽  
Diabetic Rats ◽  
Control Group ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Ethanolic Leaf Extract ◽  
Antioxidant Effects

  Objective: This study was conducted to scientifically evaluate the antidiabetic and antioxidant effects of ethanolic leaf extract of Erythrina abbysinica (EEA).Methods: Acute and sub-chronic effects of EEA at 100, 200, and 400 mg/kg/bwt and glibenclamide (GL) at 5 mg/kg/bwt. were evaluated in both normal and streptozotocin (STZ)-induced diabetic male Wistar rats (250–300 g). The acute studies were performed using oral glucose tolerance test (OGTT). In sub-chronic studies, animals were orally administered with EEA and GL daily for 6 w. Brine shrimp assay was used to determine the toxicity of EEA. 1, 1-diphenyl-2-picrylhydrazyl, ferric reducing capacity of plasma, and thiobarbituric acid reactive substances assays were used to determine antioxidant properties of EEA.Results: Following OGTT, EEA significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in both normal and STZ-induced diabetic rats when compared with positive and negative control counterparts at all-time points, whereas GL significantly (p<0.05) decreased blood glucose only in normal rats but not in diabetic rats. Daily, oral administration of EEA for 6 w significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in STZ-induced diabetic rats when compared with the diabetic control group. EEA revealed weak toxicity with a lethal concentration50 value of 997 μg/ml). Furthermore, EEA showed significant free radical scavenging, total antioxidant, and anti-lipid peroxidative capacities.Conclusion: The study has shed more light on the scientific basis for the use of E. abbysinica in management of diabetes in some communities of Eastern Cape of South Africa.

Effect of Aloe vera leaf extract on blood glucose levels in alloxan induced diabetic rats

2016 ◽  
Vol 6 (5) ◽  
pp. 471 ◽  
Author(s):  
Manjunath K ◽  
Bhanu G ◽  
Subash KR ◽  
Tadvi NA ◽  
Manikanta M ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

2021 ◽  
Vol 10 (4) ◽  
pp. 394-400
Author(s):  
Godwin Christian Akuodor ◽  
Pius Monday Udia ◽  
Sylvester Chika Ohadoma ◽  
Ifeanyi M. Obi ◽  
Anthony Uchenna Megwas ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
New Drugs ◽  
Haematological Parameters ◽  
Potential Candidate ◽  
Glucose Levels ◽  
Blood Glucose Levels

Introduction: Salacia lehmbachii is used traditionally for the treatment of diabetes mellitus. This study investigated the hypoglycaemic potentials of ethanol leaf extract of S. lehmbachii and its effects on alloxan-induced diabetic rats’ haematological parameters. Methods: A total of 36 male Wistar rats including normal, diabetic untreated, and diabetic treated ones were used in this study. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. When confirmed diabetes, the rats were orally administered 100 mg/kg, 200 mg/kg, and 400 mg/kg daily of the leaf extract for 21 days. The blood glucose levels and haematological parameters were determined in diabetic treated rats compared with the controls. Results: The ethanol leaf extract of S. lehmbachii significantly reduced the blood glucose levels of alloxan-induced diabetic rats when compared with the diabetic control (P < 0.01). The extract also significantly (P < 0.01) improved the haematological parameters of treated rats at three doses employed. Conclusion: It can be concluded that the ethanol leaf extract of S. lehmbachii possesses antihyperglycaemic properties and could be considered a potential candidate for the development of new drugs in the treatment of anaemic conditions.

NEUROPROTECTIVE POTENTIAL OF AZADIRACHTA INDICA LEAVES IN DIABETIC RATS

2017 ◽  
Vol 10 (4) ◽  
pp. 243
Author(s):  
Nidhi Srivastva ◽  
Naveen Kumar Gupta ◽  
Sanjeev Puri ◽  
Veena Puri
Keyword(s):  
Blood Glucose ◽  
Azadirachta Indica ◽  
Leaf Extract ◽  
Microscopic Analysis ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sprague Dawley Rats ◽  
Neuro Protection

Objective: Azadirachta indica is a treasure of multiple pharmacological properties and presently leaves of this plant have been explored to evaluate the neuroprotective potential in diabetic rats.Methods: Male Sprague-Dawley rats were injected with single intra peritoneal dose of streptozotocin (60mg/ Kg body weight (BW.) to develop animal model of diabetes. Post twenty one days of streptozotocin induction, animals were treated with aqueous Azadirachta indica Leaf Extract (ALE, 600mg/Kg BW.) for seven consecutive days. Followed this, all animals were evaluated for the levels of blood glucose, lipid peroxidation (LPO), C Reactive Proteins (CRP), pro oxidant biomarkers and histological changes.Results: Streptozotocin treated rats exhibited elevated levels of blood glucose, LPO, CRP and altered pro oxidant biomarkers in comparison to control rats. Additionally, histological alterations/damage was evidenced as fragmentation, vacuolization, inflammation etc. However, ALE treatment to these rats significantly decreased blood glucose levels, LPO, CRP levels and restored pro-oxidants status. Light microscopic and ultra microscopic analysis also indicated less damage, tissue architectural changes in comparison to untreated diabetic rats. Further decrease in hyperalgesia and inflammation levels; along with protective and restorative changes following ALE treatment suggested the neuroprotective potential of Azadirachta indica leaves in diabetic rats.Conclusion: The oral administration of ALE to streptozotocin induced diabetic animals resulted in neuro-protection against degenerative oxidative stress associated with metabolic and histopathological damage in the brain.Key words:  Azadirachta indica, Antioxidants, Hyperalgesia, Neuroprotection  

INSIGHT OF METHANOLIC EXTRACT OF VENTILAGO MADERASPATANA LEAVES ON HEPATOPROTECTIVE ACTIVITY UNDER STREPTOZOTOCIN-INDUCED DIABETIC RATS

2020 ◽  
pp. 73-76
Author(s):  
VENUGOPAL REDDY B ◽  
RAMANA REDDY M ◽  
VENKATA SUBBAIAH G ◽  
SATHYAVELU REDDY K
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Positive Control ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective: The methanolic leaf extract of Ventilago maderaspatana (MEVML, 200 mg/kg body weight [b.w.]) was investigate to hepatoprotective activity under streptozotocin-induced (45 mg/kg b.w.) diabetic (Di) rats. Methods: In the present study, we determined the blood glucose levels, b.w., insulin, creatinine, and bilirubin levels in normal, Di, Di treated with MEVML and positive control rats. Results: The Di rats shown adverse changes in blood glucose levels, b.w., insulin, creatinine, and bilirubin levels when compared to other group rats. Reverse the adverse changes in the above parameters when treated the Di rats with MEVML Conclusion: The MEVML shown anti-diabetic activity and reverse the adverse changes in the above parameters in liver so that the MEVML supported the traditional claim of the hepatoprotective activity under Di condition.

scholarly journals Phytochemical compositions, and hypoglycemic effect of methanol leaf extract of Telfairia Occidentalis in alloxan-induced diabetic rats

2021 ◽  
Vol 01 (01) ◽  
pp. 52-60
Author(s):  
Asmau N. Abubakar ◽  
Fatimah O. Badmos ◽  
Abubakar N. Saidu ◽  
Ibrahim O. Yunus ◽  
Bashir Lawal
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Appreciable Amount ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Telfairia Occidentalis ◽  
Alloxan Monohydrate

Background: The use of medicinal plants for the treatment of diabetes is increasing due to several reasons such as safety, affordability and efficacy. In the present study, the phytochemical compositions and hypoglycemic effect of the methanol leaf extract of Telfairia occidentalis (ML-TO) were investigated. Methods: Phytochemical screening was conducted using standard methods. Fifteen rats were divided into 5 groups (n=3). Diabetes was induced in rats allocated to groups A-D using alloxan monohydrate (120 mg/kg BW) and was treated with 200 and 400 mg/kg BW ML-TO, 5 mg/kg BW glibenclamide and 5 ml/kg BW normal saline respectively. All treatments were administered orally, once daily for 29 days. Results: The results revealed that the ML-TO contains phenols, alkaloids, tannins, steroids, glycosides while flavonoids and saponins were not detected. Quantitatively, total phenols (9570±13.24 µg/mg) was the most abundant phytochemicals identified while tannins (3000.56±23.45 µg/mg) and alkaloids (0.2378±0.013µg/mg) were also present in appreciable amount in ML-TO. The extract produced a significant (p <0.05) and dose-dependent hypoglycemic effect with maximum activities occurring at 400 mg/kg BW having suppressed the fasting blood glucose levels from 334±33.62 to 137±37.31 mg/dL while the rats treated with 200 mg/kg BW lowered blood glucose level from 386±171 to 174±108.55mg/dL. The standard antidiabetic drug (Glibenclamide) produced a comparable hypoglycemic effect and suppressed the FBS from 350±169.74 to125±76.35 mg/dL. Conclusion: ML-To had a significant hypoglycemic effect and was able to ameliorate the weight loss in the diabetic rats, hence it could serve as a source of potential hypoglycemic agent

ANTIDIABETIC EFFECTS OF KNEMA GLAUCA LEAF EXTRACT TOWARD INHIBITIONS OF Α-AMYLASE AND Α-GLUCOSIDASE ASSAYS

2016 ◽  
Vol 78 (5-3) ◽  
Author(s):  
Faridahanim Mohd Jaafar ◽  
Mohamad Jemain Mohamad Ridhwan ◽  
Nik Musa’adah Mustapha ◽  
Asmah Alias ◽  
Nor Hadiani Ismail
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Challenge Test ◽  
Diabetic Rats ◽  
Biologically Active ◽  
Postprandial Hyperglycaemia ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Inhibitory Activities

This study was part of our preliminary work in the search for biologically active compounds from endemic plants of Kuala Keniam National Park, Pahang, Malaysia. Postprandial hyperglycaemia is linked to the development of diabetes complications such as micro and macro vascular diseases. Inhibitions of carbohydrate digestive key enzymes, α-amylase and α-glucosidase using plant extracts are possible therapeutic strategies to suppress postprandial hyperglycaemia. The aim of this study was to investigate the effects of the dichloromethane leaf extract of Knema glauca (DLKG) in vitro and in vivo α-amylase and α-glucosidase inhibitory activities. The antidiabetic property of DLKG was investigated by using in vitro α-amylase and α-glucosidase inhibitory activity assays. The effects of DLKG on oral starch and sucrose challenge tests were investigated by administering 125, 250 and 500 mg/kg of the extract to normal and diabetic rats. DLKG demonstrated potent α-amylase and α-glucosidase inhibitory activities with IC50 values of 1.26 and 4.09 µg/ml, respectively. In the oral starch challenge test, the extract significantly (p<0.05) reduced blood glucose levels in both normal and diabetic rats. On the other hand, DLKG showed significant (p<0.05) reduction of blood glucose levels in normal rats in the oral sucrose challenge test. The results showed that the leaves of K. glauca possessed a beneficial effect in reducing postprandial hyperglycaemia and have potential as an alternative antidiabetic agent.

scholarly journals Antidiabetic and anti-oxidant activities of the methanol leaf extract of Vernonia amygdalina in alloxan-induced diabetes in Wistar rats

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Adegbolagun T. Adeoye ◽  
Ademola A. Oyagbemi ◽  
Aduragbenro D. Adedapo ◽  
Temidayo O. Omobowale ◽  
Abiodun E. Ayodele ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Biochemical Indices

The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p < 0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p < 0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

Mentha pulegium Aqueous Extract Exhibits Antidiabetic and Hepatoprotective Effects in Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (3) ◽  
pp. 292-301
Author(s):  
Omar Farid ◽  
Naoufel Ali Zeggwagh ◽  
Fadwa EL Ouadi ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Aqueous Extract ◽  
Morphometric Analysis ◽  
Diabetic Rats ◽  
Mentha Pulegium ◽  
Glucose Levels ◽  
Histological Sections ◽  
Blood Glucose Levels ◽  
Liver And Pancreas

Objective: The aim of this work was to evaluate the antihyperglycemic activity of aerial parts aqueous extract (A.P.A.E) of Mentha pulegium (M. pulegium) on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rat. The glucose tolerance was evaluated in normal rats. Moreover, the histological sections and morphometric analysis at the liver and pancreas have been carried out in this investigation both in normal and STZ-diabetic rats. Methods: The effect of A.P.A.E of M. pulegium (20 mg/kg) on blood glucose levels was investigated in normal and diabetic rats (n=6). Histopathological changes in liver and pancreas were examined under phase contrast microscope and a preliminary screening for various bioactive constituents was realized according to standard methods. Key Findings: Both single and repeated oral administration of A.P.A.E (20 mg/kg) caused a significant reduction in blood glucose levels in STZ-diabetic rats (p<0.0001). The morphometric analysis and histological sections realized in pancreas and liver have showed the beneficial effect of the A.P.A.E in cellular population. According to oral glucose tolerance test (OGTT), the aqueous extract has revealed an improvement of glucose tolerance in normal rat. Furthermore, the preliminary phytochemical screening of A.P.A.E of M. pulegium has demonstrated the presence of various metabolite compounds including polyphenols, flavonoids, terpenoids tannins, cyanidins, sesquiterpenes, and glycosides. Conclusion: We conclude that the A.P.A.E of M. pulegium (20 mg/kg) exhibits a potent antihyperglycemic activity in STZ diabetic rats.

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