B Values of Pearson's r correlation coefficient for different levels of significance

2014 ◽  
pp. 208-208
Author(s):  
Prasanthi Polamreddy ◽  
Vinita Vishwakarma ◽  
Manoj Kumar Mahto

Objective: The objective of the current study was to elucidate the 3D pharmacophoric features of benzothiadiazine derivatives that are crucial for inhibiting Hepatitis C virus (HCV) Non-structural protein 5B (NS5B) and quantifying the features by building an atom based 3D quantitative structure-activity relationship (3D QSAR) model.Methods: Generation of QSAR model was carried out using PHASE 3.3.Results: A five-point pharmacophore model with two hydrogen bond acceptors, one negative ionization potential and two aromatic rings (AANRR) was found to be common among a maximum number of benzothiadiazine based NS5B inhibitors. A statistically significant 3D QSAR model was obtained from AANRR.6 which had correlation-coefficient (R2) value of 0.924, cross-validated correlation-coefficient (Q2) of 0.774, high Fisher ratio of 138 and low root mean square standard error (RMSE=0.29). There is another parameter, Pearson’s R, its value emphasizes correlation between predicted and observed activities of the test set. For the current model, Pearson’s R-value is 0.90, hence underlining the good quality of the model. The present study suggests that nitrogen atom of benzothiadiazine sulfamide ring, oxyacetamide group attached to C7 carbon of benzothiadiazine and sulfonamide oxygens are crucial for NS5B inhibitory activity. Prediction of activities of hit drugs generated in earlier research suggests that Aprepitant (Phase predicted activity: 6.9) could be a potential NS5B inhibitor.Conclusion: This 3D QSAR model developed was statistically good and can be used to predict the activities of newly designed NS5B inhibitors and virtual screening as well. Predict the activities of newly designed NS5B inhibitors and virtual screening as well.


1984 ◽  
Vol 55 (3) ◽  
pp. 967-976 ◽  
Author(s):  
Clive G. Hazell

This study explored the relationships of experienced levels of emptiness and existential concern with level of emotional development, as measured by the Definition/Response instrument of Gage, Morse, and Piechowski and profile of values as measured by the Allport, Vernon, and Lindzey Study of Values. 24 respondents completed measures of experienced levels of emptiness and existential concern, the Definition/Response instrument and the Study of Values. Hypotheses were tested using Pearson's r and multiple regression. Experienced level of emptiness was positively correlated with theoretical interest and level of emotional development and was inversely correlated with economic interest. Experienced existential concern was correlated directly with religious interest and with emotional development. These results question hypotheses about emptiness that (a) argue the experience of emptiness results solely from developmental deficits, (b) do not differentiate between “revealed emptiness” and “concealed emptiness,” and (c) neglect to include profile of values in the explanation.


2016 ◽  
Vol 61 (8) ◽  
pp. 18-31
Author(s):  
Mirosława Kaczmarek

The article presents the results of the clustering voivodships based on variables characterizing the phenomenon of poverty. The analysis is based on data available in the CSO’s Local Data Bank. The selection of diagnostic features was made on the basis of the coefficients of variation and Pearson’s r correlation coefficient. The grouping of voivodships was made using the k-means method. There were created four categories of voivodships differing in the symptoms of poverty. In order to answer the question whether the changes in the symptoms of poverty are taking place on the map of Poland, an analysis was conducted in two periods: for 2013 and 2008.


GeroPsych ◽  
2014 ◽  
Vol 27 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Anne Kuemmel (This author contributed eq ◽  
Julia Haberstroh (This author contributed ◽  
Johannes Pantel

Communication and communication behaviors in situational contexts are essential conditions for well-being and quality of life in people with dementia. Measuring methods, however, are limited. The CODEM instrument, a standardized observational communication behavior assessment tool, was developed and evaluated on the basis of the current state of research in dementia care and social-communicative behavior. Initially, interrater reliability was examined by means of videoratings (N = 10 people with dementia). Thereupon, six caregivers in six German nursing homes observed 69 residents suffering from dementia and used CODEM to rate their communication behavior. The interrater reliability of CODEM was excellent (mean κ = .79; intraclass correlation = .91). Statistical analysis indicated that CODEM had excellent internal consistency (Cronbach’s α = .95). CODEM also showed excellent convergent validity (Pearson’s R = .88) as well as discriminant validity (Pearson’s R = .63). Confirmatory factor analysis verified the two-factor solution of verbal/content aspects and nonverbal/relationship aspects. With regard to the severity of the disease, the content and relational aspects of communication exhibited different trends. CODEM proved to be a reliable, valid, and sensitive assessment tool for examining communication behavior in the field of dementia. CODEM also provides researchers a feasible examination tool for measuring effects of psychosocial intervention studies that strive to improve communication behavior and well-being in dementia.


Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 146
Author(s):  
Ivan Peric ◽  
Miodrag Spasic ◽  
Dario Novak ◽  
Sergej Ostojic ◽  
Damir Sekulic

Background: Due to its association with the risk of falling and consequent injury, the importance of agility is widely recognized, but no study so far has examined the different facets of agility in an untrained/clinical population. The aim of this study was to evaluate the reliability, validity, and correlates of newly developed tests of non-planned agility (NPA) and pre-planned agility (PPA) in an untrained/clinical sample. Methods: The sample comprised 38 participants older than 40 years (22 females, age: 56.1 ± 17.3 years, height: 170.4 ± 10.8 cm, mass: 82.54 ± 14.79 kg) who were involved in a rehabilitation program following total knee arthroplasty and knee arthroscopy. Variables included age, gender, type of surgery, history of fall, anthropometrics/body composition, and newly developed tests of NPA and PPA. Results: The results showed the high inter-testing- (ICC > 0.95, CV < 9%), and intra-testing-reliability (ICC > 0.96, CV < 9) of the newly developed tests. PPA and NPA were found to be valid in differentiation between age groups (>50 yrs. vs. <50 yrs.), and genders, with better performance in younger participants and males. Only NPA differentiated participants according to type of surgery, with better performance in those who had arthroscopic surgery, than those who had total knee arthroplasty. No differences in NPA and PPA were established between groups based on fall-history. In females, the body mass (Pearson’s r = 0.58 and 0.59, p < 0.001) and body fatness (Pearson’s r = 0.64 and 0.66, p < 0.001) were negatively correlated, while the lean body mass (Pearson’s r = 0.70 and 0.68, p < 0.001) was positively correlated with PPA and NPA. The NPA and PPA were highly correlated (Pearson’s r = 0.98, p < 0.001). Conclusions: We found that the proposed tests are reliable when evaluating agility characteristics in an untrained/clinical population after knee arthroplasty/arthroscopy. Further evaluation of the specific validity of the proposed tests in other specific subsamples is warranted.


2016 ◽  
Vol 41 (4) ◽  
pp. 625-632 ◽  
Author(s):  
MA Mannan ◽  
N Tarannum

An experiment was conducted to find out the influence of three irrigation levels (no irrigation, one irrigation and two irrigation) on four mustard varieties (Tori- 7, BARI Sharisha-6, BARI Sharisha-9 and BARI Sharisha-8). The non-irrigated plots had highest aphid population (34.96/plant) and lowest (11.16 aphids/plant) in two irrigation. The variety BARI Sharisha-8 showed lowest (5.34 aphids/plant) aphid infestation and its yield was highest (2.05 ton/ha). Interaction effects indicated that the crop escaped from the aphid incidence in the variety BARI Sharisha-8 irrigated 2 times and produced highest yield (2.37 ton/ha). The differences in the aphid population at three irrigation levels affected the yield contributing characters and it was negatively correlated (correlation coefficient value ‘r’ ranged from -0.91 to 1.0).Bangladesh J. Agril. Res. 41(4): 625-632, December 2016


2019 ◽  
Vol 2 (2) ◽  
pp. 55-60
Author(s):  
Ayuk Naimah
Keyword(s):  

Beberapa faktor risiko yang dapat menyebabkan ISPA adalah menyelimuti berlebihan, pemberian makanan tambahan terlalu dini, kurangnya pemberian ASI, imunisasi, polusi udara, tempat tinggal yang padat, kurangnya ventilasi dan sosial ekonomi. Desain penelitian ini adalah analitik survey sampai peneliti memenuhi target yang diinginkan dalam waktu satu bulan secara bertahap dengan menyebarkan kuesioner pada 35 responden. Subyek yang diteliti ditarik dari populasi dengan cara Teknik pengambilan sampel dalam penelitian menggunakan total sampling. Penelitian ini dilakukan pada bulan September 2017 yang ditabulasi silang diperoleh hasil hampir seluruhnya responden tingkat pengetahuan kurang sejumlah 32 responden (91.4%) terjadi ISPA, dan sebagian kecil responden tingkat pengetahuan cukup sejumlah 3 responden (8.6%) tidak terjadi ISPA. Analisis data dengan menggunakan uji Krusskal Wallis didapatkan interprestasi hasil Pearson's R = 1.000, sehingga dibanding dengan Krusskal-Wallis Correlation = 1.000. Dari hasil data tersebut dikatakan ada hubungan jika Pearson's R = Kruskal-Wallis Correlation maka H1 diterima. Setelah dilakukan perhitungan menggunakan SPSS maka didapatkan hubungan koefisien korelasi 0,80 – 1,000 korelasi sangat kuat. Kesimpulan dari penelitian ini bahwa tingkat pengetahuan ibu bekerja dalam pemberian ASI dengan kejadian ISPA pada bayi usia ? 1 tahun berhubung sangat kuat. Pada ibu bekerja tingkat pengetahuan dalam pemberian ASI kurang maka akan terjadi ISPA. Dalam pemberian ASI pada waktu ibu bekerja tidak dapat dijadikan alasan untuk tidak memberikan ASI pada bayinya, banyak upaya yang dapat dilakukan oleh ibu dan yang terpenting adalah perubahan pikiran serta komitmen sebagai orang tua untuk mengutamakan kesehatan dan tumbuh kembang pada bayinya.Kata Kunci : Kejadian ISPA, Pengetahuan Ibu Bekerja, Pemberian ASI


2020 ◽  
Vol 5 (2) ◽  
pp. 186-193
Author(s):  
Mella Yusef Fintiya ◽  
Imanuel Sri Mei Wulandari

Tuberkulosis adalah penyakit infeksi paru yang disebabkan oleh Mycobacterium Tuberculosis. Di Indonesia kasus tuberkulosis setiap tahunnya semakin meningkat. Indonesia menepati urutan ke-6 penderita tuberkulosis tertinggi di dunia, sedangkan Jawa Barat menepati urutan pertama. Tujuan penelitian ini adalah untuk melihat adanya hubungan anatar efikasi diri dengan kepatuhan minum obat OAT. Metode penelitian menggunakan desain deskriptif korelasional dengan pendekatan cross sectional dengan melibatkan 23 responden yang sedang menjalani pengobatan di puskesmas parongpong, responden dipilih dengan menggunakan Purposive sampling. Variabel independen adalah efikasi diri, variabel dependent adalah kepatuhan minum obat. Instrumen dalam penelitian ini adalah kuesioner yang dianalisis menggunakan pearson’s r . Hasil dan analisis Efikasi Diri dengan Kepatuhan Minum obat mempunyai hubungan  dengan nilai  p-value 0,030 atau (p ≤ 0,05) dengan tingkat hubungan sedang (0,454). Efikasi merupakan salah satu faktor yang mempengaruhi kepatuhan minum obat pasien tuberkulosis di wilayah kerja Puskesmas Parongpong. Saran untuk penelitian selanjutnya perlu mengetahui peran kader kesehatan dalam kepatuhan minum obat.


Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2839
Author(s):  
Ayane S. Resende ◽  
Geovana S. F. Leite ◽  
Antonio H. Lancha Junior

Nutrient consumption and body mass index (BMI) are closely related to the gut microbiota, and exercise effects on gut bacteria composition may be related to those variables. Thus, we aimed to investigate the effect of 10-week moderate aerobic exercise on the cardiorespiratory fitness and gut bacteria composition of non-obese men with the same nutritional profile. Twenty-four previously sedentary men (age 25.18 [SD 4.66] years, BMI 24.5 [SD 3.72] kg/m2) were randomly assigned into Control (CG; n = 12) or Exercise Groups (EG; n = 12). Body composition, cardiorespiratory parameters, blood markers, dietary habits and gut bacteria composition were evaluated. EG performed 150 min per week of supervised moderate (60–65% of VO2peak) aerobic exercise, while CG maintained their daily routine. The V4 16S rRNA gene was sequenced and treated using QIIME software. Only EG demonstrated marked improvements in cardiorespiratory fitness (VO2peak, p < 0.05; Effect Size = 0.971) without changes in other gut bacteria-affecting variables. Exercise did not promote clustering based on diversity indices (p > 0.05), although significant variations in an unclassified genus from Clostridiales order and in Streptococcus genus were observed (p < 0.05). Moreover, α-diversity was correlated with VO2peak (Pearson’s R: 0.47; R2 0.23: 95%CI: 0.09 to 0.74, p = 0.02) and BMI (Pearson’s R: −0.50; R2 0.25: 95%CI: −0.75 to −0.12, p = 0.01). Roseburia, Sutterella and Odoribacter genera were associated with VO2peak, while Desulfovibrio and Faecalibacterium genera were associated with body composition (p < 0.05). Our study indicates that aerobic exercise at moderate intensity improved VO2peak and affected gut bacteria composition of non-obese men who maintained a balanced consumption of nutrients.


1958 ◽  
Vol 13 (9) ◽  
pp. 545-546 ◽  
Author(s):  
Paul Hanly Furfey
Keyword(s):  

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