AN ANALYTICAL STUDY ON VALMIKA MRITTIKA (ANTHILL SOIL)

Valmika Mrittika (ant hill soil) is widely used in clinical practice by folklore practitioners in most of the skin ailments. Lepa of Valmika Mrittika has wonderful effects on skin. Many temples in South Canara, give this Valmika Mrittika as Prasadam for the skin disorders. Acne Vulgaris is a common skin disorder of pilosebaceous unit that primarily affects the face, chest and back which if not treated may lead to permanent scarring. Youvana Pidaka (Acne vulgaris) occurs due to vitiation of Kapha, Vata as Doshas, Rakta and Twak as Dooshyas. Valmika Mrittika is very effective in Kapha-Vataja disorder. As disease limited to skin, Lepa Chikitsa is most suitable and convenient treatment suggested for acne. Hence, an in vitro analytical study of Valmika Mrittika w.s.r to Youvana Pidaka (Acne vulgaris) was conducted. Valmika Mrittika collected and analytical study was done including macronutrients and micronutrients. Analytical study revealed the contents such as Protein – 800 μg/g, Phenols-0.03μg/g, Tannins-0.24μg/g in the sample of Valmika Mrittika which are found to have anti acne and Varnya properties.

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Sidharthakadi Lepa in Mukhadushika - A Clinical Study

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i01.11631 ◽

2018 ◽

Vol 3 (01) ◽

Author(s):

Ravindra Angadi ◽

Rekha J.

Keyword(s):

Skin Disorder ◽

Acne Vulgaris ◽

Response To Therapy ◽

Inclusion Criteria ◽

Pilosebaceous Unit ◽

External Application ◽

Acne Lesion ◽

Common Skin ◽

The Face ◽

Inflammatory Component

Background: Acne vulgaris is a very common malady of adolescents. It is common enough to be called as a physiological process but is better regarded as a disease due to its inflammatory component and the disfigurement. Acne vulgaris is a common skin disorder of pilosebaceous unit that primarily affects the face which if not treated leads to pigmentation. Mukhadushika is a Kshudra Roga which mainly involves Kapha and Vatadosa with Raktha. This is a common illness affecting 80 % of adolescents. Lepa is one of the external therapies explained in Ayurvedic classics. Objectives: To evaluate the efficacy of Sidharthakadilepa in the management of mukhadushikaw.s.r. to acne vulgaris. Methods: 30 patients fulfilling the inclusion criteria were selected. They were given Sidharthakadi Lepa for external application over face for one month. Patients were observed for changes on 7th, 14th, 21st and 28th day. The response to therapy was evaluated at the end of 28 days by calculating acne lesion score and the efficacy was determined by the percentage reduction in ALS. Results: The analysis revealed that 40% of patients had complete remission, 30% patients showed marked improvement and 30% showed moderate improvement.

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Dermatology

Oxford Handbook of Clinical Specialties ◽

10.1093/med/9780198719021.003.0008 ◽

2016 ◽

pp. 582-611

Author(s):

Andrew Baldwin ◽

Nina Hjelde ◽

Charlotte Goumalatsou ◽

Gil Myers

Keyword(s):

Malignant Melanoma ◽

Acne Vulgaris ◽

Systemic Disease ◽

Pyogenic Granuloma ◽

Skin Disorders ◽

Venous Ulcers ◽

Drug Eruptions ◽

Skin Cancers ◽

Common Skin ◽

Skin Signs

This chapter explores dermatology. It includes history and examination, creams and ointments, describing a lesion, patterns of skin disease, itch, skin signs in systemic disease, common skin cancers, malignant melanoma, moles, psoriasis, eczema (dermatitis), skin infections (fungi, bacteria, viruses), acne vulgaris, rosacea, drug eruptions, specific skin disorders (pemphigus and pemphigoid, strawberry naevus, pyogenic granuloma, lichen planus, pityriasis rosea, alopecia, photosensitivity, urticaria), venous ulcers, pressure sores, skin disorders and HIV, infestations, and psychodermatoses.

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DEVLOPMENT AND INVITRO EVALUATION OF NANOSUSPENSION GEL OF BENZOYL PEROXIDE

Asian Journal of Pharmaceutical Research and Development ◽

10.22270/ajprd.v7i4.515 ◽

1970 ◽

Vol 7 (4) ◽

pp. 49-55

Author(s):

Rahul Kumar Ancheria ◽

Saloni Jain ◽

Deepak Kumar ◽

Shankar Lal Soni

Keyword(s):

Benzoyl Peroxide ◽

Acne Vulgaris ◽

Antifungal Drugs ◽

The Body ◽

Specific Site ◽

Pilosebaceous Unit ◽

Site Of Action ◽

Common Skin ◽

Novel Drug ◽

Active Entity

Novel drug delivery systems are designed with an intend to deliver drugs to the specific site at a rate and extent directed by the needs of the body and it directs an active entity to specific site of action during the period of treatment. Acne vulgaris is a common skin disease, affecting about 70-80% of adolescents and young adults. It is a multifactorial disease of the pilosebaceous unit. it has been developed as possible carriers to deliver antifungal drugs to the target site and to enhance an epidermal permeation across the skin.this article we present benzoyl peroxide can increase solubility and permeability of topical used.when benzoyl peroxide is very widely used in the mild to moderate acne vulgaris and rosacea. KEYWORDS-

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To Study Effect of Dashang Lepa in Mukhdushika

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v5i5.202 ◽

2018 ◽

Vol 5 (5) ◽

Author(s):

Chandrasekhar Yadavrao Bangarwar

Keyword(s):

Clinical Practice ◽

Traditional Medicine ◽

Systematic Study ◽

Health Problem ◽

Acne Vulgaris ◽

Research Work ◽

Social Health ◽

Sebaceous Glands ◽

The Face

Though Ayurveda is India's ancient traditional medicine written Thousands of years back, its concepts and principles are useful in today's era also. My small research work can be one example of it. Mukhdushika also was known as Youvanpeetika is a common health problem found in Adolescence which disturbs physical psychological and social health. Mukhdushika known as acne vulgaris is the classical stigma of adolescence and inflammation of sebaceous glands which produces physiological and psychological scarring. Dashang lepa is commonly used for shotha in clinical practice, but when it was applied as lepa on the face, its effectiveness was observed in mukhadushika. So after considering effective experience in mukhadushika I decided to go for its systematic study through this small research work, to study the effect of dashang lepa in mukhadushika.

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Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

Pharmaceutics ◽

10.3390/pharmaceutics13010046 ◽

2020 ◽

Vol 13 (1) ◽

pp. 46

Author(s):

Khaled M. Hosny ◽

Khalid S. Al Nahyah ◽

Nabil A. Alhakamy

Keyword(s):

Ex Vivo ◽

Acne Vulgaris ◽

Topical Administration ◽

Hepatoprotective Activity ◽

In Vivo Studies ◽

Enhanced Solubility ◽

Staphyloccocus Aureus ◽

Common Skin

Acne vulgaris is a common skin disease that affects everybody at least once in their lives. The treatment is challenging because the stratum corneum contains rigid corneocytes surrounded by intercellular lamellae that are difficult to bypass. In the present study, we intended to formulate an effective nanoemulsion that could deliver isotretinoin (ITT) with enhanced solubility, permeability, and bioavailability across the skin. ITT can have a serious hepatotoxic effect if given too frequently or erratically. Therefore, to overcome the aforesaid limitation, quercetin (QRS), a hepatoprotective agent, was incorporated into the formulation. Initially, the ITT solubility was determined in various surfactants and cosurfactants to select the essential ingredients to be used in the formulation and to optimize a nanoemulsion that could enhance the solubility and permeability of ITT and its antimicrobial activity against Staphyloccocus aureus, which is the main microorganism responsible for acne vulgaris. The mixture design was applied to study the interactions and optimize the independent variables that could match the prerequisites of selected dependent responses. A formulation containing 0.25 g of rosehip oil, 0.45 g of surfactant (Lauroglycol-90), and 0.3 g of cosurfactant (propylene glycol) was chosen as an optimized desirable formulation. The optimized batch was loaded with QRS and evaluated for in vitro and ex vivo permeation. The in vivo hepatotoxicity was assessed through topical administration. Permeability studies confirmed the enhanced permeation percentage of ITT (52.11 ± 2.85%) and QRS (25.44 ± 3.18%) of the optimized formulation, with an enhanced steady-state flux (Jss). The in vivo studies conducted on experimental animals demonstrated superior hepatoprotective activity of the prepared optimized formulation compared with other formulations of drugs and commercially marketed products. We anticipate that this optimized ITT formulation, followed up with good clinical evaluations, can be a breakthrough in the safe treatment of acne vulgaris.

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Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety

Cosmetics ◽

10.3390/cosmetics7030070 ◽

2020 ◽

Vol 7 (3) ◽

pp. 70 ◽

Cited By ~ 2

Author(s):

Muhammed Majeed ◽

Shaheen Majeed ◽

Kalyanam Nagabhushanam ◽

Lakshmi Mundkur ◽

H. R. Rajalakshmi ◽

...

Keyword(s):

Antimicrobial Activity ◽

Benzoyl Peroxide ◽

Pathogenic Bacteria ◽

Reductase Activity ◽

Acne Vulgaris ◽

Visual Assessment ◽

Open Label ◽

Cutibacterium Acnes ◽

Common Skin

Acne vulgaris is a common skin disorder of pilosebaceous units. The therapy for mild-to-moderate acne includes topical antibiotics, benzoyl peroxide and retinoids. In this open-label, randomized monocentric study, we compared the efficacy of LactoSporin® 2% w/w cream with benzoyl peroxide in 64 male and female subjects with mild-to-moderate acne for three weeks. The efficacy parameters were evaluated based on the dermatologist visual assessment and instrumental measurements using Sebumeter® MPA580, Antera 3DTM and VISIA CR 2.2 and subject self-assessment questionnaires. Adverse events were recorded throughout the study period. In order to understand the mechanism of action and properties of LactoSporin, the pH stability, thermostability, antimicrobial activity and 5-alpha reductase activity were evaluated in vitro. A significant improvement was observed in the dermatological assessment of closed comedones (p < 0.0001), open comedones (p = 0.0069) and papules count (p < 0.0001) in comparison to the baseline in both LactoSporin and benzoyl peroxide groups. The antera analysis showed significant improvement in redness (p < 0.0001) and elevation (p < 0.0001) (small and medium) in both the treatment groups. The sebumeter analysis showed a significant decrease in sebaceous secretion (p < 0.0001) for LactoSporin, which resulted in reduced oiliness, pimples, acne spots and redness around the acne spot. The product was found to be safe without any irritancy. LactoSporin was stable at an acidic pH and temperature range of 70 to 90 °C, with antimicrobial activity against various pathogenic bacteria, including Cutibacterium acnes. It was also a potent inhibitor of 5-alpha reductase activity. Thus, it can be concluded that the efficacy of LactoSporin is equivalent to benzoyl peroxide in the treatment of mild-to-moderate acne lesions and better than benzoyl peroxide for reducing the sebaceous secretion and oily, greasy nature of the skin, implying its efficacy in other sebohorriec conditions.

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Ayurvedic treatment of Yuvan pidika w.s.r to acne vulgaris: a case study.

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v9i01.751 ◽

2021 ◽

Vol 9 (01) ◽

Author(s):

Sanket Shirode ◽

Dr Yogesh Wane ◽

Dr.Kirtibala Tawade

Keyword(s):

Acne Vulgaris ◽

Immune Surveillance ◽

Primary Immune Response ◽

Sebaceous Glands ◽

Microbial Invasion ◽

Chronic Inflammatory Condition ◽

Common Skin ◽

The Face ◽

Ayurvedic Treatment

Ayurveda is the most ancient system of health of the world. Skin forms a barrier against microbial invasion and has properties, which can protect against mechanism, chemical, osmotic, thermal and uv radiation damage. Skin is an important site of immune surveillance against the entry of pathogens and the initiation of primary immune response. Skin is the target of a variety of hormones. These activities can affect the appearance and the functional of individual skin component such as sebaceous glands, hairs and pigment producing cells. Acne is the most common skin disease of now a day. So we decided to take the help of this ancient system of science to fight against this acne vulgaris. An acne vagary is a chronic inflammatory condition of the pilo-sebaceous follicles on the face and upper trunk. It is characterized by the development of black heads, papules, pustules and cysts, which may resolve to leave pitted scars. In Ayurvedic classics we get the knows about this disease in the name of Yuvan pidika, the eruptions like Salmali thorn, on the face during adulthood, caused by Kapha, Vata and Rakta are known as 'Yuvan pidika'.

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Clinical Cosmetology

International Journal of Clinical & Experimental Dermatology ◽

10.33140/ijced.04.01.04 ◽

2019 ◽

Vol 4 (1) ◽

Keyword(s):

Young Adults ◽

Salicylic Acid ◽

Young Adult ◽

Economic Burden ◽

Skin Disorder ◽

Glycolic Acid ◽

Acne Vulgaris ◽

Common Skin ◽

Chemical Peeling ◽

Good Agent

Chemical peeling is a widely used procedure in the management of acne and acne scars. Acne vulgaris is the most common skin disorder in adolescents and young adults. It carries a significant psychological and economic burden to patients and society. Salicylic acid has been used to treat various skin disorders for more than 2,000 years. The ability of salicylic acid to exfoliate the stratum corneum makes it a good agent for peeling. This report entitles the young adult female with acne and was treated with Salicylic acid and glycolic acid peel and the desired outcome was assessed.

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Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic Resistant Acne-Related Bacteria

10.20944/preprints201704.0076.v1 ◽

2017 ◽

Cited By ~ 1

Author(s):

Ji-Hoon Kim ◽

Daeung Yu ◽

Sung-Hwan Eom ◽

Song-Hee Kim ◽

Junghwan Oh ◽

...

Keyword(s):

Antibacterial Activity ◽

Caffeic Acid ◽

Inhibitory Concentration ◽

Skin Diseases ◽

Acne Vulgaris ◽

Bacterial Strains ◽

Antibiotic Resistant ◽

Common Skin ◽

Acid Conjugate

The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, which is one of the most common skin diseases. Acne vulgaris often associates with acne-related bacteria such as Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, some of which exhibit a resistant against commercial antibiotics used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). In the current study, we evaluated in vitro antibacterial activity of chitosan-phytochemical conjugates against acne-related bacteria. Three of chitosan-phytochemical conjugates used in this study showed stronger antibacterial activity than that of chitosan (unmodified control). Chitosan-caffeic acid conjugate (CCA) exhibited the highest antibacterial activity against acne-related bacteria with minimum inhibitory concentration values of 8 μg/mL to 256 μg/mL. In addition, the MICs of antibiotics against antibiotic resistant P. acnes and P. aeruginosa strains were dramatically reduced in the combination with CCA, suggesting that CCA would restore the antibacterial activity of the antibiotics. The analysis of fractional inhibitory concentration indices clearly revealed a synergistic antibacterial effect between CCA and the antibiotics. Thus, the median ∑FIC values against the antibiotic resistant bacterial strains were ranged from 0.375 to 0.533 in the combination mode of CCA and antibiotics.

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A Comparative Formulation Development and Evaluation of Tazarotene Ethosomal and Transfersomal Gel for Effective Management of Acne

International Journal of Nanoscience ◽

10.1142/s0219581x20500052 ◽

2020 ◽

Vol 19 (06) ◽

pp. 2050005

Author(s):

Bera Piumitali ◽

Upmanyu Neeraj ◽

Dubey Rupal ◽

Pandey Arun Kumar

Keyword(s):

Prolonged Exposure ◽

Acne Vulgaris ◽

In Vitro Release ◽

Formulation Development ◽

Adrenal Androgen ◽

Permeation Study ◽

Causative Agents ◽

The Face

Acne vulgaris is the most prevalent disorder in the period before puberty when increased adrenal androgen level causes enlargement of the sebaceous glands and it increased the production of sebum on the face, chest, and back. This disease is caused due to interaction between many causative agents or pathogenic components which lead to formation of the acne and those are seborrhea, follicular hyper keratinization, microbial formation of pilosebaceous unit by Propionibacterium acne and arrival of inflammatory mediators. Tazarotene is a well-known retinoid related to vitamin A that belongs to an acetylenic class of retinoid, used in the management of acne. Oral administration of Tazarotene causes changes in bone morphology after prolonged exposure to high doses, which also exhibit teratogenicity but this does not occur with topical delivery. Ethosomes are non-invasive delivery carriers enabling drugs to reach to the bottom of the skin layers and/or the system and transfersomes are the self-adaptable ultra-deformable flexible elastic bilayer vesicles composed of phospholipids able to penetrate through the pores of skin even smaller than its size. Present research aims the comparative evaluation of ethosomal and transfersomal gels loaded with Tazarotene in the treatment of acne. In the present study, ethosomes and transfersomes were formulated by the cold method and hand-shaking method, respectively, followed by loading of Tazarotene and development into gel formulation. The formulated gel samples were evaluated for in vitro release study, in vitro permeation study, in vitro anti-acne study, in vivo percutaneous permeation study by CLSM, and in vivo anti-acne study. The results proved that both the formulated ethosomal and transfersomal gels have better permeation through the skin but ethosomal gel showed better release in comparison to transfersomal gel, also final gels exhibited the anti-acne potentiality.

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